The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Breaking bad: Manipulation of the host response by Porphyromonas gingivalis
Open accessAbstract
Recent metagenomic and mechanistic studies are consistent with a new model of periodontal pathogenesis. This model proposes that periodontal disease is initiated by a synergistic and dysbiotic microbial community rather than by a select few bacteria traditionally known as “periopathogens.” Low‐abundance bacteria with community‐wide effects that are critical for the development of dysbiosis are now known as keystone pathogens, the best‐documented example of which is P orphyromonas gingivalis. Here, we review established mechanisms by which P. gingivalis interferes with host immunity and enables the emergence of dysbiotic communities. We integrate the role of P. gingivalis with that of other bacteria acting upstream and downstream in pathogenesis. Accessory pathogens act upstream to facilitate P. gingivalis colonization and co‐ordinate metabolic activities, whereas commensals‐turned pathobionts act downstream and contribute to destructive inflammation. The recent concepts of keystone pathogens, along with polymicrobial synergy and dysbiosis, have profound implications for the development of therapeutic options for periodontal disease.
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Cites
Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050
Dewhirst, F. E., Chen, T., Izard, J., Paster, B. J., Tanner, A. C. R., Yu, W.-H., Lakshmanan, A., & Wade, W. G. (2010) · Journal of Bacteriology · doi:10.1128/jb.00542-10 · Cited by 3,352
The keystone-pathogen hypothesis
Hajishengallis, G., Darveau, R. P., & Curtis, M. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2873 · Cited by 1,790
Self-citationPeriodontitis: a polymicrobial disruption of host homeostasis
Darveau, R. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2337 · Cited by 1,688
Targeting IL-17 and TH17 cells in chronic inflammation
Miossec, P., & Kolls, J. K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3794 · Cited by 1,414
“Blooming” in the gut: how dysbiosis might contribute to pathogen evolution.
Stecher, B., Maier, L., & Hardt, W.-D. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2989 · Cited by 378
Gaffen, S. L., & Hajishengallis, G. (2008) · Journal of Dental Research · doi:10.1177/154405910808700908 · Cited by 334
Self-citationHayashi, C., Gudino, C. V., Gibson III, F. C., & Genco, C. A. (2010) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2010.00582.x · Cited by 244
Comparison of neutrophil functions in aggressive and chronic periodontitis
Ryder, M. I. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00327.x · Cited by 199
Microbial interactions in building of communities
Wright, C. J., Burns, L. H., Jack, A. A., Back, C. R., Dutton, L. C., Nobbs, A. H., Lamont, R. J., & Jenkinson, H. F. (2013) · Molecular Oral Microbiology · doi:10.1111/omi.12012 · Cited by 185
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Cited by
Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046
Self-citationThe Oral Microbiota: Dynamic Communities and Host Interactions
Lamont, R. J., Koo, H., & Hajishengallis, G. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0089-x · Cited by 2,217
Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line
How, K. Y., Song, K. P., & Chan, K. G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00053 · Cited by 858
Polymicrobial synergy and dysbiosis in inflammatory disease
Lamont, R. J., & Hajishengallis, G. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.11.004 · Cited by 585
Self-citationBasic biology and role of interleukin‐17 in immunity and inflammation
Zenobia, C., & Hajishengallis, G. (2015) · Periodontology 2000 · doi:10.1111/prd.12083 · Cited by 470
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Metadata
- Authors
- Hajishengallis, G., & Lamont, R. J.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2014-02
- Volume
- 44
- Issue
- 2
- Pages
- 328-338
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W1571823809
- Cited by
- 336
- References
- 11
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hajishengallis, G., & Lamont, R. J. (2014). Breaking bad: Manipulation of the host response by Porphyromonas gingivalis. European Journal of Immunology. https://doi.org/10.1002/eji.201344202
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
