Three sides of the same coin: Measuring global cognitive impairment with the MMSE, ADAS‐cog and CAMCOG
Abstract
OBJECTIVE: The total scores of the ADAS-cog, MMSE and CAMCOG, comprising various cognitive tasks, are widely used to measure a dimension of global cognitive impairment. It is unknown, however, whether this dimension is common to these instruments. This hampers comparisons when either of these instruments is used. The extent to which these instruments share a common dimension of global cognitive impairment and how their scores relate was examined. METHODS: Rasch analysis of CAMCOG and MMSE data of participants from a population based study and two memory clinics pooled with ADAS-cog and MMSE data of participants from three RCTs (overall N = 1566) to estimate a common dimension of global cognitive impairment and to examine the goodness of fit of the individual items to this dimension. RESULTS: Using the estimated common dimension of global cognitive impairment, the total scores of the instruments could be related, e.g. a mean level of global cognitive impairment corresponded to a predicted score of 11.4 (ADAS-cog), 72.6 (CAMCOG) and 22.2 (MMSE). When revised according to The Rasch validity analyses, every individual item could be fitted to the dimension. CONCLUSIONS: The MMSE, ADAS-cog and CAMCOG reflect a valid common dimension of global cognitive impairment, which enables comparisons of RCTs that use the ADAS-cog and observational studies that use the CAMCOG and MMSE.
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The CAMCOG has good inter-rater reliability (r = .97), high sensitivity (92%) and specificity (96%).
“The CAMCOG has good inter-rater reliability (r = .97),high sensitivity (92%) and specificity (96%: Roth et al., 1986;Wouters, van Gool, Schmand, Zwinderman, & Lindeboom, 2010).”
From Living alone and cognitive function in later life (2019) · cites this paper as Wouters et al., 2010
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Living alone and cognitive function in later life
Evans, I. E. M., Llewellyn, D. J., Matthews, F. E., Woods, R. T., Brayne, C., & Clare, L. (2019) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2018.12.014 · Cited by 142 · see citing works
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- Authors
- Wouters, H., van Gool, W. A., Schmand, B., Zwinderman, A. H., & Lindeboom, R.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Wouters, Hans
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 2010-07-07
- Volume
- 25
- Issue
- 8
- Pages
- 770-779
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- OpenAlex
- W2081353032
- Cited by
- 43
- References
- 70
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 7
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Internationale Stichting Alzheimer Onderzoek
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
- Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
- Keywords
- global cognitive impairment, Montreal Cognitive Assessment, Alzheimer's Disease Assessment Scale, CAMCOG, Mini-Mental State Examination, Rasch analysis, construct validity, cognitive assessment tools, instrument comparability, dementia
- MeSH terms
- Aged, Aged, 80 and over, Cognition Disorders, Female, Humans, Male, Neuropsychological Tests, Psychiatric Status Rating Scales
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