Dissociating stimulus-driven semantic and phonological effect during reading and naming
Open accessAbstract
The aim of the present study was to dissociate the neural correlates of semantic and phonological processes during word reading and picture naming. Previous studies have addressed this issue by contrasting tasks involving semantic and phonological decisions. However, these tasks engage verbal short-term memory and executive functions that are not required for reading and naming. Here, 20 subjects were instructed to overtly name written words and pictures of objects while their neuronal responses were measured using functional magnetic resonance imaging (fMRI). Each trial consisted of a pair of successive stimuli that were either semantically related (e.g., "ROBIN-nest"), phonologically related (e.g., "BELL-belt"), unrelated (e.g., "KITE-lobster"), or semantically and phonologically identical (e.g., "FRIDGE-fridge"). In addition, a pair of stimuli could be presented in either the same modality (word-word or picture-picture) or a different modality (word-picture or picture-word). We report that semantically related pairs modulate neuronal responses in a left-lateralized network, including the pars orbitalis of the inferior frontal gyrus, the middle temporal gyrus, the angular gyrus, and the superior frontal gyrus. We propose that these areas are involved in stimulus-driven semantic processes. In contrast, phonologically related pairs modulate neuronal responses in bilateral insula. This region is therefore implicated in the discrimination of similar, competing phonological and articulatory codes. The above effects were detected with both words and pictures and did not differ between the two modalities even with a less conservative statistical threshold. In conclusion, this study dissociates the effects of semantic and phonological relatedness between successive items during reading and naming aloud.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bilateral insula activation increases during overt picture naming when phonological/articulatory interference increases.
“A similar explanation may account for why bilateral insula activation increases during overt picture naming when phonological/articulatory interference increases (Mechelli et al., 2007).”
From A review and synthesis of the first 20years of PET and fMRI studies of heard speech, spoken language and reading (2012) · cites this paper as Mechelli et al., 2007
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688 · see citing works
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., & Frith, C. D. (2004) · Science · doi:10.1126/science.1093535 · Cited by 3,929 · see citing works
Spatial registration and normalization of images
Friston, K. J., Ashburner, J., Frith, C., Poline, J.-B., Heather, J. D., & Frackowiak, R. S. J. (1995) · Human Brain Mapping · doi:10.1002/hbm.460030303 · Cited by 3,744 · see citing works
DISCONNEXION SYNDROMES IN ANIMALS AND MAN
Geschwind, N. (1965) · Brain · doi:10.1093/brain/88.2.237 · Cited by 3,419 · see citing works
Models of reading aloud: Dual-route and parallel-distributed-processing approaches.
Coltheart, M., Curtis, B., Atkins, P., & Haller, M. (1993) · Psychological Review · doi:10.1037/0033-295x.100.4.589 · Cited by 1,735 · see citing works
SEMANTIC DEMENTIA: PROGRESSIVE FLUENT APHASIA WITH TEMPORAL LOBE ATROPHY
HODGES, J. R., PATTERSON, K., OXBURY, S., & FUNNELL, E. (1992) · Brain · doi:10.1093/brain/115.6.1783 · Cited by 1,710 · see citing works
Meta-analysis of the functional neuroanatomy of single-word reading: method and validation
Turkeltaub, P. E., Eden, G. F., Jones, K. M., & Zeffiro, T. A. (2002) · NeuroImage · doi:10.1006/nimg.2002.1131 · Cited by 1,604 · see citing works
Poldrack, R. A., Wagner, A. D., Prull, M. W., Desmond, J. E., Glover, G. H., & Gabrieli, J. D. E. (1999) · NeuroImage · doi:10.1006/nimg.1999.0441 · Cited by 1,448 · see citing works
Human Brain Language Areas Identified by Functional Magnetic Resonance Imaging
Binder, J. R., Frost, J. A., Hammeke, T. A., Cox, R. W., Rao, S. M., & Prieto, T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00353.1997 · Cited by 1,424 · see citing works
A new brain region for coordinating speech articulation
Dronkers, N. F. (1996) · Nature · doi:10.1038/384159a0 · Cited by 1,192 · see citing works
THE ANATOMY OF PHONOLOGICAL AND SEMANTIC PROCESSING IN NORMAL SUBJECTS
Démonet, J., Chollet, F., Ramsay, S. C., Cardebat, D., Nespoulous, J., WISE, R., Rascol, A., & Frackowiak, R. S. J. (1992) · Brain · doi:10.1093/brain/115.6.1753 · Cited by 1,145 · see citing works
Patterns of paralexia: A psycholinguistic approach
Marshall, J. C., & Newcombe, F. (1973) · Journal of Psycholinguistic Research · doi:10.1007/bf01067101 · Cited by 1,039 · see citing works
Generalisability, Random Effects & Population Inference
Holmes, A. P., & Friston, K. J. (1998) · NeuroImage · doi:10.1016/s1053-8119(18)31587-8 · Cited by 906 · see citing works
Non-verbal semantic impairment in semantic dementia
Bozeat, S., Lambon Ralph, M. A., Patterson, K., Garrard, P., & Hodges, J. R. (2000) · Neuropsychologia · doi:10.1016/s0028-3932(00)00034-8 · Cited by 884 · see citing works
Self-citationSchacter, D. L., & Buckner, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80448-1 · Cited by 837 · see citing works
Neuroimaging studies of priming
Henson, R. N. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00086-8 · Cited by 745 · see citing works
The cognitive neuropsychology of language
Lavorel, P. M. (1988) · Neuropsychologia · doi:10.1016/0028-3932(88)90068-1 · Cited by 656 · see citing works
Dapretto (1999) · doi:10.1016/s0896-6273(00)80855-7 · Cited by 655 · see citing works
Buckner, R. L., Goodman, J. M., Burock, M. A., Rotte, M., Koutstaal, W., Schacter, D. L., Rosen, B. R., & Dale, A. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80456-0 · Cited by 622 · see citing works
Context effects in Stroop-like word and picture processing.
Glaser, W. R., & Glaser, M. O. (1989) · Journal of Experimental Psychology General · doi:10.1037//0096-3445.118.1.13 · Cited by 615 · see citing works
Devlin, J. T., Matthews, P. M., & Rushworth, M. F. S. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903321107837 · Cited by 577 · see citing works
Brain regions involved in articulation
Wise, R., Greene, J., Büchel, C., & Scott, S. (1999) · The Lancet · doi:10.1016/s0140-6736(98)07491-1 · Cited by 517 · see citing works
Context effects in Stroop-like word and picture processing.
Glaser, W. R., & Glaser, M. O. (1989) · Journal of Experimental Psychology General · doi:10.1037/0096-3445.118.1.13 · Cited by 495 · see citing works
Segregating Semantic from Phonological Processes during Reading
Price, C. J., Moore, C. J., Humphreys, G. W., & Wise, R. J. S. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.6.727 · Cited by 445 · see citing works
Self-citationSusceptibility-Induced Loss of Signal: Comparing PET and fMRI on a Semantic Task
Devlin, J. T., Russell, R. P., Davis, M. H., Price, C. J., Wilson, J. L., Moss, H. E., Matthews, P. M., & TYLER, L. K. (2000) · NeuroImage · doi:10.1006/nimg.2000.0595 · Cited by 439 · see citing works
Self-citationEvent-related functional magnetic resonance imaging: modelling, inference and optimization
Josephs, O., & Henson, R. N. A. (1999) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1999.0475 · Cited by 425 · see citing works
Self-citationRegional cerebral blood flow during object naming and word reading
Bookheimer, S. Y., Zeffiro, T. A., Blaxton, T., Gaillard, W., & Theodore, W. (1995) · Human Brain Mapping · doi:10.1002/hbm.460030206 · Cited by 410 · see citing works
Functional Neuroanatomy of the Semantic System: Divisible by What?
Mummery, C. J., Patterson, K. E., Hodges, J. R., & Price, C. J. (1998) · Journal of Cognitive Neuroscience · doi:10.1162/089892998563059 · Cited by 400 · see citing works
Self-citationMcDermott, K. B., Petersen, S. E., Watson, J. M., & Ojemann, J. G. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(02)00162-8 · Cited by 393 · see citing works
Three Distinct Ventral Occipitotemporal Regions for Reading and Object Naming
Moore, C. J., & Price, C. J. (1999) · NeuroImage · doi:10.1006/nimg.1999.0450 · Cited by 383 · see citing works
Self-citationKoutstaal, W., Wagner, A. D., Rotte, M., Maril, A., Buckner, R. L., & Schacter, D. L. (2001) · Neuropsychologia · doi:10.1016/s0028-3932(00)00087-7 · Cited by 355 · see citing works
The role of conceptual knowledge in object use Evidence from semantic dementia
Hodges, J. R. (2000) · Brain · doi:10.1093/brain/123.9.1913 · Cited by 351 · see citing works
The contribution of the insula to motor aspects of speech production: A review and a hypothesis
Ackermann, H., & Riecker, A. (2004) · Brain and Language · doi:10.1016/s0093-934x(03)00347-x · Cited by 343 · see citing works
Speech production: Wernicke, Broca and beyond
Blank, S. C. (2002) · Brain · doi:10.1093/brain/awf191 · Cited by 342 · see citing works
Contribution a l'etude anatomo-pathologique et clinique des differentes varietes de cecite verbale
Dejerine, J. (2000) · Neurocase · doi:10.1093/neucas/6.4.275 · Cited by 341 · see citing works
The cognitive neuropsychology of language
Coltheart, M., Sartori, G., & Job, R. (1987) · Cited by 325 · see citing works
Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula
Nestor, P. J. (2003) · Brain · doi:10.1093/brain/awg240 · Cited by 324 · see citing works
Riecker, A., Ackermann, H., Wildgruber, D., Dogil, G., & Grodd, W. (2000) · Neuroreport · doi:10.1097/00001756-200006260-00038 · Cited by 318 · see citing works
Kotz, S. A. (2002) · NeuroImage · doi:10.1006/nimg.2002.1316 · Cited by 290 · see citing works
Delineation of single‐word semantic comprehension deficits in aphasia, with anatomical correlation
Hart, J., & Gordon, B. (1990) · Annals of Neurology · doi:10.1002/ana.410270303 · Cited by 280 · see citing works
An Event-Related fMRI Investigation of Implicit Semantic Priming
Rissman, J., Eliassen, J., & Blumstein, S. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903322598120 · Cited by 280 · see citing works
Speak and Spell: Dissociations and Word-Class Effects
Coltheart, M., Sartori, G., & Job, R. (2013) · Psychology Press eBooks · doi:10.4324/9781315832807-39 · Cited by 278 · see citing works
Reading and reading disturbance
Price, C. J., & Mechelli, A. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.03.003 · Cited by 255 · see citing works
Self-citationContribution à l’étude anatomopathologique et clinique des différents variétés de cécité verbale
Dejerine, J. (1892) · Max Planck Digital Library · Cited by 255 · see citing works
Task-specific Repetition Priming in Left Inferior Prefrontal Cortex
Wagner, A. D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.12.1176 · Cited by 249 · see citing works
The anatomy and time course of semantic priming investigated by fMRI and ERPs
Rossell, S. L., Price, C. J., & Nobre, A. C. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(02)00181-1 · Cited by 241 · see citing works
Self-citationWagner, A. D., Desmond, J. E., Demb, J. B., Glover, G. H., & Gabrieli, J. D. E. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.6.714 · Cited by 233 · see citing works
A PET study of cognitive strategies in normal subjects during language tasks
Démonet, J., Price, C. J., Wise, R., & Frackowiak, R. S. J. (1994) · Brain · doi:10.1093/brain/117.4.671 · Cited by 199 · see citing works
Self-citationMeta‐analyses of object naming: Effect of baseline
Price, C. J., Devlin, J. T., Moore, C. J., Morton, C., & Laird, A. R. (2005) · Human Brain Mapping · doi:10.1002/hbm.20132 · Cited by 191 · see citing works
Self-citationDual-Process Model in Semantic Priming: A Functional Imaging Perspective
Mummery, C. J., Shallice, T., & Price, C. J. (1999) · NeuroImage · doi:10.1006/nimg.1999.0434 · Cited by 165 · see citing works
Self-citationA PET Study of Stimulus- and Task-Induced Semantic Processing
Noppeney, U., & Price, C. J. (2002) · NeuroImage · doi:10.1006/nimg.2001.1015 · Cited by 141 · see citing works
Self-citationGorno‐Tempini, M. L., Murray, R. C., Rankin, K. P., Weiner, M. W., & Miller, B. L. (2004) · Neurocase · doi:10.1080/13554790490894011 · Cited by 141 · see citing works
Computational approaches to network analysis in functional brain imaging
Gonzalez-Lima, F., McIntosh, A. R., & Fox, P. T. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020103 · Cited by 138 · see citing works
On the Status of Object Concepts in Aphasia
Chertkow, H. M., Bub, D. N., Deaudon, C., & Whitehead, V. (1997) · Brain and Language · doi:10.1006/brln.1997.1771 · Cited by 130 · see citing works
Copland, D. A., de Zubicaray, G. I., McMahon, K. L., Wilson, S. J., Eastburn, M., & Chenery, H. J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00279-9 · Cited by 130 · see citing works
How reading differs from object naming at the neuronal level
Price, C. J., McCrory, E. J. P., Noppeney, U., Mechelli, A., Moore, C. J., Biggio, N., & Devlin, J. T. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.044 · Cited by 87 · see citing works
Self-citationNoppeney, U., & Price, C. J. (2003) · Brain and Language · doi:10.1016/s0093-934x(02)00525-4 · Cited by 85 · see citing works
Self-citationORAL NAMING AND ORAL READING: DO THEY SPEAK THE SAME LANGUAGE?
Ralph, M. A. L. (1999) · Cognitive Neuropsychology · doi:10.1080/026432999380933 · Cited by 27 · see citing works
Kensinger, E. A., Siri, S., Cappa, S. F., et al. (2002) · Neuropsychologia · doi:10.1016/s0028-3932(02)00131-8 · Cited by 13 · see citing works
Herbster (1997) · doi:10.1002/(sici)1097-0193(1997)5:2
Flagged first, then by citations
Cited by
Sorted by citations
Price, C. J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.062 · Cited by 2,159 · see citing works
Self-citationMenenti, L., Petersson, K. M., Scheeringa, R., & Hagoort, P. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.21163 · Cited by 114 · see citing works
The impact of second language learning on semantic and nonsemantic first language reading
Nosarti, C., Mechelli, A., Green, D. W., & Price, C. J. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp101 · Cited by 96 · see citing works
Self-citationThe separation of processing stages in a lexical interference fMRI-paradigm
Abel, S., Dressel, K., Bitzer, R., Kümmerer, D., Mader, I., Weiller, C., & Huber, W. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.018 · Cited by 90 · see citing works
Less is more: neural mechanisms underlying anomia treatment in chronic aphasic patients
Nardo, D., Holland, R., Leff, A. P., Price, C. J., & Crinion, J. T. (2017) · Brain · doi:10.1093/brain/awx234 · Cited by 80 · see citing works
Self-citation
- Authors
- Mechelli, A., Josephs, O., Lambon Ralph, M. A., McClelland, J. L., & Price, C. J.
- Affiliations
- King's College London (GB)
- Wellcome Trust (GB)
- Center for the Neural Basis of Cognition (US)
- Corresponding author
- Mechelli, Andrea
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2007-02-13
- Volume
- 28
- Issue
- 3
- Pages
- 205-217
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC3261378
- OpenAlex
- W2097117521
- Cited by
- 97
- References
- 60
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 8 · 2018: 8 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 4 · 2012: 9
- FWCI
- 10.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust (051067)
- Topics
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- semantic relatedness, phonological relatedness, word reading, picture naming, phonological processing, insula, inferior frontal gyrus, angular gyrus, middle temporal gyrus, superior frontal gyrus, modality effects
- MeSH terms
- Adolescent, Adult, Brain, Brain Mapping, Child, Child, Preschool, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Phonetics, Photic Stimulation, Reading, Semantics, Speech, Visual Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
