A cross-modal system linking primary auditory and visual cortices: evidence from intrinsic fMRI connectivity analysis
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Recent anatomical and electrophysiological evidence in primates indicates the presence of direct connections between primary auditory and primary visual cortex that constitute cross-modal systems. We examined the intrinsic functional connectivity (fcMRI) of putative primary auditory cortex in 32 young adults during resting state scanning. We found that the medial Heschl's gyrus was strongly coupled, in particular, to visual cortex along the anterior banks of the calcarine fissure. This observation was confirmed using novel group-level, tensor-based independent components analysis. fcMRI analysis revealed that although overall coupling between the auditory and visual cortex was significantly reduced when subjects performed a visual perception task, coupling between the anterior calcarine cortex and auditory cortex was not disrupted. These results suggest that primary auditory cortex has a functionally distinct relationship with the anterior visual cortex, which is known to represent the peripheral visual field. Our study provides novel, fcMRI-based, support for a neural system involving low-level auditory and visual cortices.
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There is evidence for multisensory integration on the subcortical level and for direct anatomical connections between early auditory and early visual areas, mostly reaching peripheral regions.
“Apart from the route via multisensory areas, there is evidence for multisensory integration on the subcortical level [27] and for direct anatomical connections between early auditory and early visual areas [12, 28, 29], mostly reaching peripheral regions [12–14], consistent with both our eccentricity and searchlight results.”
From Decoding sound and imagery content in early visual cortex (2014) · cites this paper as [12]
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- Authors
- Eckert, M. A., Kamdar, N. V., Chang, C. E., Beckmann, C. F., Greicius, M. D., & Menon, V.
- Affiliations
- Medical University of South Carolina (US)
- Stanford Medicine (US)
- University of Oxford (GB)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2008-04-15
- Volume
- 29
- Issue
- 7
- Pages
- 848-857
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC2605422
- OpenAlex
- W2028394375
- Cited by
- 138
- References
- 51
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 11 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 13 · 2019: 7 · 2018: 4 · 2017: 8 · 2016: 10 · 2015: 7 · 2014: 4 · 2013: 5 · 2012: 8
- FWCI
- 15.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH62430, MH-19938, MH01142, K02MH001142, R03MH062430, T32MH019938)
- National Institute of Neurological Disorders and Stroke (K23NS048302, NS048302, NS058899, R21NS058899)
- National Center for Research Resources (C06RR014516)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD33113, K25HD040761, HD047520, P01HD033113, HD40761, R01HD031715, HD31715, R01HD047520)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- cross-modal integration, primary auditory cortex, primary visual cortex, functional connectivity, resting-state fMRI, calcarine fissure, peripheral visual field
- MeSH terms
- Adult, Auditory Cortex, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways, Visual Cortex, Principal Component Analysis
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