The Default Mode Network in Healthy Aging and Alzheimer′s Disease

Mevel, Katell; Chételat, Gaël; Eustache, Francis; Desgranges, Béatrice

doi:10.4061/2011/535816

Cited by 302Functional Brain Connectivity StudiesDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

The Default Mode Network in Healthy Aging and Alzheimer′s Disease

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Mevel, Katell, Chételat, Gaël, Eustache, Francis, Desgranges, Béatrice·2011·International Journal of Alzheimer’s Disease

DOI 10.4061/2011/535816PMC PMC3132539

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Abstract

In the past decade, a “default mode network” (DMN) has been highlighted in neuroimaging studies as a set of brain regions showing increased activity in task‐free state compared to cognitively demanding task, and synchronized activity at rest. Changes within this network have been described in healthy aging as well as in Alzheimer′s disease (AD) and populations at risk for AD, that is, amnestic Mild Cognitive Impairment (aMCI) patients and APOE‐ ε 4 carriers. This is of particular interest in the context of early diagnosis and more generally for our understanding of the physiopathological mechanisms of AD. This paper gives an overview of the anatomical and physiological characteristics of this network as well as its relationships with cognition, before focusing on changes in the DMN over normal aging and Alzheimer′s disease. While perturbations of the DMN have been consistently reported, especially within the posterior cingulate, further studies are needed to understand their clinical implication.

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AD patients show reduced ability to deactivate the DMN during memory encoding.
“Reduced ability to deactivate the DMN during memory encoding is found in AD patients [168–170]”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [169]

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Authors: Mevel, K., Chételat, G., Eustache, F., & Desgranges, B.
Affiliations: Inserm (FR)
Corresponding author: Desgranges, Béatrice
ORCID: Mevel, Katell
Chételat, Gaël
Eustache, Francis
Desgranges, Béatrice
Venue: International Journal of Alzheimer’s Disease
Publisher: Wiley
Published: 2011-01
Volume: 2011
Issue: 1
Pages: 535816-535816
ISSN: 2090-0252 (ISSN-L)
2090-8024
DOI: 10.4061/2011/535816
PMC: PMC3132539
OpenAlex: W2017033087
Cited by: 302
References: 103
Citations by year: 2026: 13 · 2025: 24 · 2024: 23 · 2023: 28 · 2022: 26 · 2021: 31 · 2020: 17 · 2019: 24 · 2018: 22 · 2017: 18 · 2016: 20 · 2015: 15 · 2014: 18 · 2013: 13 · 2012: 9
FWCI: 6.58
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor, 164 d)
Locations: International Journal of Alzheimer s Disease (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Agence Nationale de la Recherche
Institut National de la Santé et de la Recherche Médicale
Région Normandie
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords: default mode network, healthy aging, Alzheimer's disease, amnestic mild cognitive impairment, APOE ε4 carriers, posterior cingulate cortex, resting-state brain activity, early detection of Alzheimer's disease, cognitive function

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The Default Mode Network in Healthy Aging and Alzheimer′s Disease

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