Alcohol Intake Revisited: Risks and Benefits
Abstract
The relationship between alcohol consumption and health outcomes has a long history and has generated much research. Heavy drinking is detrimental to health; however, there is considerable and convincing evidence from both short-term biochemical experimental studies and observational studies of a beneficial association with certain health outcomes related to atherosclerotic processes. This beneficial association is most important for an average alcohol intake of one to two drinks per day. Important factors in determining the magnitude or direction of effects have been identified. Most criticisms based on methodological issues have been dismissed in recent years from an epidemiological point of view. However, important questions remain about the circumstances of such a beneficial association. The net effect of alcohol consumption on health outcomes is detrimental overall, owing to the negative effect of cancers, infectious disease, gastrointestinal diseases, alcohol-use disorders and injuries.
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The relationship between alcohol use and cardiovascular disease outcomes is complex, as different dimensions play a role for different outcomes.
“The relationship between alcohol use and cardiovascular disease outcomes is complex, as different dimensions play a role for different outcomes 238, 239, 240.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [238]
Cites
International Agency for Research on Cancer
National Cancer Institute (2020) · Definitions · doi:10.32388/pfg7jq · Cited by 9,493 · see citing works
Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60746-7 · Cited by 3,870 · see citing works
Self-citationGlobal Burden of Disease and Risk Factors
López, A. D., Mathers, C. D., Ezzati, M., Jamison, D. T. T., & Murray, C. J. L. (2006) · World Bank, Washington, DC eBooks · doi:10.1596/978-0-8213-6262-4 · Cited by 2,693 · see citing works
Systematic review and meta-analysis
Gillies, A. (2019) · CRC Press eBooks · doi:10.1201/9781315377315-19 · Cited by 2,659 · see citing works
Systematic Review and Meta-analysis
Garg, A. X., Hackam, D. G., & Tonelli, M. A. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01430307 · Cited by 2,252 · see citing works
Excess mortality of mental disorder
Harris, C., & Barraclough, B. (1998) · British Journal of Psychiatry · doi:10.1192/bjp.173.1.11 · Cited by 1,881 · see citing works
Theories of reasoned action and planned behavior as models of condom use: A meta-analysis.
Albarracín, D., Johnson, B. T., Fishbein, M., & Muellerleile, P. A. (2001) · Psychological Bulletin · doi:10.1037/0033-2909.127.1.142 · Cited by 1,806 · see citing works
Ronksley, P. E., Brien, S. E., Turner, B. J., Mukamal, K. J., & Ghali, W. A. (2011) · BMJ · doi:10.1136/bmj.d671 · Cited by 1,610 · see citing works
Dietary Guidelines for Americans, 2010
(2011) · Choice Reviews Online · doi:10.5860/choice.49-0615 · Cited by 1,571 · see citing works
Dietary Guidelines for Americans, 2010
Marshall, T. A. (2011) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2011.0248 · Cited by 1,401 · see citing works
Rimm, E. B., Williams, P., Fosher, K., Criqui, M., & Stampfer, M. J. (1999) · BMJ · doi:10.1136/bmj.319.7224.1523 · Cited by 1,360 · see citing works
Drivers of tuberculosis epidemics: The role of risk factors and social determinants
Lönnroth, K., Jaramillo, E., Williams, B. G., Dye, C., & Raviglione, M. C. (2009) · Social Science & Medicine · doi:10.1016/j.socscimed.2009.03.041 · Cited by 1,195 · see citing works
The relation between different dimensions of alcohol consumption and burden of disease: an overview
Rehm, J., Baliunas, D., Borges, G. L. G., Graham, K., Irving, H., Kehoe, T., Parry, C. D., Patra, J., Popova, S., Poznyak, V., et al. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.02899.x · Cited by 1,174 · see citing works
Self-citationCollaborative Group on Hormonal Factors in Breast Cancer (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600596 · Cited by 1,083 · see citing works
Di Castelnuovo, A. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.22.2437 · Cited by 930 · see citing works
Carcinogenicity of alcoholic beverages
Baan, R., Straif, K., Grosse, Y., Secretan, B., El Ghissassi, F., Bouvard, V., Altieri, A., & Cogliano, V. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70099-2 · Cited by 877 · see citing works
Alcohol and coronary heart disease: a meta-analysis.
Corrao, G., Rubbiati, L., Bagnardi, V., Zambon, A., & Poikolainen, K. (2000) · Addiction · doi:10.1046/j.1360-0443.2000.951015056.x · Cited by 875 · see citing works
Psychosocial correlates of heterosexual condom use: A meta-analysis.
Sheeran, P., Abraham, C., & Orbell, S. (1999) · Psychological Bulletin · doi:10.1037/0033-2909.125.1.90 · Cited by 853 · see citing works
Brien, S. E., Ronksley, P. E., Turner, B. J., Mukamal, K. J., & Ghali, W. A. (2011) · BMJ · doi:10.1136/bmj.d636 · Cited by 791 · see citing works
Alcohol as a Risk Factor for Type 2 Diabetes
Baliunas, D. O., Taylor, B. J., Irving, H., Roerecke, M., Patra, J., Mohapatra, S., & Rehm, J. (2009) · Diabetes Care · doi:10.2337/dc09-0227 · Cited by 703 · see citing works
Self-citationFedirko, V., Tramacere, I., Bagnardi, V., Rota, M., Scotti, L., Islami, F., Negri, E., Straíf, K., Romieu, I., Vecchia, C. L., et al. (2011) · Annals of Oncology · doi:10.1093/annonc/mdq653 · Cited by 681 · see citing works
Alcohol as a risk factor for liver cirrhosis: A systematic review and meta‐analysis
REHM, J., TAYLOR, B., MOHAPATRA, S., IRVING, H., BALIUNAS, D., PATRA, J., & ROERECKE, M. (2010) · Drug and Alcohol Review · doi:10.1111/j.1465-3362.2009.00153.x · Cited by 668 · see citing works
Self-citationEffect of alcohol consumption on systemic markers of inflammation
Imhof, A., Froehlich, M., Brenner, H., Boeing, H., Pepys, M. B., & Koenig, W. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04170-2 · Cited by 559 · see citing works
Alcohol use as a risk factor for tuberculosis – a systematic review
Lönnroth, K., Williams, B. G., Stadlin, S., Jaramillo, E., & Dye, C. (2008) · BMC Public Health · doi:10.1186/1471-2458-8-289 · Cited by 548 · see citing works
The quanitification of drug caused morbidity and mortality in Australia: Part 1
English, D. R., Holman, D., Milne, E., Winter, M., Hulse, G. K., Codde, J., Bower, C., Giles‐Corti, B., Dawes, V. P., de Klerk, N. H., et al. (1995) · UWA Profiles and Research Repository (UWA) · Cited by 464 · see citing works
Davies, M. J., Baer, D. J., Judd, J. T., Brown, E. D., Campbell, W. S., & Taylor, P. R. (2002) · JAMA · doi:10.1001/jama.287.19.2559 · Cited by 459 · see citing works
Rehm, J., Samokhvalov, A. V., Neuman, M. G., Room, R., Parry, C., Lönnroth, K., Patra, J., Poznyak, V., & Popova, S. (2009) · BMC Public Health · doi:10.1186/1471-2458-9-450 · Cited by 458 · see citing works
Self-citationDo intentions predict condom use? Metaanalysis and examination of six moderator variables
Sheeran, P., & Orbell, S. (1998) · British Journal of Social Psychology · doi:10.1111/j.2044-8309.1998.tb01167.x · Cited by 421 · see citing works
Demonstration of deductive meta-analysis: ethanol intake and risk of myocardial infarction
Maclure, M. (1993) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036124 · Cited by 397 · see citing works
Patra, J., Taylor, B., Irving, H. M., Roerecke, M., Baliunas, D. O., Mohapatra, S., & Rehm, J. T. (2010) · BMC Public Health · doi:10.1186/1471-2458-10-258 · Cited by 397 · see citing works
Self-citationAlcohol-related morbidity and mortality.
Rehm, J. T., Gmel, G. E., Sempos, C. T., & Trevisan, M. (2003) · Europe PMC (PubMed Central) · Cited by 395 · see citing works
Self-citationA Recent Perspective on Alcohol, Immunity, and Host Defense
Szabo, G., & Mandrekar, P. (2009) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00842.x · Cited by 387 · see citing works
Alcohol consumption and ethyl carbamate
Allen, N. E., Anderson, L. M., Beland, F. A., Bénichou, J., Beral, V., Bloomfield, K., Brooks, P. J., Cai, L., Cho, S., Crabb, D. W., et al. (2010) · Scopus (Elsevier) · Cited by 354 · see citing works
Self-citationRehm, J., Shield, K. D., Joharchi, N., & Shuper, P. A. (2012) · Addiction · doi:10.1111/j.1360-0443.2011.03621.x · Cited by 344 · see citing works
Self-citation[Alcohol-related morbidity and mortality].
Becker, U., & Tolstrup, J. S. (2021) · PubMed · Cited by 344 · see citing works
Kiechl, S. J., Willeit, J., Poewe, W. H., Egger, G., Oberhollenzer, F., Muggeo, M., & Bonora, E. (1996) · BMJ · doi:10.1136/bmj.313.7064.1040 · Cited by 343 · see citing works
Cardiovascular risk factors and confounders among nondrinking and moderate-drinking U.S. adults
Naimi, T. S., Brown, D. W., Brewer, R. D., Giles, W. H., Mensah, G. A., Serdula, M. K., Mokdad, A. H., Hungerford, D. W., Lando, J. F., Naimi, S., et al. (2005) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2005.01.011 · Cited by 319 · see citing works
Influence of pattern of drinking on cardiovascular disease and cardiovascular risk factors–a review.
Puddey, I. B., Rakic, V., Dimmitt, S. B., & Beilin, L. J. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9456493.x · Cited by 309 · see citing works
Causal Considerations on Alcohol and HIV/AIDS -- A Systematic Review
Shuper, P. A., Neuman, M. G., Kanteres, F., Baliunas, D. O., Joharchi, N., & Rehm, J. T. (2010) · Alcohol and Alcoholism · doi:10.1093/alcalc/agp091 · Cited by 307 · see citing works
Self-citationRoerecke, M., & Rehm, J. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwp451 · Cited by 307 · see citing works
Self-citationAlcohol consumption and risk of incident human immunodeficiency virus infection: a meta-analysis
Baliunas, D., Rehm, J., Irving, H., & Shuper, P. (2010) · International Journal of Public Health · doi:10.1007/s00038-009-0095-x · Cited by 307 · see citing works
Self-citationSchütze, M., Boeing, H., Pischon, T., Rehm, J. T., Kehoe, T., Gmel, G. E., Olsen, A., Tjønneland, A. M., Dahm, C. C., Overvad, K., et al. (2011) · BMJ · doi:10.1136/bmj.d1584 · Cited by 274 · see citing works
Self-citationMckee, M., & Britton, A. (1998) · Journal of the Royal Society of Medicine · doi:10.1177/014107689809100802 · Cited by 264 · see citing works
Alcohol consumption and ethyl carbamate.
(2010) · PubMed Central · Cited by 261 · see citing works
Roerecke, M., & Rehm, J. (2012) · Addiction · doi:10.1111/j.1360-0443.2012.03780.x · Cited by 249 · see citing works
Self-citationCostanzo, S., Castelnuovo, A. F. D., Donati, M. B., Iacoviello, L., & de Gaetano, G. (2011) · European Journal of Epidemiology · doi:10.1007/s10654-011-9631-0 · Cited by 244 · see citing works
Sierksma, A., van der Gaag, M., Kluft, C., & Hendriks, H. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601459 · Cited by 231 · see citing works
Alcohol and Health in Canada: A Summary of Evidence and Guidelines for Low-Risk Drinking
Butt, P. R., Beirness, D. J., Gliksman, L., Paradis, C., & Stockwell, T. R. (2011) · Cited by 226 · see citing works
Rehm, J., Irving, H., Ye, Y., Kerr, W. C., Bond, J., & Greenfield, T. K. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn093 · Cited by 215 · see citing works
Self-citationAlcohol Intake and Insulin Levels: The Normative Aging Study
Lazarus, R. M., Sparrow, D., & Weiss, S. T. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009050 · Cited by 204 · see citing works
Mayer, E. J., Newman, B. M., Quesenberry, C. P., FRIEDMAN, G. D., & Selby, J. V. (1993) · Circulation · doi:10.1161/01.cir.88.5.2190 · Cited by 193 · see citing works
Alcohol as a risk factor for pancreatitis. A systematic review and meta-analysis.
Irving, H. M., Samokhvalov, A. V., & Rehm, J. T. (2009) · PubMed · Cited by 193 · see citing works
Self-citationAddictive drugs and their relationship with infectious diseases
Friedman, H. P., Pross, S. H., & Klein, T. (2006) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2006.00097.x · Cited by 188 · see citing works
Islami, F., Fedirko, V., Tramacere, I., Bagnardi, V., Jenab, M., Scotti, L., Rota, M., Corrao, G., Garavello, W., Schüz, J., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25885 · Cited by 181 · see citing works
Carcinogenicity of acetaldehyde in alcoholic beverages: risk assessment outside ethanol metabolism
Lachenmeier, D. W., Kanteres, F., & Rehm, J. T. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02516.x · Cited by 169 · see citing works
Self-citationRuidavets, J., Ducimetière, P., Evans, A., Montaye, M., Haas, B., Bingham, A., Yarnell, J., Amouyel, P., Arveiler, D., Kee, F., et al. (2010) · BMJ · doi:10.1136/bmj.c6077 · Cited by 167 · see citing works
Alcohol and type 2 diabetes. A review
Pietraszek, A., Gregersen, S., & Hermansen, K. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.05.001 · Cited by 166 · see citing works
Bagnardi, V, Zatonski, W., Scotti, L., La Vecchia, C., & Corrao, G. (2008) · Journal of Epidemiology and Community Health · doi:10.1136/jech.2007.065607 · Cited by 165 · see citing works
Krenz, M., & Korthuis, R. J. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.10.011 · Cited by 163 · see citing works
Alcohol consumption as a risk factor for pneumonia: a systematic review and meta-analysis
SAMOKHVALOV, A. V., IRVING, H. M., & REHM, J. (2010) · Epidemiology and Infection · doi:10.1017/s0950268810000774 · Cited by 159 · see citing works
Self-citationIncreased Stroke Risk Is Related to a Binge Drinking Habit
Sundell, L., Salomaa, V. V., Vartiainen, E. A., Poikolainen, K., & Laatikainen, T. K. (2008) · Stroke · doi:10.1161/strokeaha.108.520817 · Cited by 151 · see citing works
Alcohol Consumption, Blood Pressure, and the Risk of Stroke
Hillbom, M., Saloheimo, P., & Juvela, S. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0194-y · Cited by 133 · see citing works
Disability Associated With Alcohol Abuse and Dependence
Samokhvalov, A. V., Popova, S., Room, R., Ramonas, M., & Rehm, J. T. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01275.x · Cited by 131 · see citing works
Self-citationKerr, W. C., Fillmore, K. M., & Bostrom, A. (2002) · Journal of Studies on Alcohol · doi:10.15288/jsa.2002.63.325 · Cited by 128 · see citing works
Alcohol's contribution to compromised immunity.
Szabó, G. (1997) · PubMed · Cited by 118 · see citing works
Lachenmeier, D. W., Przybylski, M. C., & Rehm, J. T. (2012) · International Journal of Cancer · doi:10.1002/ijc.27553 · Cited by 116 · see citing works
Self-citationTramacere, I., Negri, E., Bagnardi, V., Garavello, W., Rota, M., Scotti, L., Islami, F., Corrao, G., Boffetta, P., & Vecchia, C. L. (2010) · Oral Oncology · doi:10.1016/j.oraloncology.2010.03.024 · Cited by 114 · see citing works
Islami, F., Tramacere, I., Rota, M., Bagnardi, V., Fedirko, V., Scotti, L., Garavello, W., Jenab, M., Corrao, G., Straíf, K., et al. (2010) · Oral Oncology · doi:10.1016/j.oraloncology.2010.07.015 · Cited by 110 · see citing works
Alcohol consumption: Risks and benefits
Mukamal, K. J., & Rimm, E. B. (2008) · Current Atherosclerosis Reports · doi:10.1007/s11883-008-0083-2 · Cited by 109 · see citing works
[Alcohol consumption and mortality].
Allebeck, P. (2002) · PubMed · Cited by 108 · see citing works
Costanzo, S., Castelnuovo, A. F. D., Donati, M. B., Iacoviello, L., & de Gaetano, G. (2010) · Circulation · doi:10.1161/circulationaha.109.865840 · Cited by 102 · see citing works
Shield, K. D., & Rehm, J. T. (2012) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1345 · Cited by 93 · see citing works
Self-citationAlcohol drinking cessation and its effect on esophageal and head and neck cancers: A pooled analysis
Rehm, J., Patra, J., & Popova, S. (2007) · International Journal of Cancer · doi:10.1002/ijc.22798 · Cited by 91 · see citing works
Self-citationModerate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels
Sierksma, A., van der Gaag, M. S., Kluft, C., & Hendriks, H. F. J. (2001) · TNO Repository · Cited by 91 · see citing works
A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 2: Results by subsites
Turati, F., Garavello, W., Tramacere, I., Bagnardi, V., Rota, M., Scotti, L., Islami, F., Corrao, G., Boffetta, P., Vecchia, C. L., et al. (2010) · Oral Oncology · doi:10.1016/j.oraloncology.2010.07.010 · Cited by 79 · see citing works
Caldwell, T., Rodgers, B., Power, C., Clark, C., & Stansfeld, S. A. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl088 · Cited by 58 · see citing works
EDITORIAL Alcohol consumption and mortality. What do we know and where should we go?
Rehm, J. (2000) · Addiction · doi:10.1046/j.1360-0443.2000.9579891.x · Cited by 56 · see citing works
Self-citationTime pattern of reduction in risk of oesophageal cancer following alcohol cessation—a meta‐analysis
Jarl, J., & Gerdtham, U. (2011) · Addiction · doi:10.1111/j.1360-0443.2011.03772.x · Cited by 44 · see citing works
Rehm, J. T., & Patra, J. (2011) · Drug and Alcohol Review · doi:10.1111/j.1465-3362.2011.00395.x · Cited by 43 · see citing works
Self-citationRoerecke, M., Greenfield, T. K., Kerr, W. C., Bondy, S. J., Cohen, J., & Rehm, J. T. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr129 · Cited by 43 · see citing works
Self-citationBinge Drinking and Hypertension on Cardiovascular Disease Mortality in Korean Men and Women
Sull, J. W., Yi, S., Nam, C. M., Choi, K.-S., & Ohrr, H. (2010) · Stroke · doi:10.1161/strokeaha.110.586347 · Cited by 38 · see citing works
Drinking pattern and socio-cultural aspects on immune response: an overview
Romeo, J., Wärnberǵ, J., & Marcos, A. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110001904 · Cited by 31 · see citing works
Pearl, R. A. (1924) · BMJ · doi:10.1136/bmj.1.3309.948 · Cited by 9 · see citing works
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The relationship between different dimensions of alcohol use and the burden of disease—an update
Rehm, J., Gmel, G. E., Gmel, G., Hasan, O. S. M., Imtiaz, S., Popova, S., Probst, C., Roerecke, M., Room, R., Samokhvalov, A. V., et al. (2017) · Addiction · doi:10.1111/add.13757 · Cited by 1,204 · see citing works
Self-citationA narrative review of alcohol consumption as a risk factor for global burden of disease
Rehm, J., & Imtiaz, S. (2016) · Substance Abuse Treatment, Prevention, and Policy · doi:10.1186/s13011-016-0081-2 · Cited by 177 · see citing works
“Other categories of alcohol-attributable disease and mortality included in current CRAs are fetal alcohol syndrome (by definition), epilepsy [69], gastrointestinal disease (liver cirrhosis [70] and pancreatitis [37, 38]; the latter new for the CRA associated with GBD study 2010 and after), diabetes [71], cardiovascula…”
BackgroundSelf-citationRehm, J. T. (2013) · Alcohol research · doi:10.35946/arcr.v35.2.07 · Cited by 145 · see citing works
Self-citationBindon, K. A., Holt, H. E., Williamson, P., Varela, C., Herderich, M. J., & Francis, I. L. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2013.12.099 · Cited by 117 · see citing works
The Influence of Alcohol Consumption on Intestinal Nutrient Absorption: A Comprehensive Review
Butts, M. R., Sundaram, V. L., Murughiyan, U., Borthakur, A., & Singh, S. (2023) · Nutrients · doi:10.3390/nu15071571 · Cited by 97 · see citing works
Quantifying the contribution of alcohol to cardiomyopathy: A systematic review
Rehm, J., Hasan, O. S. M., Imtiaz, S., & Neufeld, M. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.01.011 · Cited by 92 · see citing works
Self-citationFama, R. (2020) · Alcohol research · doi:10.35946/arcr.v40.2.03 · Cited by 91 · see citing works
Moderate alcohol consumption and depression – a longitudinal population‐based study in Sweden
Gémes, K., Forsell, Y., Janszky, I., László, K. D., Lundin, A., de León, A. P., Mukamal, K. J., & Möller, J. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13034 · Cited by 90 · see citing works
“Whether the observed lower risk of ill-health among moderate alcohol consumers as compared to non-drinkers is causal or related to some form of systematic error remains an ongoing debate (30,31).”
BackgroundResultRehm, J. T., Shield, K. D., Roerecke, M., & Gmel, G. E. (2016) · BMC Public Health · doi:10.1186/s12889-016-3026-9 · Cited by 63 · see citing works
“2) For both IHD and IS, there is evidence that with either irregular or regular heavy drinking occasions, the beneficial effect disappears [2, 6, 8, 14, 16, 32], which must be taken into account even for light to medium drinkers.”
BackgroundInfluentialSelf-citationEpisodic Heavy Drinking and 20-Year Total Mortality Among Late-Life Moderate Drinkers
Holahan, C. J., Brennan, P., Schutte, K., Holahan, C. K., & Moos, R. (2014) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12381 · Cited by 53 · see citing works
Alcohol: taking a population perspective
Gilmore, W., Chikritzhs, T. N., Stockwell, T. R., Jernigan, D. H., Naimi, T. S., & Gilmore, I. T. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.70 · Cited by 68 · see citing works
Windle, M. T., & Windle, R. C. (2015) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2015.76.465 · Cited by 53 · see citing works
“…heavier alcohol use among this population has been associated with a host of medical conditions, including cardiovascular and cerebrovascular diseases, cancer, and gastrointestinal disorders (Roerecke & Rehm, 2012), as well as compromised psychological functioning (Choi & DiNitto, 2011a, 2011b).”
BackgroundChiappetta, V., García–Rodríguez, O., Jin, C. J., Secades‐Villa, R., & Blanco, C. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.05.019 · Cited by 48 · see citing works
Gémes, K., Malmo, V., Laugsand, L. E., Loennechen, J. P., Ellekjær, H., László, K. D., Ahnve, S., VATTEN, L. J., Mukamal, K. J., & Janszky, I. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.007094 · Cited by 46 · see citing works
SIRT6 Minor Allele Genotype Is Associated with >5-Year Decrease in Lifespan in an Aged Cohort
Tennapel, M. J., Lynch, C. F., Burns, T. L., Wallace, R. B., Smith, B. J., Button, A. M., & Domann, F. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115616 · Cited by 46 · see citing works
“An average of 1 drink per day for females and 2 drinks per day for males was used to distinguish between current low and current high alcohol consumption [21].”
BackgroundFang, L., & McNeil, S. R. (2017) · Public Health · doi:10.1016/j.puhe.2017.05.005 · Cited by 38 · see citing works
Shield, K. D., & Rehm, J. (2015) · BMC Research Notes · doi:10.1186/s13104-015-1207-8 · Cited by 35 · see citing works
“(This may be due, in part, to alcohol having a protective effect on ischemic cardiovascular diseases and diabetes at low consumption amounts [20]).”
Self-citationGémes, K., Janszky, I., Laugsand, L. E., László, K. D., Ahnve, S., VATTEN, L. J., & Mukamal, K. J. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12428 · Cited by 32 · see citing works
Genetic variations in taste perception modify alcohol drinking behavior in Koreans
Choi, J., Lee, J., Yang, S. S., & Kim, J. (2017) · Appetite · doi:10.1016/j.appet.2017.02.022 · Cited by 32 · see citing works
Temporal changes in alcohol‐related mortality and morbidity in Australia
Ogeil, R. P., Gao, C. X., Rehm, J. T., Gmel, G. E., & Lloyd, B. K. (2015) · Addiction · doi:10.1111/add.13213 · Cited by 26 · see citing works
Self-citationPrincipales daños sanitarios y sociales relacionados con el consumo de alcohol
Sarasa‐Renedo, A., Sordo, L., Molist, G., Hoyos, J., Guitart, A. M., & Barrio, G. (2014) · Revista Española de Salud Pública · doi:10.4321/s1135-57272014000400004 · Cited by 23 · see citing works
Choi, N. G., DiNitto, D. M., Marti, C. N., & Choi, B. Y. (2015) · Academic Emergency Medicine · doi:10.1111/acem.12803 · Cited by 21 · see citing works
Light-to-moderate drinking and incident heart failure — the Norwegian HUNT study
Gémes, K., Janszky, I., Ahnve, S., László, K. D., Laugsand, L. E., VATTEN, L. J., & Mukamal, K. J. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.10.179 · Cited by 21 · see citing works
“However, light-to-moderate intake of alcohol has been consistently associated with a lower risk of coronary heart disease and ischemic stroke [6,7].”
BackgroundGémes, K., Moeller, J., Engström, K., & Sidorchuk, A. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-028878 · Cited by 18 · see citing works
Alcohol Use as Risk Factors for Older Adults’ Emergency Department Visits: A Latent Class Analysis
Choi, N. G., Marti, C., DiNitto, D. M., & Choi, B. Y. (2015) · Western Journal of Emergency Medicine · doi:10.5811/westjem.2015.9.27704 · Cited by 17 · see citing works
Alcohol Consumption Among Adolescents — Implications for Public Health
Carvajal, F., & Lerma-Cabrera, J. M. (2015) · InTech eBooks · doi:10.5772/58930 · Cited by 17 · see citing works
“hypertension, atrial fibrillation and hemorrhagic stroke [6] and diabetes mellitus [7] are causally related to ethanol consumption; also, alcohol has been related to gastrointestinal diseases such as liver cirrhosis and pancreatitis in 16.”
BackgroundMiquel, L., Rehm, J. T., Shield, K. D., Vela, E., Bustins, M., Segura, L., Colom, J., Anderson, P., & Gual, A. (2017) · European Journal of Public Health · doi:10.1093/eurpub/ckx236 · Cited by 17 · see citing works
Self-citationUto‐Kondo, H., Hase, A., Yamaguchi, Y., Sakurai, A., Akao, M., Saito, T. H., & Kumagaı, H. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2018.1447357 · Cited by 17 · see citing works
“However, their excessive intake is associated with an increased risk of several diseases [1].”
BackgroundPinto, J. W., Bradbury, K. J., Newell, D., & Bishop, F. L. (2020) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2020.0365 · Cited by 15 · see citing works
Asciutto, R., Lugo, A., Pacifici, R., Colombo, P., Rota, M., Vecchia, C. L., & Gallus, S. (2015) · Alcohol and Alcoholism · doi:10.1093/alcalc/agv121 · Cited by 14 · see citing works
Dobbels, F., Denhaerynck, K., Klem, M. L., Sereika, S. M., Geest, S. D., SIMONE, P. D., Berben, L., Binet, I., Burkhalter, H., Drent, G., et al. (2018) · Transplantation Reviews · doi:10.1016/j.trre.2018.09.003 · Cited by 13 · see citing works
Gémes, K., Janszky, I., Strand, L. B., László, K. D., Ahnve, S., VATTEN, L. J., Dalen, H., & Mukamal, K. J. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-020777 · Cited by 12 · see citing works
“It is associated with higher risk for CVD, even if the overall alcohol consumption stays at a moderate level.(16) 32–34 Indeed, one binge-drinking episode (ie, consuming more than five drinks in one setting during a short period of time) can cause a pronounced inflammatory response in the myocardium.”
BackgroundAlcohol-induced hypertension: an important healthcare target in Belgium
Collart, F., de Timary, P., Dom, G., Dor, B., Duprez, D. A., Lengelé, J., Matthys, F., Peuskens, H., Rehm, J. T., & Stärkel, P. (2015) · Acta Clinica Belgica · doi:10.1179/2295333715y.0000000039 · Cited by 12 · see citing works
Self-citationErvasti, J. M., Mika Kivimaki, B., Head, J. A., Goldberg, M., Airagnes, G., Pentti, J., Oksanen, T., Salo, P., Suominen, S., Jokela, M. M., et al. (2017) · Alcohol and Alcoholism · doi:10.1093/alcalc/agx079 · Cited by 11 · see citing works
Using behavioral skills training to teach goal setting for health behaviors
Beaulieu, M., Normand, M. P., & Miltenberger, R. G. (2024) · Behavioral Interventions · doi:10.1002/bin.2041 · Cited by 9 · see citing works
Huang, J.-Y., Chen, W.-K., Lin, C.-L., Lai, C.-Y., Kao, C., & Yang, T.-Y. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.06.003 · Cited by 3 · see citing works
Alcohol Promotes Lipogenesis in Sebocytes—Implications for Acne
Kleemann, J., Cinatl, J. J., Hoffmann, S., Zöller, N. N., Özistanbullu, D., Zouboulis, C. C., Kaufmann, R., & Kippenberger, S. (2024) · Cells · doi:10.3390/cells13040328 · Cited by 6 · see citing works
Тhe impact of alcohol abuse on the development of non-communicable diseases (analytical review)
Kaigorodova, T. V., & Kryukova, I. A. (2021) · Public Health · doi:10.21045/2782-1676-2021-1-2-48-61 · Cited by 6 · see citing works
Altitud geográfica de residencia y dependencia alcohólica en pobladores peruanos
Quiñones-Laveriano, D. M., Espinoza-Chiong, C., Scarsi-Mejia, O., Rojas-Camayo, J., & Mejia, C. R. (2015) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2015.11.002 · Cited by 5 · see citing works
The role of the comparison group in epidemiology and general limitations
Rehm, J. T. (2013) · Addiction · doi:10.1111/add.12189 · Cited by 5 · see citing works
Self-citationVerhalle, L., Bockstaele, K. V., Duerinckx, N., Vanhoof, J. M. M., Dierickx, K., Neyens, L., Cleemput, J. V., Gryp, S., Kums, D., Bondt, K. D., et al. (2020) · Clinical Transplantation · doi:10.1111/ctr.14137 · Cited by 4 · see citing works
Oshima, S., Shiiya, S., Tokumaru, Y., & Kanda, T. (2015) · Journal of Nutrition and Metabolism · doi:10.1155/2015/280781 · Cited by 4 · see citing works
“Alcoholic beverages comprise themost commonly consumed foods by adults worldwide, and their inappropriate and excessive use is associated with an increased risk of several diseases [1].”
BackgroundChoi, N. G., DiNitto, D. M., Marti, C. N., & Choi, B. Y. (2016) · Springer eBooks · doi:10.1007/978-3-319-47233-1_7 · Cited by 4 · see citing works
The Risks and Benefits of Moderate Alcohol Consumption
Leifer, E. (2017) · JACC Heart Failure · doi:10.1016/j.jchf.2017.09.005 · Cited by 4 · see citing works
Надеждин, А. В., Tetenova, E. J., Петухов, А. Е., & Davydova, E. N. (2024) · Medicina · doi:10.29234/2308-9113-2024-12-2-90-113 · Cited by 3 · see citing works
Árokszállási, T., Nagy, A. C., Balogh, E. E., Nagy, E. B., Sik, M., Fülesdi, Z., Orbán-Kálmándi, R., Árokszállási, A., Juhász, P., Fekete, G., et al. (2025) · Neurology and Therapy · doi:10.1007/s40120-025-00866-z · Cited by 2 · see citing works
Plant-Based and Plant-Predominant Diets Among Healthcare Students: A Systematic Review
Abbaspour, R., Weisbrodt, S. E., Nauhria, S., Chan, M. Y. L., Rawji, A. K., Jazi, P. B., & Maity, S. (2025) · Cureus · doi:10.7759/cureus.87294 · Cited by 2 · see citing works
Soto, M. T. D., & Miranda, J. M. C. (2020) · REVISTA BIOMÉDICA · doi:10.32776/revbiomed.v31i2.722 · Cited by 2 · see citing works
“El síntoma cardinal del alcoholismo es la dificultad para controlar el consumo de alcohol y guarda relación con el funcionamiento alterado de diversos sistemas de neurotransmisión, entre los cuales se destacan los sistemas glutamatérgico, GABAérgico, dopaminérgico y opioide (8-15).”
BackgroundEffects of changes in drinking habits on lifestyle-related diseases
Kojima, S., Watanabe, N., Takashimizu, S., Anzai, K., TSUDA, S., Hiroyuki, I. T. O., Nagata, J., Ichikawa, H., Shiraishi, K., & Nishizaki, Y. (2019) · Health Evaluation and Promotion · doi:10.7143/jhep.46.431 · Cited by 1 · see citing works
Alcohol Dependence: A Major Health and Socio-Economic Problem
Ayenigbara, I. O. (2018) · Journal of Health Education Research & Development · doi:10.4172/2380-5439.1000274
“Higher levels of alcohol consumption create an exponential increase in risk [17].”
BackgroundCascio, W. E. (2015) · Atherosclerosis · doi:10.1002/9781118828533.ch8
Young adult women with problematic alcohol use: The impact of social capital on recovery
Edwards, R. (2020) · Queensland University of Technology · doi:10.5204/thesis.eprints.201788
Alcohol Consumption and Socialization in Public Accounting FirmsPreprint
Knutson, M., Seifert, S. G., & Westermann, K. D. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4286312
Wojciechowski, T. W. (2024) · Journal of Drug Issues · doi:10.1177/00220426241252347
“Health problems stemming from alcohol use indicates the need to identify predictors of progression to diagnosis of alcohol-related disorders in order to mitigate public health harm (Rehm, 2011; Roerecke & Rehm, 2012; Standridge et al., 2004).”
Collart, F. (2015) · VUBIR (Vrije Universiteit Brussel)
Berge, M. T., Lid, T. G., & Husberg-Bru, V. (2026) · BMC Public Health · doi:10.1186/s12889-026-26515-0
- Authors
- Roerecke, M., & Rehm, J.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Roerecke, Michael
- Venue
- Current Atherosclerosis Reports
- Published
- 2012-08-04
- Volume
- 14
- Issue
- 6
- Pages
- 556-562
- ISSN
- 1523-3804 (ISSN-L)
- 1534-6242
- OpenAlex
- W2094065763
- Cited by
- 58
- References
- 83
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 10 · 2016: 4 · 2015: 14 · 2014: 5 · 2013: 2
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Atherosclerosis Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- alcohol consumption, health effects of alcohol, cardiovascular risk, atherosclerosis, moderate drinking, heavy drinking, alcohol and cancer, alcoholism, alcohol-related injuries, infectious diseases, gastrointestinal diseases
- MeSH terms
- Alcohol Drinking, Cardiovascular Diseases, Communicable Diseases, Humans, Neoplasms, Risk, Alcohol-Related Disorders
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