Intestinal organoids containing poly(lactic‐co‐glycolic acid) nanoparticles for the treatment of inflammatory bowel diseases
Open accessAbstract
Inflammatory bowel disease (IBD) causes inflammation to the gastrointestinal tract. Local administration of anti‐inflammatory drugs such as 5‐aminosalicylic acid (5‐ASA) can alleviate the symptoms of IBD. The application of nanoparticles for IBD treatment in direct rectal administration showed high drug availability and treatment efficacy. However, relying on size‐dependent adsorption of smaller particles is not sufficient for making the formulation capable of targeting. Intestinal organoids can improve the functionality of the nanoparticles due to their ability to adsorb small nanoparticle inside the lumen and attach to the damaged area. In this study, intestinal organoids were used as carriers of 5‐ASA‐loaded poly(lactic‐co‐glycolic acid) nanoparticles. The nanoparticle sizes, confirmed by scanning electron microscopy, were 200–300 nm and the zeta potential were negative. The nanoparticles did not have any noticeable pernicious effect on organoid growth and viability. After mixing the nanoparticles with Matrigel and organoids, Rhodamine B loaded inside the nanoparticles was highly detected inside the organoid's lumen after 3 days by confocal fluorescent microscopy and no longer detected in the lumen after day 4. It may be attributed to the ability of the lumen to digest particles. Thus, the organoid Trojan horse system is a possible approach for delivering drugs to inflamed areas. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 876–886, 2018.
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Growth factors can be encapsulated within nanoparticles and conjugated onto cell surfaces for controlled release.
“these growth factors can be encapsulated within nanoparticles, and conjugated onto cell surfaces for controlled release85–88.”
From Organoids (2022) · cites this paper as [86]
The Introduction describes drug-loaded nanoparticles carried by cells and identifies controlled drug release as an advantage of cell-mediated delivery. But the paper studies 5-ASA-loaded nanoparticles taken into organoid lumens; it does not describe encapsulating growth factors or conjugating them onto cell surfaces. The indexed passages have section labels but no page numbers. (LLM, conf=0.83)
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- Authors
- Davoudi, Z., Peroutka‐Bigus, N., Bellaire, B., Wannemuehler, M., Barrett, T. A., Narasimhan, B., & Wang, Q.
- Affiliations
- Iowa State University (US)
- University of Kentucky (US)
- Corresponding author
- Wang, Qun
- ORCID
- Venue
- Journal of Biomedical Materials Research Part A
- Publisher
- Wiley
- Published
- 2017-12-21
- Volume
- 106
- Issue
- 4
- Pages
- 876-886
- ISSN
- 1549-3296 (ISSN-L)
- 1552-4965
- PMC
- PMC5826879
- OpenAlex
- W2773219502
- Cited by
- 118
- References
- 43
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 6 · 2023: 16 · 2022: 12 · 2021: 20 · 2020: 23 · 2019: 11 · 2018: 10
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Biomedical Materials Research Part A (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Crohn's and Colitis Foundation of America (348137)
- PhRMA Foundation (RSGTMT17, Research Starter Award No. RSGTMT17)
- National Institutes of Health (R01DK095662)
- U.S. Department of Veterans Affairs (I01CX001353)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- intestinal organoids, PLGA nanoparticles, inflammatory bowel disease, 5-aminosalicylic acid, targeted drug delivery, rectal drug delivery, nanoparticle adsorption, Matrigel, rhodamine B, anti-inflammatory drug delivery
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Animals, Intestines, Mice, Inbred C57BL, Organoids, Particle Size, Inflammatory Bowel Diseases, Mesalamine, Nanoparticles, Static Electricity
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