Cited by 28Suicide and Self-Harm StudiesFunctional Brain Connectivity StudiesBipolar Disorder and Treatment

Conflict-Related Anterior Cingulate Functional Connectivity Is Associated With Past Suicidal Ideation and Behavior in Recent-Onset Psychotic Major Mood Disorders

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Minzenberg, Michael J., Lesh, Tyler A., Niendam, Tara A., Cheng, Yaoan, Carter, Cameron S.·2016·The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

Suicidal ideation and behavior are highly prevalent in psychotic major mood disorders, yet their relationship to brain function remains unclear. Thirty patients with recent-onset of bipolar disorder type I (N=21) or major depressive disorder (N=9) with past psychosis were evaluated for past suicidal ideation/behavior and functional MRI during conflict-monitoring. Suicidal ideation was related to relatively higher dorsal anterior cingulate cortex (dACC)-seeded functional connectivity with dorsal fronto-parietal and inferior temporal-occipital cortex, as well as lower dACC connectivity with bilateral ventrolateral prefrontal cortex (PFC) and adjacent fronto-striatal regions. Past suicidal behavior was associated with lower dACC functional connectivity with dorsolateral PFC and premotor cortex, as well as temporal-parietal cortex.

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Crossref · 10.1176/appi.neuropsych.15120422

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  • Suicidal ideation-related increased frontal-subcortical connectivity may be confined to ideators who do not attempt suicide, because better executive control prevents acting on suicidal thoughts.

    “Suicidal ideation–related increased frontal-subcortical connectivity may be confined to suicidal ideators who do not attempt suicide (94), because better executive control prevents acting on suicidal thoughts.”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [94]

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Research works printed but not linked: 1

  1. Hawton K, van Heeringen K: Suicide. Lancet 2009; 373:1372-1381

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Authors
Minzenberg, M. J., Lesh, T. A., Niendam, T. A., Cheng, Y., & Carter, C. S.
Affiliations
University of California, San Francisco (US)
Venue
The Journal of Neuropsychiatry and Clinical Neurosciences
Published
2016-10
Volume
28
Issue
4
Pages
299-305
ISSN
  • 0895-0172 (ISSN-L)
  • 1545-7222
OpenAlex
W2318787377
Cited by
28
References
38
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 1
FWCI
4.92
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuropsychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords
suicidal ideation, suicidal behavior, bipolar I disorder, major depressive disorder, recent-onset psychosis, conflict monitoring, anterior cingulate cortex, functional connectivity, dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, premotor cortex, temporal-parietal cortex, frontostriatal connectivity

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