Conflict-Related Anterior Cingulate Functional Connectivity Is Associated With Past Suicidal Ideation and Behavior in Recent-Onset Psychotic Major Mood Disorders
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Suicidal ideation and behavior are highly prevalent in psychotic major mood disorders, yet their relationship to brain function remains unclear. Thirty patients with recent-onset of bipolar disorder type I (N=21) or major depressive disorder (N=9) with past psychosis were evaluated for past suicidal ideation/behavior and functional MRI during conflict-monitoring. Suicidal ideation was related to relatively higher dorsal anterior cingulate cortex (dACC)-seeded functional connectivity with dorsal fronto-parietal and inferior temporal-occipital cortex, as well as lower dACC connectivity with bilateral ventrolateral prefrontal cortex (PFC) and adjacent fronto-striatal regions. Past suicidal behavior was associated with lower dACC functional connectivity with dorsolateral PFC and premotor cortex, as well as temporal-parietal cortex.
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Suicidal ideation-related increased frontal-subcortical connectivity may be confined to ideators who do not attempt suicide, because better executive control prevents acting on suicidal thoughts.
“Suicidal ideation–related increased frontal-subcortical connectivity may be confined to suicidal ideators who do not attempt suicide (94), because better executive control prevents acting on suicidal thoughts.”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [94]
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- Authors
- Minzenberg, M. J., Lesh, T. A., Niendam, T. A., Cheng, Y., & Carter, C. S.
- Affiliations
- University of California, San Francisco (US)
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2016-10
- Volume
- 28
- Issue
- 4
- Pages
- 299-305
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W2318787377
- Cited by
- 28
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 1
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- suicidal ideation, suicidal behavior, bipolar I disorder, major depressive disorder, recent-onset psychosis, conflict monitoring, anterior cingulate cortex, functional connectivity, dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, premotor cortex, temporal-parietal cortex, frontostriatal connectivity
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