Cited by 534Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryProtein purification and stability

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Delivery of Therapeutic Proteins

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Pisal, Dipak S., Kosloski, Matthew P., Balu-Iyer, Sathy V.·2010·Journal of Pharmaceutical Sciences

DOI 10.1002/jps.22054PMC PMC2857543

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Abstract

The safety and efficacy of protein therapeutics are limited by three interrelated pharmaceutical issues, in vitro and in vivo instability, immunogenicity and shorter half-lives. Novel drug modifications for overcoming these issues are under investigation and include covalent attachment of poly(ethylene glycol) (PEG), polysialic acid, or glycolic acid, as well as developing new formulations containing nanoparticulate or colloidal systems (e.g., liposomes, polymeric microspheres, polymeric nanoparticles). Such strategies have the potential to develop as next generation protein therapeutics. This review includes a general discussion on these delivery approaches.

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Authors: Pisal, D. S., Kosloski, M. P., & Balu-Iyer, S. V.
Affiliations: University at Buffalo, State University of New York (US)
ORCID: Pisal, Dipak S.
Kosloski, Matthew P.
Venue: Journal of Pharmaceutical Sciences
Publisher: Elsevier BV
Published: 2010-06
Volume: 99
Issue: 6
Pages: 2557-2575
ISSN: 0022-3549 (ISSN-L)
DOI: 10.1002/jps.22054
PMC: PMC2857543
OpenAlex: W1985516113
Cited by: 532
References: 160
Citations by year: 2026: 8 · 2025: 19 · 2024: 14 · 2023: 38 · 2022: 25 · 2021: 31 · 2020: 42 · 2019: 44 · 2018: 45 · 2017: 43 · 2016: 48 · 2015: 40 · 2014: 48 · 2013: 26 · 2012: 28
FWCI: 3.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Pharmaceutical Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Pfizer
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL070227, HL-70227)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein purification and stability
Keywords: therapeutic proteins, drug delivery, protein stability, immunogenicity, protein half-life, PEGylation, polysialic acid, glycolic acid, nanoparticle drug delivery, liposomes, polymeric nanoparticles, polymer microspheres, colloidal drug delivery
MeSH terms: Chemistry, Pharmaceutical, Half-Life, Humans, Liposomes, Microspheres, Polyethylene Glycols, Polymers, Proteins, Sialic Acids, Nanoparticles

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