The DOI matches its Crossref record; 159 of the 160 references it cites were found in a registry or an index.
Delivery of Therapeutic Proteins
Open accessAbstract
The safety and efficacy of protein therapeutics are limited by three interrelated pharmaceutical issues, in vitro and in vivo instability, immunogenicity and shorter half-lives. Novel drug modifications for overcoming these issues are under investigation and include covalent attachment of poly(ethylene glycol) (PEG), polysialic acid, or glycolic acid, as well as developing new formulations containing nanoparticulate or colloidal systems (e.g., liposomes, polymeric microspheres, polymeric nanoparticles). Such strategies have the potential to develop as next generation protein therapeutics. This review includes a general discussion on these delivery approaches.
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“PEGylation is widely used in such modification for the delivery of proteins/peptides into the human body.35”
From Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor (2019) · cites this paper as [35]
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Cites
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Metadata
- Authors
- Pisal, D. S., Kosloski, M. P., & Balu-Iyer, S. V.
- Affiliations
- University at Buffalo, State University of New York (US)
- Venue
- Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 99
- Issue
- 6
- Pages
- 2557-2575
- ISSN
- 0022-3549 (ISSN-L)
- PMC
- PMC2857543
- OpenAlex
- W1985516113
- Cited by
- 532
- References
- 160
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 14 · 2023: 38 · 2022: 25 · 2021: 31 · 2020: 42 · 2019: 44 · 2018: 45 · 2017: 43 · 2016: 48 · 2015: 40 · 2014: 48 · 2013: 26 · 2012: 28
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Pharmaceutical Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pfizer
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL070227, HL-70227)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein purification and stability
- Keywords
- therapeutic proteins, drug delivery, protein stability, immunogenicity, protein half-life, PEGylation, polysialic acid, glycolic acid, nanoparticle drug delivery, liposomes, polymeric nanoparticles, polymer microspheres, colloidal drug delivery
- MeSH terms
- Chemistry, Pharmaceutical, Half-Life, Humans, Liposomes, Microspheres, Polyethylene Glycols, Polymers, Proteins, Sialic Acids, Nanoparticles
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