Delivery of Therapeutic Proteins

Recent advances with liposomes as pharmaceutical carriers

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Biodegradable polymeric nanoparticles as drug delivery devices

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Effect of pegylation on pharmaceuticals

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The dawning era of polymer therapeutics

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Biodegradable Long-Circulating Polymeric Nanospheres

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An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System

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PEGylation, successful approach to drug delivery

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Chemistry for peptide and protein PEGylation

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Optimizing Liposomes for Delivery of Chemotherapeutic Agents to Solid Tumors

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Formulation of functionalized PLGA-PEG Nanoparticles for in vivo targeted drug delivery

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Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties

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Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

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Peptide and protein PEGylation

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Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery

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Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives

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Pharmacokinetic and biodistribution properties of poly(ethylene glycol)–protein conjugates

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Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS

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Microencapsulation by solvent extraction/evaporation: Reviewing the state of the art of microsphere preparation process technology

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Pegylation

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Antibody Pharmacokinetics and Pharmacodynamics

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Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C

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Biodegradable microspheres for protein delivery

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Solid lipid nanoparticles as a drug delivery system for peptides and proteins☆

Almeida, A. J., & Souto, E. B. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.04.007 · Cited by 817

Responsive polymeric delivery systems

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PLGA–lecithin–PEG core–shell nanoparticles for controlled drug delivery

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A Randomized, Double–Blind Trial Comparing Pegylated Interferon Alfa–2B to Interferon Alfa–2B As Initial Treatment for Chronic Hepatitis C

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Polymer–drug conjugation, recent achievements and general strategies

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PEGylated PLGA nanoparticles as protein carriers: Synthesis, preparation and biodistribution in rats

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Diversity in cell surface sialic acid presentations: implications for biology and disease

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Preparation and characterization of cationic PLGA nanospheres as DNA carriers

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Which polymers can make nanoparticulate drug carriers long-circulating?

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The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics

Fishburn, C. S. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21278 · Cited by 475

Lipid-based systemic delivery of siRNA

Tseng, Y.-C., Mozumdar, S., & Huang, L. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.003 · Cited by 468

Glycoengineering: The effect of glycosylation on the properties of therapeutic proteins

Sinclair, A. M., & Elliott, S. (2005) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20319 · Cited by 461

PEG conjugates in clinical development or use as anticancer agents: An overview

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The uses and properties of PEG-linked proteins.

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Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes

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Lipid-based colloidal carriers for peptide and protein delivery--liposomes versus lipid nanoparticles.

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Recombinant expression systems in the pharmaceutical industry

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Suggestions for “safe” residue substitutions in site-directed mutagenesis

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Lymphatic uptake and biodistribution of liposomes after subcutaneous injection.

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Steric exclusion is the principal source of the preferential hydration of proteins in the presence of polyethylene glycols

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Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase

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Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

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Development and characterization of novel erythropoiesis stimulating protein (NESP)

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Mono-N-terminal poly(ethylene glycol)–protein conjugates

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Enzymatic conversion of proteins to glycoproteins.

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A month–long effect from a single injection of microencapsulated human growth hormone

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Pharmacokinetic aspects of biotechnology products.

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Short Communication: Renal Tubular Vacuolation in Animals Treated with Polyethylene-Glycol-Conjugated Proteins

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The therapeutic value of poly(ethylene glycol)-modified proteins

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Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers.

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Biochemical, immunological, and in vivo functional characterization of B-domain-deleted factor VIII

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A Branched Monomethoxypoly(ethylene glycol) for Protein Modification

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Liposome circulation time and tumor targeting: implications for cancer chemotherapy

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Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies

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Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase

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Polyethylene glycol-conjugated pharmaceutical proteins

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Characterization and Stability of N-terminally PEGylated rhG-CSF

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Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies

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Introduction and overview of peptide and protein pegylation

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Interaction between Phosphatidylserine and the Phosphatidylserine Receptor Inhibits Immune Responses In Vivo

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Site-specific PEGylation of a lysine-deficient TNF-α with full bioactivity

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Improving the therapeutic efficacy of peptides and proteins: A role for polysialic acids

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Recent advances in liposomal drug-delivery systems

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Design of surface-modified poly(d,l-lactide-co-glycolide) nanoparticles for targeted drug delivery to bone

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The effect of carbohydrate on the structure and stability of erythropoietin.

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Epoetin‐associated pure red cell aplasia: past, present, and future considerations

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Enzymatic procedure for site-specific pegylation of proteins

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Lipid excipients and delivery systems for pharmaceutical development: A regulatory perspective

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PEGylation: An Approach for Drug Delivery. A Review

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Improvements in protein PEGylation: pegylated interferons for treatment of hepatitis C

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Non-aqueous encapsulation of excipient-stabilized spray-freeze dried BSA into poly(lactide-co-glycolide) microspheres results in release of native protein

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The safety and efficacy of B‐domain deleted recombinant factor VIII concentrate in patients with severe haemophilia A

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Preparation and Characterization of Poly(ethylene glycol) Vinyl Sulfone

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Polysialic acid: three-dimensional structure, biosynthesis and function

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Functional Characterization of an Endosome-disruptive Peptide and Its Application in Cytosolic Delivery of Immunoliposome-entrapped Proteins

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PEG-ADA replacement therapy for adenosine deaminase deficiency: an update after 8.5 years

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Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat

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Enzymatic degradation behavior and mechanism of Poly(lactide-co-glycolide) foams by trypsin

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PLGA nanoparticles of different surface properties: Preparation and evaluation of their body distribution

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Nanostructured lipid carrier-based hydrogel formulations for drug delivery: A comprehensive review

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Site-Directed Pegylation of Recombinant Interleukin-2 at its Glycosylation Site

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%Thermogelling Biodegradable Copolymer Aqueous Solutions for Injectable Protein Delivery and Tissue Engineering

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Modulation of protein aggregation by polyethylene glycol conjugation: GCSF as a case study

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Efficacy and safety of liposomal anthracyclines in Phase I/II clinical trials

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Proteins and Peptides: Strategies for Delivery to and Across the Skin

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Tocol emulsions for drug solubilization and parenteral delivery

Constantinides, P. P., Tustian, A. K., & Kessler, D. R. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.12.005 · Cited by 136

Polysialylated insulin: synthesis, characterization and biological activity in vivo

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Polymers for controlled parenteral delivery of peptides and proteins

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The effect of polysialylation on the immunogenicity and antigenicity of asparaginase: implication in its pharmacokinetics

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Lipid Carriers: A Versatile Delivery Vehicle for Proteins and Peptides

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Polysialylated asparaginase: preparation, activity and pharmacokinetics

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Superoxide dismutase entrapped in long-circulating liposomes: formulation design and therapeutic activity in rat adjuvant arthritis

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Stabilization of proteins in dry powder formulations using supercritical fluid technology

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Nature-Inspired Creation of Protein−Polysaccharide Conjugate and Its Subsequent Assembly onto a Patterned Surface

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De Novo Adipose Tissue Generation through Long-Term, Local Delivery of Insulin and Insulin-Like Growth Factor-1 by PLGA/PEG Microspheres in an in Vivo Rat Model: A Novel Concept and Capability

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A new liposomal formulation for antisense oligodeoxynucleotides with small size, high incorporation efficiency and good stability

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