Cited by 534Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryProtein purification and stability

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Delivery of Therapeutic Proteins

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Pisal, Dipak S., Kosloski, Matthew P., Balu-Iyer, Sathy V.·2010·Journal of Pharmaceutical Sciences

DOI 10.1002/jps.22054PMC PMC2857543

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Abstract

The safety and efficacy of protein therapeutics are limited by three interrelated pharmaceutical issues, in vitro and in vivo instability, immunogenicity and shorter half-lives. Novel drug modifications for overcoming these issues are under investigation and include covalent attachment of poly(ethylene glycol) (PEG), polysialic acid, or glycolic acid, as well as developing new formulations containing nanoparticulate or colloidal systems (e.g., liposomes, polymeric microspheres, polymeric nanoparticles). Such strategies have the potential to develop as next generation protein therapeutics. This review includes a general discussion on these delivery approaches.

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Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552
Biodegradable polymeric nanoparticles as drug delivery devices
Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00339-4 · Cited by 3,549
Effect of pegylation on pharmaceuticals
Harris, J. M., & Chess, R. B. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1033 · Cited by 3,431
The dawning era of polymer therapeutics
Duncan, R. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1088 · Cited by 3,312
Biodegradable Long-Circulating Polymeric Nanospheres
Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,951
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
PEGylation, successful approach to drug delivery
Veronese, F. M., & Pasut, G. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03575-0 · Cited by 2,344
Chemistry for peptide and protein PEGylation
Roberts, M. J., Bentley, M. D., & Harris, J. M. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00022-4 · Cited by 1,628
Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol.
Abuchowski, A., Es, T. V., Palczuk, N. C., & Davis, F. F. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40291-2 · Cited by 1,358

Show all 160 references

Research works printed but not linked: 2

Kinstler, 1999, N-terminally chemically modified protein compositions and methods, United States Patent 5985265
Mundargi, 2008, Nano/micro technologies for delivering macro- molecular therapeutics using poly(d, l-lactide-co-glycolide) and its derivatives, J Control Release, 125, 193, 10.1016/j.jconrel.2007.09.013 · DOI · Paper page

Sorted by citations

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Vargason, A. M., Anselmo, A. C., & Mitragotri, S. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00698-w · Cited by 1,361
The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems—A review
Fredenberg, S., Wahlgren, M., Reslow, M., & Axelsson, A. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.05.049 · Cited by 1,293
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073
Basics and Recent Advances in Peptide and Protein Drug Delivery
Bruno, B. J., Miller, G. D., & Lim, C. S. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.104 · Cited by 771
Strategic Approaches to Optimizing Peptide ADME Properties
Di, L. (2015) · The AAPS Journal · doi:10.1208/s12248-014-9687-3 · Cited by 669
PEG — A versatile conjugating ligand for drugs and drug delivery systems
Kolate, A., Baradia, D., Patil, S., Vhora, I., Kore, G. G., & Misra, A. R. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.046 · Cited by 650
Polymeric Conjugates for Drug Delivery
Larson, N., & Ghandehari, H. (2012) · Chemistry of Materials · doi:10.1021/cm2031569 · Cited by 580
Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier
Upadhyay, R. K. (2014) · BioMed Research International · doi:10.1155/2014/869269 · Cited by 544
PEGylated liposomes: immunological responses
Sayed, M. M. E., Lila, A. S. A., Shimizu, T., Alaaeldin, E., Hussein, A. K., Sarhan, H. A., Szebeni, J., & Ishida, T. (2019) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2019.1627174 · Cited by 551
Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development
Kamerzell, T. J., Esfandiary, R., Joshi, S. B., Middaugh, C. R., & Volkin, D. B. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.07.006 · Cited by 524
Stimuli-responsive nanomaterials for therapeutic protein delivery
Lu, Y., Sun, W., & Gu, Z. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.08.015 · Cited by 415
Nanotechnology for protein delivery: Overview and perspectives
Yu, M., Wu, J., Shi, J., & Farokhzad, O. C. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.10.012 · Cited by 410
PEGylation in anti-cancer therapy: An overview
Mishra, P., Nayak, B., & Dey, R. K. (2015) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2015.08.011 · Cited by 384
Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor
Phua, S. Z. F., Yang, G., Lim, W. Q., Verma, A., Chen, H., Thanabalu, T., & Zhao, Y. (2019) · ACS Nano · doi:10.1021/acsnano.9b01087 · Cited by 375
Polysaccharide‐Based Controlled Release Systems for Therapeutics Delivery and Tissue Engineering: From Bench to Bedside
Miao, T., Wang, J., Zeng, Y., Liu, G., & Chen, X. S. (2018) · Advanced Science · doi:10.1002/advs.201700513 · Cited by 369
Nanozymes for nanohealthcare
Zhang, Y., Wei, G., Liu, W., Li, T., Wang, Y., Zhou, M., Liu, Y., Wang, X., & Wei, H. (2024) · Nature Reviews Methods Primers · doi:10.1038/s43586-024-00315-5 · Cited by 380
Protein Encapsulation via Polypeptide Complex Coacervation
Black, K. A., Priftis, D., Perry, S. L., Yip, J., Byun, W. Y., & Tirrell, M. (2014) · ACS Macro Letters · doi:10.1021/mz500529v · Cited by 319
Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications
Banerjee, S. S., Aher, N. D., Patil, R. B., & Khandare, J. J. (2012) · Journal of Drug Delivery · doi:10.1155/2012/103973 · Cited by 285
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Whitham, M., & Febbraio, M. A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.153 · Cited by 279
PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing
Chereddy, K. K., Her, C.-H., Comune, M., Moia, C., Lopes, A., Porporato, P. E., Vanacker, J., Lam, M. C., Steinstraesser, L., Sonveaux, P., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.08.016 · Cited by 268
Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics
Verhoef, J. J. F., Carpenter, J. F., Anchordoquy, T. J., & Schellekens, H. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.08.015 · Cited by 267
Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout
Lipsky, P. E., Calabrese, L. H., Kavanaugh, A., Sundy, J. S., Wright, D. D., Wolfson, M., & Becker, M. A. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4497 · Cited by 266
ARMMs as a versatile platform for intracellular delivery of macromolecules
Wang, Q., Yu, J., Kadungure, T., Beyene, J., Zhang, H., & Lu, Q. (2018) · Nature Communications · doi:10.1038/s41467-018-03390-x · Cited by 275
Dual Roles of Graphene Oxide To Attenuate Inflammation and Elicit Timely Polarization of Macrophage Phenotypes for Cardiac Repair
Han, J., Kim, Y. S., Lim, M.-Y., Kim, H. Y., Kong, S., Kang, M., Choo, Y. W., Jun, J. H., Ryu, S., Jeong, H.-Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b09107 · Cited by 261
Extracellular vesicles as a platform for membrane‐associated therapeutic protein delivery
Yang, Y., Hong, Y., Cho, E., Kim, G. B., & Kim, I. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1440131 · Cited by 266
In vitro and in vivo delivery of therapeutic proteins using cell penetrating peptides
Bolhassani, A., Jafarzade, B. S., & Mardani, G. (2016) · Peptides · doi:10.1016/j.peptides.2016.11.011 · Cited by 236
Co-delivery of chemotherapeutics and proteins for synergistic therapy
He, C., Tang, Z., Tian, H., & Chen, X. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.021 · Cited by 231
PLGA based drug delivery systems: promising carriers for wound healing activity
Chereddy, K. K., Vandermeulen, G., & Préat, V. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12404 · Cited by 215
PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery
Butreddy, A., Gaddam, R. P., Kommineni, N., Dudhipala, N. R., & Voshavar, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168884 · Cited by 222
Thiol–Ene Photopolymerizations Provide a Facile Method To Encapsulate Proteins and Maintain Their Bioactivity
McCall, J. D., & Anseth, K. S. (2012) · Biomacromolecules · doi:10.1021/bm300671s · Cited by 203
Review of the current state of protein aggregation inhibition from a materials chemistry perspective: special focus on polymeric materials
Rajan, R., Ahmed, S. G., Sharma, N., Kumar, N., Debas, A., & Matsumura, K. (2021) · Materials Advances · doi:10.1039/d0ma00760a · Cited by 202
Long-term delivery of protein therapeutics
Vaishya, R. D., Khurana, V., Patel, S. P., & Mitra, A. K. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.961420 · Cited by 195
Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems
Shi, M., & McHugh, K. J. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114904 · Cited by 194
Recent Advancements in Non-Invasive Formulations for Protein Drug Delivery
Bajracharya, R., Song, J. G., Back, S. Y., & Han, H. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.09.004 · Cited by 183
Protein Encapsulation Using Complex Coacervates: What Nature Has to Teach Us
McTigue, W. C. B., & Perry, S. L. (2020) · Small · doi:10.1002/smll.201907671 · Cited by 185
The effect of protein structure on their controlled release from an injectable peptide hydrogel
Branco, M. C., Pochan, D. J., Wagner, N. J., & Schneider, J. P. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.047 · Cited by 181
Core‐Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra‐large Cavity for Protein Delivery
Xu, C., Yu, M., Noonan, O., Zhang, J., Song, H., Zhang, H., Lei, C., Niu, Y., Huang, X., Yang, Y., et al. (2015) · Small · doi:10.1002/smll.201501449 · Cited by 180
High efficiency and long-term intracellular activity of an enzymatic nanofactory based on metal-organic frameworks
Lian, X., Erazo‐Oliveras, A., Pellois, J., & Zhou, H.-C. “. (2017) · Nature Communications · doi:10.1038/s41467-017-02103-0 · Cited by 177
Clinical Developments in Nanotechnology for Cancer Therapy
Heidel, J. D., & Davis, M. E. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0178-7 · Cited by 173
Nanoscale platforms for messenger RNA delivery
Li, B., Zhang, X., & Dong, Y. (2019) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1530 · Cited by 170
Clinically established biodegradable long acting injectables: An industry perspective
Nkanga, C. I., Fisch, A., Rad‐Malekshahi, M., Romić, M. D., Kittel, B., Ullrich, T., Wang, J., Krause, R. W. M., Adler, S., Lammers, T., et al. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.11.008 · Cited by 172
Recent Developments in Protein and Peptide Parenteral Delivery Approaches
Patel, A., Cholkar, K., & Mitra, A. K. (2014) · Therapeutic Delivery · doi:10.4155/tde.14.5 · Cited by 166
Protein PEGylation for cancer therapy: bench to bedside
Gupta, V. G., Bhavanasi, S., Quadir, M., Singh, K., Ghosh, G., Vasamreddy, K., Ghosh, A., Siahaan, T. J., Banerjee, S., & Banerjee, S. K. (2018) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-018-0492-0 · Cited by 165
Stabilization challenges and aggregation in protein-based therapeutics in the pharmaceutical industry
Rahban, M., Ahmad, F., Piatyszek, M. A., Haertlé, T., Saso, L., & Saboury, A. A. (2023) · RSC Advances · doi:10.1039/d3ra06476j · Cited by 166
Cytosolic Delivery of Proteins by Bioreversible Esterification
Mix, K. A., Lomax, J. E., & Raines, R. T. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b06597 · Cited by 156
Liposomal Antioxidants for Protection against Oxidant-Induced Damage
Suntres, Z. E. (2011) · Journal of Toxicology · doi:10.1155/2011/152474 · Cited by 164
Overview of Antibody Drug Delivery
Awwad, S., & Angkawinitwong, U. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030083 · Cited by 159
Synthetic Cells Synthesize Therapeutic Proteins inside Tumors
Krinsky, N., Kaduri, M., Zinger, A., Shainsky‐Roitman, J., Goldfeder, M., Benhar, I., Hershkovitz, D., & Schroeder, A. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201701163 · Cited by 151
Virus‐Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes
Yang, Y., Hong, Y., Nam, G., Chung, J. H., Koh, E., & Kim, I. (2017) · Advanced Materials · doi:10.1002/adma.201605604 · Cited by 151
Levan-based nanocarrier system for peptide and protein drug delivery: Optimization and influence of experimental parameters on the nanoparticle characteristics
Sezer, A. D., Kazak, H., Öner, E. T., & Akbuğa, J. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.11.046 · Cited by 139
Pegaspargase: A Review in Acute Lymphoblastic Leukaemia
Heo, Y., Syed, Y. Y., & Keam, S. J. (2019) · Drugs · doi:10.1007/s40265-019-01120-1 · Cited by 139
Unnatural amino acid incorporation in E. coli: current and future applications in the design of therapeutic proteins
Wals, K., & Ovaa, H. (2014) · Frontiers in Chemistry · doi:10.3389/fchem.2014.00015 · Cited by 151
Protein nanoparticles for therapeutic protein delivery
Estrada, L. P. H., & Champion, J. A. (2015) · Biomaterials Science · doi:10.1039/c5bm00052a · Cited by 136
Liposomal delivery of proteins and peptides
Swaminathan, J., & Ehrhardt, C. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.735658 · Cited by 135
Cell-penetrating peptides meditated encapsulation of protein therapeutics into intact red blood cells and its application
He, H., Ye, J., Wang, Y., Liu, Q., Chung, H. S., Kwon, Y. M., Shin, M. C., Lee, K., & Yang, V. C.-M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.12.019 · Cited by 134
Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging
Glasgow, M. D. K., & Chougule, M. B. (2015) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2015.2145 · Cited by 137
Pharmacokinetic considerations for targeted drug delivery
Yamashita, F., & Hashida, M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.11.006 · Cited by 136
Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins in Vitro and in Vivo
Li, M., Tao, Y., Shu, Y., LaRochelle, J. R., Steinauer, A., Thompson, D. B., Schepartz, A., Chen, Z., & Liu, D. R. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b05694 · Cited by 136
Local Delivery of Ox40l , Cd80 , and Cd86 mRNA Kindles Global Anticancer Immunity
Haabeth, O. A. W., Blake, T. R., McKinlay, C. J., Tveita, A. A., Sallets, A., Waymouth, R. M., Wender, P. A., & Levy, R. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2867 · Cited by 129
Encapsulation of bioactive whey peptides in soy lecithin-derived nanoliposomes: Influence of peptide molecular weight
Mohan, A., McClements, D. J., & Udenigwe, C. C. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.06.075 · Cited by 128
One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer
Luginbuhl, K. M., Schaal, J. L., Umstead, B. R., Mastria, E. M., Li, X., Banskota, S., Arnold, S. E., Feinglos, M. N., D’Alessio, D. A., & Chilkoti, A. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0078 · Cited by 129
Designing carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide
Bi, L., Yang, L. J., Narsimhan, G., Bhunia, A. K., & Yao, Y. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.024 · Cited by 127
Recruitment of CD103 + dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy
Williford, J., Ishihara, J., Ishihara, A., Mansurov, A., Hosseinchi, P., Marchell, T. M., Potin, L., Swartz, M. A., & Hubbell, J. A. (2019) · Science Advances · doi:10.1126/sciadv.aay1357 · Cited by 125
Polymer-based nanoparticles for protein delivery: design, strategies and applications
Zhao, H., Lin, Z. Y., Yildirimer, L., Dhinakar, A., Zhao, X., & Wu, J. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb00308g · Cited by 128
EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo
Chen, J., Ouyang, J., Chen, Q., Deng, C., Meng, F., Zhang, J., Cheng, R., Lan, Q., & Zhong, Z. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b06879 · Cited by 124
Dynamic protein assembly by programmable DNA strand displacement
Chen, R. P., Blackstock, D., Sun, Q. H., & Chen, W. (2018) · Nature Chemistry · doi:10.1038/s41557-018-0016-9 · Cited by 121
Commercial Applications for Enzyme-Mediated Protein Conjugation: New Developments in Enzymatic Processes to Deliver Functionalized Proteins on the Commercial Scale
Milczek, E. M. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00832 · Cited by 116
Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia
Krishnamurthy, S., Wohlford-Lenane, C., KANDIMALLA, S., Sartre, G., Meyerholz, D. K., Théberge, V., Hallée, S., Duperré, A.-M., Del’Guidice, T., Lepetit-Stoffaes, J.-P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12922-y · Cited by 116
Agile delivery of protein therapeutics to CNS
Yi, X., Manickam, D. S., Brynskikh, A. M., & Kabanov, A. V. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.017 · Cited by 116
Novel strategies in the oral delivery of antidiabetic peptide drugs – Insulin, GLP 1 and its analogs
Ismail, R., & Csóka, I. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.03.015 · Cited by 116
Design rules for encapsulating proteins into complex coacervates
McTigue, W. C. B., & Perry, S. L. (2019) · Soft Matter · doi:10.1039/c9sm00372j · Cited by 120
Shape control in engineering of polymeric nanoparticles for therapeutic delivery
Williford, J., Santos, J. L., Shyam, R., & Mao, H. (2015) · Biomaterials Science · doi:10.1039/c5bm00006h · Cited by 113
Nanomaterials engineering for drug delivery: a hybridization approach
Mohammadi, M. R., Nojoomi, A., Mozafari, M., Dubņika, A., Inayathullah, M., & Rajadas, J. (2017) · Journal of Materials Chemistry B · doi:10.1039/c6tb03247h · Cited by 113
Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel
Liu, F., Park, J., Qian, W., Lim, D., Gräber, M., Berg, T., Yaffe, M. B., Lee, K. S., & Burke, T. R. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.614 · Cited by 110
Amylin structure–function relationships and receptor pharmacology: implications for amylin mimetic drug development
Bower, R. L., & Hay, D. L. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13496 · Cited by 104
Lignin, lipid, protein, hyaluronic acid, starch, cellulose, gum, pectin, alginate and chitosan-based nanomaterials for cancer nanotherapy: Challenges and opportunities
Carrion, C. C., Nasrollahzadeh, M., Sajjadi, M., Jaleh, B., Soufi, G. J., & Iravani, S. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.02.123 · Cited by 110
Multidimensional methods for the formulation of biopharmaceuticals and vaccines
Maddux, N. R., Joshi, S. B., Volkin, D. B., Ralston, J. P., & Middaugh, C. R. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22618 · Cited by 107
Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges
Basavaraj, S., & Betageri, G. V. (2014) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2013.12.003 · Cited by 110
Strategies for the production of long-acting therapeutics and efficient drug delivery for cancer treatment
AlQahtani, A. D., O’Connor, D., Dömling, A. S. S., & Goda, S. K. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108750 · Cited by 109
Nanoparticles for retinal gene therapy
Conley, S. M., & Naash, M. I. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.04.004 · Cited by 106
Site‐Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome
Kuan, S. L., Wang, T., & Weil, T. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201602298 · Cited by 102
PEG-stabilized lipid disks as carriers for amphiphilic antimicrobial peptides
Morin, M., Reijmar, K., Pränting, M., Engström, Å., Andersson, D. I., & Edwards, K. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.029 · Cited by 101
Nanoparticle-Based Modulation of the Immune System
Fang, R. H., & Zhang, L. (2016) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-080615-034446 · Cited by 99
Protein– and Peptide–Drug Conjugates
Vhora, I., Patil, S., Bhatt, P., & Misra, A. R. (2015) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2014.11.001 · Cited by 98
Pegylation and Its Impact on the Design of New Protein-Based Medicines
Ginn, C., Khalili, H., Lever, R., & Brocchini, S. (2014) · Future Medicinal Chemistry · doi:10.4155/fmc.14.125 · Cited by 93
Structure-based design for binding peptides in anti-cancer therapy
Wang, S., & Yu, J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.024 · Cited by 99
Self-Assembling Peptides as Building Blocks of Functional Materials for Biomedical Applications
Fukunaga, K., Tsutsumi, H., & Mihara, H. (2018) · Bulletin of the Chemical Society of Japan · doi:10.1246/bcsj.20180293 · Cited by 92
Perspectives on Subcutaneous Route of Administration as an Immunogenicity Risk Factor for Therapeutic Proteins
Hamuro, L., Kijanka, G., Kinderman, F. S., Kropshofer, H., Bu, D., Zepeda, M. L., & Jawa, V. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.05.030 · Cited by 94
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Authors: Pisal, D. S., Kosloski, M. P., & Balu-Iyer, S. V.
Affiliations: University at Buffalo, State University of New York (US)
ORCID: Pisal, Dipak S.
Kosloski, Matthew P.
Venue: Journal of Pharmaceutical Sciences
Publisher: Elsevier BV
Published: 2010-06
Volume: 99
Issue: 6
Pages: 2557-2575
ISSN: 0022-3549 (ISSN-L)
DOI: 10.1002/jps.22054
PMC: PMC2857543
OpenAlex: W1985516113
Cited by: 532
References: 160
Citations by year: 2026: 8 · 2025: 19 · 2024: 14 · 2023: 38 · 2022: 25 · 2021: 31 · 2020: 42 · 2019: 44 · 2018: 45 · 2017: 43 · 2016: 48 · 2015: 40 · 2014: 48 · 2013: 26 · 2012: 28
FWCI: 3.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Pharmaceutical Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Pfizer
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL070227, HL-70227)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein purification and stability
Keywords: therapeutic proteins, drug delivery, protein stability, immunogenicity, protein half-life, PEGylation, polysialic acid, glycolic acid, nanoparticle drug delivery, liposomes, polymeric nanoparticles, polymer microspheres, colloidal drug delivery
MeSH terms: Chemistry, Pharmaceutical, Half-Life, Humans, Liposomes, Microspheres, Polyethylene Glycols, Polymers, Proteins, Sialic Acids, Nanoparticles

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