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Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease
Open accessAbstract
Parkinson's disease (PD) is a multifocal degenerative disorder for which there is no cure. The majority of cases are sporadic with unknown etiology. Recent data indicate that untreated patients with de novo PD have increased colonic permeability and that both de novo and premotor patients have pathological expression of α‐synuclein (α‐syn) in their colon. Both endpoints potentially can serve as disease biomarkers and even may initiate PD events through gut‐derived, lipopolysaccharide (LPS)‐induced neuronal injury. Animal models could be ideal for interrogating the potential role of the intestines in the pathogenesis of PD; however, few current animal models of PD encompass these nonmotor features. We sought to establish a progressive model of PD that includes the gastrointestinal (GI) dysfunction present in human patients. C57/BL6 mice were systemically administered one dose of either LPS (2.5 mg/kg) or saline and were sacrificed in monthly intervals (n = 5 mice for 5 months) to create a time‐course. Small and large intestinal permeability was assessed by analyzing the urinary output of orally ingested sugar probes through capillary column gas chromatography. α‐Syn expression was assessed by counting the number of mildly, moderately, and severely affected myenteric ganglia neurons throughout the GI tract, and the counts were validated by quantitative optical density measurements. Nigrostriatal integrity was assessed by tyrosine hydroxylase immunohistochemistry stereology and densitometry. LPS caused an immediate and progressive increase in α‐syn expression in the large intestine but not in the small intestine. Intestinal permeability of the whole gut (large and small intestines) progressively increased between months 2 and 4 after LPS administration but returned to baseline levels at month 5. Selective measurements demonstrated that intestinal permeability in the small intestine remained largely intact, suggesting that gut leakiness was predominately in the large intestine. Phosphorylated serine 129‐α‐syn was identified in a subset of colonic myenteric neurons at months 4 and 5. Although these changes were observed in the absence of nigrostriatal degeneration, an abrupt but insignificant increase in brainstem α‐syn was observed that paralleled the restoration of permeability. No changes were observed over time in controls. LPS, an endotoxin used to model PD, causes sequential increases in α‐syn immunoreactivity, intestinal permeability, and pathological α‐syn accumulation in the colon in a manner similar to that observed in patients with PD. These features are observed without nigrostriatal degeneration and incorporate PD features before the motor syndrome. This allows for the potential use of this model in testing neuroprotective and disease‐modifying therapies, including intestinal‐directed therapies to fortify intestinal barrier integrity. © 2013 International Parkinson and Movement Disorder Society
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“A leaky gut barrier has been linked to PD pathogenesis involving local flux of bacterial toxins, microbes, and potentially molecules like α-synuclein across the gastrointestinal epithelium [29–31]”
From The gut–brain axis in early Parkinson’s disease: from prodrome to prevention (2025) · cites this paper as [30]
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“LPS produced by gut microbiota treatment can increase the accumulation of a-synuclein in the enteric nervous system and increase intestinal permeability.128”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [128]
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“injection of endotoxin into mice induces α-synuclein production and aggregation, as well as loss of dopaminergic neurons in the substantia nigra.”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [99]
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“A single dose of peripheral endotoxin in mice caused increased expression of α-synuclein in neurons of the large intestine, followed by an increase in large intestinal permeability, in a manner similar to that observed in patients with PD [99].”
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Citations
Cites
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144
Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354
Gastrointestinal Dysfunction in Parkinson’s Disease
Fasano, A., Visanji, N. P., Liu, L. W. C., Lang, A. E., & Pfeiffer, R. F. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00007-1 · Cited by 1,016
SIC Task Force appraisal of clinical diagnostic criteria for parkinsonian disorders
Litvan, I., Bhatia, K. P., Burn, D. J., Goetz, C. G., Lang, A. E., McKeith, I. G., Quinn, N. P., Sethi, K. D., Shults, C. W., & Wenning, G. K. (2003) · Movement Disorders · doi:10.1002/mds.10459 · Cited by 1,011
Forsyth, C. B., Shannon, K. M., Kordower, J. H., Voigt, R. M., Shaikh, M., Jaglin, J. A., Estes, J. D., Dodiya, H. B., & Keshavarzian, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028032 · Cited by 974
Self-citationGastrointestinal dysfunction in Parkinson's disease
Pfeiffer, R. F. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00307-7 · Cited by 933
Intestinal permeability: an overview
Bjarnason, I., Macpherson, A., & Hollander, D. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90708-4 · Cited by 927
Arizona Parkinson’s Disease Consortium, Beach, T. G., Adler, C. H., Sue, L. I., Vedders, L., Lue, L., White III, C. L., Akiyama, H., Caviness, J. N., Shill, H. A., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0664-3 · Cited by 911
Frequency of Bowel Movements and the Future Risk of Parkinson’s Disease
Abbott, R. D., Petrovitch, H., White, L. R., Masaki, K. H., Tanner, C. M., Curb, J. D., Grandinetti, A., Blanchette, P. L., Popper, J. S., & Ross, G. W. (2001) · Neurology · doi:10.1212/wnl.57.3.456 · Cited by 839
Toxin-induced models of Parkinson’s disease
Bové, J., Prou, D., Perier, C., & Przedborski, S. (2005) · NeuroRX · doi:10.1602/neurorx.2.3.484 · Cited by 739
Colonic inflammation in Parkinson's disease
Devos, D., Lebouvier, T., Lardeux, B., Biraud, M., Rouaud, T., Pouclet, H., Coron, E., Bruley des Varannes, S., Naveilhan, P., Nguyen, J.-M., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.09.007 · Cited by 627
Intestinal barrier: An interface between health and disease
Farhadi, A., Banan, A., Fields, J. Z., & Keshavarzian, A. (2003) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2003.03032.x · Cited by 532
Self-citationParkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses
Wakabayashi, K., Takahashi, H., Takeda, S., Ohama, E., & Ikuta, F. (1988) · Acta Neuropathologica · doi:10.1007/bf00687767 · Cited by 528
Pan-Montojo, F., Anichtchik, O., Dening, Y., Knels, L., Pursche, S., Jung, R., Jackson, S., Gille, G., Spillantini, M. G., Reichmann, H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008762 · Cited by 524
Alpha-synuclein in colonic submucosa in early untreated Parkinson’s disease
Shannon, K. M., Keshavarzian, A., Mutlu, E., Dodiya, H. B., Daian, D., Jaglin, J. A., & Kordower, J. H. (2012) · Movement Disorders · doi:10.1002/mds.23838 · Cited by 469
Self-citationIs alpha-synuclein in the colon a biomarker for premotor Parkinson’s disease? Evidence from 3 cases
Shannon, K. M., Keshavarzian, A., Dodiya, H. B., Jakate, S., & Kordower, J. H. (2012) · Movement Disorders · doi:10.1002/mds.25020 · Cited by 464
Self-citationPrevalence of Dementia in Older Japanese-American Men in Hawaii: The Honolulu-Asia Aging Study
White, L. (1996) · JAMA · doi:10.1001/jama.1996.03540120033030 · Cited by 437
Medical records documentation of constipation preceding Parkinson disease
Savica, R., Carlin, J. M., Grossardt, B. R., Bower, J. H., Ahlskog, J. E., Maraganore, D. M., Bharucha, A. E., & Rocca, W. A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c34af5 · Cited by 431
Lebouvier, T., Neunlist, M., Bruley des Varannes, S., Coron, E., Drouard, A., N'Guyen, J.-M., Chaumette, T., Tasselli, M., Paillusson, S., Flamand, M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012728 · Cited by 427
Chu, Y., & Kordower, J. H. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.08.021 · Cited by 423
Self-citationNeuropathology of Autonomic Nervous System in Parkinson's Disease
Wakabayashi, K., & Takahashi, H. (2008) · European Neurology · doi:10.1159/000113469 · Cited by 407
Pan-Montojo, F., Schwarz, M., Winkler, C., Arnhold, M., O'Sullivan, G. A., Pal, A., Said, J., Marsico, G., Verbavatz, J.-M., Rodrigo-Angulo, M., et al. (2012) · Scientific Reports · doi:10.1038/srep00898 · Cited by 405
Forsyth, C. B., Farhadi, A., Jakate, S. M., Tang, Y., Shaikh, M. W., & Keshavarzian, A. (2009) · Alcohol · doi:10.1016/j.alcohol.2008.12.009 · Cited by 404
Self-citationCastaño, A., Herrera, A. J., Cano, J., & Machado, A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041584.x · Cited by 393
Herrera, A. J., Castaño, A., Venero, J. L., Cano, J., & Machado, A. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0289 · Cited by 392
Topography of efferent vagal innervation of the rat gastrointestinal tract
Berthoud, H., Carlson, N. R., & Powley, T. L. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.1.r200 · Cited by 366
Keshavarzian, A., Farhadi, A., Forsyth, C. B., Rangan, J., Jakate, S. M., Shaikh, M. W., Banan, A., & Fields, J. Z. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.10.028 · Cited by 359
Self-citationBloch, A., Probst, A., Bissig, H., Adams, H., & Tolnay, M. (2006) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2006.00727.x · Cited by 337
Wakabayashi, K., Takahashi, H., Ohama, E., & Ikuta, F. (1990) · Acta Neuropathologica · doi:10.1007/bf00294234 · Cited by 324
Cersosimo, M. G., Raina, G. B., Pecci, C., Pellene, A., Calandra, C. R., Gutiérrez, C., Micheli, F. E., & Benarroch, E. E. (2013) · Journal of Neurology · doi:10.1007/s00415-012-6801-2 · Cited by 314
Esophageal Lewy bodies associated with ganglion cell loss in achalasia
Qualman, S. J., Haupt, H. M., Yang, P. H., & Hamilton, S. R. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90079-9 · Cited by 305
Tredici, K. D., Hawkes, C. H., Ghebremedhin, E., & Braak, H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0665-2 · Cited by 303
Qualman, S. J., Haupt, H. M., Yang, P. H., & Hamilton, S. R. (1984) · PubMed · Cited by 295
Kuo, Y., Li, Z., Jiao, Y., Gaborit, N., Pani, A. K., Orrison, B. M., Bruneau, B. G., Giasson, B. I., Smeyne, R. J., Gershon, M. D., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq038 · Cited by 289
Keita, Å. V., & Söderholm, J. D. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01498.x · Cited by 286
Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology
Drolet, R. E., Cannon, J. R., Montero, L. M., & Greenamyre, J. T. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.017 · Cited by 262
Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?
Tomé, C. M. L., Tyson, T., Rey, N. L., Grathwohl, S. A., Britschgi, M., & Brundin, P. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8267-8 · Cited by 247
Pathological lesions in colonic biopsies during Parkinson’s disease
Lebouvier, T., Chaumette, T., Damier, P., Coron, E., Touchefeu, Y., Vrignaud, S., Naveilhan, P., Galmiche, J.-P., Varannes, S. B. D., Derkinderen, P., et al. (2008) · Gut · doi:10.1136/gut.2008.162503 · Cited by 237
Farhadi, A., Gundlapalli, S., Shaikh, M. W., Frantzides, C. T., Harrell, L. E., Kwasny, M., & Keshavarzian, A. (2008) · Liver International · doi:10.1111/j.1478-3231.2008.01723.x · Cited by 233
Self-citationParkinson's disease and megacolon
Kupsky, W. J., Grimes, M. M., Sweeting, J. C., Bertsch, R., & Cote, L. J. (1987) · Neurology · doi:10.1212/wnl.37.7.1253 · Cited by 232
Parkinson’s disease is not associated with gastrointestinal myenteric ganglion neuron loss
Annerino, D. M., Arshad, S., Taylor, G. M., Adler, C. H., Beach, T. G., & Greene, J. G. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1040-2 · Cited by 204
Bowel movement frequency in late‐life and incidental Lewy bodies
Abbott, R. D., Ross, G. W., Petrovitch, H., Tanner, C. M., Davis, D. G., Masaki, K., Launer, L. J., Curb, J. D., & White, L. R. (2007) · Movement Disorders · doi:10.1002/mds.21560 · Cited by 203
Phillips, R. J., Walter, G. C., Wilder, S. L., Baronowsky, E. A., & Powley, T. L. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.074 · Cited by 189
Pre-motor features of Parkinson's disease: the Honolulu-Asia Aging Study experience
Ross, G. W., Abbott, R. D., Petrovitch, H., Tanner, C. M., & White, L. R. (2011) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70062-1 · Cited by 170
Striatal Neuroinflammation Promotes Parkinsonism in Rats
Choi, D.-Y., Liu, M., Hunter, R. L., Cass, W. A., Pandya, J. D., Sullivan, P. G., Shin, E.-J., Kim, H.-C., Gash, D. M., & Bing, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005482 · Cited by 141
Expression pattern and localization of alpha-synuclein in the human enteric nervous system
Böttner, M., Zorenkov, D., Hellwig, I., Barrenschee, M., Harde, J., Fricke, T., Deuschl, G., Egberts, J. D., Becker, T., Fritscher‐Ravens, A., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.07.018 · Cited by 140
A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease
Pouclet, H., Lebouvier, T., Coron, E., Bruley des Varannes, S., Rouaud, T., Roy, M., Neunlist, M., & Derkinderen, P. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.08.014 · Cited by 138
Wang, L., Magen, I., Yuan, P. Q., Subramaniam, S., Richter, F., Chesselet, M. ‐., & Taché, Y. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01974.x · Cited by 118
A prospective study of bowel movement frequency and risk of Parkinson's disease
Gao, X., Chen, H., Schwarzschild, M. A., & Ascherio, A. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr119 · Cited by 115
Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits
Hallett, P. J., McLean, J. R., Kartunen, A., Langston, J. W., & Ole Isacson, A. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.04.009 · Cited by 111
Effects of oral administration of rotenone on gastrointestinal functions in mice
Tasselli, M., Chaumette, T., Paillusson, S., Monnet, Y., Lafoux, A., Huchet, C., Aubert, P., Hunot, S., Derkinderen, P., & Neunlist, M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12070 · Cited by 89
Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits
Liu, Y., Qin, L., Wilson, B., Wu, X., Qian, L., Granholm, A.-C., Crews, F. T., & Hong, J.-S. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.02.014 · Cited by 84
Noorian, A. R., Rha, J., Annerino, D. M., Bernhard, D., Taylor, G. M., & Greene, J. G. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.06.005 · Cited by 80
Zhang, J., Stanton, D. M., Nguyen, X. V., Liu, M., Zhang, Z., Gash, D. M., & Bing, G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.049 · Cited by 64
Parkinson's disease with involvement of the parasympathetic ganglia
Takeda, S., Yamazaki, K., Miyakawa, T., & Arai, H. (1993) · Acta Neuropathologica · doi:10.1007/bf00369454 · Cited by 63
Farhadi, A., Keshavarzian, A., Fields, J. Z., Sheikh, M., & Banan, A. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.03.046 · Cited by 44
Self-citationLee, H.-J., Suk, J., Lee, K.-W., Park, S.-H., Blumbergs, P. C., Gai, W., & Lee, S. (2011) · Experimental Neurobiology · doi:10.5607/en.2011.20.4.181 · Cited by 41
Ciliax (1999) · doi:10.1002/(sici)1096-9861(19990621)409:1
Self-citation
Research works printed but not linked: 2
- Bing G, 1998, Microglia mediated dopaminergic cell death in the substantia nigra: a new animal model for Parkinson's disease [abstract], Neurosci Abstracts, 24, 44
- 10.1016/S1353-8020(11)70062-1 · DOI
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Metadata
- Authors
- Kelly, L. P., Carvey, P. M., Keshavarzian, A., Shannon, K. M., Shaikh, M., Bakay, R. A. E., & Kordower, J. H.
- Affiliations
- Rush University (US)
- Utrecht University (NL)
- Corresponding author
- Kordower, Jeffrey H.
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2013-11-04
- Volume
- 29
- Issue
- 8
- Pages
- 999-1009
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- PMC
- PMC4050039
- OpenAlex
- W2108108635
- Cited by
- 308
- References
- 61
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 28 · 2023: 55 · 2022: 34 · 2021: 54 · 2020: 29 · 2019: 24 · 2018: 18 · 2017: 13 · 2016: 6 · 2015: 9 · 2014: 6
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS055143)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, intestinal permeability, alpha-synuclein, lipopolysaccharide, gastrointestinal dysfunction, nigrostriatal degeneration, tyrosine hydroxylase, disease biomarkers, mouse model, gut-brain axis
- MeSH terms
- Animals, Brain, Chromatography, Gas, Colon, Disease Models, Animal, Gastrointestinal Agents, Male, Mice, Inbred C57BL, Parkinson Disease, Permeability, Polysaccharides, Severity of Illness Index, Time Factors, Tyrosine 3-Monooxygenase, Vagus Nerve, Linear Models, Disease Progression, Mice, alpha-Synuclein
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