Cited by 186Gut microbiota and healthPotato Plant ResearchAnimal Nutrition and Physiology

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Metabolism of Maillard reaction products by the human gut microbiota – implications for health

Tuohy, Kieran M., Hinton, Davinia J. S., Davies, Sarah J., Crabbe, M. James C., Gibson, Glenn R., Ames, Jennifer M.·2006·Molecular Nutrition & Food Research

DOI 10.1002/mnfr.200500126

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Abstract

The human colonic microbiota imparts metabolic versatility on the colon, interacts at many levels in healthy intestinal and systemic metabolism, and plays protective roles in chronic disease and acute infection. Colonic bacterial metabolism is largely dependant on dietary residues from the upper gut. Carbohydrates, resistant to digestion, drive colonic bacterial fermentation and the resulting end products are considered beneficial. Many colonic species ferment proteins but the end products are not always beneficial and include toxic compounds, such as amines and phenols. Most components of a typical Western diet are heat processed. The Maillard reaction, involving food protein and sugar, is a complex network of reactions occurring during thermal processing. The resultant modified protein resists digestion in the small intestine but is available for colonic bacterial fermentation. Little is known about the fate of the modified protein but some Maillard reaction products (MRP) are biologically active by, e. g. altering bacterial population levels within the colon or, upon absorption, interacting with human disease mechanisms by induction of inflammatory responses. This review presents current understanding of the interactions between MRP and intestinal bacteria. Recent scientific advances offering the possibility of elucidating the consequences of microbe‐MRP interactions within the gut are discussed.

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Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659
Self-citation
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Encyclopedia of food sciences and nutrition
Caballero, B. H., Trugo, L. C., & Finglas, P. M. (2003) · Academic eBooks · Cited by 1,639
The control and consequences of bacterial fermentation in the human colon
Cummings, J. H., & Macfarlane, G. T. (1991) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1991.tb02739.x · Cited by 1,499
Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut
Suau, A., Bonnet, R., Sutren, M., Godon, J.-J., Gibson, G. R., Collins, M. D., & Doré, J. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.11.4799-4807.1999 · Cited by 1,490
Self-citation
A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis
Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V., & Gordon, J. I. (2003) · Science · doi:10.1126/science.1080029 · Cited by 1,353
The microbiology of butyrate formation in the human colon
Pryde, S. E., Duncan, S. H., Hold, G. L., Stewart, C. S., & Flint, H. J. (2002) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2002.tb11467.x · Cited by 1,320
Cancer statistics, 1994
Boring, C. C., Squires, T. S., Tong, T., & Montgomery, S. (1994) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.44.1.7 · Cited by 1,313
Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product
Duncan, S. H., Louis, P., & Flint, H. J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.5810-5817.2004 · Cited by 1,178

Show all 116 references

Research works printed but not linked: 14

Jenkins L., 2004, Nurs. Times, 100, 56
Gibson G. R. An overview of the composition and activities of the human colonic microbiota in: Mälkki Y. and Cummings J. H. (Eds.) COST Action 92 Dietary fibre and fermentation in the colon.Proceedings of COST Action 92 workshop Espoo Finland 15–17thJune 1995. 1996 pp. 11–23.
Cummings J. H. Short chain fatty acids in: Gibson G. R. and Macfarlane G. T. (Eds.) Human colonic bacteria: role in nutrition physiology and health CRC Press Boca Raton 1995 pp. 101–130.
Engelhardt W. Busche R. Gros G. Rechkemmer G. Absorption of short‐chain fatty acids: mechanisms and regional differences in the large intestine in: Cummings J. H. Rombeau J. L. and Sakata T. (Eds.) Short‐chain fatty acids: metabolism and clinical importance Ross Laboratories Press Columbus 1991 pp. 60–62.
Cummings J. H. Macfarlane G. T. Draser B. S. The gut microflora and its significance in: Whithead R. (Ed.) Gastrointestinal and Oesophageal Pathology Churchill Livingstone Edingurgh 1989 pp. 201–219.
Weber F. L., 1987, J. Lab. Clin. Med., 110, 259
Matsui T., 1995, Eur. J. Gastroenterol. Hepatol, 7, S79
Shepard S. E. Schlatter C. Lutz W. K. N‐nitrosocompounds: relevance to human cancer in: Bartels H. O'Neill I.K. and Herman R. S. (Eds.) IARC Scientific Publications No. 57 IARC Scientific Publications Lyons 1987 pp. 328–332.
Ames J. M., 2000, Czech. J. Food Sci., 18, 58
Rowland I. R. Toxicology of the colon: role of the intestinal microflora in: Gibson G. R. and Macfarlane G. T. (Eds.) Human Colonic Bacteria: role in nutrition physiology and pathology CRC Press Boca Raton 1995 pp. 155–174.
Canzian F., 1994, Cancer Res., 54, 6315
Boobis A. R., 1994, Cancer Res., 54, 89
Finot P. A., 1981, Prog. Food Nutr. Sci., 5, 193
Chadwick V. S. Anderson R. P. The role of intestinal bacteria in etiology and maintenance of inflammatory bowel disease in: Gibson G. R. Macfarlane G. T. (Eds.) Human colonic bacteria: role in nutrition physiology and pathology CRC Press Boca Raton 1995 pp. 227–256.

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Authors: Tuohy, K. M., Hinton, D. J. S., Davies, S. J., Crabbe, M. J. C., Gibson, G. R., & Ames, J. M.
Affiliations: University of Reading (GB)
Queen's University Belfast (GB)
Corresponding author: Tuohy, Kieran M.
ORCID: Tuohy, Kieran M.
Crabbe, M. James C.
Gibson, Glenn R.
Ames, Jennifer M.
Venue: Molecular Nutrition & Food Research
Publisher: Wiley
Published: 2006-08-30
Volume: 50
Issue: 9
Pages: 847-857
ISSN: 1613-4125 (ISSN-L)
1613-4133
DOI: 10.1002/mnfr.200500126
OpenAlex: W2132804221
Cited by: 186
References: 116
Citations by year: 2026: 4 · 2025: 8 · 2024: 4 · 2023: 9 · 2022: 8 · 2021: 10 · 2020: 13 · 2019: 8 · 2018: 15 · 2017: 13 · 2016: 9 · 2015: 11 · 2014: 12 · 2013: 9 · 2012: 9
FWCI: 0.53
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Nutrition & Food Research (publishedVersion)
PubMed (publishedVersion)
Research Portal (Queen's University Belfast) (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords: Maillard reaction products, gut microbiota, colonic fermentation, modified proteins, thermal food processing, amines, phenols, inflammation, Western diet, microbial metabolism
MeSH terms: Bacteria, Colon, Dietary Carbohydrates, Dietary Proteins, Fermentation, Food Handling, Health, Hot Temperature, Humans, Nutritive Value, Maillard Reaction, Acrylamide

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Metabolism of Maillard reaction products by the human gut microbiota – implications for health

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