Cited by 195Gut microbiota and healthAdvanced Glycation End Products researchAnimal Nutrition and Physiology

Dietary advanced glycation end products modify gut microbial composition and partially increase colon permeability in rats

Qu, Wanting, Yuan, Xiaojin, Zhao, Jinsong, Zhang, Yingxiao, Hu, Jing, Wang, Jiawei, Li, Juxiu·2017·Molecular Nutrition & Food Research

Abstract

Scope: The adverse impacts of dietary advanced glycation end products (AGEs) on health are currently of interest. These compounds are inevitably formed during thermal food processing and make foods less digestible because of protein cross‐linking. This study examined not only whether dietary AGEs alter cecal microbiota and their metabolites but also their effects on colon permeability. Methods and results: Sprague–Dawley rats were exposed to a high‐AGEs diet (AGEs content was increased by heating food at 125°C/3 h) for 6, 12, or 18 weeks. Cecal microbiota was analyzed by 16S rDNA gene sequencing. Colon permeability was assessed through histopathology, immunohistochemistry and endotoxin testing. Microbial metabolites (e.g. ammonia and short‐chain fatty acids (SCFAs)) were also measured. AGEs treatment reduced the diversity and richness of the microbiota, especially saccharolytic bacteria such as Ruminococcaceae and Alloprevotella, which can produce SCFAs, whereas some putatively harmful bacteria (Desulfovibrio and Bacteroides) were increased. Protein fermentation was enhanced, supported by elevated ammonia and branched‐chain fatty acid levels (p < 0.05). Additionally, the colonocytes structure changed and the expression of tight junction proteins in colon were decreased. Conclusion: Dietary AGEs detrimentally modulate gut microbial ecology and may partially increase colon permeability, which can adversely impact host health.

Integrity signals

Registry

Crossref · 10.1002/mnfr.201700118

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Qu, W., Yuan, X., Zhao, J., Zhang, Y., Hu, J., Wang, J., & Li, J.
Affiliations
  • Northwest A&F University (CN)
  • Shaanxi Research Institute of Agricultural Products Processing Technology Xi'an P. R. China
Corresponding author
Li, Juxiu
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2017-07-31
Volume
61
Issue
10
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W2626757016
Cited by
195
References
73
Citations by year
2026: 12 · 2025: 23 · 2024: 18 · 2023: 26 · 2022: 31 · 2021: 32 · 2020: 19 · 2019: 20 · 2018: 13 · 2017: 1
FWCI
5.92
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (31471579)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
advanced glycation end products, gut microbiota, short-chain fatty acids, protein fermentation, ammonia, tight junction proteins, Ruminococcaceae, Alloprevotella, Desulfovibrio, Bacteroides, thermal food processing
MeSH terms
Bacillota, Gastrointestinal Microbiome, Cyanobacteria, Ammonia, Animals, Colon, Diet, DNA, Bacterial, Fatty Acids, Volatile, Fermentation, Male, Permeability, RNA, Ribosomal, 16S, Glycation End Products, Advanced, Rats, Sprague-Dawley, Sequence Analysis, DNA, Proteobacteria, Bacteroidetes, Rats, Verrucomicrobia, Occludin, Zonula Occludens-1 Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review