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Cited by 218Metabolomics and Mass Spectrometry StudiesPhytochemicals and Antioxidant ActivitiesNutrition, Genetics, and Disease

The DOI matches its Crossref record; 101 of the 102 references it cites were found in a registry or an index.

The complex links between dietary phytochemicals and human health deciphered by metabolomics

Manach, Claudine, Hubert, Jane, Llorach, Rafael, Scalbert, Augustin·2009·Molecular Nutrition & Food Research
DOI 10.1002/mnfr.200800516
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Abstract

A large variety of phytochemicals commonly consumed with the human diet, influence health and may contribute to the prevention of diseases. However, it is still difficult to make nutritional recommendations for these bioactive compounds. Current studies of phytochemicals are generally focused on specific compounds and their effects on a limited number of markers. New approaches are needed to take into account both the diversity of phytochemicals found in the diet and the complexity of their biological effects. Recent progress in high-throughput analytical technologies and in bioinformatics now allows the simultaneous analysis of the hundreds or more metabolites constituting the metabolome in urine or plasma. These analyses give complex metabolic fingerprints characteristic of a given phenotype. The exploitation of the wealth of information it contains, in randomized controlled trials and cohort studies, should lead to the discovery of new markers of intake for phytochemicals and new markers of effects. In this paper, we briefly review the current methods used to evaluate intake of phytochemicals and their effects on health. We then describe the applications of metabolomics in this field. Recent metabolomics studies illustrate the potential of such a global approach to explore the complex relationships linking phytochemical intake and metabolism and health.

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Research works printed but not linked: 3

  1. 10.1016/S0025-6196(11)63144-3 · DOI
  2. Neveu V. Vos F. du Chaffaut L. Mennen L. et al. 10th European Nutrition Conference Paris 2007 p. 122 (abstract).
  3. 10.1002/(SICI)1097-0010(20000515)80:7<985::AID-JSFA572>3.0.CO;2-7 · DOI

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Metadata

Authors
Manach, C., Hubert, J., Llorach, R., & Scalbert, A.
Affiliations
Unité de Nutrition Humaine (FR)
Corresponding author
Scalbert, Augustin
ORCID
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2009-10
Volume
53
Issue
10
Pages
1303-1315
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
DOI
10.1002/mnfr.200800516
OpenAlex
W2030179947
Cited by
218
References
102
Citations by year
2026: 4 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 10 · 2019: 18 · 2018: 11 · 2017: 11 · 2016: 13 · 2015: 26 · 2014: 18 · 2013: 30 · 2012: 20
FWCI
1.25
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
dietary phytochemicals, metabolomics, bioactive compounds, disease prevention, dietary recommendations, urinary metabolome, plasma metabolome, biomarkers of effect
MeSH terms
Animals, Diet, Health Status, Humans, Plants, Edible, Metabolomics

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