Cited by 218Metabolomics and Mass Spectrometry StudiesPhytochemicals and Antioxidant ActivitiesNutrition, Genetics, and Disease

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The complex links between dietary phytochemicals and human health deciphered by metabolomics

Manach, Claudine, Hubert, Jane, Llorach, Rafael, Scalbert, Augustin·2009·Molecular Nutrition & Food Research

DOI 10.1002/mnfr.200800516

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Abstract

A large variety of phytochemicals commonly consumed with the human diet, influence health and may contribute to the prevention of diseases. However, it is still difficult to make nutritional recommendations for these bioactive compounds. Current studies of phytochemicals are generally focused on specific compounds and their effects on a limited number of markers. New approaches are needed to take into account both the diversity of phytochemicals found in the diet and the complexity of their biological effects. Recent progress in high-throughput analytical technologies and in bioinformatics now allows the simultaneous analysis of the hundreds or more metabolites constituting the metabolome in urine or plasma. These analyses give complex metabolic fingerprints characteristic of a given phenotype. The exploitation of the wealth of information it contains, in randomized controlled trials and cohort studies, should lead to the discovery of new markers of intake for phytochemicals and new markers of effects. In this paper, we briefly review the current methods used to evaluate intake of phytochemicals and their effects on health. We then describe the applications of metabolomics in this field. Recent metabolomics studies illustrate the potential of such a global approach to explore the complex relationships linking phytochemical intake and metabolism and health.

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Dettmer, K., Aronov, P. A., & Hammock, B. D. (2006) · Mass Spectrometry Reviews · doi:10.1002/mas.20108 · Cited by 2,379
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Liu, R. H. (2004) · Journal of Nutrition · doi:10.1093/jn/134.12.3479s · Cited by 2,295
Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
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Liu, R. H. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.517s · Cited by 2,213
Flavonoids: antioxidants or signalling molecules?
Williams, R. J., Spencer, J. P. E., & Rice-Evans, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.001 · Cited by 2,016
Polyphenols and disease risk in epidemiologic studies
Arts, I. C., & Hollman, P. C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.317s · Cited by 1,916
Polyphenols: Antioxidants and beyond
Scalbert, A., Johnson, I. T., & Saltmarsh, M. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.215s · Cited by 1,836
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Trygg, J., Holmes, E. C., & Lundstedt, T. (2006) · Journal of Proteome Research · doi:10.1021/pr060594q · Cited by 1,276
Polyphenolic Flavanols as Scavengers of Aqueous Phase Radicals and as Chain-Breaking Antioxidants
Salah, N., Miller, N. J., Paganga, G., Tijburg, L. B. M., Bolwell, G. P., & Rice-Evans, C. A. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1473 · Cited by 1,276
The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones
Setchell, K. D. R., Brown, N. M., & Lydeking-Olsen, E. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.12.3577 · Cited by 1,209
Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk
Ríboli, E., & Norat, T. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.559s · Cited by 1,173
Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials
Hooper, L., Kroon, P. A., Rimm, E. B., Cohn, J. S., Harvey, I., Le Cornu, K. A., Ryder, J. J., Hall, W. L., & Cassidy, A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.38 · Cited by 1,097
Efficacy and Safety of Plant Stanols and Sterols in the Management of Blood Cholesterol Levels
Katan, M., Grundy, S. M., Jones, P. J. H., Law, M., Miettinen, T. A., & Paoletti, R. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.8.965 · Cited by 1,078
Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics
Brindle, J. T., Antti, H., Holmes, E. C., Tranter, G. E., Nicholson, J. K., Bethell, H., Clarke, S., Schofield, P. M., McKilligin, E., Mosedale, D. E., et al. (2002) · Nature Medicine · doi:10.1038/nm1202-802 · Cited by 1,035
Gut microorganisms, mammalian metabolism and personalized health care
Nicholson, J. K., Holmes, E., & Wilson, I. D. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1152 · Cited by 945
Plant-based foods and prevention of cardiovascular disease: an overview
Hu, F. B. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.544s · Cited by 700
Metabolomics: applications to food science and nutrition research
Wishart, D. S. (2008) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2008.03.003 · Cited by 694
Phytochemical dictionary. A handbook of bioactive compounds from plants.
Harborne, J. B., Baxter, H., & Moss, G. P. (1999) · Taylor & Francis eBooks · Cited by 633
Cancer Chemoprevention Through Dietary Antioxidants: Progress and Promise
Khan, N., Afaq, F., & Mukhtar, H. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1740 · Cited by 592
A Liquid Chromatography-Mass Spectrometry-Based Metabolome Database for Tomato
Moco, S., Bino, R. J., Vorst, O., Verhoeven, H. A., de Groot, J., van Beek, T. A., Vervoort, J. J. M., & Vos, C. H. R. D. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.078428 · Cited by 578
Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research
Scalbert, A., Brennan, L., Fiehn, O., Hankemeier, T., Kristal, B. S., van Ommen, B., Pujos-Guillot, E., Verheij, E., Wishart, D., & Wopereis, S. (2009) · Metabolomics · doi:10.1007/s11306-009-0168-0 · Cited by 565
Self-citation
Polyphenolic phytochemicals – just antioxidants or much more?
Stevenson, D. E., & Hurst, R. D. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7237-1 · Cited by 551
Carotenoid Content of U.S. Foods: An Update of the Database
Holden, J. M., Eldridge, A. L., Beecher, G. R., Buzzard, I. M., Bhagwat, S. A., Davis, C. S., Douglass, L. W., Gebhardt, S. E., Haytowitz, D. B., & Schakel, S. F. (1999) · Journal of Food Composition and Analysis · doi:10.1006/jfca.1999.0827 · Cited by 536
C AROTENOID B IOAVAILABILITY AND B IOCONVERSION
Yeum, K., & Russell, R. M. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102834 · Cited by 535
Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research
Spencer, J., Mohsen, M. M. A. E., Minihane, A., & Mathers, J. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507798938 · Cited by 481
Metabolomics in human nutrition: opportunities and challenges
Gibney, M. J., Walsh, M. C., Brennan, L., Roche, H. M., German, B. J., & van Ommen, B. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.497 · Cited by 458
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
Orešič, M., Simell, S., Sysi-Aho, M., Näntö-Salonen, K., Seppänen-Laakso, T., Parikka, V., Katajamaa, M., Hekkala, A., Mattila, I., Keskinen, P., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081800 · Cited by 449
Metabolism of Antioxidant and Chemopreventive Ellagitannins from Strawberries, Raspberries, Walnuts, and Oak-Aged Wine in Humans: Identification of Biomarkers and Individual Variability
Cerdá, B., Tomás-Barberán, F. A., & Espı́n, J. C. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049144d · Cited by 448
A critical review of the bioavailability of glucosinolates and related compounds
Holst, B., & Williamson, G. (2004) · Natural Product Reports · doi:10.1039/b204039p · Cited by 421
Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions
Mullen, W., Edwards, C. A., & Crozier, A. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061809 · Cited by 421
Intestinal absorption of dietary carotenoids
Yonekura, L., & Nagao, A. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600145 · Cited by 409
Effects of Dosing Condition on the Oral Bioavailability of Green Tea Catechins after Single-Dose Administration of Polyphenon E in Healthy Individuals
Chow, H.-H. S., Hakim, I. A., Vining, D. R., Crowell, J. A., Ranger-Moore, J., Chew, W. M., Celaya, C. A., Rodney, S. R., Hara, Y., & Alberts, D. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2549 · Cited by 400
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
Shaham, O., Wei, R., Wang, T. J., Ricciardi, C., Lewis, G. D., Vasan, R. S., Carr, S. A., Thadhani, R., Gerszten, R. E., & Mootha, V. K. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.50 · Cited by 399
Activity and Concentration of Polyphenolic Antioxidants in Apple: Effect of Cultivar, Harvest Year, and Storage Conditions
van der Sluis, A. A., Dekker, M., de Jager, A., & Jongen, W. M. F. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf001493u · Cited by 398
Flavonoids: modulators of brain function?
Spencer, J. P. E. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508965776 · Cited by 385
Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection
Brown, M. J., Ferruzzi, M. G., Nguyen, M. L., Cooper, D. A., Eldridge, A. L., Schwartz, S. J., & White, W. S. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.396 · Cited by 376
The human cerebrospinal fluid metabolome
Wishart, D. S., Lewis, M., Morrissey, J. A., Flegel, M. D., Jeroncic, K., Xiong, Y., Cheng, D., Eisner, R., Gautam, B., Tzur, D., et al. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.05.001 · Cited by 346
Detection of epithelial ovarian cancer using 1 H‐NMR‐based metabonomics
Odunsi, K. O., Wollman, R. M., Ambrosone, C. B., Hutson, A. D., McCann, S. E., Tammela, J., Geisler, J. P., Miller, G., Sellers, T. A., Cliby, W. A., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20651 · Cited by 319
Plant Secondary Metabolites: Occurrence, Structure And Role In The Human Diet
Crozier, A., Clifford, M. B., & Ashihara, H. (2014) · Wiley eBooks · doi:10.1002/9780470988558 · Cited by 287
Nonlinear Data Alignment for UPLC−MS and HPLC−MS Based Metabolomics: Quantitative Analysis of Endogenous and Exogenous Metabolites in Human Serum
Nordström, A., O’Maille, G., Qin, C., & Siuzdak, G. E. (2006) · Analytical Chemistry · doi:10.1021/ac060245f · Cited by 278
Nutritional metabonomics: applications and perspectives.
Rezzi, S., Ramadan, Z., Fay, L., & Kochhar, S. (2007) · Journal of Proteome Research · doi:10.1021/pr060522z · Cited by 274
Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolk
Grace, P. B., Taylor, J. I., Low, Y.-L., Luben, R. N., Mulligan, A. A., Botting, N. P., Dowsett, M., Welch, A. A., Khaw, K.-T., Wareham, N. J., et al. (2004) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.698.13.5 · Cited by 264
The role of analytical sciences in medical systems biology
van der Greef, J., Stroobant, P., & van der Heijden, R. (2004) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2004.08.013 · Cited by 263
Structure elucidation of phase II metabolites by tandem mass spectrometry: an overview
Levsen, K., Schiebel, H., Behnke, B., Dötzer, R., Dreher, W., Elend, M., & Thiele, H. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.08.165 · Cited by 244
A Metabonomic Strategy for the Detection of the Metabolic Effects of Chamomile (Matricaria recutita L.) Ingestion
Wang, Y., Tang, H., Nicholson, J. K., Hylands, P. J., Sampson, J. N., & Holmes, E. C. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0403282 · Cited by 237
Mass spectrometry for the identification of the discriminating signals from metabolomics: Current status and future trends
Werner, E., Heilier, J.-F., Ducruix, C., Ezan, É., Junot, C., & Tabet, J. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.07.004 · Cited by 223
Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation11G. Loo, K. Takahashi, A. Powolny, R.A. Hopkins, Induction of GADD45 gene expression by phenylethyl isothiocyanate in HCT-116 human colon adenocarcinoma cells, FASEB J 16 (2002) A264-A265 (abstract #216.15). Also, unpublished data. (review)
Loo, G. T. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00251-6 · Cited by 215
Phytochemicals and cancer
Johnson, I. T. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005459 · Cited by 213
Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases
Yang, J., Xu, G., ZHENG, Y., Kong, H., Pang, T., Sagbo Ada, L. V., & Yang, Q. X. (2004) · Journal of Chromatography B · doi:10.1016/j.jchromb.2004.09.032 · Cited by 210
Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study
Rissanen, T. H., Voutilainen, S., Nyyssönen, K., Salonen, R., Kaplan, G. A., & Salonen, J. T. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.133 · Cited by 206
Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetables
McNaughton, S. A., & Marks, G. C. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2003917 · Cited by 197
Untitled work
(2002) · PubMed · Cited by 188
Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods
Mennen, L. I., Sapinho, D., Ito, H., Bertrais, S., Galan, P., Hercberg, S., & Scalbert, A. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061808 · Cited by 174
Self-citation
Metabonomics Approach To Determine Metabolic Differences between Green Tea and Black Tea Consumption
van Dorsten, F. A., Daykin, C. A., MULDER, T. P. J., & van Duynhoven, J. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061016x · Cited by 170
Polyphenol levels in human urine after intake of six different polyphenol-rich beverages
Ito, H., Gonthier, M., Manach, C., Morand, C., Mennen, L. I., Rémésy, C., & Scalbert, A. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051522 · Cited by 165
Self-citation
Absorption of lycopene from single or daily portions of raw and processed tomato
Porrini, M., Riso, P., & Testolin, G. (1998) · British Journal Of Nutrition · doi:10.1017/s000711459800141x · Cited by 163
Estimation of plant sterol and cholesterol intake in Finland: quality of new values and their effect on intake
Valsta, L. M., Lemström, A., Ovaskainen, M., Lampi, A., Toivo, J., Korhonen, T., & Piironen, V. I. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041234 · Cited by 162
Variations in Isoflavone Levels in Soy Foods and Soy Protein Isolates and Issues Related to Isoflavone Databases and Food Labeling
Setchell, K. D. R., & Cole, S. J. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf026199b · Cited by 158
Metabolomics: an emerging post-genomic tool for nutrition
Whitfield, P. D., German, A. J., & Noble, P. M. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041243 · Cited by 152
Statistical methods for comparing comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry results: Metabolomic analysis of mouse tissue extracts
Shellie, R. A., Welthagen, W., Zrostlı́ková, J., Spranger, J., Ristow, M., Fiehn, O., & Zimmermann, R. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.05.088 · Cited by 151
Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables
Erlund, I., Silaste, M.-L., Alfthan, G., Rantala, M., Kesäniemi, Y. A., & Aro, A. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601409 · Cited by 151
Health Effects of Phytoestrogens
Branca, F., & Lorenzetti, S. (2005) · Forum of nutrition/Bibliotheca Nutritio et dieta · doi:10.1159/000083773 · Cited by 149
Biofluid 1H NMR-based metabonomic techniques in nutrition research — metabolic effects of dietary isoflavones in humans
Solanky, K. S., Bailey, N. J. C., Beckwith-Hall, B. M., Bingham, S. A., Davis, A. L., Holmes, E. C., Nicholson, J. K., & Cassidy, A. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.12.005 · Cited by 148
Influence of acute phytochemical intake on human urinary metabolomic profiles
Walsh, M. C., Brennan, L., Pujos‐Guillot, E., Sébédio, J., Scalbert, A., Fagan, A., Higgins, D. G., & Gibney, M. J. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1687 · Cited by 142
Self-citation
Interindividual differences in phytochemical metabolism and disposition
Lampe, J. W., & Chang, J. H. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.05.003 · Cited by 139
Computer systems for the prediction of xenobiotic metabolism
Langowski, J., & Long, A. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00011-x · Cited by 138
Assessment of usual dietary intake in population studies of gene–diet interaction
Tucker, K. L. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.07.010 · Cited by 137
Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids
Anto, R. J., George, J., Babu, K. V. D., Rajasekharan, K. N., & Kuttan, R. (1996) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(96)00074-2 · Cited by 136
Soy isoflavone genistein in prevention and treatment of prostate cancer
Perabo, F., Löw, E. C. V., Ellinger, J., von Rücker, A., Müller, S. C., & Bastian, P. J. (2007) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4501000 · Cited by 128
Is molecular profiling ready for use in clinical decision making?
Ioannidis, J. (2007) · The Oncologist · doi:10.1634/theoncologist.12-3-301 · Cited by 126
Detection of Urinary Drug Metabolite (Xenometabolome) Signatures in Molecular Epidemiology Studies via Statistical Total Correlation (NMR) Spectroscopy
Holmes, E. C., Loo, R. L., Cloarec, O., Coen, M., Tang, H., Maibaum, E., Bruce, S., Chan, Q. M., Elliott, P., Stamler, J., et al. (2007) · Analytical Chemistry · doi:10.1021/ac062305n · Cited by 124
Absorption of lycopene from single or daily portions of raw and processed tomato
Porrini, M., Riso, P., & Testolin, G. (1998) · British Journal Of Nutrition · doi:10.1079/096582198388300 · Cited by 122
Health‐related Interactions of Phytochemicals
Lila, M. A., & Raskin, I. (2005) · Journal of Food Science · doi:10.1111/j.1365-2621.2005.tb09054.x · Cited by 114
An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers
Ippolito, J. E., Xu, J., Jain, S. R., Moulder, K. L., Mennerick, S. J., Crowley, J. R., Townsend, R. R., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500756102 · Cited by 107
GC–MS methods for metabolic profiling of microbial fermentation products of dietary polyphenols in human and in vitro intervention studies
Grün, C. H., van Dorsten, F. A., Jacobs, D. M., Belleguic, M. L., van Velzen, E. J. J., Bingham, M. O., Janssen, H., & van Duynhoven, J. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.04.039 · Cited by 101
Intracellular signaling network as a prime chemopreventive target of (–)‐epigallocatechin gallate
Na, H., & Surh, Y. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500154 · Cited by 98
Food sources of plant sterols in the EPIC Norfolk population
Klingberg, S., Andersson, H., Mulligan, A. A., Bhaniani, A., Welch, A., Bingham, S. A., Khaw, K., Andersson, S., & Ellegård, L. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602765 · Cited by 94
Regulation of Nrf2, NF-κB, and AP-1 Signaling Pathways by Chemopreventive Agents
Shen, G., Jeong, W., Hu, R., & Kong, A. T. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1648 · Cited by 94
Lycopene in Cancer Prevention and Treatment
Seren, S., Lieberman, R., Bayraktar, U. D., Heath, E. I., Şahin, K., Andiç, F., & Küçük, Ö. (2008) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31804c7120 · Cited by 94
Chemopreventive Functions of Isothiocyanates
Keum, Y., Jeong, W., & Kong, A. T. (2005) · Drug News & Perspectives · doi:10.1358/dnp.2005.18.7.939350 · Cited by 93
Pattern Recognition Used to Investigate Multivariate Data in Analytical Chemistry
Jurs, P. C. (1986) · Science · doi:10.1126/science.3704647 · Cited by 80
Metabolomics in Practice: Emerging Knowledge to Guide Future Dietetic Advice toward Individualized Health
German, J. B., Watkins, S. M., & Fay, L. B. (2005) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2005.06.006 · Cited by 74
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Fardet, A., Llorach, R., Martin, J., Besson, C., Lyan, B., Pujos‐Guillot, E., & Scalbert, A. (2008) · Journal of Proteome Research · doi:10.1021/pr800034h · Cited by 73
Self-citation
Metabolomic approach to identifying bioactive compounds in berries: Advances toward fruit nutritional enhancement
Stewart, D., McDougall, G. J., Sungurtas, J., Verrall, S. R., Graham, J., & Martinussen, I. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700056 · Cited by 72
Metabolomics Provide New Insight on the Metabolism of Dietary Phytochemicals in Rats
Fardet, A., Llorach, R., Orsoni, A., Martin, J., Pujos‐Guillot, E., Lapierre, C., & Scalbert, A. (2008) · Journal of Nutrition · doi:10.1093/jn/138.7.1282 · Cited by 70
Self-citation
Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats
Felgines, C., Texier, O., Besson, C., Lyan, B., Lamaison, J., & Scalbert, A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507764772 · Cited by 70
Self-citation
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Untitled work
Faulks (2000) · doi:10.1002/(sici)1097-0010(20000515)80:7

Research works printed but not linked: 3

10.1016/S0025-6196(11)63144-3 · DOI
Neveu V. Vos F. du Chaffaut L. Mennen L. et al. 10th European Nutrition Conference Paris 2007 p. 122 (abstract).
10.1002/(SICI)1097-0010(20000515)80:7<985::AID-JSFA572>3.0.CO;2-7 · DOI

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See all 218

Authors: Manach, C., Hubert, J., Llorach, R., & Scalbert, A.
Affiliations: Unité de Nutrition Humaine (FR)
Corresponding author: Scalbert, Augustin
ORCID: Manach, Claudine
Hubert, Jane
Scalbert, Augustin
Venue: Molecular Nutrition & Food Research
Publisher: Wiley
Published: 2009-10
Volume: 53
Issue: 10
Pages: 1303-1315
ISSN: 1613-4125 (ISSN-L)
1613-4133
DOI: 10.1002/mnfr.200800516
OpenAlex: W2030179947
Cited by: 218
References: 102
Citations by year: 2026: 4 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 10 · 2019: 18 · 2018: 11 · 2017: 11 · 2016: 13 · 2015: 26 · 2014: 18 · 2013: 30 · 2012: 20
FWCI: 1.25
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Nutrition & Food Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords: dietary phytochemicals, metabolomics, bioactive compounds, disease prevention, dietary recommendations, urinary metabolome, plasma metabolome, biomarkers of effect
MeSH terms: Animals, Diet, Health Status, Humans, Plants, Edible, Metabolomics

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The complex links between dietary phytochemicals and human health deciphered by metabolomics

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