Cited by 218Metabolomics and Mass Spectrometry StudiesPhytochemicals and Antioxidant ActivitiesNutrition, Genetics, and Disease

The DOI matches its Crossref record; 101 of the 102 references it cites were found in a registry or an index.

The complex links between dietary phytochemicals and human health deciphered by metabolomics

Manach, Claudine, Hubert, Jane, Llorach, Rafael, Scalbert, Augustin·2009·Molecular Nutrition & Food Research

DOI 10.1002/mnfr.200800516

Open this paper in CoChat — free account

Abstract

A large variety of phytochemicals commonly consumed with the human diet, influence health and may contribute to the prevention of diseases. However, it is still difficult to make nutritional recommendations for these bioactive compounds. Current studies of phytochemicals are generally focused on specific compounds and their effects on a limited number of markers. New approaches are needed to take into account both the diversity of phytochemicals found in the diet and the complexity of their biological effects. Recent progress in high-throughput analytical technologies and in bioinformatics now allows the simultaneous analysis of the hundreds or more metabolites constituting the metabolome in urine or plasma. These analyses give complex metabolic fingerprints characteristic of a given phenotype. The exploitation of the wealth of information it contains, in randomized controlled trials and cohort studies, should lead to the discovery of new markers of intake for phytochemicals and new markers of effects. In this paper, we briefly review the current methods used to evaluate intake of phytochemicals and their effects on health. We then describe the applications of metabolomics in this field. Recent metabolomics studies illustrate the potential of such a global approach to explore the complex relationships linking phytochemical intake and metabolism and health.

Integrity signals

Registry

Crossref · 10.1002/mnfr.200800516

Cites

101 of 101 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Self-citation
Dietary polyphenols and the prevention of diseases
Scalbert, A., Manach, C., Morand, C., Rémésy, C., & Jiménez, L. (2005) · Critical Reviews in Food Science and Nutrition · doi:10.1080/1040869059096 · Cited by 2,999
Self-citation
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
Miller, E. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-1-200501040-00110 · Cited by 2,577
Mass spectrometry‐based metabolomics
Dettmer, K., Aronov, P. A., & Hammock, B. D. (2006) · Mass Spectrometry Reviews · doi:10.1002/mas.20108 · Cited by 2,379
Potential Synergy of Phytochemicals in Cancer Prevention: Mechanism of Action
Liu, R. H. (2004) · Journal of Nutrition · doi:10.1093/jn/134.12.3479s · Cited by 2,295
Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals
Liu, R. H. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.517s · Cited by 2,213
Flavonoids: antioxidants or signalling molecules?
Williams, R. J., Spencer, J. P. E., & Rice-Evans, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.001 · Cited by 2,016
Polyphenols and disease risk in epidemiologic studies
Arts, I. C., & Hollman, P. C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.317s · Cited by 1,916
Polyphenols: Antioxidants and beyond
Scalbert, A., Johnson, I. T., & Saltmarsh, M. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.215s · Cited by 1,836
Self-citation

Flagged first, then by citations

Show all 102 references

1 of the 102 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

10.1016/S0025-6196(11)63144-3 · DOI
Neveu V. Vos F. du Chaffaut L. Mennen L. et al. 10th European Nutrition Conference Paris 2007 p. 122 (abstract).
10.1002/(SICI)1097-0010(20000515)80:7<985::AID-JSFA572>3.0.CO;2-7 · DOI

Sorted by citations

Phenol-Explorer: an online comprehensive database on polyphenol contents in foods
Neveu, V., Pérez‐Jiménez, J., Vos, F., Crespy, V., Chaffaut, L. D., Mennen, L. I., Knox, C., Eisner, R., Cruz, J., Wishart, D. S., et al. (2010) · Database · doi:10.1093/database/bap024 · Cited by 1,442
Self-citation
Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research
Scalbert, A., Brennan, L., Fiehn, O., Hankemeier, T., Kristal, B. S., van Ommen, B., Pujos-Guillot, E., Verheij, E., Wishart, D., & Wopereis, S. (2009) · Metabolomics · doi:10.1007/s11306-009-0168-0 · Cited by 565
Self-citation
Metabolic fate of polyphenols in the human superorganism
van Duynhoven, J., Vaughan, E. E., Jacobs, D. M., A. Kemperman, R., van Velzen, E. J. J., Gross, G., Roger, L. C., Possemiers, S., Smilde, A. K., Doré, J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000098107 · Cited by 540
The food metabolome: a window over dietary exposure
Scalbert, A., Brennan, L., Manach, C., Andres-Lacueva, C., Dragsted, L. O., Draper, J., Rappaport, S. M., van der Hooft, J. J., & Wishart, D. S. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.076133 · Cited by 519
Self-citation
Phenolic compounds: from plants to foods
Cheynier, V. (2012) · Phytochemistry Reviews · doi:10.1007/s11101-012-9242-8 · Cited by 548
Encapsulation, protection, and release of hydrophilic active components: Potential and limitations of colloidal delivery systems
McClements, D. J. (2015) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2015.02.002 · Cited by 466
Plants, seaweeds, microalgae and food by-products as natural sources of functional ingredients obtained using pressurized liquid extraction and supercritical fluid extraction
Herrero, M., Sánchez‐Camargo, A. D. P., Cifuentes, A., & Ibáñez, E. (2015) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.01.018 · Cited by 344
A comprehensive review on carotenoids in foods and feeds: status quo, applications, patents, and research needs
Meléndez‐Martínez, A. J., Mandić, A., Bantis, F., Böhm, V., Borge, G. I. A., Brnčić, M., Bysted, A., Cano, M. P., Dias, M. D. G., Elgersma, A., et al. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1867959 · Cited by 369
Metabolomics Analysis for Biomarker Discovery: Advances and Challenges
Monteiro, M. S., Carvalho, M. C., Bastos, M. D. L., & de Pinho, P. G. (2012) · Current Medicinal Chemistry · doi:10.2174/092986713804806621 · Cited by 309
Evolution of Phenolic Compounds from Color and Flavor Problems to Health Benefits
Soto‐Vaca, A., Gutierrez, A., Losso, J. N., Xu, Z., & Finley, J. W. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300861c · Cited by 250
Addressing the inter‐individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction
Manach, C., Milenković, D., de Wiele, T. V., Rodriguez‐Mateos, A., de Roos, B., García‐Conesa, M., Landberg, R., Gibney, E. R., Heinonen, M., Tomás-Barberán, F. A., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600557 · Cited by 247
Self-citation
The relationship between phenolic compounds from diet and microbiota: impact on human health
Valdés, L., Cuervo, A. J. V., Salazar, N., Ruas‐Madiedo, P., Gueimonde, M., & González, S. (2015) · Food & Function · doi:10.1039/c5fo00322a · Cited by 243
Phytochemicals in Cancer Prevention and Therapy: Truth or Dare?
Russo, M., Spagnuolo, C., Tedesco, I., & Russo, G. L. (2010) · Toxins · doi:10.3390/toxins2040517 · Cited by 225
Polyphenols and health: Update and perspectives
Sies, H. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.04.006 · Cited by 224
Databases on food phytochemicals and their health promoting effects
Scalbert, A., Andres-Lacueva, C., Arita, M., Kroon, P., Manach, C., Urpi-Sarda, M., & Wishart, D. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200591d · Cited by 211
Self-citation
Recent and potential developments in the analysis of urine: A review
Ryan, D., Robards, K., Prenzler, P. D., & Kendall, M. (2010) · Analytica Chimica Acta · doi:10.1016/j.aca.2010.10.035 · Cited by 211
Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities
Kemperman, R., Bolca, S., Roger, L. C., & Vaughan, E. E. (2010) · Microbiology · doi:10.1099/mic.0.042127-0 · Cited by 202
Gut metabotypes govern health effects of dietary polyphenols
Bolca, S., de Wiele, T. V., & Possemiers, S. (2012) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.09.009 · Cited by 201
Interactions between CYP3A4 and Dietary Polyphenols
Basheer, L., & Kerem, Z. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/854015 · Cited by 204
Dietary Flavonoids from Modified Apple Reduce Inflammation Markers and Modulate Gut Microbiota in Mice
Espley, R. V., Butts, C. A., Laing, W. A., Martell, S., Dinnan, H., McGhie, T. K., Zhang, J., Paturi, G., HEDDERLEY, D. I., Bovy, A. G., et al. (2013) · Journal of Nutrition · doi:10.3945/jn.113.182659 · Cited by 189
“Notame”: Workflow for Non-Targeted LC–MS Metabolic Profiling
Klåvus, A., Kokla, M., Noerman, S., Koistinen, V., Tuomainen, M. H., Zarei, I., Meuronen, T., Häkkinen, M. R., Rummukainen, S., Babu, A. F., et al. (2020) · Metabolites · doi:10.3390/metabo10040135 · Cited by 187
Mass spectrometry-based metabolomics for the discovery of biomarkers of fruit and vegetable intake: citrus fruit as a case study
Pujos-Guillot, E., Hubert, J., Martin, J.-F., Lyan, B., Quintana, M., Claude, S., Chabanas, B., Rothwell, J. A., Bennetau-Pelissero, C., Scalbert, A., et al. (2013) · Journal of Proteome Research · doi:10.1021/pr300997c · Cited by 166
Self-citation
The phytochemical, EGCG , extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy rats
Niu, Y., Na, L., Feng, R., Gong, L., Zhao, Y., Li, Q., Li, Y., & Sun, C. (2013) · Aging Cell · doi:10.1111/acel.12133 · Cited by 163
Phytochemicals as Potential Anticancer Drugs: Time to Ponder Nature’s Bounty
Ashraf, M. A. (2020) · BioMed Research International · doi:10.1155/2020/8602879 · Cited by 161
Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy
Žiberna, L., Šamec, D., Mocan, A., Nabavi, S. F., Bishayee, A., Farooqı, A. A., Sureda, A., & Nabavi, S. F. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030643 · Cited by 161
Hydroxycinnamic acids and human health: recent advances
Coman, V., & Vodnar, D. C. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10010 · Cited by 158
Dietary flavonoids and nitrate: effects on nitric oxide and vascular function
Bondonno, C. P., Croft, K. D., Ward, N., Considine, M. J., & Hodgson, J. M. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuu014 · Cited by 150
Measuring exposure to the polyphenol metabolome in observational epidemiologic studies: current tools and applications and their limits
Zamora‐Ros, R., Touillaud, M. S., Rothwell, J. A., Romieu, I., & Scalbert, A. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.077743 · Cited by 141
Self-citation
Metabolomic Pattern Analysis after Mediterranean Diet Intervention in a Nondiabetic Population: A 1- and 3-Year Follow-up in the PREDIMED Study
Vázquez‐Fresno, R., Llorach, R., Urpí-Sardà, M., Lupianez-Barbero, A., Estruch, R., Corella, D., Fitó, M., Arós, F., Ruiz‐Canela, M., Salas‐Salvadó, J., et al. (2014) · Journal of Proteome Research · doi:10.1021/pr5007894 · Cited by 137
Self-citation
Structural Elucidation and Quantification of Phenolic Conjugates Present in Human Urine after Tea Intake
van der Hooft, J. J. J., de Vos, R. C. H., Mihaleva, V. V., Bino, R. J., Ridder, L., de Roo, N., Jacobs, D. M., van Duynhoven, J., & Vervoort, J. J. M. (2012) · Analytical Chemistry · doi:10.1021/ac3017339 · Cited by 137
Lactobacillus acidophilus Metabolizes Dietary Plant Glucosides and Externalizes Their Bioactive Phytochemicals
Theilmann, M. C., Goh, Y. J., Nielsen, K. F., Klaenhammer, T. R., Barrangou, R., & Hachem, M. A. (2017) · mBio · doi:10.1128/mbio.01421-17 · Cited by 130
The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high‐fat diet‐fed obese rats
Yuan, H., Li, Y., Ling, F., Guan, Y., Zhang, D., Zhu, Q., Liu, J., Wu, Y., & Niu, Y. (2020) · Aging Cell · doi:10.1111/acel.13199 · Cited by 122
Profiling of phenolic compounds from different apple varieties using comprehensive two-dimensional liquid chromatography
Montero, L., Herrero, M., Ibáñez, E., & Cifuentes, A. (2013) · Journal of Chromatography A · doi:10.1016/j.chroma.2013.06.015 · Cited by 115
An Emerging Role for Metabolomics in Nutrition Science
Astarita, G., & Langridge, J. (2013) · Lifestyle Genomics · doi:10.1159/000354403 · Cited by 110
Nanotechnology-Based Strategies for Berberine Delivery System in Cancer Treatment: Pulling Strings to Keep Berberine in Power
Iqbal, M. J., Quispe, C., Javed, Z., Sadia, H., Qadri, Q. R., Raza, S., Salehi, B., Martins, N. A., Mohamed, Z. A., Mohammed, J. S., et al. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.624494 · Cited by 106
Metabolomics Study of Human Urinary Metabolome Modifications After Intake of Almond (Prunus dulcis(Mill.) D.A. Webb) Skin Polyphenols
Llorach, R., Garrido, I., Monagas, M., Urpí-Sardà, M., Tulipani, S., Bartolomé, B., & Andrés‐Lacueva, C. (2010) · Journal of Proteome Research · doi:10.1021/pr100639v · Cited by 107
Self-citation
Impact of Short-Term Intake of Red Wine and Grape Polyphenol Extract on the Human Metabolome
Jacobs, D. M., Fuhrmann, J. C., van Dorsten, F. A., Rein, D., Peters, S., van Velzen, E. J. J., Hollebrands, B., Draijer, R., van Duynhoven, J., & Garczarek, U. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2044247 · Cited by 103
Multi‐omics profiling reveals comprehensive microbe–plant–metabolite regulation patterns for medicinal plant Glycyrrhiza uralensis Fisch
Zhong, C., Chen, C., Gao, X., Tan, C., Bai, H., & Ning, K. (2022) · Plant Biotechnology Journal · doi:10.1111/pbi.13868 · Cited by 93
Berries and anthocyanins: promising functional food ingredients with postprandial glycaemia-lowering effects
Castro-Acosta, M. L., Lenihan-Geels, G. N., Corpe, C. P., & Hall, W. L. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000240 · Cited by 92
Nutrimetabolomic Strategies To Develop New Biomarkers of Intake and Health Effects
Llorach, R., Garcia‐Aloy, M., Tulipani, S., Vázquez‐Fresno, R., & Andrés‐Lacueva, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301142b · Cited by 95
Self-citation
Dietary polyphenols and chromatin remodeling
Russo, G. L., Vastolo, V., Ciccarelli, M., Albano, L., Macchia, P. E., & Ungaro, P. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1062353 · Cited by 90
Glycyrrhiza uralensis Transcriptome Landscape and Study of Phytochemicals
Ramilowski, J. A., Sawai, S., Seki, H., Mochida, K., Yoshida, T., Sakurai, T., Muranaka, T., Saito, K., & Daub, C. O. (2013) · Plant and Cell Physiology · doi:10.1093/pcp/pct057 · Cited by 85
Structural Annotation and Elucidation of Conjugated Phenolic Compounds in Black, Green, and White Tea Extracts
van der Hooft, J. J. J., Akermi, M., Ünlü, F. Y., Mihaleva, V. V., Roldán, M. V. G., Bino, R. J., de Vos, R. C. H., & Vervoort, J. J. M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300297y · Cited by 84
Release of Antioxidant Capacity from Five Plant Foods during a Multistep Enzymatic Digestion Protocol
Papillo, V. A., Vitaglione, P., Graziani, G., Gökmen, V., & Fogliano, V. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf500695a · Cited by 83
Assessment of dietary intake: NuGO symposium report
Penn, L., Boeing, H., Boushey, C. J., Dragsted, L. O., Kaput, J., Scalbert, A., Welch, A. A., & Mathers, J. C. (2010) · Genes & Nutrition · doi:10.1007/s12263-010-0175-9 · Cited by 78
Self-citation
Unravelling of the health effects of polyphenols is a complex puzzle complicated by metabolism
Hollman, P. C. H. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.04.013 · Cited by 80
Bananas as an Energy Source during Exercise: A Metabolomics Approach
Nieman, D. C., Gillitt, N. D., Henson, D. A., Sha, W., Shanely, R. A., Knab, A. M., Cialdella-Kam, L. A., & Jin, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037479 · Cited by 89
UPLC-MS metabolome based classification of Lupinus and Lens seeds: A prospect for phyto-equivalency of its different accessions
Farag, M. A., Khattab, A. R., Maamoun, A. A., Kropf, M., & Heiss, A. G. (2018) · Food Research International · doi:10.1016/j.foodres.2018.11.003 · Cited by 72
Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies
van Ommen, B., Bouwman, J., Dragsted, L. O., Drevon, C. A., Elliott, R. M., de Groot, P., Kaput, J., Mathers, J. C., Müller, M. M., Pepping, F., et al. (2010) · Genes & Nutrition · doi:10.1007/s12263-010-0167-9 · Cited by 76
Self-citation
Metabolomic profiling of urine: response to a randomised, controlled feeding study of select fruits and vegetables, and application to an observational study
May, D. H., Navarro, S. L., Ruczinski, I., Hogan, J., Ogata, Y., Schwarz, Y., Levy, L., Holzman, T., McIntosh, M. W., & Lampe, J. W. (2013) · British Journal Of Nutrition · doi:10.1017/s000711451300127x · Cited by 69
Oleuropein and Cancer Chemoprevention: The Link is Hot
Farooqı, A. A., Fayyaz, S., Sanches-Silva, A. T., Sureda, A., Nabavi, S. M., MOCAN, A., Nabavi, S., & Bishayee, A. (2017) · Molecules · doi:10.3390/molecules22050705 · Cited by 66
Effect of resveratrol and quercetin supplementation on redox status and inflammation after exercise
McAnulty, L. S., Miller, L., Hosick, P. A., Utter, A. C., Quindry, J. C., & McAnulty, S. R. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0455 · Cited by 64
Metabolomics and human nutrition
Primrose, S. B., Draper, J., Elsom, R. L., Kirkpatrick, V., Mathers, J. C., Seal, C. J., Beckmann, M., Haldar, S., Beattie, J. H., Lodge, J. K., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114510004812 · Cited by 64
Self-citation
Phenolics of Green Pea ( Pisum sativum L.) Hulls, Their Plasma and Urinary Metabolites, Bioavailability, and in Vivo Antioxidant Activities in a Rat Model
Guo, F., Xiong, H., Wang, X., Jiang, L., Yu, N., Hu, Z., Sun, Y., & Tsao, R. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b04501 · Cited by 66
The efficacy of polyphenols as an antioxidant agent: An updated review
El-Hack, M. E. A., de Oliveira, M. C., Attia, Y. A., Kamal, M., Almohmadi, N. H., Youssef, I. M., Khalifa, N. E., Moustafa, M., Al-Shehri, M., & Taha, A. E.-S. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126525 · Cited by 64
Regular Consumption of an Antioxidant-rich Juice Improves Oxidative Status and Causes Metabolome Changes in Healthy Adults
Diaz-Rubio, M. E., Pérez‐Jiménez, J., Martínez-Bartolomé, M. Á., Álvarez, I., & Saura-Calixto, F. D. (2014) · Plant Foods for Human Nutrition · doi:10.1007/s11130-014-0455-4 · Cited by 59
Analytical metabolomics: nutritional opportunities for personalized health
McNiven, E. M. S., German, J. B., & Slupsky, C. M. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.05.016 · Cited by 58
DATA MINING METHODS FOR OMICS AND KNOWLEDGE OF CRUDE MEDICINAL PLANTS TOWARD BIG DATA BIOLOGY
Afendi, F. M., Ono, N., Nakamura, Y. K., Nakamura, K., Darusman, L. K., Kibinge, N., Morita, A. H., Tanaka, K., Horai, H., Altaf‐Ul‐Amin, M., et al. (2013) · Computational and Structural Biotechnology Journal · doi:10.5936/csbj.201301010 · Cited by 61
Polyphenols, the new frontiers of prebiotics
Nazzaro, F., Fratianni, F., Feo, V. D., Battistelli, A., da Cruz, A. G., & Coppola, R. (2020) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2020.06.002 · Cited by 58
Reductive Metabolism of Xanthohumol and 8‐Prenylnaringenin by the Intestinal Bacterium Eubacterium ramulus
Paraiso, I. L., Plagmann, L. S., Yang, L., Zielke, R. A., Gombart, A. F., Maier, C. S., Sikora, A. E., Blakemore, P. R., & Stevens, J. F. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800923 · Cited by 56
Toxicometabolomics: Small Molecules to Answer Big Toxicological Questions
Araújo, A. M., Carvalho, F. D., de Pinho, P. G., & Carvalho, M. C. (2021) · Metabolites · doi:10.3390/metabo11100692 · Cited by 54
Impact of multi-functional fermented goat milk beverage on gut microbiota in a dynamic colon model
Freire, F., Adorno, M. Â. T., Sakamoto, I. K., Antoniassi, R., Chaves, A. C. S. D., dos Santos, K. M. O., & Sivieri, K. (2017) · Food Research International · doi:10.1016/j.foodres.2017.05.028 · Cited by 54
Nutrimetabonomics:Applications for Nutritional Sciences, with Specific Reference to Gut Microbial Interactions
Claus, S. P., & Swann, J. R. (2013) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030212-182612 · Cited by 58
The phytochemical composition, metabolites, bioavailability and in vivo antioxidant activity of Tetrastigma hemsleyanum leaves in rats
Sun, Y., Tsao, R., Chen, F., Li, H., Wang, J., Peng, H., Zhang, K., & Deng, Z. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.01.004 · Cited by 53
Effects of psoralens as anti-tumoral agents in breast cancer cells
Panno, M. L. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i3.348 · Cited by 51
Pomegranate vinegar attenuates adiposity in obese rats through coordinated control of AMPK signaling in the liver and adipose tissue
Ok, E., Do, G.-M., Lim, Y., Park, J., Park, Y.-J., & Kwon, O. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-163 · Cited by 52
6‐Gingerol Prevents Patulin‐induced Genotoxicity in HepG2 Cells
Yang, G., Zhong, L., Jiang, L., Geng, C., Cao, J., Sun, X., Liu, X., Chen, M., & Ma, Y. (2011) · Phytotherapy Research · doi:10.1002/ptr.3446 · Cited by 51
Metabolomics for measuring phytochemicals, and assessing human and animal responses to phytochemicals, in food science
McGhie, T. K., & Rowan, D. D. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100545 · Cited by 50
Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice
Villaseca, P. (2011) · Climacteric · doi:10.3109/13697137.2011.624214 · Cited by 50
A role for dietary macroalgae in the amelioration of certain risk factors associated with cardiovascular disease
Cornish, M. L., Critchley, A. T., & Mouritsen, O. G. (2015) · Phycologia · doi:10.2216/15-77.1 · Cited by 49
Metabolomic fingerprint in patients at high risk of cardiovascular disease by cocoa intervention
Llorach, R., Urpí-Sardà, M., Tulipani, S., Garcia‐Aloy, M., Monagas, M., & Andrés‐Lacueva, C. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200736 · Cited by 51
Self-citation
UHPLC-Q-Orbitrap-HRMS-based global metabolomics reveal metabolome modifications in plasma of young women after cranberry juice consumption
Liu, H., Garrett, T. J., Su, Z., Khoo, C., & Gu, L. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.03.007 · Cited by 49
MicroRNA-Mediated Health-Promoting Effects of Phytochemicals
Kang, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102535 · Cited by 48
Impacts of polyphenols on laying hens' productivity and egg quality: A review
El-Hack, M. E. A., Salem, H. M., Khafaga, A. F., Soliman, S. M., & El‐Saadony, M. T. (2022) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13758 · Cited by 53
Stimulation of DNA repair in Saccharomyces cerevisiae by Ginkgo biloba leaf extract
Marques, F., Azevedo, F., Johansson, B., & de Oliveira, R. P. S. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.03.020 · Cited by 45
Bioinformatics tools for the analysis of NMR metabolomics studies focused on the identification of clinically relevant biomarkers
Puchades‐Carrasco, L., Palomino‐Schätzlein, M., Pérez-Rambla, C., & Pineda‐Lucena, A. (2015) · Briefings in Bioinformatics · doi:10.1093/bib/bbv077 · Cited by 45
A 1H NMR-based approach to investigate metabolomic differences in the plasma and urine of young women after cranberry juice or apple juice consumption
Liu, H., Tayyari, F., Khoo, C., & Gu, L. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.01.018 · Cited by 45
Mass spectrometry-based metabolomics approach to determine differential metabolites between regular and non-alcohol beers
Andrés‐Iglesias, C., Blanco, C. A., Blanco, J., & Montero, O. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.01.123 · Cited by 43
Probiotic low-fat fermented goat milk with passion fruit by-product: In vitro effect on obese individuals’ microbiota and on metabolites production
Neves, S. J. F., Borgonovi, T. F., Tieghi, T. D. M., Sivieri, K., & Penna, A. L. B. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109453 · Cited by 43
Polyphenolic bioactives as an emerging group of nutraceuticals for promotion of gut health: A review
Ashwin, K., Pattanaik, A. K., & Howarth, G. S. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101376 · Cited by 48
Application of Dietary Phenolic Biomarkers in Epidemiology: Past, Present, and Future
Zamora‐Ros, R., Rabassa, M., Llorach, R., Gonzalez, C. A., & Andrés‐Lacueva, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf204742e · Cited by 43
Self-citation
Antitumoural and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models
Silva-Carvalho, R., Miranda‐Gonçalves, V., Ferreira, A., Cardoso, S. M., SOBRAL, A. J. F. N., Aguiar, C. A., & Baltazar, F. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.09.009 · Cited by 41
The interaction effect and mechanism between tea polyphenols and intestinal microbiota: Role in human health
Cheng, M., Zhang, X., Guo, X., Wu, Z., & Weng, P. (2017) · Journal of Food Biochemistry · doi:10.1111/jfbc.12415 · Cited by 42
Comparative Nontargeted Profiling of Metabolic Changes in Tissues and Biofluids in High-Fat Diet-Fed Ossabaw Pig
Hanhineva, K., Barri, T., Kolehmainen, M., Pekkinen, J., Pihlajamäki, J., Vesterbacka, A., Solano-Aguilar, G. I., Mykkänen, H. M., Dragsted, L. O., Urban, J. F., et al. (2013) · Journal of Proteome Research · doi:10.1021/pr400257d · Cited by 41
New findings on the in vivo antioxidant activity of Curcuma longa extract by an integrated 1H NMR and HPLC–MS metabolomic approach
Dall’Acqua, S., Stocchero, M., Boschiero, I., Schiavon, M., Golob, S., Uddin, J., Voinovich, D., Mammi, S., & Schievano, E. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.12.013 · Cited by 40
Brassica-enriched wheat bread: Unraveling the impact of ontogeny and breadmaking on bioactive secondary plant metabolites of pak choi and kale
Klopsch, R., Baldermann, S., Hanschen, F. S., Voß, A., Rohn, S., Schreiner, M., & Neugart, S. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.05.113 · Cited by 40
Cyclodextrin-based delivery systems for dietary pharmaceuticals
Arora, D., Saneja, A., & Jaglan, S. (2019) · Environmental Chemistry Letters · doi:10.1007/s10311-019-00878-w · Cited by 39
Nutrigenomics: An inimitable interaction amid genomics, nutrition and health
Mishra, U. N., Jena, D., Sahu, C., Devi, R., Kumar, R., Jena, R., Irondi, E. A., Rout, S., Tiwari, R. K., Lal, M. K., et al. (2022) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2022.103196 · Cited by 39
Opportunities and challenges for metabolic engineering of secondary metabolite pathways for improved human health characters in fruit and vegetable crops
Davies, K. M., & Espley, R. V. (2013) · New Zealand Journal of Crop and Horticultural Science · doi:10.1080/01140671.2013.793730 · Cited by 38
Phytochemicals in Cancer Prevention and Therapy
Pratheeshkumar, P., Son, Y., Korangath, P. C., Manu, K. A., & Siveen, K. S. (2015) · BioMed Research International · doi:10.1155/2015/324021 · Cited by 38
Multicompartmental LC-Q-TOF-Based Metabonomics as an Exploratory Tool to Identify Novel Pathways Affected by Polyphenol-Rich Diets in Mice
Jové, M., Serrano, J. C. E., Ortega-Olivé, N., Ayala, V., Anglès, N., Reguant, J., Morelló, J. R., Romero, M., Motilva, M., Prat, J., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr200132s · Cited by 39
SPE–NMR metabolite sub-profiling of urine
Jacobs, D. M., Spiesser, L., Garnier, M., de Roo, N., van Dorsten, F. A., Hollebrands, B., van Velzen, E. J. J., Draijer, R., & van Duynhoven, J. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6339-2 · Cited by 36
Evaluation of Turkish propolis for its chemical composition, antioxidant capacity, anti-proliferative effect on several human breast cancer cell lines and proliferative effect on fibroblasts and mouse mesenchymal stem cell line
Özdal, T., Sarı, G., Altundağ, E. M., Boyacıoğlu, D., & Çapanoğlu, E. (2018) · Journal of Apicultural Research · doi:10.1080/00218839.2018.1494888 · Cited by 35
Nutrikinetics: Concept, technologies, applications, perspectives
van Duynhoven, J., van Velzen, E. J. J., Westerhuis, J. A., Foltz, M., Jacobs, D. M., & Smilde, A. K. (2012) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2012.01.004 · Cited by 36
Doping Control Using High and Ultra-High Resolution Mass Spectrometry Based Non-Targeted Metabolomics-A Case Study of Salbutamol and Budesonide Abuse
Kiss, A., Lucio, M., Fildier, A., Buisson, C., Schmitt‐Kopplin, P., & Cren‐Olivé, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074584 · Cited by 34
NMR-Based Metabolomic Investigation of Bioactivity of Chemical Constituents in Black Raspberry (Rubus occidentalis L.) Fruit Extracts
Paudel, L., Wyzgoski, F. J., Giusti, M. M., Johnson, J. L., Rinaldi, P. L., Scheerens, J. C., Chanon, A. M., Bomser, J. A., Miller, A. R., Hardy, J. K., et al. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404998k · Cited by 34
Fat-soluble vitamin and phytochemical metabolites: Production, gastrointestinal absorption, and health effects
Borel, P., Dangles, O., & Kopec, R. E. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101220 · Cited by 35
Web-Enabled and Improved Software Tools and Data Are Needed to Measure Nutrient Intakes and Physical Activity for Personalized Health Research
Stumbo, P. J., Weiss, R., Newman, J. W. I., Pennington, J. A. T., Tucker, K. L., Wiesenfeld, P. L., Illner, A., Klurfeld, D. M., & Kaput, J. (2010) · Journal of Nutrition · doi:10.3945/jn.110.128371 · Cited by 33
Identification and selection of algae for food, feed, and fuel applications
Rajauria, G., Cornish, M. L., Ometto, F., Msuya, F. E., & Villa, R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418697-2.00012-x · Cited by 34
Effect of Mixed Flavonoids, n-3 Fatty Acids, and Vitamin C on Oxidative Stress and Antioxidant Capacity Before and After Intense Cycling
McAnulty, S. R., Nieman, D. C., McAnulty, L. S., Lynch, W. S., Jin, F., & Henson, D. A. (2011) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.21.4.328 · Cited by 33

Authors: Manach, C., Hubert, J., Llorach, R., & Scalbert, A.
Affiliations: Unité de Nutrition Humaine (FR)
Corresponding author: Scalbert, Augustin
ORCID: Manach, Claudine
Hubert, Jane
Scalbert, Augustin
Venue: Molecular Nutrition & Food Research
Publisher: Wiley
Published: 2009-10
Volume: 53
Issue: 10
Pages: 1303-1315
ISSN: 1613-4125 (ISSN-L)
1613-4133
DOI: 10.1002/mnfr.200800516
OpenAlex: W2030179947
Cited by: 218
References: 102
Citations by year: 2026: 4 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 10 · 2019: 18 · 2018: 11 · 2017: 11 · 2016: 13 · 2015: 26 · 2014: 18 · 2013: 30 · 2012: 20
FWCI: 1.25
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Nutrition & Food Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords: dietary phytochemicals, metabolomics, bioactive compounds, disease prevention, dietary recommendations, urinary metabolome, plasma metabolome, biomarkers of effect
MeSH terms: Animals, Diet, Health Status, Humans, Plants, Edible, Metabolomics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The complex links between dietary phytochemicals and human health deciphered by metabolomics

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks