Effect of Synbiotic Supplementation in a Very-Low-Calorie Ketogenic Diet on Weight Loss Achievement and Gut Microbiota: A Randomized Controlled Pilot Study
Abstract
Scope: Little is known about the changes that a very‐low‐calorie ketogenic diet (VLCKD) produces in gut microbiota or the effect of synbiotics during the diet. The aim of this study is to evaluate changes in gut microbiota produced by a VLCKD and synbiotic supplementation. Methods and results: A randomized, single‐blind, parallel‐design trial is conducted in 33 obese patients who follow a weight‐loss program (PnK‐Method) that include a VLCKD followed by a low‐calorie diet (LCD). Subjects are randomly allocated to three groups: one supplemented with synbiotics, a second group supplemented with a placebo during the VLCKD and synbiotics during the LCD phase, and a control group given a placebo. Although symbiotic administration do not produce an effect on microbial diversity, an increase in short‐chain fatty aciding producing bacteria and anti‐inflammatory mediator signals such as Odoribacter and Lachnospira is shown. The administration of Bifidobacterium animalis subsp. lactis and prebiotics fiber during the LCD is significantly associated with the percentage of weight loss and change in glucose, C‐reactive protein and lipopolysaccharide‐binding protein. Conclusions: VLCKD produces important changes in gut microbiota. The administration of synbiotics during VLCKD can improve weight loss through the amelioration of inflammation, which may be mediated by the gut microbiota.
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Odoribacter is a beneficial bacterium known for producing short-chain fatty acids and reducing inflammation.
“Odoribacter is a beneficial bacteria known for producing SCFAs and reducing inflammation [59].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [59]
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- Authors
- Gutiérrez‐Repiso, C., Hernández‐García, C., García‐Almeida, J. M., Bellido, D., Martín‐Núñez, G. M., Sánchez‐Alcoholado, L., Alcaide‐Torres, J., Sajoux, I., Tinahones, F. J., & Moreno‐Indias, I.
- Affiliations
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria Instituto de Investigación Biomédica de Málaga (IBIMA) Universidad de Málaga Málaga 29010 Spain
- Universidade da Coruña (ES)
- PronoKal Group (Spain) (ES)
- Corresponding author
- Tinahones, Francisco J.
- ORCID
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2019-08-29
- Volume
- 63
- Issue
- 19
- Pages
- e1900167-e1900167
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2961898694
- Cited by
- 80
- References
- 52
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 15 · 2023: 19 · 2022: 16 · 2021: 10 · 2020: 3
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III
- Ministerio de Economía y Competitividad (IJCI‐2017‐33065)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- synbiotic supplementation, very low-calorie ketogenic diet, gut microbiota, weight loss, obesity, short-chain fatty acid-producing bacteria, Bifidobacterium animalis subsp. lactis, prebiotic fiber, inflammation, C-reactive protein, lipopolysaccharide-binding protein, hypocaloric diet
- MeSH terms
- Gastrointestinal Microbiome, Adult, Anthropometry, Bacteria, Feces, Female, Humans, Inflammation, Male, Middle Aged, Obesity, Pilot Projects, Placebos, Weight Loss, Single-Blind Method, Dietary Supplements, Caloric Restriction, Diet, Ketogenic, Synbiotics
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