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Cited by 263

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: Implications for BOLD fMRI

Open access
Lee, Sang‐Pil, Duong, Timothy Q., Yang, Guang, Iadecola, Costantino, Kim, Seong‐Gi·2001·Magnetic Resonance in Medicine
DOI 10.1002/mrm.1107
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Abstract

Measurement of cerebral arterial and venous blood volumes during increased cerebral blood flow can provide important information regarding hemodynamic regulation under normal, pathological, and neuronally active conditions. In particular, the change in venous blood volume induced by neural activity is one critical component of the blood oxygenation level‐dependent (BOLD) signal because BOLD contrast is dependent only on venous blood, not arterial blood. Thus, relative venous and arterial blood volume (rCBV) and cerebral blood flow (rCBF) in α‐chlorolase‐anesthetized rats under hypercapnia were measured by novel diffusion‐weighted 19 F NMR following an i.v. administration of intravascular tracer, perfluorocarbons, and continuous arterial spin labeling methods, respectively. The relationship between rCBF and total rCBV during hypercapnia was rCBV(total) = rCBF0.40, which is consistent with previous PET measurement in monkeys. This relationship can be linearized in a CBF range of 50–130 ml/100 g/min as Δ rCBV(total)/ Δ rCBF = 0.31 where ΔrCBV and ΔrCBF represent rCBV and rCBF changes. The average arterial volume fraction was 0.25 at a basal condition with CBF of ∼60 ml/100 g/min and increased up to 0.4 during hypercapnia. The change in venous rCBV was 2‐fold smaller than that of total rCBV (Δ rCBV(vein)/Δ rCBF = 0.15), while the arterial rCBV change was 2.5 times larger than that of total rCBV (Δ rCBV(artery)/Δ rCBF = 0.79). These NMR results were confirmed by vessel diameter measurements with in vivo videomicroscopy. The absolute venous blood volume change contributes up to 36% of the total blood volume change during hypercapnia. Our findings provide a quantitative physiological model of BOLD contrast. Magn Reson Med 45:791–800, 2001. © 2001 Wiley‐Liss, Inc.

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Cites

Research works printed but not linked: 2

  1. Hamberg LM, 1996, Measurement of cerebral blood volume with subtraction three‐dimensional functional CT, AJNR Am J Neuroradiol, 17, 1861
  2. Wei EP, 1984, Comparative responses of cerebellar and cerebral arterioles to changes in PaCO2 in cats, Am J Physiol, 246, H386

Cited by

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Metadata

Authors
Lee, S., Duong, T. Q., Yang, G., Iadecola, C., & Kim, S.
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
2001-04-16
Volume
45
Issue
5
Pages
791-800
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
DOI
10.1002/mrm.1107
OpenAlex
W2154020722
Cited by
263
References
39
FWCI
11.78
Type
journal article
Language
en
Open access
bronze
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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