Effects of combined lower body endurance and upper body resistance training on the satellite cell pool in elderly subjects.
Abstract
To distinguish the respective potential of endurance and resistance training to increase the satellite cell pool, we investigated the effects of 14 weeks of concurrent lower body endurance and upper body resistance training (3 sessions/week) on vastus lateralis (VLat) and deltoid (Del) muscles of 10 active elderly men. NCAM+ satellite cells and myonuclear number were assessed in VLat and Del. After 14 weeks of training the NCAM+ satellite cell pool increased similarly (+38%) in both muscles, mainly in type II muscle fibers (P < 0.05). There was no significant change in myonuclear number or myonuclear domain in either muscle. Combining resistance training in the upper limbs with endurance training in the lower limbs is an efficient strategy to enhance the satellite cell pool in upper and lower body muscles in elderly subjects. Our results provide a practical reference for the determination of optimal exercise protocols to improve muscle function and regeneration in the elderly.
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Increases in satellite cell content have been reported following prolonged endurance training, with or without myofibre hypertrophy.
“Nonetheless, increases in satellite cell content have been reported following prolonged endurance training both in the presence (Charifi et al., 2003; Verney et al., 2008; Murach et al., 2016) and absence (Joanisse et al., 2013) of myofibre hypertrophy.”
From Myofibre Hypertrophy in the Absence of Changes to Satellite Cell Content Following Concurrent Exercise Training in Young Healthy Men (2021) · cites this paper as Verney et al., 2008
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- Authors
- Verney, J., Kadi, F., Charifi, N., Féasson, L., Saafi, M. A., Castells, J., Piehl‐Aulin, K., & Denis, C.
- Affiliations
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
- Örebro University (SE)
- Corresponding author
- Kadi, Fawzi
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2008-07-31
- Volume
- 38
- Issue
- 3
- Pages
- 1147-1154
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2169112943
- Cited by
- 148
- References
- 45
- Citations by year
- 2025: 6 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 8 · 2017: 9 · 2016: 16 · 2015: 17 · 2014: 13 · 2013: 13 · 2012: 13
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- satellite cells, endurance training, resistance training, concurrent training, older adults, vastus lateralis, deltoid muscle, CD56, myonuclear number, myonuclear domain, fast-twitch muscle, muscle regeneration, muscle function
- MeSH terms
- Aged, Biopsy, Humans, Male, Muscle Contraction, Physical Education and Training, Exercise, Geriatric Assessment, Confidence Intervals, Muscle, Skeletal, Muscle Fibers, Skeletal, Cell Culture Techniques, Neural Cell Adhesion Molecules, Satellite Cells, Skeletal Muscle, Upper Extremity, Lower Extremity, Muscle Strength
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