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Cited by 82Muscle Physiology and DisordersMuscle metabolism and nutritionCardiovascular and exercise physiology

Evidence for the contribution of muscle stem cells to nonhypertrophic skeletal muscle remodeling in humans

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Joanisse, Sophie, Gillen, Jenna B., Bellamy, Leeann M., McKay, Bryon R., Tarnopolsky, Mark A., Gibala, Martin. J., Parise, Gianni·2013·The FASEB Journal
DOI 10.1096/fj.13-229799PMC PMC3804745
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Abstract

The purpose of this study was to explore the possible role of muscle stem cells, also referred to as satellite cells (SCs), in adaptation and remodeling following a nonhypertrophic stimulus in humans. Muscle biopsies were obtained from the vastus lateralis of previously untrained women ( n =15; age: 27±8 yr, BMI: 29±6 kg/m 2 ) before and after 6 wk of aerobic interval training. The fiber type‐specific SC response to training was analyzed using immunofluorescent microscopy of muscle cross sections. Following training, the number of SCs associated with fibers expressing myosin heavy‐chain type I and II isoforms (hybrid fibers) increased (pre: 0.062±0.035 SC/hybrid fiber; post: 0.38±0.063 SC/hybrid fiber; P <0.01). In addition, there was a greater number of MyoD + /Pax7 – SCs, indicative of differentiating SCs, associated with hybrid fibers (0.18±0.096 MyoD + /Pax7 – SC/hybrid fiber) compared to type I (0.015±0.00615 MyoD + /Pax7 – SC/type I fiber) or II (0.012±0.00454 MyoD + /Pax7 – SC/type II fiber) fibers ( P <0.05). There was also a training‐induced increase in the number of hybrid fibers containing centrally located nuclei (15.1%) compared to either type I (3.4%) or II fibers (3.6%) ( P <0.01). These data are consistent with the hypothesis that SCs contribute to the remodeling of muscle fibers even in the absence of hypertrophy.—Joanisse, S., Gillen, J. B., Bellamy, L. M., McKay, B. R., Tarnopolsky, M. A., Gibala, M. J., Parise, G. Evidence for the contribution of muscle stem cells to nonhypertrophic skeletal muscle remodeling in humans. FASEB J . 27, 4596–4605 (2013). www.fasebj.org

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  • Different exercise modes appear to generate a fibre type specific satellite cell response.

    “The different exercise modes also appear to generate a fibre type specific satellite cell response which may also increase the complexity in delineating its role in the specificity of adaptation and any incompatibility with concurrent training (Babcock et al., 2012;Joanisse et al., 2013;Bellamy et al., 2014).”

    From Concurrent exercise training: do opposites distract? (2017) · cites this paper as Joanisse et al., 2013

  • Resistance and aerobic exercise independently have the potential to induce satellite cell responses for skeletal muscle remodelling.

    “It should be noted that resistance and aerobic exercise independently have the potential to induce satellite cell responses for skeletal muscle remodelling”

    From Concurrent exercise training: do opposites distract? (2017) · cites this paper as Joanisse et al., 2013

  • Aerobic interval training (6 weeks, 3 session/week) expands the muscle satellite cell pool and increases satellite cell activity without subsequent hypertrophy, indicating exercise-induced satellite cell activation in skeletal muscle is not limited to resistance exercise.

    “Joanisse and colleagues (2013) have shown that aerobic interval training (6 weeks, 3 session/week) expands the muscle satellite cell pool and increases satellite cell activity without subsequent hypertrophy, indicating exerciseinduced satellite cell activation in skeletal muscle is not limited to resistance exercise.”

    From Concurrent exercise training: do opposites distract? (2017) · cites this paper as Joanisse et al., 2013

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Authors
Joanisse, S., Gillen, J. B., Bellamy, L. M., McKay, B. R., Tarnopolsky, M. A., Gibala, M. J., & Parise, G.
Affiliations
McMaster University (CA)
Corresponding author
Parise, Gianni
ORCID
Venue
The FASEB Journal
Publisher
Wiley
Published
2013-08-08
Volume
27
Issue
11
Pages
4596-4605
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
DOI
10.1096/fj.13-229799
PMC
PMC3804745
OpenAlex
W2146822434
Cited by
82
References
44
Citations by year
2026: 1 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 8 · 2017: 2 · 2016: 15 · 2015: 9 · 2014: 7 · 2013: 3
FWCI
5.08
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The FASEB Journal (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
muscle stem cells, satellite cells, skeletal muscle remodeling, aerobic interval training, vastus lateralis, myosin heavy chain isoforms, hybrid muscle fibers, MyoD, Pax7, muscle fiber composition
MeSH terms
Adaptation, Physiological, Adult, Female, Humans, Stem Cells, Exercise, MyoD Protein, Muscle Fibers, Skeletal, Myosin Heavy Chains, Protein Isoforms, PAX7 Transcription Factor

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