The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Why do we need some large, simple randomized trials?
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Beta blockade during and after myocardial infarction: An overview of the randomized trials
Yusuf, S., Peto, R., Lewis, J., Collins, R., & Sleight, P. (1985) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(85)80003-7 · Cited by 3,205
Self-citation
Research works printed but not linked: 4
- Peto R., 1981, Treatment of Cancer
- 1980, Aspirin After myocardial infarction, Lancet, 1, 1172
- Aspirin Myocardial Infarction Research Group, 1980, Randomised controlled trial of aspirin in persons recovered from myocardical infarction, Journal of the American Medical Association, 243, 661, 10.1001/jama.1980.03300330019023 · DOI · Paper page
- 10.1038/bjc.1976.220 · DOI · Paper page
Cited by
Dexamethasone in Hospitalized Patients with Covid-19
The RECOVERY Collaborative Group (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2021436 · Cited by 11,477
Why Most Published Research Findings Are False
Ioannidis, J. P. A. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020124 · Cited by 10,505
Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gotzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2010) · BMJ · doi:10.1136/bmj.c869 · Cited by 8,883
“[124] In general, the reported sample sizes in trials seem small.”
BackgroundWhy Most Published Research Findings Are False
Ioannidis, J. P. A. (2005) · CHANCE · doi:10.1080/09332480.2005.10722754 · Cited by 4,702
Blood pressure, stroke, and coronary heart disease
Collins, R., Peto, R., MacMahon, S., Godwin, J., Qizilbash, N., Collins, R., MacMahon, S., Hebert, P., Eberlein, K. A., Taylor, J. O., et al. (1990) · The Lancet · doi:10.1016/0140-6736(90)90944-z · Cited by 4,491
Self-citationThe Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration
Altman, D. G., Schulz, K. F., Moher, D., Egger, M., Davidoff, F., Elbourne, D., Gøtzsche, P. C., Lang, T., & for the CONSORT Group (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-8-200104170-00012 · Cited by 3,835
(1988) · The Lancet · doi:10.1016/s0140-6736(88)92833-4 · Cited by 3,687
Self-citationMoher, D., Hopewell, S., Schulz, K. F., Montori, V., Gøtzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2012) · International Journal of Surgery · doi:10.1016/j.ijsu.2011.10.001 · Cited by 2,345
Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gøtzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2010) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.03.004 · Cited by 1,858
An introduction to implementation science for the non-specialist
Bauer, M. S., Damschroder, L., Hagedorn, H., Smith, J., & Kilbourne, A. M. (2015) · BMC Psychology · doi:10.1186/s40359-015-0089-9 · Cited by 1,611
Sterne, J. A. C. (2001) · BMJ · doi:10.1136/bmj.322.7280.226 · Cited by 1,466
Ford, I., & Norrie, J. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1510059 · Cited by 1,405
Subgroup analysis in randomised controlled trials: importance, indications, and interpretation
Rothwell, P. M. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17709-5 · Cited by 942
A consumer's guide to subgroup analyses
Oxman, A. D., & Guyatt, G. H. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-1-78 · Cited by 914
Effect of Dexamethasone in Hospitalized Patients with COVID-19 – Preliminary Report
Horby, P., Lim, W. S., Emberson, J., Mafham, M., Bell, J., Linsell, L., Staplin, N., Brightling, C., Ustianowski, A., Elmahi, E., et al. (2020) · doi:10.1101/2020.06.22.20137273 · Cited by 11,475
“23-25 It has progressed at unprecedented speed, as is essential for studies during epidemics.”
BackgroundBias in clinical intervention research.
Gluud, L. L. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj069 · Cited by 636
Statistical Power, Sample Size, and Their Reporting in Randomized Controlled Trials
Moher, D. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03520020048013 · Cited by 608
Influence of trial sample size on treatment effect estimates: meta-epidemiological study
Dechartres, A., Trinquart, L., Boutron, I., & Ravaud, P. (2013) · BMJ · doi:10.1136/bmj.f2304 · Cited by 544
Characteristics of Clinical Trials Registered in ClinicalTrials.gov, 2007-2010
Califf, R. M. (2012) · JAMA · doi:10.1001/jama.2012.3424 · Cited by 516
Peto, R. (1987) · Statistics in Medicine · doi:10.1002/sim.4780060306 · Cited by 409
Self-citationLarge-scale randomized evidence: Large, simple trials and overviews of trials
Peto, R., Collins, R., & Gray, R. (1995) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(94)00150-o · Cited by 365
Self-citationLarge Trials vs Meta-analysis of Smaller Trials: How Do Their Results Compare?
Cappelleri, J. C. (1996) · JAMA · doi:10.1001/jama.1996.03540160054033 · Cited by 336
Devereaux, P. J., Choi, P. T.-L., El-Dika, S., Bhandari, M., Montori, V. M., Schünemann, H. J., Garg, A. X., Busse, J. W., Heels-Ansdell, D., Ghali, W. A., et al. (2004) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2004.03.017 · Cited by 209
Dahabreh, I. J., Sheldrick, R. C., Paulus, J. K., Chung, M., Varvarigou, V., Jafri, H., Rassen, J. A., Trikalinos, T. A., & Kitsios, G. D. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs114 · Cited by 204
The effect of low-intensity pulsed ultrasound therapy on time to fracture healing: a meta-analysis.
(2002) · PubMed Central · Cited by 196
Exploring the ethical and regulatory issues in pragmatic clinical trials
Califf, R. M., & Sugarman, J. (2015) · Clinical Trials · doi:10.1177/1740774515598334 · Cited by 191
Randomised clinical trials in general practice: lessons from a failure.
Tognoni, G., Alli, C., Avanzini, F., Bettelli, G., Colombo, F., Corso, R., Marchioli, R., & Zussino, A. (1991) · BMJ · doi:10.1136/bmj.303.6808.969 · Cited by 139
Early stopping of randomized clinical trials for overt efficacy is problematic.
Bassler, D., Montori, V. M., Briel, M., Glasziou, P., & Guyatt, G. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.07.016 · Cited by 130
Timeline of History of Hypertension Treatment
Saklayen, M. G., & Deshpande, N. V. (2016) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2016.00003 · Cited by 96
Risk factors and interventions with statistically significant tiny effects
Siontis, G. C., & Ioannidis, J. P. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr099 · Cited by 80
Franzen, S. R. P., Chandler, C., Enquselassie, F., Siribaddana, S., Atashili, J., Angus, B., & Lang, T. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-003616 · Cited by 45
Isaksson, E., Wester, P., Laska, A. C., Näsman, P., & Lundström, E. (2019) · Trials · doi:10.1186/s13063-019-3737-1 · Cited by 43
Klonoff, D. C., Gutierrez, A., Fleming, A., & Kerr, D. (2019) · Journal of Diabetes Science and Technology · doi:10.1177/1932296819839996 · Cited by 41
Catalá-López, F., Aleixandre-Benavent, R., Caulley, L., Hutton, B., Tabarés-Seisdedos, R., Moher, D., & Alonso-Arroyo, A. (2020) · Trials · doi:10.1186/s13063-019-3944-9 · Cited by 38
Beyond evidence‐based medicine: complexity and stories of maternity care
Downe, S. (2010) · Journal of Evaluation in Clinical Practice · doi:10.1111/j.1365-2753.2009.01357.x · Cited by 24
Metadata
- Authors
- Yusuf, S., Collins, R., & Peto, R.
- Venue
- Statistics in Medicine
- Publisher
- Wiley
- Published
- 1984-10
- Volume
- 3
- Issue
- 4
- Pages
- 409-420
- ISSN
- 0277-6715 (ISSN-L)
- 1097-0258
- OpenAlex
- W1982375973
- Cited by
- 699
- References
- 1
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
