Dopamine Modulation of Prefrontal Cortical Interneurons Changes during Adolescence
Open accessAbstract
Adolescence is marked by profound psychological and neuroendocrine changes. Cognitive functions that depend on the prefrontal cortex and dopamine (DA), such as decision making, are acquired or refined during adolescence; yet, little is known about how neural circuits mature in the transition to adulthood. Here, we conducted electrophysiological recordings in rat brain slices, unveiling an enhancement of the excitability of interneurons, which are important for cortical network activity, by D(1) and D(2) DA receptors. The D(2) effect was observed in slices from adult (postnatal day [PD] > 50) but not preadolescent (PD < 36) animals suggesting a possible neural substrate for the maturation of DA-dependent prefrontal cortical functions during or after adolescence and identifying a critical neural population that could be involved in the periadolescent onset of neuropsychiatric disorders, such as schizophrenia.
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Prior to adolescence, D2 stimulation elicits either no effect or only weak inhibition on interneurons; in adult animals, stimulation of D2 receptors is strongly excitatory and results in robust firing of interneurons and potent inhibition of their pyramidal cell targets.
“Prior to adolescence, D2 stimulation elicits either no effect or only weak inhibition on interneurons. However, in adult animals stimulation of D2 receptors is strongly excitatory and therefore results in robust firing of interneurons and potent inhibition of their pyramidal cell targets.”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [64]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredRecent evidence has established that D2 dopamine receptors on interneurons undergo a profound maturational change during adolescence.
“recent evidence has established that D2 dopamine receptors on interneurons undergo a profound maturational change during adolescence.62, 63, 64”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [64]
The Abstract and Discussion report that D2-mediated excitation of rat prefrontal interneurons is present in adults but not preadolescent animals, supporting a maturational change in D2 modulation. The Discussion says it remains unclear whether the effect is a direct action on interneurons, so the paper does not establish that the receptors on those cells themselves change during adolescence. (LLM, conf=0.87)
Experimental — accuracy not yet measuredD2 receptors switch from inhibitory to excitatory on parvalbumin interneurons in the mPFC during adolescence.
“D2 receptors switch from inhibitory to excitatory on parvalbumin interneurons in the mPFC during adolescence (Tseng and O'Donnell, 2007).”
From Sensitive periods of substance abuse: Early risk for the transition to dependence (2017) · cites this paper as Tseng and O'Donnell, 2007
In the adult PFC, D2 agonists become strongly excitatory over fast-spiking interneurons.
“In the adult PFC, however, D 2 agonists become strongly excitatory over fast-spiking interneurons, 12”
From Adolescent Onset of Cortical Disinhibition in Schizophrenia: Insights From Animal Models (2011) · cites this paper as [12]
In juvenile rats, D1 agonists increase GABA interneuron firing, whereas D2 agonists have either a weak inhibitory effect or no effect.
“In juvenile rats, D 1 agonists increase GABA interneuron firing, whereas D 2 agonists have either a weak inhibitory effect or no effect.12,13”
From Adolescent Onset of Cortical Disinhibition in Schizophrenia: Insights From Animal Models (2011) · cites this paper as [12]
Interneuron recruitment by DA is not efficient in juvenile stages (prior to PD45 in rats).
“As interneuron recruitment by DA is not efficient in juvenile stages (prior to PD45 in rats) 12”
From Adolescent Onset of Cortical Disinhibition in Schizophrenia: Insights From Animal Models (2011) · cites this paper as [12]
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- Authors
- Tseng, K.-Y., & O'Donnell, P.
- Affiliations
- Rosalind Franklin University of Medicine and Science (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06-13
- Volume
- 17
- Issue
- 5
- Pages
- 1235-1240
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC2204087
- OpenAlex
- W2128508619
- Cited by
- 339
- References
- 40
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 8 · 2023: 21 · 2022: 12 · 2021: 19 · 2020: 11 · 2019: 10 · 2018: 24 · 2017: 15 · 2016: 31 · 2015: 13 · 2014: 18 · 2013: 36 · 2012: 16
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH57683, R56MH057683, R01MH057683)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- dopamine, prefrontal cortex, cortical interneurons, adolescence, dopamine D1 receptor, dopamine D2 receptor, neuronal excitability, neural circuit maturation, decision-making, schizophrenia, neuropsychiatric disorders, rat brain slices
- MeSH terms
- Adaptation, Physiological, Aging, Animals, Cells, Cultured, Dopamine, Interneurons, Nerve Net, Neuronal Plasticity, Receptors, Dopamine, Prefrontal Cortex, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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