Mammary gland development

Molecular portraits of human breast tumours

Perou, C. M., Sørlie, T., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., Rees, C. A., Pollack, J. R., Ross, D. T., Johnsen, H., Akslen, L. A., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,261

Prospective identification of tumorigenic breast cancer cells

Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,370

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Bonnet, D., & Dick, J. E. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 5,864

Generation of a functional mammary gland from a single stem cell

Shackleton, M., Vaillant, F., Simpson, K. J., Stingl, J., Smyth, G. K., Asselin-Labat, M.-L., Wu, L., Lindeman, G. J., & Visvader, J. E. (2006) · Nature · doi:10.1038/nature04372 · Cited by 2,005

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

Lubahn, D. B., Moyer, J. S., Golding, T. S., Couse, J. F., Korach, K. S., & Smithies, O. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11162 · Cited by 1,898

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.

Lydon, J. P., DeMayo, F. J., Funk, C. R., Mani, S. K., Hughes, A. R., Montgomery, C. A., Shyamala, G., Conneely, O. M., & O'Malley, B. W. (1995) · Genes & Development · doi:10.1101/gad.9.18.2266 · Cited by 1,862

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

Hankinson, S. E., Willett, W. C., Colditz, G. A., Hunter, D. J., Michaud, D. S., Deroo, B., Rosner, B., Speizer, F. E., & Pollak, M. (1998) · The Lancet · doi:10.1016/s0140-6736(97)10384-1 · Cited by 1,823

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

Li, X., Lewis, M. T., Huang, J., Gutierrez, C., Osborne, C. K., Wu, M.-F., Hilsenbeck, S. G., Pavlick, A., Zhang, X., Chamness, G. C., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn123 · Cited by 1,794

Generation and reproductive phenotypes of mice lacking estrogen receptor β

Krege, J. H., Hodgin, J. B., Couse, J. F., Enmark, E., Warner, M., Mahler, J. F., Sar, M., Korach, K. S., Gustafsson, J.-Å., & Smithies, O. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15677 · Cited by 1,691

Purification and unique properties of mammary epithelial stem cells

Stingl, J., Eirew, P., Ricketson, I., Shackleton, M., Vaillant, F., Choi, D., Li, H. I., & Eaves, C. J. (2006) · Nature · doi:10.1038/nature04496 · Cited by 1,559

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

kConFab, Lim, E., Vaillant, F., Wu, D., Forrest, N. C., Pal, B., Hart, A. H., Asselin-Labat, M.-L., Gyorki, D. E., Ward, T., et al. (2009) · Nature Medicine · doi:10.1038/nm.2000 · Cited by 1,492

Cells of origin in cancer

Visvader, J. E. (2011) · Nature · doi:10.1038/nature09781 · Cited by 1,449

A G Protein-Linked Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide

Jüppner, H., Abou-Samra, A.-B., Freeman, M., Kong, X. F., Schipani, E., Richards, J., Kolakowski, L. F., Hock, J., Potts, J. T., Kronenberg, H. M., et al. (1991) · Science · doi:10.1126/science.1658941 · Cited by 1,249

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.

van Genderen, C., Okamura, R. M., Fariñas, I., Quo, R. G., Parslow, T. G., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 965

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

Asselin-Labat, M.-L., Sutherland, K. D., Barker, H., Thomas, R., Shackleton, M., Forrest, N. C., Hartley, L., Robb, L., Grosveld, F. G., van der Wees, J., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1530 · Cited by 840

Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.

Ormandy, C. J., Camus, A., Barra, J., Damotte, D., Lucas, B., Buteau, H., Edery, M., Brousse, N., Babinet, C., Binart, N., et al. (1997) · Genes & Development · doi:10.1101/gad.11.2.167 · Cited by 808

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)

Zhou, Y., Xu, B. C., Maheshwari, H. G., He, L., Reed, M., Lozykowski, M., Okada, S., Cataldo, L., Coschigamo, K., Wagner, T. E., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13215 · Cited by 802

The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini

Debnath, J., Mills, K. R., Collins, N. L., Reginato, M. J., Muthuswamy, S. K., & Brugge, J. S. (2002) · Cell · doi:10.1016/s0092-8674(02)01001-2 · Cited by 763

The osteoclast differentiation factor osteoprotegerin ligand is essential for mammary gland development.

Fata, J. E., Kong, Y.-Y., Li, J., Sasaki, T., Irie-Sasaki, J., Moorehead, R. A., Elliott, R., Scully, S., Voura, E. B., Lacey, D. L., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00103-3 · Cited by 756

Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform

Mulac-Jericevic, B., Mullinax, R. A., DeMayo, F. J., Lydon, J. P., & Conneely, O. M. (2000) · Science · doi:10.1126/science.289.5485.1751 · Cited by 704

Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene

Horseman, N. D. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.6926 · Cited by 650

Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

Ewald, A. J., Brenot, A., Duong, M., Chan, B. S., & Werb, Z. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.003 · Cited by 619

Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures

Nelson, C. M., VanDuijn, M. M., Inman, J. L., Fletcher, D. A., & Bissell, M. J. (2006) · Science · doi:10.1126/science.1131000 · Cited by 608

RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

Gonzalez-Suarez, E., Jacob, A. P., Jones, J., Miller, R., Roudier-Meyer, M. P., Erwert, R., Pinkas, J., Branstetter, D., & Dougall, W. C. (2010) · Nature · doi:10.1038/nature09495 · Cited by 596

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

Schramek, D., Leibbrandt, A., Sigl, V., Kenner, L., Pospisilik, J. A., Lee, H. J., Hanada, R., Joshi, P. A., Aliprantis, A., Glimcher, L., et al. (2010) · Nature · doi:10.1038/nature09387 · Cited by 592

Asymmetric cell division: recent developments and their implications for tumour biology

Knoblich, J. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3010 · Cited by 578

Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells

Richer, J. K., Jacobsen, B. M., Manning, N. G., Abel, M. G., Horwitz, K. B., & Wolf, D. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110090200 · Cited by 572

Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development

Luetteke, N. C., Qiu, T. H., Fssssenton, S. E., Troyer, K. L., Riedel, R. F., Chang, A., & Lee, D. C. (1999) · Development · doi:10.1242/dev.126.12.2739 · Cited by 567

An entire functional mammary gland may comprise the progeny from a single cell

Kordon, E. C., & Smith, G. H. (1998) · Development · doi:10.1242/dev.125.10.1921 · Cited by 558

Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform

Mulac-Jericevic, B., Lydon, J. P., DeMayo, F. J., & Conneely, O. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1732707100 · Cited by 547

Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome

Bamshad, M., Lin, R. C., Law, D. J., Watkins, W. S., Krakowiak, P. A., Moore, M. E., Franceschini, P., Lala, R., Holmes, L. B., Gebuhr, T. C., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-311 · Cited by 540

Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation

Cui, Y., Riedlinger, G., Miyoshi, K., Tang, W., Li, C., Deng, C.-X., Robinson, G. W., & Hennighausen, L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.8037-8047.2004 · Cited by 497

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

Chapman, R. S., Lourenco, P. C., Tonner, E., Flint, D. J., Selbert, S., Takeda, K., Akira, S., Clarke, A. R., & Watson, C. J. (1999) · Genes & Development · doi:10.1101/gad.13.19.2604 · Cited by 479

A paracrine role for the epithelial progesterone receptor in mammary gland development

Brisken, C., Park, S., Vass, T., Lydon, J. P., O’Malley, B. W., & Weinberg, R. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5076 · Cited by 479

Pregnancy-associated breast cancer and metastasis

Schedin, P. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1839 · Cited by 466

Mammary ductal elongation: Differentiation of myoepithelium and basal lamina during branching morphogenesis

Williams, J. M., & Daniel, C. W. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90086-6 · Cited by 461

Paracrine signaling through the epithelial estrogen receptor α is required for proliferation and morphogenesis in the mammary gland

Mallepell, S., Krust, A., Chambon, P., & Brisken, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510974103 · Cited by 432

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

Sympson, C. J. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.3.681 · Cited by 400

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

Silberstein, G. B., & Daniel, C. W. (1987) · Science · doi:10.1126/science.3474783 · Cited by 400

Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia

Monreal, A. W., Ferguson, B. M., Headon, D. J., Street, S. L., Overbeek, P. A., & Zonana, J. (1999) · Nature Genetics · doi:10.1038/11937 · Cited by 397

Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution

Li, M., Liu, X., Robinson, G., Bar-Peled, U., Wagner, K.-U., Young, W. S., Hennighausen, L., & Furth, P. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3425 · Cited by 375

Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue

Stingl, J., Eaves, C. J., Zandieh, I., & Emerman, J. T. (2001) · Breast Cancer Research and Treatment · doi:10.1023/a:1010615124301 · Cited by 367

Mammary Stem Cells and Breast Cancer—Role of Notch Signalling

Farnie, G., & Clarke, R. B. (2007) · Stem Cell Reviews · doi:10.1007/s12015-007-0023-5 · Cited by 356

Mesenchyme-Dependent Morphogenesis and Epithelium-Specific Cytodifferentiation in Mouse Mammary Gland

Sakakura, T., Nishizuka, Y., & Dawe, C. J. (1976) · Science · doi:10.1126/science.827022 · Cited by 355

Prolactin Controls Mammary Gland Development via Direct and Indirect Mechanisms

Brisken, C., Kaur, S., Chavarria, T. E., Binart, N., Sutherland, R. L., Weinberg, R. A., Kelly, P. A., & Ormandy, C. J. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9271 · Cited by 339

Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse

Kratochwil, K. (1969) · Developmental Biology · doi:10.1016/0012-1606(69)90004-9 · Cited by 331

Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia.

Jobert, A. S., Zhang, P., Couvineau, A., Bonaventure, J., Roume, J., Le Merrer, M., & Silve, C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2918 · Cited by 328

Amphiregulin is an essential mediator of estrogen receptor α function in mammary gland development

Ciarloni, L., Mallepell, S., & Brisken, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611647104 · Cited by 316

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene

Lubahn, J. S. (1993) · Medical Entomology and Zoology · Cited by 315

Stat3 controls lysosomal-mediated cell death in vivo

Kreuzaler, P. A., Staniszewska, A. D., Li, W., Omidvar, N., Kedjouar, B., Turkson, J., Poli, V., Flavell, R. A., Clarkson, R. W. E., & Watson, C. J. (2011) · Nature Cell Biology · doi:10.1038/ncb2171 · Cited by 312

Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin

Sternlicht, M. D., Sunnarborg, S. W., Kouros-Mehr, H., Yu, Y., Lee, D. C., & Werb, Z. (2005) · Development · doi:10.1242/dev.01966 · Cited by 309

Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland

Beleut, M., Rajaram, R. D., Caikovski, M., Ayyanan, A., Germano, D., Choi, Y., Schneider, P., & Brisken, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915148107 · Cited by 307

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis

Wiseman, B. S., Sternlicht, M. D., Lund, L. R., Alexander, C. M., Mott, J., Bissell, M. J., Soloway, P., Itohara, S., & Werb, Z. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302090 · Cited by 303

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

Chu, E. Y., Hens, J., Andl, T., Kairo, A., Yamaguchi, T. P., Brisken, C., Glick, A., Wysolmerski, J. J., & Millar, S. E. (2004) · Development · doi:10.1242/dev.01347 · Cited by 299

Mammary gland, limb and yolk sac defects in mice lacking Tbx3,the gene mutated in human ulnar mammary syndrome

Davenport, T. G., Jerome-Majewska, L. A., & Papaioannou, V. E. (2003) · Development · doi:10.1242/dev.00431 · Cited by 295

Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development

Wysolmerski, J. J., Philbrick, W. M., Dunbar, M. E., Lanske, B., Kronenberg, H., Karaplis, A., & Broadus, A. E. (1998) · Development · doi:10.1242/dev.125.7.1285 · Cited by 291

The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study.

Daniel, C. W., De Ome, K. B., Young, J. T., Blair, P. B., & Faulkin, L. J. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.61.1.53 · Cited by 286

Endocrine Control of Mammary-Gland Development and Function in the C3H/He Crgl Mouse 2

(1958) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/21.6.1039 · Cited by 283

Human breast development

Gusterson, B. A., & Stein, T. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.03.013 · Cited by 277

Estrogen receptor-α expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice

Feng, Y., Manka, D., Wagner, K.-U., & Khan, S. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706933104 · Cited by 274

Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks

Cheng, N., Bhowmick, N. A., Chytil, A., Gorksa, A. E., Brown, K. A., Muraoka, R., Arteaga, C. L., Neilson, E. G., Hayward, S. W., & Moses, H. L. (2005) · Oncogene · doi:10.1038/sj.onc.1208685 · Cited by 267

Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development

Wiesen, J. F., Young, P., Werb, Z., & Cunha, G. R. (1999) · Development · doi:10.1242/dev.126.2.335 · Cited by 266

Netrin-1/Neogenin Interaction Stabilizes Multipotent Progenitor Cap Cells during Mammary Gland Morphogenesis

Srinivasan, K., Strickland, P., Valdes, A., Shin, G. C., & Hinck, L. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00054-6 · Cited by 263

Tissue interaction in androgen response of embryonic mammary rudiment of mouse: identification of target tissue for testosterone.

Kratochwil, K., & Schwartz, P. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.4041 · Cited by 253

Stimulation of ectodermal organ development by Ectodysplasin-A1

Mustonen, T., Pispa, J., Mikkola, M. L., Pummila, M., Kangas, A. T., Pakkasjärvi, L., Jaatinen, R., & Thesleff, I. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00157-x · Cited by 252

The Mammary Gland and Its Origin During Synapsid Evolution

Oftedal, O. T. (2002) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1022896515287 · Cited by 249

A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland

Smith, G. H., & Medina, D. (1988) · Journal of Cell Science · doi:10.1242/jcs.90.1.173 · Cited by 248

Impaired Alveologenesis and Maintenance of Secretory Mammary Epithelial Cells in Jak2 Conditional Knockout Mice

Wagner, K.-U., Krempler, A., Triplett, A. A., Qi, Y., George, N. M., Zhu, J., & Rui, H. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5510-5520.2004 · Cited by 247

Human Breast Development

Howard, B. A., & Gusterson, B. A. (2000) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1026487120779 · Cited by 245

Insulin-Like Growth Factor I Is Essential for Terminal End Bud Formation and Ductal Morphogenesis during Mammary Development1

Ruan, W., & Kleinberg, D. L. (1999) · Endocrinology · doi:10.1210/endo.140.11.7095 · Cited by 241

Wnt signaling in stem and cancer stem cells

Wend, P., Holland, J. D., Ziebold, U., & Birchmeier, W. (2010) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2010.09.004 · Cited by 237

Prolactin, Growth Hormone, and Epidermal Growth Factor Activate Stat5 in Different Compartments of Mammary Tissue and Exert Different and Overlapping Developmental Effects

Gallego, M. I., Binart, N., Robinson, G. W., Okagaki, R., Coschigano, K. T., Perry, J., Kopchick, J. J., Oka, T., Kelly, P. A., & Hennighausen, L. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9961 · Cited by 235

Remodeling of the Mammary Microenvironment after Lactation Promotes Breast Tumor Cell Metastasis

McDaniel, S. M., Rumer, K. K., Biroc, S. L., Metz, R. P., Singh, M., Porter, W., & Schedin, P. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.050677 · Cited by 234

Ductal morphogenesis in the mouse mammary gland: Evidence supporting a role for epidermal growth factor

Coleman, S., Silberstein, G. B., & Daniel, C. W. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90317-x · Cited by 233

Ablation of β1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation

Naylor, M. J., Li, N., Cheung, J., Lowe, E. T., Lambert, E., Marlow, R., Wang, P., Schatzmann, F., Wintermantel, T., Schüetz, G., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200503144 · Cited by 225

Insulin-Like Growth Factor-I in Relation to Premenopausal Ductal Carcinoma in Situ of the Breast

Bohlke, K., Cramer, D. W., Trichopoulos, D., & Mantzoros, C. S. (1998) · Epidemiology · doi:10.1097/00001648-199809000-00018 · Cited by 215

Mouse GLI3 Regulates Fgf8 Expression and Apoptosis in the Developing Neural Tube, Face, and Limb Bud

Aoto, K., Nishimura, T., Eto, K., & Motoyama, J. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0811 · Cited by 209

Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development

Wysolmerski, J. J., McCaughern-Carucci, J. F., Daifotis, A. G., Broadus, A. E., & Philbrick, W. M. (1995) · Development · doi:10.1242/dev.121.11.3539 · Cited by 202

A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland

Kritikou, E. A., Sharkey, A., Abell, K., Came, P. J., Anderson, E., Clarkson, R. W. E., & Watson, C. J. (2003) · Development · doi:10.1242/dev.00578 · Cited by 201

Direct action of 17 beta-estradiol on mouse mammary ducts analyzed by sustained release implants and steroid autoradiography.

Daniel, C. W., Silberstein, G. B., & Strickland, P. A. (1987) · PubMed · Cited by 195

Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development.

Witty, J. P., Wright, J. H., & Matrisian, L. M. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.10.1287 · Cited by 191

Estrogen control of prolactin synthesis in vitro.

Lieberman, M. E., Maurer, R. A., & Gorski, J. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.12.5946 · Cited by 189

Three division-competent, structurally-distinct cell populations contribute to murine mammary epithelial renewal

Chepko, G., & Smith, G. H. (1997) · Tissue and Cell · doi:10.1016/s0040-8166(97)80024-9 · Cited by 189

Regulation of Mammary Gland Development by Tissue Interaction

Robinson, G. W., Karpf, A. B. C., & Kratochwil, K. (1999) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1018748418447 · Cited by 186

Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage

Mailleux, A. A., Kelly, R., Veltmaat, J. M., De Langhe, S. P., Zaffran, S., Thiery, J. P., & Bellusci, S. (2005) · Development · doi:10.1242/dev.01795 · Cited by 184

Accelerated apoptosis in the Timp-3–deficient mammary gland

Fata, J. E., Leco, K. J., Voura, E. B., Yu, H.-Y. E., Waterhouse, P., Murphy, G., Moorehead, R. A., & Khokha, R. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13171 · Cited by 183

Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development

Foley, J., Dann, P., Hong, J., Cosgrove, J., Dreyer, B., Rimm, D., Dunbar, M. E., Philbrick, W., & Wysolmerski, J. J. (2001) · Development · doi:10.1242/dev.128.4.513 · Cited by 181

Wnt5a is required for proper mammary gland development and TGF-β-mediated inhibition of ductal growth

Roarty, K., & Serra, R. (2007) · Development · doi:10.1242/dev.008250 · Cited by 180

Persistent Parity-Induced Changes in Growth Factors, TGF-β3, and Differentiation in the Rodent Mammary Gland

D’Cruz, C. M., Moody, S. E., Master, S. R., Hartman, J. L., Keiper, E. A., Imielinski, M. B., Cox, J. D., Wang, J. Y., Ha, S. I., Keister, B. A., et al. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0073 · Cited by 175

Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia

Moraes, R. C., Zhang, X., Harrington, N., Fung, J. Y., Wu, M.-F., Hilsenbeck, S. G., Allred, D. C., & Lewis, M. T. (2007) · Development · doi:10.1242/dev.02797 · Cited by 175

Mammary epithelial stem cells

Smith, G. H., & Chepko, G. (2001) · Microscopy Research and Technique · doi:10.1002/1097-0029(20010115)52:2<182::aid-jemt1004>3.0.co;2-m · Cited by 172

Mammary gland involution is delayed by activated Akt in transgenic mice

Schwertfeger, K. L., Richert, M. M., & Anderson, S. M. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.6.0663 · Cited by 169

Characterization of progesterone receptor A and B expression in human breast cancer.

Graham, J. D., Yeates, C., Balleine, R. L., Harvey, S. S., Milliken, J. S., Bilous, A. M., & Clarke, C. L. (1995) · PubMed · Cited by 168

Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis

Lu, P., Ewald, A. J., Martin, G. R., & Werb, Z. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.06.005 · Cited by 167

C/EBP (CCAAT/Enhancer Binding Protein) Controls Cell Fate Determination during Mammary Gland Development

Seagroves, T. N., Lydon, J. P., Hovey, R. C., Vonderhaar, B. K., & Rosen, J. M. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.3.0434 · Cited by 163

Molecular Mechanisms Guiding Embryonic Mammary Gland DevelopmentPreprint

Cowin, P., & Wysolmerski, J. J. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003251 · Cited by 162

Estrogen receptor-negative epithelial cells in mouse mammary gland development and growth

Zeps, N., Bentel, J. M., Papadimitriou, J. M., D'Antuono, M. F., & Dawkins, H. J. S. (1998) · Differentiation · doi:10.1046/j.1432-0436.1998.6250221.x · Cited by 161

Latent Transforming Growth Factor-β Activation in Mammary Gland

Ewan, K., Shyamala, G., Ravani, S. A., Tang, Y., Akhurst, R. J., Wakefield, L. M., & Barcellos‐Hoff, M. H. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61158-3 · Cited by 160

Prolactin Regulation of Mammary Gland Development

Oakes, S. R., Rogers, R. L., Naylor, M. J., & Ormandy, C. J. (2008) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-008-9069-5 · Cited by 155

Hormonal Control of Insulin-Like Growth Factor-Binding Protein-5 Production in the Involuting Mammary Gland of the Rat1

Tonner, E., BARBER, M. C., Travers, M. T., Logan, A., & Flint, D. J. (1997) · Endocrinology · doi:10.1210/endo.138.12.5619 · Cited by 153

Essential role of endogenous estrogen in directly stimulating mammary growth demonstrated by implants containing pure antiestrogens

Silberstein, G. B., Horn, K. V., Shyamala, G., & Daniel, C. W. (1994) · Endocrinology · doi:10.1210/endo.134.1.8275973 · Cited by 142

BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction

Hens, J. R., Dann, P. R., Zhang, J., Harris, S. E., Robinson, G. W., & Wysolmerski, J. J. (2007) · Development · doi:10.1242/dev.000182 · Cited by 141

The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse

Fernandez‐Valdivia, R., Mukherjee, A., Yan, Y., Li, J., Paquet, M., DeMayo, F. J., & Lydon, J. P. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.01.019 · Cited by 140

Identification of the mammary line in mouse by Wnt10b expression

Veltmaat, J. M., van Veelen, W., Thiery, J. P., & Bellusci, S. (2004) · Developmental Dynamics · doi:10.1002/dvdy.10441 · Cited by 136

Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes

Veltmaat, J., Relaix, F., Le, L. T., Kratochwil, K., Sala, F., van Veelen, W., Rice, R., Spencer-Dene, B., Mailleux, A., Rice, D., et al. (2006) · Development · doi:10.1242/dev.02394 · Cited by 135

Receptor Activator of NF-κB Ligand Induction via Jak2 and Stat5a in Mammary Epithelial Cells

Srivastava, S., Matsuda, M., Hou, Z., Bailey, J. P., Kitazawa, R., Herbst, M. P., & Horseman, N. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308545200 · Cited by 134

The Genes Induced by Signal Transducer and Activators of Transcription (STAT)3 and STAT5 in Mammary Epithelial Cells Define the Roles of these STATs in Mammary Development

Clarkson, R. W. E., Boland, M. P., Kritikou, E. A., Lee, J. M., Freeman, T. C., Tiffen, P. G., & Watson, C. J. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0392 · Cited by 131

Overexpression of a Kinase-deficient Transforming Growth Factor-β Type II Receptor in Mouse Mammary Stroma Results in Increased Epithelial Branching

Joseph, H., Gorska, A. E., Sohn, P., et al. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.4.1221 · Cited by 124

Elvax 40P implants: Sustained, local release of bioactive molecules influencing mammary ductal development

Silberstein, G. B., & Daniel, C. W. (1982) · Developmental Biology · doi:10.1016/0012-1606(82)90259-7 · Cited by 123

Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos

Eblaghie, M. C., Song, S., Kim, J., Akita, K., Tickle, C., & Jung, H. (2004) · Journal of Anatomy · doi:10.1111/j.0021-8782.2004.00309.x · Cited by 121

Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes

Fliniaux, I., Mikkola, M. L., Lefebvre, S., & Thesleff, I. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.04.023 · Cited by 120

Gli3-mediated repression of Hedgehog targets is required for normal mammary development

Hatsell, S. J., & Cowin, P. (2006) · Development · doi:10.1242/dev.02542 · Cited by 117

The influence of host and tissue age on life span and growth rate of serially transplanted mouse mammary gland

Young, L. J. T., Medina, D., DeOme, K. B., & Daniel, C. W. (1971) · Experimental Gerontology · doi:10.1016/0531-5565(71)90048-9 · Cited by 116

Dual origin of mesenchymal tissues participating in mouse mammary gland embryogenesis

Sakakura, T., Sakagami, Y., & Nishizuka, Y. (1982) · Developmental Biology · doi:10.1016/0012-1606(82)90024-0 · Cited by 116

Lactational competence and involution of the mouse mammary gland require plasminogen

Lund, L. R., Bjørn, S. F., Sternlicht, M. D., Nielsen, B. S., Solberg, H., Usher, P. A., Østerby, R., Christensen, I. J., Stephens, R. W., Bugge, T. H., et al. (2000) · Development · doi:10.1242/dev.127.20.4481 · Cited by 116

Reproductive state of rat mammary gland stroma modulates human breast cancer cell migration and invasion.

Bemis, L., & Schedin, P. S. (2000) · PubMed · Cited by 115

Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice.

Gorska, A. E., Joseph, H., Derynck, R., Moses, H. L., & Serra, R. A. (1998) · PubMed · Cited by 115

Developmental Regulation of Murine Mammary Progesterone Receptor Gene Expression*

Shyamala, G., SCHNEIDER, W., & Schott, D. R. (1990) · Endocrinology · doi:10.1210/endo-126-6-2882 · Cited by 114

Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition

Abell, K., Bilancio, A., Clarkson, R. W. E., Tiffen, P. G., Altaparmakov, A. I., Burdon, T. G., Asano, T., Vanhaesebroeck, B., & Watson, C. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1242 · Cited by 112

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

Wang, C., Rüther, U., & Wang, B. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.029 · Cited by 109

Mfge8 Is Critical for Mammary Gland Remodeling during Involution

Atabai, K., Fernandez, R. J., Huang, X., Ueki, I. F., Kline, A., Li, Y., Sadatmansoori, S., Smith-Steinhart, C., Zhu, W., Pytela, R., et al. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-02-0128 · Cited by 105

Influence of cell division on an aging process*Life span of mouse mammary epithelium during serial propagation in vivo

DANIEL, C., & YOUNG, L. (1971) · Experimental Cell Research · doi:10.1016/s0014-4827(71)80046-0 · Cited by 104

IKKβ/2 induces TWEAK and apoptosis in mammary epithelial cells

Baxter, F. O., Came, P. J., Abell, K., Kedjouar, B., Huth, M., Rajewsky, K., Pasparakis, M., & Watson, C. J. (2006) · Development · doi:10.1242/dev.02502 · Cited by 97

On the prenatal growth of the mammary gland rudiment in the mouse.

Bi, B. (1950) · PubMed · Cited by 96

Roles of Fas and Fas ligand during mammary gland remodeling

Song, J. H., Sapi, E., Brown, W., Nilsen, J., Tartaro, K. R., Kacinski, B. M., Craft, J. E., Naftolin, F. N., & Mor, G. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10411 · Cited by 95

Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development

Cho, K., Kim, J., Song, S., Farrell, E. R., Eblaghie, M. C., Kim, H.-J., Tickle, C. A., & Jung, H.-S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604645103 · Cited by 90

Mammary Gland Branching Morphogenesis Is Diminished in Mice with a Deficiency of Insulin-like Growth Factor-I (IGF-I), But Not in Mice with a Liver-Specific Deletion of IGF-I

Richards, R. G., Klotz, D. M., Walker, M. P., & DiAugustine, R. P. (2004) · Endocrinology · doi:10.1210/en.2003-1112 · Cited by 89

Stat5 Promotes Survival of Mammary Epithelial Cells through Transcriptional Activation of a Distinct Promoter in Akt1

Creamer, B. A., Sakamoto, K., Schmidt, J. W., Triplett, A. A., Moriggl, R., & Wagner, K. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00851-09 · Cited by 87

Tbx3, the ulnar‐mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53‐independent pathway

Jerome‐Majewska, L. A., Jenkins, G. P., Ernstoff, E., Zindy, F., Sherr, C. J., & Papaioannou, V. E. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20575 · Cited by 86

Transcriptional Response of the Murine Mammary Gland to Acute Progesterone Exposure

Fernandez‐Valdivia, R., Mukherjee, A., Creighton, C. J., Buser, A. C., DeMayo, F. J., Edwards, D. P., & Lydon, J. P. (2008) · Endocrinology · doi:10.1210/en.2008-0768 · Cited by 82

Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression

Mukherjee, A., Soyal, S. M., Li, J., Yan, Y., He, B., DeMayo, F. J., & Lydon, J. P. (2010) · The FASEB Journal · doi:10.1096/fj.10-157982 · Cited by 82

Alterations of Gene Expression in the Development of Early Hyperplastic Precursors of Breast Cancer

Lee, S., Medina, D., Tsimelzon, A. I., Mohsin, S. K., Mao, S., Wu, Y., & Allred, D. C. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061010 · Cited by 82

Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis

Strickland, P. A., Shin, G. C., Plump, A. S., Tessier‐Lavigne, M., & Hinck, L. (2006) · Development · doi:10.1242/dev.02261 · Cited by 75

Lumen formation in the developing mouse mammary gland

Hogg, N., Harrison, C. J., & Tickle, C. (1983) · Development · doi:10.1242/dev.73.1.39 · Cited by 75

The influence of mammogenic hormones on serially transplanted mouse mammary gland

Daniel, C. W., Young, L. J. T., Medina, D., & DeOme, K. B. (1971) · Experimental Gerontology · doi:10.1016/0531-5565(71)90053-2 · Cited by 74

Genomic signature induced by pregnancy in the human breast

Balogh, G., Heulings, R., Mailo, D., Russo, P. A., Sheriff, F. S., Russo, I. H., Moral, R., & Russo, J. (2006) · International Journal of Oncology · doi:10.3892/ijo.28.2.399 · Cited by 74

Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specificationPreprint

Howard, B. A., Panchal, H., McCarthy, A., & Ashworth, A. (2005) · Genes & Development · doi:10.1101/gad.338505 · Cited by 72

Isolation and characterization of human mammary stem cells

Clarke, R. B. (2005) · Cell Proliferation · doi:10.1111/j.1365-2184.2005.00357.x · Cited by 71

Microarray Analysis of the Involution Switch

Clarkson, R. W. E., & Watson, C. J. (2003) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000010031.53310.92 · Cited by 69

Distinct roles of the three Akt isoforms in lactogenic differentiation and involution

Maroulakou, I. G., Oemler, W., Naber, S. P., Klebba, I., Kuperwasser, C., & Tsichlis, P. N. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21518 · Cited by 68

Alveolar progenitor cells develop in mouse mammary glands independent of pregnancy and lactation

Booth, B. W., Boulanger, C. A., & Smith, G. H. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21071 · Cited by 67

Influence of microenvironment on mammary epithelial cell survival in primary culture

Blatchford, D. R., Quarrie, L. H., Tonner, E., McCarthy, C., Flint, D. J., & Wilde, C. J. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199911)181:2<304::aid-jcp12>3.0.co;2-5 · Cited by 67

Wandering epithelial cells in the rabbit embryo milk line

Propper, A. Y. (1978) · Developmental Biology · doi:10.1016/0012-1606(78)90311-1 · Cited by 66

The EGF repeat and discoidin domain protein, SED1/MFG-E8, is required for mammary gland branching morphogenesis

Ensslin, M. A., & Shur, B. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610296104 · Cited by 66

Mammary Gland Development in Transforming Growth Factor Beta1 Null Mutant Mice: Systemic and Epithelial Effects1

Ingman, W. V., & Robertson, S. A. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.107.067272 · Cited by 55

Historical Perspectives of Prolactin and Growth Hormone as Mammogens, Lactogens and Galactagogues—Agog for the Future!

Trott, J. F., Vonderhaar, B. K., & Hovey, R. C. (2008) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-008-9064-x · Cited by 53

Neuregulin3 alters cell fate in the epidermis and mammary gland

Panchal, H., Wansbury, O., Parry, S., Ashworth, A., & Howard, B. A. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-105 · Cited by 50

JAK2 and STAT5, but not JAK1 and STAT1, Are Required for Prolactin-Induced -Lactoglobulin Transcription

Han, Y., Watling, D., Rogers, N. C., & Stark, G. R. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.8.9952 · Cited by 50

Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution

Lilla, J. N., Joshi, R. V., Craik, C. S., & Werb, Z. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900508200 · Cited by 50

Elevated Circulating IGF-I Promotes Mammary Gland Development and Proliferation

Cannata, D., Lann, D. E., Wu, Y., Elis, S., Sun, H., Yakar, S., Lazzarino, D. A., Wood, T. L., & LeRoith, D. (2010) · Endocrinology · doi:10.1210/en.2010-0792 · Cited by 43

Effect of Exogenous Epidermal-Like Growth Factors on Mammary Gland Development and Differentiation in the Estrogen Receptor-Alpha Knockout (ERKO) Mouse

Kenney, N. J., Bowman, A., Korach, K. S., Barrett, J. C., & Salomon, D. S. (2003) · Breast Cancer Research and Treatment · doi:10.1023/a:1023938510508 · Cited by 41

Mouse mammary gland involution is associated with cytochrome c release and caspase activation

Marti, A., Ritter, P. M., Jäger, R., Lazar, H., Baltzer, A., Schenkel, J., Declercq, W., Vandenabeele, P., & Jaggi, R. B. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00381-1 · Cited by 39

Disruption of reelin signaling alters mammary gland morphogenesis

Khialeeva, E., Lane, T. F., & Carpenter, E. M. (2011) · Development · doi:10.1242/dev.057588 · Cited by 31

Hedgehog Signaling in the Normal and Neoplastic Mammary Gland

Visbal, A. P., & Lewis, M. T. (2010) · Current Drug Targets · doi:10.2174/138945010792006753 · Cited by 26

Mapping mammary gland architecture using multi-scale in situ analysis

Fernández‐González, R., Illa-Bochaca, I., Welm, B. E., Fleisch, M. C., Werb, Z., Ortíz-de-Solórzano, C., & Barcellos‐Hoff, M. H. (2008) · Integrative Biology · doi:10.1039/b816933k · Cited by 24

Risk to human health related to the presence of perfluoroalkyl substances in food

Panel), E. P. O. C. I. T. F. C. (. C., Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl‐Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Leblanc, J., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.6223 · Cited by 989

Breast milk, a source of beneficial microbes and associated benefits for infant health

Lyons, K. E., Ryan, C. A., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020) · Nutrients · doi:10.3390/nu12041039 · Cited by 613

Breast Tumor Heterogeneity: Source of Fitness, Hurdle for Therapy

Koren, S., & Bentires-Alj, M. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.031 · Cited by 284

What have we learned about GPER function in physiology and disease from knockout mice

Prossnitz, E. R., & Hathaway, H. J. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.06.014 · Cited by 157

Loss of vitamin D receptor signaling from the mammary epithelium or adipose tissue alters pubertal glandular development

Johnson, A. L., Zinser, G. M., & Waltz, S. E. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00200.2014 · Cited by 22