Correlations between mental state and quantitative neuropathology in the Vienna Longitudinal Study on Dementia
Abstract
Quantitative clinicopathological correlation studies are one way to address the question of the relevance of morphological abnormalities in Alzheimer's dementia (AD). This paper summarizes results of the Vienna Longitudinal Study on Dementia obtained during the past few years and presents a critical discussion on the relevance of clinicopathological correlation studies for the pathogenesis of AD. Plotting of psychometric test scores against the numbers of plaques, tangles and neuropil threads in various cortical areas shows that significant correlations are due primarily to very high lesion counts in severely demented patients. These data indicate that neocortical neurofibrillary pathology can be considered an end-stage marker in the pathology of AD. On the other hand, the topographical staging of neuritic Alzheimer changes proposed by Braak and Braak (1991) appears to be a better reflection of the progression of the degenerative process than numerical lesion counts; there is a linear correlation between the Braak stages and Mini-Mental State scores in 122 aged individuals. Significant correlations are further obtained between the severity of dementia and the levels of a number of synaptic proteins including synaptophysin and the chromogranins. Taken together, our data suggest that none of the classical AD lesions, plaques and tangles, play a central role in the pathogenesis of dementia, a fact that is supported by a molecular biological study showing that there is no close relationship between these lesions and the neurons undergoing degeneration in AD. Whereas neuritic pathology is a useful histopathological marker for the diagnosis and staging of AD, the major correlate of cognitive deficits is the loss of corticocortical and subcorticocortical connections reflected by a depletion of synapses. This pathology may be induced by a mismetabolism of the beta-amyloid precursor proteins or their interaction with cytoskeletal proteins related to neuronal degeneration.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Most brains from elderly human subjects show abnormalities that fall somewhere along particular continua of pathologic severity.
“We consider it to be an important clue that most brains from elderly human subjects show abnormalities that fall somewhere along particular continua of pathologic severity (60, 96-100).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [98]
Subsequent studies have established that the densities of NPs correlate with antemortem cognitive impairment better than the densities of diffuse AβPs.
“Subsequent studies have established that the densities of NPs correlate with antemortem cognitive impairment better than the densities of diffuse AβPs (45, 98, 106, 154, 189, 261).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [98]
More than 40 CPC studies have assessed the correlation between AβPs and severity of antemortem cognitive impairment.
“More than 40 CPC studies have assessed the correlation between AβPs and severity of antemortem cognitive impairment (38, 98, 103, 105-108, 158, 162, 171, 185, 189, 191, 223-260).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [98]
Numerous CPC studies have assessed the association between NFTs and cognitive status.
“Numerous CPC studies have assessed the association between NFTs and cognitive status (38, 98, 154, 158, 162, 185, 188, 189, 191, 223-232, 235-240, 244, 250-252, 258, 261, 264, 287-296).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [98]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,803 · see citing works
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,003 · see citing works
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444 · see citing works
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117 · see citing works
SPSS: statistical package for the social sciences
Nie, N. H. (1975) · Infoscience (Ecole Polytechnique Fédérale de Lausanne) · Cited by 3,461 · see citing works
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499 · see citing works
(1995) · Choice Reviews Online · doi:10.5860/choice.32-5931 · Cited by 2,337 · see citing works
Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides
Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975 · see citing works
THE TOKEN TEST: A SENSITIVE TEST TO DETECT RECEPTIVE DISTURBANCES IN APHASICS
Renzi, E. D., & Vignolo, L. A. (1962) · Brain · doi:10.1093/brain/85.4.665 · Cited by 1,868 · see citing works
Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R)
Spitzer, R. L., & Williams, J. (1987) · Cited by 1,621 · see citing works
Evaluating storage, retention, and retrieval in disordered memory and learning
Buschke, H., & Fuld, P. (1974) · Neurology · doi:10.1212/wnl.24.11.1019 · Cited by 1,614 · see citing works
The distribution of tau in the mammalian central nervous system.
Binder, L. I., Frankfurter, A., & Rebhun, L. I. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.4.1371 · Cited by 1,588 · see citing works
Influence of education and occupation on the incidence of Alzheimer's disease
Stern, Y. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03510370056032 · Cited by 1,434 · see citing works
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
Price, J. L., Davis, P. B., Morris, J. C., & White, D. L. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90006-6 · Cited by 818 · see citing works
Alzheimer's Disease: A Central Role for Amyloid
Selkoe, D. J. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00003 · Cited by 752 · see citing works
Gold, R., Schmied, M. C., Giegerich, G., Breitschopf, H., Hartung, H., Toyka, K. V., & Lassmann, H. (1994) · PubMed · Cited by 675 · see citing works
Self-citationPerforant pathway changes and the memory impairment of Alzheimer's disease
Hyman, B. T., Van Hoesen, G. W., Kromer, L. J., & Damasio, A. R. (1986) · Annals of Neurology · doi:10.1002/ana.410200406 · Cited by 672 · see citing works
Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease
Rumble, B. A., Retallack, R. W., Hilbich, C., Simms, G., Multhaup, G., Martins, R. N., Hockey, A., Montgomery, P., Beyreuther, K. T., & Masters, C. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906013202203 · Cited by 652 · see citing works
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643 · see citing works
Tierney, M. C., Fisher, R. H., Lewis, A. J., Zorzitto, M. L., Snow, W. G., Reid, D. W., & Nieuwstraten, P. (1988) · Neurology · doi:10.1212/wnl.38.3.359 · Cited by 613 · see citing works
Wilcock, G. K., & Esiri, M. M. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90155-1 · Cited by 608 · see citing works
Crystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Masdeu, J., Kawas, C., Aronson, M., & Wolfson, L. (1988) · Neurology · doi:10.1212/wnl.38.11.1682 · Cited by 586 · see citing works
Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease
Bierer, L. M., Hof, P. R., Purohit, D. P., Carlin, L., Schmeidler, J., Davis, K. L., & Perl, D. P. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540250089017 · Cited by 514 · see citing works
Morris, J. C., McKeel, D. W., Storandt, M., Rubin, E. H., Price, J. L., Grant, E. A., Ball, M. J., & Berg, L. (1991) · Neurology · doi:10.1212/wnl.41.4.469 · Cited by 473 · see citing works
Mann, D. M. A., & Esiri, M. M. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90019-1 · Cited by 471 · see citing works
Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ
Lassmann, H., Bancher, C., Breitschopf, H., Węgiel, J., Bobinski, M., Jellinger, K. A., & Wı́sniewski, H. M. (1995) · Acta Neuropathologica · doi:10.1007/bf00294257 · Cited by 458 · see citing works
Self-citationMaking the diagnosis of Alzheimer's disease. A primer for practicing pathologists.
Mirra, S. S., Hart, M. N., & Terry, R. D. (1993) · PubMed · Cited by 412 · see citing works
Correlations of synaptic and pathological markers with cognition of the elderly
Dickson, D. W., Crystal, H. A., Bevona, C., Honer, W., Vincent, I., & Davies, P. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00013-5 · Cited by 410 · see citing works
Neuritic pathology and dementia in alzheimer's disease
McKee, A. C., Kosik, K. S., & Kowall, N. W. (1991) · Annals of Neurology · doi:10.1002/ana.410300206 · Cited by 358 · see citing works
Yamamoto, T., & Hirano, A. (1986) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1986.tb00677.x · Cited by 330 · see citing works
Haass, C., Hung, A. Y., Selkoe, D. J., & Teplow, D. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32503-6 · Cited by 315 · see citing works
Bancher, C., Braak, H., Fischer, P., & Jellinger, K. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90590-h · Cited by 314 · see citing works
Self-citationLevel of education and change in cognitive function in a community population of older persons
Evans, D. A., Beckett, L. A., Albert, M., Hebert, L. E., Scherr, P. A., Funkenstein, H. H., & Taylor, J. O. (1993) · Annals of Epidemiology · doi:10.1016/1047-2797(93)90012-s · Cited by 312 · see citing works
Nagy, Z., Esiri, M. M., Jobst, K. A., Morris, J. H., King, E. M.-F., McDonald, B., Litchfield, S., Smith, A. D., Barnetson, L. P. D., & Smith, A. D. (1995) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106918 · Cited by 283 · see citing works
Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia
Wisniewski, K. E., Jervis, G. A., Moretz, R. C., & Wı́sniewski, H. M. (1979) · Annals of Neurology · doi:10.1002/ana.410050311 · Cited by 281 · see citing works
Gold, R., Schmied, M. C., Rothe, G., Zischler, H., Breitschopf, H., Wekerle, H., & Lassmann, H. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.7.8515045 · Cited by 269 · see citing works
Self-citationLocalization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites
SCHUBERT, W. J., Prior, R., Weidemann, A., Dircksen, H., Multhaup, G., Masters, C. L., & Beyreuther, K. T. (1991) · Brain Research · doi:10.1016/0006-8993(91)91532-6 · Cited by 265 · see citing works
Berg, L., McKeel, D. W., Miller, J. P., Baty, J., & Morris, J. C. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540040011008 · Cited by 257 · see citing works
Ohm, T. G., Müller, H., Braak, H., & Böhl, J. (1995) · Neuroscience · doi:10.1016/0306-4522(95)90397-p · Cited by 222 · see citing works
DeKosky, S. T., Harbaugh, R. E., Schmitt, F. A., Bakay, R. A. E., Chui, H. C., Knopman, D. S., Reeder, T. M., Shetter, A. G., Senter, H. J., Markesbery, W. R., et al. (1992) · Annals of Neurology · doi:10.1002/ana.410320505 · Cited by 222 · see citing works
Amyloid β peptide induces necrosis rather than apoptosis
Behl, C., Davis, J. B., Klier, F. G., & Schubert, D. (1994) · Brain Research · doi:10.1016/0006-8993(94)91659-4 · Cited by 219 · see citing works
Diffuse plaques do not accentuate synapse loss in Alzheimer's disease.
(1990) · Europe PMC (PubMed Central) · Cited by 209 · see citing works
β-Amyloid and the Pathogenesis of Alzheimer's Disease
Flier, J. S., Underhill, L. H., Yankner, B. A., & Mesulam, M. M. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112263252605 · Cited by 207 · see citing works
Bancher, C., Grundke, I., Iqbal, K., Fried, V. A., Smith, H. T., & Wisniewski, H. M. (1991) · Brain Research · doi:10.1016/0006-8993(91)90681-k · Cited by 185 · see citing works
Self-citation(1995) · PubMed · Cited by 167 · see citing works
Mann, D. M. A., Marcyniuk, B., Yates, P. O., Neary, D., & Snowden, J. S. (1988) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1988.tb00880.x · Cited by 162 · see citing works
THE TOPOGRAPHY OF PLAQUES AND TANGLES IN DOWN'S SYNDROME PATIENTS OF DIFFERENT AGES
Mann, D. M. A., Yates, P. O., Marcyniuk, B., & Ravindra, C. (1986) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1986.tb00053.x · Cited by 161 · see citing works
Lassmann, H., Weiler, R., Fischer, P. A., Bancher, C., Jellinger, K. A., Floor, E., Danielczyk, W., SEITELBERGER, F., & Winkler, H. J. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90003-k · Cited by 160 · see citing works
Self-citationAlzheimer's disease: Advances in clinical and basic research
Absher, J. R. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90166-x · Cited by 152 · see citing works
Clinical Correlates of Cortical and Nucleus Basalis Pathology in Alzheimer Dementia
Samuel, W., Terry, R. D., DeTeresa, R. M., Butters, N., & Masliah, E. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540200048015 · Cited by 140 · see citing works
D�laere, P., Duyckaerts, C. J., Brion, J., Poulain, V., & Hauw, J. (1989) · Acta Neuropathologica · doi:10.1007/bf00687893 · Cited by 135 · see citing works
Clinicopathologic Correlates in Alzheimer Disease
Kazee, A. M., Eskin, T. A., Lapham, L. W., Gabriel, K., McDaniel, K. D., & Hamill, R. W. (1993) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199307030-00004 · Cited by 111 · see citing works
Hippocampal connectivity and Alzheimer's dementia
Samuel, W., Masliah, E., Hill, L., Butters, N., & Terry, R. D. (1994) · Neurology · doi:10.1212/wnl.44.11.2081 · Cited by 108 · see citing works
McGeer, P. L., Harada, N., Kimura, H., McGeer, E. G., & Schulzer, M. (1992) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107010 · Cited by 105 · see citing works
Alzheimer neurofibrillary tangles: Monoclonal antibodies to inherent antigen(s)
Wang, G. P., Grundke, I., Kascsak, R., Iqbal, K., & Wisniewski, H. M. (1984) · Acta Neuropathologica · doi:10.1007/bf00687608 · Cited by 104 · see citing works
Barcikowska, M., Wisniewski, H. M., Bancher, C., & Grundke, I. (1989) · Acta Neuropathologica · doi:10.1007/bf00687751 · Cited by 103 · see citing works
Self-citationFelsenstein, K. M., Hunihan, L. W., & Roberts, S. B. (1994) · Nature Genetics · doi:10.1038/ng0394-251 · Cited by 90 · see citing works
Relationship between plaques, tangles, and dystrophic processes in Alzheimer's disease
Trojanowski, J. Q., Shin, R., Schmidt, M. L., & Lee, V. M.-Y. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(94)00176-2 · Cited by 89 · see citing works
DNA strand breaks in rat tissues as detected by in situ nick translation
Iseki, S. (1986) · Experimental Cell Research · doi:10.1016/0014-4827(86)90172-2 · Cited by 89 · see citing works
Lukka, M., Metso, J., & Ehnholm, C. (1988) · Human Heredity · doi:10.1159/000153814 · Cited by 74 · see citing works
Pathological changes in frontal cortex from biopsy to autopsy in Alzheimer's disease
Bennett, D. A., Cochran, E. J., Saper, C. B., Leverenz, J. B., Gilley, D. W., & Wilson, R. S. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90043-b · Cited by 67 · see citing works
Duyckaerts, C., Delaère, P., Poulain, V., Brion, J.-P., & Hauw, J.-J. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90706-9 · Cited by 65 · see citing works
Anatomical basis of memory disorders.
Markowitsch, H. J. (1995) · Cited by 63 · see citing works
Silver Staining of Senile Plaques and Neurofibrillary Tangles in Paraffin Sections
Reusche, E. (1991) · Pathology - Research and Practice · doi:10.1016/s0344-0338(11)81084-8 · Cited by 60 · see citing works
Increased tau accumulation in senile plaques as a hallmark in Alzheimer's disease.
Shin, R., Ogomori, K., Kitamoto, T., & Tateishi, J. (1989) · Europe PMC (PubMed Central) · Cited by 58 · see citing works
Chromogranin A and B and secretogranin II in bronchial and intestinal carcinoids
Weiler, R., Feichtinger, H. G., Schmid, K. W., Fischer‐Colbrie, R., Grimelius, L., Cedermark, B., Papotti, M. G., Bussolati, G., & Winkler, H. J. S. (1987) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00716181 · Cited by 53 · see citing works
Dexamethasone induces an increased biosynthesis of chromogranin A in rat pituitary gland
Fischer‐Colbrie, R., Wohlfarter, T., Schmid, K. W., Grino, M., & Winkler, H. J. S. (1989) · Journal of Endocrinology · doi:10.1677/joe.0.1210487 · Cited by 43 · see citing works
Identification of Amyloid Precursor Protein in Synaptic Plasma Membrane
Shimokawa, M., Yanagisawa, K., Nishiye, H., & Miyatake, T. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2240 · Cited by 17 · see citing works
Classification of dementias based on functional morphology
Jellinger, K. A., & Bancher, C. (1994) · Key topics in brain research · doi:10.1007/978-3-7091-9376-1_2 · Cited by 10 · see citing works
Self-citation[Alzheimer dementia. A clinical long-term study with quantitative neuropathology].
Fischer, P. A., Lassmann, H., Jellinger, K. A., Simányi, M., Bancher, C., Travniczek-Marterer, A., Gatterer, G., & Danielczyk, W. (1991) · PubMed · Cited by 9 · see citing works
Self-citationWettstein, A., & Lang, W. (1990) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107153 · Cited by 6 · see citing works
Synaptic pathology in the pathogenesis of Alzheimer dementia
Terry, R. D., & Masliah, E. (1994) · Key topics in brain research · doi:10.1007/978-3-7091-9376-1_1 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works
“Sub-sequent studies have established that the densities of NPs correlate with antemortem cognitive impairment better than the densities of diffuse A A Ps (45, 98, 106, 154, 189, 261).”
BackgroundSelf-citationClassification and basic pathology of Alzheimer disease
Duyckaerts, C., Delatour, B., & Potier, M.-C. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0532-1 · Cited by 1,031 · see citing works
Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship
Nelson, P. T., Braak, H., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181919a48 · Cited by 643 · see citing works
Arendt, T., Stieler, J. T., & Holzer, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.08.018 · Cited by 609 · see citing works
Evolution of neuronal changes in the course of Alzheimer’s disease
Braak, H., & Braak, E. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_11 · Cited by 482 · see citing works
Diagnostic Criteria for Neuropathologic Assessment of Alzheimer’s Disease
Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00062-6 · Cited by 410 · see citing works
Riley, K. P., Snowdon, D. A., & Markesbery, W. R. (2002) · Annals of Neurology · doi:10.1002/ana.10161 · Cited by 392 · see citing works
Neuropathology of Alzheimer’s disease: what is new since A. Alzheimer?
Braak, E., Griffing, K., Arai, K., Böhl, J., Bratzke, H., & Braak, H. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/pl00014168 · Cited by 370 · see citing works
Nelson, P. T., Jicha, G. A., Schmitt, F. A., Liu, H., Davis, D. G., Mendiondo, M. S., Abner, E. L., & Markesbery, W. R. (2007) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/nen.0b013e31815c5efb · Cited by 292 · see citing works
Prevalence of dementia disorders in the oldest-old: an autopsy study
Jellinger, K. A., & Attems, J. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0654-5 · Cited by 276 · see citing works
Self-citationTau-aggregation inhibitor therapy for Alzheimer's disease
Wischik, C. M., Harrington, C. R., & Storey, J. M. D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.008 · Cited by 263 · see citing works
Grinberg, L. T., Rüb, U., Ferretti, R. E. L., Nitríni, R., Farfel, J. M., Polichiso, L., Gierga, K., Jacob‐Filho, W., Heinsen, H., & Brazilian Brain Bank Study Group (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.00997.x · Cited by 244 · see citing works
Nelson, P. T., Abner, E. L., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Smith, C. D., Davis, D. G., Poduska, J. W., Patel, E., Mendiondo, M. S., et al. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00244.x · Cited by 239 · see citing works
Neuropathology of Alzheimer’s disease: a critical update
Jellinger, K. A., & Bancher, C. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-7508-8_8 · Cited by 231 · see citing works
Self-citationThe enigma of vascular cognitive disorder and vascular dementia
Jellinger, K. A. (2007) · Acta Neuropathologica · doi:10.1007/s00401-006-0185-2 · Cited by 221 · see citing works
Self-citationStaging of Alzheimer-Related Cortical Destruction
Braak, H., & Braak, E. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297004973 · Cited by 217 · see citing works
Mirochnic, S., Wolf, S. A., Staufenbiel, M., & Kempermann, G. (2009) · Hippocampus · doi:10.1002/hipo.20560 · Cited by 208 · see citing works
Prevalence of Alzheimer’s disease in very elderly people: A prospective neuropathological study
Polvikoski, T., Sulkava, R., Myllykangas, L., Notkola, I.-L., Niinistö, L., Verkkoniemi, A., Kainulainen, K., Kontula, K., Pérez–Tur, J., Hardy, J., et al. (2001) · Neurology · doi:10.1212/wnl.56.12.1690 · Cited by 197 · see citing works
Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert
Sassin, I., Schultz, C., Thal, D. R., Rüb, U., Arai, K., Braak, E., & Braak, H. (2000) · Acta Neuropathologica · doi:10.1007/s004019900178 · Cited by 193 · see citing works
Neuronal Hypertrophy in Asymptomatic Alzheimer Disease
Iacono, D., O'Brien, R., Resnick, S. M., Zonderman, A. B., Pletnikova, O., Rudow, G., An, Y., West, M. J., Crain, B., & Troncoso, J. C. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181772794 · Cited by 188 · see citing works
Precortical Phase of Alzheimer's Disease ( AD )‐Related Tau Cytoskeletal Pathology
Stratmann, K., Heinsen, H., Korf, H., Turco, D. D., Ghebremedhin, E., Seidel, K., Bouzrou, M., Grinberg, L. T., Böhl, J., Wharton, S. B., et al. (2015) · Brain Pathology · doi:10.1111/bpa.12289 · Cited by 174 · see citing works
Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimer's disease
Rössler, M., Zarski, R., Bohl, J., & Ohm, T. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0475-7 · Cited by 164 · see citing works
Thal, D. R., Holzer, M., Rüb, U., Waldmann, G., Günzel, S., Zedlick, D., & Schober, R. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7380 · Cited by 160 · see citing works
Green, M. S., Kaye, J. A., & Ball, M. J. (2000) · Neurology · doi:10.1212/wnl.54.1.105 · Cited by 153 · see citing works
Chapter 20 Neuropathological hallmarks of Alzheimer's and Parkinson's diseases
Braak, H., de Vos, R. A. I., Jansen, E. N. H., Bratzke, H., & Braak, E. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)64021-2 · Cited by 150 · see citing works
Clinicopathological analysis of dementia disorders in the elderly – An update
Jellinger, K. A. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s308 · Cited by 143 · see citing works
Self-citationPrevalence of cerebrovascular lesions in Parkinson's disease. A postmortem study
Jellinger, K. A. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0676-3 · Cited by 135 · see citing works
Self-citationTau and Axonopathy in Neurodegenerative Disorders
Higuchi, M., Lee, V. M.-Y., & Trojanowski, J. Q. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:131 · Cited by 134 · see citing works
Ghebremedhin, E., Schultz, C., Braak, E., & Braak, H. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6860 · Cited by 133 · see citing works
Clinical validity of Braak neuropathological staging in the oldest-old
Gold, G., Bouras, C., Kövari, E., Canuto, A., González Glaría, B., Malky, A., Hof, P. R., Michel, J.-P., & Giannakopoulos, P. (2000) · Acta Neuropathologica · doi:10.1007/s004010051163 · Cited by 128 · see citing works
Baddeley, T. C., McCaffrey, J., Storey, J. M. D., Cheung, J. K. S., Melis, V., Horsley, D., Harrington, C. R., & Wischik, C. M. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.219352 · Cited by 128 · see citing works
Molecular and cellular pathophysiology of preclinical Alzheimer’s disease
Mufson, E. J., Ikonomović, M. D., Counts, S., Perez, S. E., Malek‐Ahmadi, M. H., Scheff, S. W., & Ginsberg, S. D. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.030 · Cited by 129 · see citing works
Grön, G., Bittner, D., Schmitz, B., Wunderlich, A. P., & Riepe, M. W. (2002) · Annals of Neurology · doi:10.1002/ana.10157 · Cited by 125 · see citing works
Small-molecule PET Tracers for Imaging Proteinopathies
Mathis, C. A., Lopresti, B. J., Ikonomović, M. D., & Klunk, W. E. (2017) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2017.06.003 · Cited by 122 · see citing works
Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease
Harper, D. G., Stopa, E. G., McKee, A. C., Satlin, A., Fish, D., & Volicer, L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.04.009 · Cited by 121 · see citing works
Šalković‐Petrišić, M., Barilar, J. O., Grünblatt, E., Riederer, P. F., & Hoyer, S. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1184 · Cited by 120 · see citing works
Mouse Models of Alzheimer's Disease: Insight into Treatment
German, D., & Eisch, A. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.5.353 · Cited by 116 · see citing works
Suicide and Alzheimer’s pathology in the elderly: a case–control study
Rubio, A., Vestner, A. L., Stewart, J. M., Forbes, N. T., Conwell, Y., & Cox, C. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00952-5 · Cited by 115 · see citing works
Neurosteroid biosynthetic pathways changes in prefrontal cortex in Alzheimer's disease
Luchetti, S., Bossers, K., de Bilt, S. V., Agrapart, V., Morales, R., Frajese, G. V., & Swaab, D. F. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.12.014 · Cited by 114 · see citing works
Kalus, P., Slotboom, J., Gallinat, J., Mahlberg, R., Cattapan-Ludewig, K., Wiest, R., Nyffeler, T., Buri, C., Federspiel, A., Kunz, D., et al. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.10.035 · Cited by 108 · see citing works
Harrington, C. R., Storey, J. M. D., Clunas, S., Harrington, K. A., Horsley, D., Ishaq, A., Kemp, S. J., Larch, C. P., Marshall, C., Nicoll, S. L., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.616029 · Cited by 107 · see citing works
Grön, G., Brandenburg, I., Wunderlich, A. P., & Riepe, M. W. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.12.005 · Cited by 105 · see citing works
Comparison of neuropathologic criteria for the diagnosis of Alzheimer's disease
Geddes, J. W., Tekirian, T. L., Soultanian, N. S., Ashford, J. W., Davis, D. G., & Markesbery, W. R. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00063-8 · Cited by 101 · see citing works
Pathological Substrates of Cognitive Decline in Alzheimer’s Disease
Giannakopoulos, P., Kövari, E., Gold, G., von Gunten, A., Hof, P. R., & Bouras, C. (2009) · Frontiers of Neurology and Neuroscience · doi:10.1159/000197881 · Cited by 101 · see citing works
Giannakopoulos, P., Gold, G., Kövari, E., von Gunten, A., Imhof, A., Bouras, C., & Hof, P. R. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0144-y · Cited by 95 · see citing works
The impact of cerebrovascular lesions in Alzheimer disease
Jellinger, K. A., & Mitter-Ferstl, E. (2003) · Journal of Neurology · doi:10.1007/s00415-003-0142-0 · Cited by 97 · see citing works
Self-citationThe neuropathological diagnosis of Alzheimer disease
Jellinger, K. A. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_9 · Cited by 97 · see citing works
Self-citationTemporal Sequence of Alzheimer’s Disease-Related Pathology
Braak, H., & Braak, E. (1999) · Cerebral cortex · doi:10.1007/978-1-4615-4885-0_14 · Cited by 94 · see citing works
Morphological substrates of dementia in parkinsonism A critical update
Jellinger, K. A. (1997) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6846-2_6 · Cited by 85 · see citing works
Self-citationTangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons
Distl, R., Meske, V., & Ohm, T. (2001) · Acta Neuropathologica · doi:10.1007/s004010000314 · Cited by 91 · see citing works
Neltner, J. H., Abner, E. L., Schmitt, F. A., Denison, S. K., Anderson, S., Patel, E., & Nelson, P. T. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182768de4 · Cited by 83 · see citing works
SantaCruz, K. S., Sonnen, J. A., Pezhouh, M. K., Desrosiers, M. F., Nelson, P. T., & Tyas, S. L. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31822e8ae9 · Cited by 79 · see citing works
Alterations in the histaminergic system in Alzheimer's disease: a postmortem study
Shan, L., Bossers, K., Unmehopa, U., Bao, A.-M., & Swaab, D. F. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.026 · Cited by 84 · see citing works
Nagy, Z., Hindley, N., Braak, H., Braak, E., Yilmazer‐Hanke, D., Schultz, C., Barnetson, L. P. D., KING, E., Jobst, K. A., & Smith, A. D. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017111 · Cited by 78 · see citing works
Alzheimer’s disease as copper deficiency
Klevay, L. M. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.04.051 · Cited by 74 · see citing works
Protein disulfide isomerase-immunopositive inclusions in patients with Alzheimer disease
Honjo, Y., Ito, H., Horibe, T., Takahashi, R., & Kawakami, K. (2010) · Brain Research · doi:10.1016/j.brainres.2010.06.016 · Cited by 73 · see citing works
Grambaitė, R., Selnes, P., Reinvang, I., Aarsland, D., Hessen, E., Gjerstad, L., & Fladby, T. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110290 · Cited by 74 · see citing works
Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly
Malek-Ahmadi, M., Perez, S. E., Chen, K., & Mufson, E. J. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160365 · Cited by 73 · see citing works
Morphological substrates of mental dysfunction in Lewy body disease: an update
Jellinger, K. A. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6781-6_21 · Cited by 70 · see citing works
Self-citationSatoh, A., & Iijima, K. (2017) · Brain Research · doi:10.1016/j.brainres.2017.12.027 · Cited by 68 · see citing works
Clinical Validity of Aß-Protein Deposition Staging in Brain Aging and Alzheimer Disease
Gold, G., Kövari, E., Corte, G., Herrmann, F. R., Canuto, A., Bussière, T., Hof, P. R., Bouras, C., & Giannakopoulos, P. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.10.946 · Cited by 67 · see citing works
Gereñu, G., Liu, K., Chojnacki, J. E., Saathoff, J. M., Martínez‐Martín, P., Perry, G. L., Zhu, X., Lee, H., & Zhang, S. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00082 · Cited by 67 · see citing works
Vienna Transdanube Aging “VITA”: study design, recruitment strategies and level of participation
Fischer, P. A., Jungwirth, S., Krampla, W. W., Weissgram, S., Kirchmeyr, W., Schreiber, W., Huber, K., Rainer, M., Bauer, P., & Tragl, K. (2002) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6139-5_11 · Cited by 67 · see citing works
Self-citationLautenschlager, N. T., Riemenschneider, M., Drzezga, A. E., & Kurz, A. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051284 · Cited by 66 · see citing works
Carter, S. F., Caine, D., Burns, A. S., Herholz, K., & Ralph, M. A. L. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2738 · Cited by 66 · see citing works
Tredici, K. D., & Braak, H. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.11.008 · Cited by 65 · see citing works
Criteria for the neuropathological diagnosis of dementing disorders: routes out of the swamp?
Jellinger, K. A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-008-0466-z · Cited by 60 · see citing works
Self-citationHsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice
Criado‐Marrero, M., Gebru, N. T., Blazier, D. M., Gould, L. A., Baker, J. D., Beaulieu‐Abdelahad, D., & Blair, L. J. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01159-w · Cited by 51 · see citing works
Thal, D. R., Arendt, T., Waldmann, G., Holzer, M., Zedlick, D., Rüb, U., & Schober, R. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00090-6 · Cited by 53 · see citing works
Structural basis of dementia in neurodegenerative disorders
Jellinger, K. A. (1996) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6892-9_1 · Cited by 54 · see citing works
Self-citationMelis, V., Zabke, C., Stamer, K., Magbagbeolu, M., Schwab, K., Marschall, P., Veh, R. W., Bachmann, S., Deiana, S., Moreau, P., et al. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1804-z · Cited by 52 · see citing works
Nagy, Z., Yilmazer-Hanke, D. M., Braak, H., Braak, E., Schultz, C., & Hanke, J. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017038 · Cited by 51 · see citing works
Mechanisms of cell death in Alzheimer’s disease
Bancher, C., Lassmann, H., Breitschopf, H., & Jellinger, K. A. (1997) · Journal of Neural Transmission. Supplementa · doi:10.1007/978-3-7091-6842-4_14 · Cited by 50 · see citing works
Self-citation“End-Stage” Neurofibrillary Tangle Pathology in Preclinical Alzheimer's Disease: Fact or Fiction?
Abner, E. L., Kryscio, R. J., Schmitt, F. A., SantaCruz, K. S., Jicha, G. A., Lin, Y., Neltner, J. M., Smith, C. D., Van Eldik, L. J., & Nelson, P. T. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101980 · Cited by 49 · see citing works
Nagy, Z., Hindley, N., Braak, H., Braak, E., Yilmazer‐Hanke, D., Schultz, C., Barnetson, L. P. D., Jobst, K. A., & Smith, A. D. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017110 · Cited by 49 · see citing works
Modeling Prion-Like Processing of Tau Protein in Alzheimer’s Disease for Pharmaceutical Development
Wischik, C. M., Schelter, B. O., Wischik, D., Storey, J. M. D., & Harrington, C. R. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170727 · Cited by 47 · see citing works
Al‐Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M. C., Raulin, A., Baddeley, T. C., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M., et al. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.08.010 · Cited by 42 · see citing works
Early Alzheimer-type lesions in cognitively normal subjects
Tsartsalis, S., Xekardaki, A., Hof, P. R., Kövari, E., & Bouras, C. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.10.002 · Cited by 43 · see citing works
Prevalence of vascular lesions in Dementia with Lewy Bodies. A postmortem study
Jellinger, K. A. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-003-0824-x · Cited by 41 · see citing works
Self-citationBraak Stage, Cerebral Amyloid Angiopathy, and Cognitive Decline in Early Alzheimer’s Disease
Malek‐Ahmadi, M. H., Perez, S. E., Chen, K., & Mufson, E. J. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191151 · Cited by 38 · see citing works
Dubelaar, E. J. G., Mufson, E. J., ter Meulen, W. G., van Heerikhuize, J. J., Verwer, R. W. H., & Swaab, D. F. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000205143.16339.cd · Cited by 33 · see citing works
Schmidt, M. L., Lee, V. M., Forman, M. S., Chiu, T.-L. S., & Trojanowski, J. Q. (1997) · Europe PMC (PubMed Central) · Cited by 33 · see citing works
Duyckaerts, C. J., Colle, M.-A., Dessi, F., Grignon, Y., Piette, F., & Hauw, J. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_10 · Cited by 32 · see citing works
Applicability of digital analysis and imaging technology in neuropathology assessment
Dunn, W. D., Gearing, M., Park, Y., Zhang, L., Hanfelt, J., Glass, J. D., & Gutman, D. A. (2015) · Neuropathology · doi:10.1111/neup.12273 · Cited by 31 · see citing works
Robinson, A., Davidson, Y. S., Horan, M. A., Pendleton, N., & Mann, D. M. A. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180171 · Cited by 29 · see citing works
Colloby, S. J., McAleese, K. E., Walker, L., Erskine, D., Toledo, J. B., Donaghy, P. C., McKeith, I. G., Thomas, A. J., Attems, J., & Taylor, J. (2024) · Brain · doi:10.1093/brain/awae372 · Cited by 30 · see citing works
Walker, L., McAleese, K. E., Johnson, M. A., Khundakar, A. A., Erskine, D., Thomas, A. J., McKeith, I. G., & Attems, J. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1702-2 · Cited by 29 · see citing works
Hoyer, A., Bardenheuer, H. J., Martin, E., & Plaschke, K. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0176-1 · Cited by 28 · see citing works
Drug Development in Alzheimer’s Disease: The Contribution of PET and SPECT
Declercq, L., Vandenberghe, R. R., Laere, K. V., Verbruggen, A., & Bormans, G. M. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00088 · Cited by 25 · see citing works
Augustinack, J. C., Huber, K. E., Postelnicu, G. M., Kakunoori, S., Wang, R., van der Kouwe, A. J. W., Wald, L. L., Stein, T. D., Frosch, M. P., & Fischl, B. R. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0929-5 · Cited by 25 · see citing works
Cortical load of PHF-tau in Alzheimer's disease is correlated to cholinergic dysfunction
Arendt, T., Holzer, M., Gertz, H., & Brückner, M. K. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050175 · Cited by 22 · see citing works
Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective
Ferrer, I. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-3806 · Cited by 21 · see citing works
Alzheimer's Disease Pathology in Non-Demented Elderly
Kazee, A. M., & Johnson, E. M. (1998) · Journal of Alzheimer s Disease · doi:10.3233/jad-1998-1202 · Cited by 21 · see citing works
Arastoo, M., Lofthouse, R. A., Penny, L. K., Harrington, C. R., Porter, A., Wischik, C. M., & Palliyil, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228673 · Cited by 21 · see citing works
Neurodegenerative Diseases and Ageing
Walker, L., McAleese, K. E., Erskine, D., & Attems, J. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_4 · Cited by 21 · see citing works
Mild neuritic changes are increased in the brains of fatally injured older motor vehicle drivers
Gorrie, C. A., Rodriguez, M. L., Sachdev, P. S., Duflou, J. A., & Waite, P. M. E. (2007) · Accident Analysis & Prevention · doi:10.1016/j.aap.2007.02.008 · Cited by 20 · see citing works
Prevalence of Alzheimer’s disease in very elderly people: A prospective neuropathological study
Jellinger, K. (2002) · Neurology · doi:10.1212/wnl.58.4.671 · Cited by 20 · see citing works
Self-citationHary, A. T., Chadha, S., Mercaldo, N. D., Smith, E. N., van der Kouwe, A. J. W., Fischl, B. R., Mount, C., Kozanno, L. N., Frosch, M. P., & Augustinack, J. C. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-01957-6 · Cited by 21 · see citing works
Alzheimer Disease and Cellular Mechanisms of Memory Storage
Arshavsky, Y. I. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000043 · Cited by 19 · see citing works
The Mini‐Mental State Examination: A Brief Cognitive Assessment
Folstein, M. F., Folstein, S. E., & Folstein, J. R. (2010) · doi:10.1002/9780470669600.ch27 · Cited by 18 · see citing works
- Authors
- Bancher, C., Jellinger, K., Lassmann, H., Fischer, P., & Leblhuber, F.
- Affiliations
- Ludwig Boltzmann für Klinische Neurobiologie (AT)
- Austrian Academy of Sciences (AT)
- University of Vienna (AT)
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 1996-05
- Volume
- 246
- Issue
- 3
- Pages
- 137-146
- ISSN
- 0003-9373 (ISSN-L)
- 0940-1334
- 1433-8491
- OpenAlex
- W2042065186
- Cited by
- 130
- References
- 81
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 5 · 2013: 1 · 2012: 4
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, clinicopathological correlation, neuropathology, neuritic plaques, neurofibrillary tangles, neuropil threads, Braak staging, synaptophysin, chromogranin, synaptic loss, cognitive decline, dementia severity, amyloid precursor protein, neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Austria, Dementia, DNA Damage, Female, Humans, Immunohistochemistry, Longitudinal Studies, Male, Nerve Degeneration, Prospective Studies, Psychiatric Status Rating Scales, Psychometrics, Immunoblotting, Amyloid beta-Peptides, Synaptophysin, Neurofibrillary Tangles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
