The DOI matches its Crossref record; 301 of the 310 references it cites were found in a registry or an index.
Leptin Regulation of Neuroendocrine Systems
Open accessAbstract
The discovery of leptin has enhanced understanding of the interrelationship between adipose energy stores and neuronal circuits in the brain involved in energy balance and regulation of the neuroendocrine axis. Leptin levels are dependent on the status of fat stores as well as changes in energy balance as a result of fasting and overfeeding. Although leptin was initially thought to serve mainly as an anti-satiety hormone, recent studies have shown that it mediates the adaptation to fasting. Furthermore, leptin has been implicated in the regulation of the reproductive, thyroid, growth hormone, and adrenal axes, independent of its role in energy balance. Although it is widely known that leptin acts on hypothalamic neuronal targets to regulate energy balance and neuroendocrine function, the specific neuronal populations mediating leptin action on feeding behavior and autonomic and neuroendocrine function are not well understood. In this review, we have discussed how leptin engages arcuate hypothalamic neurons expressing putative orexigenic peptides, e.g., neuropeptide Y and agouti-regulated peptide, and anorexigenic peptides, e.g., pro-opiomelanocortin (precursor of alpha-melanocyte-stimulating hormone) and cocaine- and amphetamine-regulated transcript. We show that leptin's effects on energy balance and the neuroendocrine axis are mediated by projections to other hypothalamic nuclei, e.g., paraventricular, lateral, and perifornical areas, as well as other sites in the brainstem, spinal cord, and cortical and subcortical regions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Sleep modulates the 24 h pattern of secretion of two key hormones involved in energy balance regulation, i.e., leptin and ghrelin [1, 193].”
From Sleep and metabolic function (2012) · cites this paper as [1]
In the citing paper
“Leptin inhibits hunger and food intake, increases EE, and promotes fat utilization [1, 193].”
From Sleep and metabolic function (2012) · cites this paper as [1]
In the citing paper
“Leptin, an adipocyte-derived hormone, is a satiety factor secreted in proportion to the amount of body energy stores, and was one of the first factors linking metabolism with the reproductive axis.93”
From Pubertal development and regulation (2016) · cites this paper as [93]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
Paxinos, G. (1985) · Cited by 3,715
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Research works printed but not linked: 6
- Crowe, 1910, Bulletin Hopkins Hospital, 21, 127
- Elias, 1998, Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area, J Comp Neurol, 402, 442, 10.1002/(SICI)1096-9861(19981228)402:4<442::AID-CNE2>3.0.CO;2-R · DOI
- Frohlich, 1901, Ein fall von tumor der hypophysis cerebri ohne akromegalie, Wien Klin Rundsch, 15, 883
- Hausberger, 1959, Parabiosis and transplantation experiments in hereditary obese mice, Anat Rec, 130, 313
- Lambert, 1997, A role for novel CART peptide fragments in the central control of food intake, Neuropeptides, 31, 620
- Sawchenko, 1998, Toward a new neurobiology of energy balance, appetite, and obesity: The anatomists weigh in, J Comp Neurol, 402, 435, 10.1002/(SICI)1096-9861(19981228)402:4<435::AID-CNE1>3.0.CO;2-M · DOI
Cited by
Sorted by citations
Items 601–700 of 763
Role of Leptin in the Reproduction and Metabolism: Focus on Regulation by Seasonality in Animals
Szczęsna, M., & Dorota, A. (2011) · InTech eBooks · doi:10.5772/16575 · Cited by 2
Oliveira, L. L. B., Borges, B. D. B., & Franci, C. R. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102096 · Cited by 2
Jackson, M. B., & Ahima, R. S. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-370-7_3 · Cited by 2
Self-citationBlackstone, R. P. (2016) · Springer eBooks · doi:10.1007/978-3-319-39409-1_11 · Cited by 2
Harris, R. B. S. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00083.2023 · Cited by 2
Souza, F. A., Martins, J. A. M., Emerick, L. L., Laskoski, L. M., Osório, J. P., de Souza, F. F., Cañón, A. L. P., & Filho, V. R. D. V. (2021) · Reproduction in Domestic Animals · doi:10.1111/rda.13987 · Cited by 2
Metabolic Signals in the Control of Food Intake
Woods, S. C. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48643-1_10 · Cited by 3
Zhang, L., Yang, F., Cai, J., Huang, C., Wang, Z., & Zhu, W. (2015) · Animal Biology · doi:10.1163/15707563-00002460 · Cited by 2
Mouse genetics in drug target discovery and validation: no simple answers to complex problems
Russ, A. P., & Grosse, J. (2007) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2.10.1379 · Cited by 2
Connecting Leptin and Alzheimer Disease
Ahima, R. S. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.132 · Cited by 2
Self-citationEfectos de la leptina en el inicio de la pubertad en animales machos
Quintero, J. C., & Cortés, Z. T. R. (2009) · Revista Colombiana de Ciencias Pecuarias · doi:10.17533/udea.rccp.324260 · Cited by 2
LEPTIN GENE TRANSCRIPTS STUDY IN IN VITRO CAPACITATED SPERMATOZOA OF BUFFALO BULL SEMEN
Kumari, K., Kumar, A., Sharma, V., Kumari, A., & Nanda, T. (2014) · Haryana Veterinarian · Cited by 2
van Dijk, G., & Kas, M. J. (2014) · Cambridge University Press eBooks · doi:10.1017/9781107360556.005 · Cited by 2
Thyroid Hormone in Neural Tissue
Lechan, R. M., Fekete, C., & Toni, R. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00039-5 · Cited by 2
Fatouros, I. G., & Mitrakou, A. (2012) · CRC Press eBooks · doi:10.1201/b12085-16 · Cited by 2
Plasticity in the physiological energetics of Apodemus chevrieri: the role of dietary fiber content
Gao, W., Wang, Z., & Zhu, W. (2016) · Animal Biology · doi:10.1163/15707563-00002503 · Cited by 2
Abreu, G. D. A. (2015) · Cited by 2
Neuroendocrine Control of Energy Stores
Cone, R. D., & Elmquist, J. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00035-6 · Cited by 2
Self-citationThe regulation of expression of the hormone leptin
Baranov, S. N. (2017) · Interactive science · doi:10.21661/r-116212 · Cited by 2
The Cross Talk Between the Central Nervous System, Bone, and Energy Metabolism
Wei, J., & Karsenty, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804182-6.00019-8 · Cited by 2
Correlation of serum leptin levels with clinical and biochemical parameters in obese children
Patil, L. G. C., & Srinivas, S. (2020) · International Journal of Contemporary Pediatrics · doi:10.18203/2349-3291.ijcp20201133 · Cited by 2
Brain Regulation of Feeding and Energy Homeostasis
Myers, M. G., Olson, D. P., Low, M. J., & Elias, C. F. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_22-1 · Cited by 2
Obesity: Genetics, Pathogenesis, Therapy
Mathew, H., Paschou, S. Α., Aramapatzi, K. M., Hsu, W. C., & Mantzoros, C. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-20797-1_30-2 · Cited by 2
Changes Within the Thyroid Axis During the Course of Critical Illness
Mebis, L., Langouche, L., & den Berghe, G. V. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-177-6_10 · Cited by 2
The impact of valproic acid treatment on weight gain in pediatric patients with epilepsy
Ferrara, P., Gatto, A., BLASI, V., Ruscio, F. D., & Battaglia, D. (2022) · Minerva Pediatrics · doi:10.23736/s2724-5276.17.04938-6 · Cited by 2
Linking Sleep Deprivation and Binge Eating: Empirical Evidence and Underlying Mechanisms
Cerolini, S. (2022) · Springer eBooks · doi:10.1007/978-3-030-67929-3_64-1 · Cited by 2
Nutrients and Peripherally Secreted Molecules in Regulation of Energy Homeostasis
Shetty, G. K., Barb, D., & Mantzoros, C. S. (2006) · Humana Press eBooks · doi:10.1007/978-1-59259-985-1_4 · Cited by 2
WATSON, R. R., & Preedy, V. R. (2003) · CRC Press eBooks · doi:10.1201/9780203507629-13 · Cited by 2
Physiological and Hormonal Factors that Influence Leptin Production
Dagogo-Jack, S. E. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_5 · Cited by 2
Sahu, A. (2006) · Springer eBooks · doi:10.1007/978-0-387-31416-7_4 · Cited by 2
The relationship between age, gender, and hedonic hunger
Ewoldt, J. (2011) · Minds at UW (University of Wisconsin) · Cited by 2
Blumer, S. E., Gardner, G. E., Ferguson, M. B., & Thompson, A. N. (2016) · Animal Production Science · doi:10.1071/an15217 · Cited by 2
Hormonal regulation of puberty onset in female rats: is leptin a missing link?
Zeinoaldini, S. (2005) · doi:10.18174/18122 · Cited by 2
Tran‐Duy, A. (2008) · doi:10.18174/122037 · Cited by 2
Leptin Actions on the Reproductive Axis
Magni, P., & Motta, M. (2003) · Encyclopedia of Hormones · doi:10.1016/b0-12-341103-3/00188-1 · Cited by 2
Trayhurn, P. (2009) · Wiley eBooks · doi:10.1002/9781444307627.ch9 · Cited by 3
Lecube, A., & López‐Cano, C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.66204-9 · Cited by 2
Metabolism, Obesity, Thinness, and Reproduction
Prati, A., Napolitano, A., Despini, G., Manzo, A., Caroli, M., & Genazzani, A. D. (2019) · ISGE series · doi:10.1007/978-3-030-14358-9_6 · Cited by 1
OBESITY AND DEPRESSION INTERTWINED – A NARRATIVE REVIEW
Soroceanu, R. P., Silistraru, I., Ciubară, A., Azoicăi, D., Timofte, D. V., Platon, R., Ciuntu, B. M., & Maxim, M. (2023) · European Conference of Psychiatry and Mental Health "Galatia" · doi:10.35630/2022/12/psy.ro.18 · Cited by 1
Efavirenz Interacts with Hormones Involved in Appetite and Satiety, Affecting Body Weight in Mice
Rojas-Osornio, S. A., Manuel‐Apolinar, L., Crespo‐Ramírez, M., Cervantes, V. P., Mata-Marín, A., Molina-López, J., de la Mora, M. P., Borroto‐Escuela, D. O., Martínez-Lara, R., & Tesoro-Cruz, E. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020735 · Cited by 1
Mahdavi, K., Zendehdel, M., Ghashghaei, E., & Lin, H. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107210 · Cited by 1
de, P. F., Alvarez‐Salas, E., Morales‐Mulia, M., & Alcántara‐Alonso, V. (2012) · InTech eBooks · doi:10.5772/30515
Adipokines in Health and Disease
Ahima, R. S., & Goncalves, M. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_4 · Cited by 1
Self-citationMalendowicz, W., & Kwias, Z. (2009) · Editor-in-Chief s Voice List of Authors is an Important Element in a Scientific Publication · doi:10.5173/ceju.2009.02.art8 · Cited by 1
Does FMF have a property to protect children from obesity?
Gök, F., Dursun, L., & Gokce, L. (2010) · Health · doi:10.4236/health.2010.23038 · Cited by 1
Thyroid hormones and multiple organ dysfunction syndrome
Peeters, R. P., & den Berghe, G. V. (2008) · Journal of Organ Dysfunction · doi:10.1080/17471060802409720 · Cited by 1
Brain Regulation of Feeding and Energy Homeostasis
Affinati, A. H., Elias, C. F., Olson, D. P., & Myers, M. G. (2023) · Springer eBooks · doi:10.1007/978-3-319-12125-3_22-2 · Cited by 1
Neural Control of Feeding and Energy Homeostasis
Caron, É., & Ahima, R. S. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_5 · Cited by 1
Self-citationRole of Postabsorptive Endocrine Factors on Human Feeding and Regulation of Body Adiposity
Teff, K. L., & KAPADIA, C. R. (2008) · CRC Press eBooks · doi:10.1201/9781420047844.ch12 · Cited by 1
The Central Control of Bone Mass
Takeda, S. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-415784-2.00003-8 · Cited by 1
Hypothalamic Obesity and Wasting Syndromes
Uwaifo, G. I. (2020) · Contemporary Endocrinology · doi:10.1007/978-3-030-62187-2_12 · Cited by 1
Reizes, O., Benoit, S. C., & Clegg, D. J. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-400-1_1 · Cited by 1
Charnay, Y. (2000) · Schweizer Archiv für Neurologie und Psychiatrie · doi:10.4414/sanp.2000.01193 · Cited by 1
Neuroendocrine and Metabolic Adaptations in the Central Nervous System That Facilitate Weight Regain
Lechan, R. M., & Fekete, C. (2010) · Springer eBooks · doi:10.1007/978-1-60327-874-4_28 · Cited by 1
IGF-I, leptine, insulin and proteins associated to seminal plasma quality: local action
Souza, F. A., Martins, J. A. M., Osório, J. P., Filho, V. R. D. V., de Andrade, V. J., D`Oliveira-Sousa, A., & Patrício, F. A. D. C. (2010) · Revista de Medicina Veterinaria · doi:10.19052/mv.578 · Cited by 1
Bauer, M., Bábelová, A., Bahela, I., & Bauerová, M. (2009) · Slovak Journal of Animal Science · Cited by 1
White Adipose Tissue: Beyond Fat Storage
Imam, S. K. (2015) · Springer eBooks · doi:10.1007/978-3-319-19821-7_1 · Cited by 1
Overview of Ghrelin, Appetite, and Energy Balance
Fernández-Fernández, R., & Tena‐Sempere, M. (2007) · CRC Press eBooks · doi:10.1201/9781420005479.ch9 · Cited by 1
Cruickshank, N. C. (2017) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont) · Cited by 1
Immunologic and Physiologic Effects of Dental Sleep Appliance Therapy
Demerjian, G. G., & Goel, P. (2018) · Springer eBooks · doi:10.1007/978-3-319-76367-5_8 · Cited by 1
Obesity: Genetics, Pathogenesis, Therapy
Paschou, S. Α., Mathew, H., & Mantzoros, C. S. (2015) · Springer eBooks · doi:10.1007/978-3-319-20797-1_30-1 · Cited by 1
Reizes, O., Benoit, S. C., & Clegg, D. J. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1203-2_1 · Cited by 1
Ribeiro-Filho, C. C. (2002) · doi:10.31274/rtd-180813-194 · Cited by 1
Obesity gene therapy: Slimming immature rats
Ahima, R. S. (2003) · Gene Therapy · doi:10.1038/sj.gt.3301920 · Cited by 1
Self-citationEffects of prolactin on metabolism - changes induced by hyperprolactinemia
Nilsson, L. V. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 1
ADIPOCYTE-DERIVED HORMONES AND CARDIOVASCULAR DISEASE
Eriksson, M. (2010) · DiVA at Umeå University (Umeå University) · Cited by 1
Broom, J. I., Speakman, J. R., & Johnstone, A. M. (2006) · Cited by 1
The Role of Lateral Hypothalamic Neuropeptides in Drug Addiction and Feeding Behavior
Georgescu, D. (2004) · Cited by 1
Bernardes, N. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2016.tde-04082016-154155 · Cited by 1
Sleep in mental and behavioural disorders
Lindberg, N. (2003) · Työväentutkimus Vuosikirja · Cited by 1
Control of reproductive function
WEBB, R. (2012) · ERA · Cited by 1
Investigating the effects of neuropeptides on human sperm function and fertility
Tomova, A.-M. (2026) · e-space (Manchester Metropolitan University) · doi:10.83056/mmu.32477769 · Cited by 1
Swoap, S. J., & Overton, J. M. (2003) · CRC Press eBooks · doi:10.1201/9780203507629.ch7 · Cited by 1
Reizes, O., Benoit, S. C., & Clegg, D. J. (2007) · Humana Press eBooks · doi:10.1007/978-1-60327-139-4_2
Hormonal and Neuropeptide Mechanisms of Appetite Control in Atlantic Salmon
Moen, A. G. (2010) · NORA - Norwegian Open Research Archives
Böttner, A., Kratzsch, J., Beck‐Sickinger, A. G., Stümvoll, M., & Kieß, W. (2006) · Springer eBooks · doi:10.1007/3-540-28782-5_18
Donato, J. (2008) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2008.tde-12032009-181647
Nuevas acciones de p53: Homeostasis metabólica y efecto orexigénico de ghrelin
Raimundo, V., & Alfredo, D. V. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Obesity – Genetics, Pathogenesis, Therapy
Hsu, W. C., Arampatzi, K. M., & Mantzoros, C. S. (2009) · Springer eBooks · doi:10.1007/978-0-387-09841-8_30
del Villar, V., & Jesús, M. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Anedda, A. (2010) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Le récepteur 4 aux mélanocortines, un paradigme de la génétique de l'obésité
Stutzmann, F. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
The Role of the Hypothalamus in the Maintenance of Energy Balance and Peripheral Glucose Control
Seeley, R. J., Clegg, D. J., Schwartz, M. W., & Woods, S. C. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0505
Opland, D. M. (2011) · Deep Blue (University of Michigan)
Teuss, G. (2009) · Research Online (University of Wollongong)
Leptin: Primary Central Site of Action?
Adam, C. L. (2010) · Endocrinology · doi:10.1210/en.2010-0277
Metabolic alterations in patients with self-inflicted aggressive behaviour
Westling, S. (2009) · Lund University Publications (Lund University)
Steiger, A. (2014) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.16948
Modulació farmacològica de l'oleoil-estrona sobre la ingesta i la composició corporal
Lorente, R. F. (2007) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Molina, N. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2014.tde-13082014-170430
protocolsleptin responses after acute resistance exercise
Smilios, I., Considine, R. V., Tokmakidis, S. P., Taxildaris, K., Mastorakos, G. M., Mitrakou, A., Jamurtas, A. Z., DOUROUDOS, I. I., Papassotiriou, I., Thomakos, P., et al. (2015)
Avaliação do sono e do sobrepeso em adolescentes após mudança do turno escolar
Rossi, M. B. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Impact of Menstrual Cycle Phase on Metabolic Effects of Sleep Restriction
Leroux, A. (2013) · Library and Archives Canada (Government of Canada)
Bioactive Peptides for Alleviating Illness Anorexia
Owusu-Apenten, R. (2010) · CRC Press eBooks · doi:10.1201/ebk1439813621-13
PROGRAMA MULTICÊNTRICO DE PÓS-GRADUAÇÃO EM CIÊNCIAS FISIOLÓGICAS- SBFIS
Gusmão, D. D. O. (2012)
Control of Appetite/Satiety and Energy Balance
Elmquist, J. K., & Horton, J. D. (2015) · Wiley eBooks · doi:10.1002/9781118512074.ch28
Self-citationConstruction of a Recombinant Fab Fragment of a Monoclonal Antibody against Leptin Receptor
Mohkam, M., Zarkesh-Es, S. H., & Fazeli, M. (2011) · Asian Journal of Biotechnology · doi:10.3923/ajbkr.2011.493.506
Metadata
- Authors
- Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K.
- Affiliations
- University of Pennsylvania (US)
- Beth Israel Deaconess Medical Center (US)
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 21
- Issue
- 3
- Pages
- 263-307
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W2039347019
- Cited by
- 767
- References
- 310
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 6 · 2023: 20 · 2022: 19 · 2021: 11 · 2020: 25 · 2019: 26 · 2018: 22 · 2017: 15 · 2016: 28 · 2015: 22 · 2014: 42 · 2013: 27 · 2012: 36
- FWCI
- 16.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Frontiers in Neuroendocrinology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-48506, DK53301, R01DK048506)
- National Institute of Neurological Disorders and Stroke (NS 33987, R01NS033987)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- leptin, neuroendocrine regulation, energy balance, hypothalamus, arcuate nucleus, neuropeptide Y, agouti-related protein, proopiomelanocortin, cocaine- and amphetamine-regulated transcript, feeding behavior, fasting adaptation, reproductive axis, hypothalamic-pituitary-thyroid axis, growth hormone axis, adrenal axis, hypothalamic projections
- MeSH terms
- Animals, Biological Transport, Brain, Energy Metabolism, Homeostasis, Humans, Neurosecretory Systems, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review