Cited by 767Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesAdipokines, Inflammation, and Metabolic Diseases

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Leptin Regulation of Neuroendocrine Systems

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Ahima, Rexford S., Saper, Clifford B., Flier, Jeffrey S., Elmquist, Joel K.·2000·Frontiers in Neuroendocrinology

DOI 10.1006/frne.2000.0197

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Abstract

The discovery of leptin has enhanced understanding of the interrelationship between adipose energy stores and neuronal circuits in the brain involved in energy balance and regulation of the neuroendocrine axis. Leptin levels are dependent on the status of fat stores as well as changes in energy balance as a result of fasting and overfeeding. Although leptin was initially thought to serve mainly as an anti-satiety hormone, recent studies have shown that it mediates the adaptation to fasting. Furthermore, leptin has been implicated in the regulation of the reproductive, thyroid, growth hormone, and adrenal axes, independent of its role in energy balance. Although it is widely known that leptin acts on hypothalamic neuronal targets to regulate energy balance and neuroendocrine function, the specific neuronal populations mediating leptin action on feeding behavior and autonomic and neuroendocrine function are not well understood. In this review, we have discussed how leptin engages arcuate hypothalamic neurons expressing putative orexigenic peptides, e.g., neuropeptide Y and agouti-regulated peptide, and anorexigenic peptides, e.g., pro-opiomelanocortin (precursor of alpha-melanocyte-stimulating hormone) and cocaine- and amphetamine-regulated transcript. We show that leptin's effects on energy balance and the neuroendocrine axis are mediated by projections to other hypothalamic nuclei, e.g., paraventricular, lateral, and perifornical areas, as well as other sites in the brainstem, spinal cord, and cortical and subcortical regions.

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See all 767

Authors: Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K.
Affiliations: University of Pennsylvania (US)
Beth Israel Deaconess Medical Center (US)
ORCID: Ahima, Rexford S.
Saper, Clifford B.
Flier, Jeffrey S.
Elmquist, Joel K.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2000-07
Volume: 21
Issue: 3
Pages: 263-307
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1006/frne.2000.0197
OpenAlex: W2039347019
Cited by: 767
References: 310
Citations by year: 2026: 9 · 2025: 6 · 2024: 6 · 2023: 20 · 2022: 19 · 2021: 11 · 2020: 25 · 2019: 26 · 2018: 22 · 2017: 15 · 2016: 28 · 2015: 22 · 2014: 42 · 2013: 27 · 2012: 36
FWCI: 16.04
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1058 d)
Locations: Frontiers in Neuroendocrinology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-48506, DK53301, R01DK048506)
National Institute of Neurological Disorders and Stroke (NS 33987, R01NS033987)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: leptin, neuroendocrine regulation, energy balance, hypothalamus, arcuate nucleus, neuropeptide Y, agouti-related protein, proopiomelanocortin, cocaine- and amphetamine-regulated transcript, feeding behavior, fasting adaptation, reproductive axis, hypothalamic-pituitary-thyroid axis, growth hormone axis, adrenal axis, hypothalamic projections
MeSH terms: Animals, Biological Transport, Brain, Energy Metabolism, Homeostasis, Humans, Neurosecretory Systems, Leptin

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Leptin Regulation of Neuroendocrine Systems

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