Cited by 535Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.

Animal Models of Depression: Molecular Perspectives

Open access

Krishnan, Vaishnav, Nestler, Eric J.·2011·Current Topics in Behavioral Neurosciences

DOI 10.1007/7854_2010_108PMC PMC3270071

Open this paper in CoChat — free account

Abstract

Much of the current understanding about the pathogenesis of altered mood, impaired concentration and neurovegetative symptoms in major depression has come from animal models. However, because of the unique and complex features of human depression, the generation of valid and insightful depression models has been less straightforward than modeling other disabling diseases like cancer or autoimmune conditions. Today's popular depression models creatively merge ethologically valid behavioral assays with the latest technological advances in molecular biology and automated video-tracking. This chapter reviews depression assays involving acute stress (e.g., forced swim test), models consisting of prolonged physical or social stress (e.g., social defeat), models of secondary depression, genetic models, and experiments designed to elucidate the mechanisms of antidepressant action. These paradigms are critically evaluated in relation to their ease, validity and replicability, the molecular insights that they have provided, and their capacity to offer the next generation of therapeutics for depression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/7854_2010_108

Cites

131 of 131 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429 · cited 1×
“Thus, the negative consequences of heightened HPA axis activity are at least partially related to the adverse effects of glucocorticoids themselves (McEwen 2007; Pittenger and Duman 2008).”
Background
Depression: a new animal model sensitive to antidepressant treatments
PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451
Depression, chronic diseases, and decrements in health: results from the World Health Surveys
Moussavi, S., Chatterji, S., Verdes, E., Tandon, A., Patel, V., & Ustun, B. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61415-9 · Cited by 4,070
Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
Trivedi, M. H., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., Warden, D., Ritz, L., Norquist, G., Howland, R. H., Lebowitz, B., McGrath, P. J., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.28 · Cited by 3,879
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
Self-citation
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881
Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307
Self-citation

Flagged first, then by citations

Show all 131 references

Sorted by citations

Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness
Calcia, M., Bonsall, D. R., Bloomfield, P. S., Selvaraj, S., Barichello, T., & Howes, O. D. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4218-9 · Cited by 748
Sex differences in depression: Insights from clinical and preclinical studies
Eid, R. S., Gobinath, A. R., & Galea, L. A. M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.006 · Cited by 481
Dendritic Spines in Depression: What We Learned from Animal Models
Qiao, H., Li, M.-X., Xu, C. S., Chen, H.-B., An, S.-C., & Ma, X. (2016) · Neural Plasticity · doi:10.1155/2016/8056370 · Cited by 460
The pharmacology of resveratrol in animals and humans
Park, E.-J., & Pezzuto, J. M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.01.014 · Cited by 302
Social Isolation Stress Induces Anxious-Depressive-Like Behavior and Alterations of Neuroplasticity-Related Genes in Adult Male Mice
Ieraci, A., Mallei, A., & Popoli, M. (2016) · Neural Plasticity · doi:10.1155/2016/6212983 · Cited by 315
Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission
Snyder, G. L., Vanover, K. E., Zhu, H., Miller, D. B., O'Callaghan, J. P., Tomesch, J., Li, P., Zhang, Q., Krishnan, V., Hendrick, J. P., et al. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3704-1 · Cited by 292
Self-citation
Faecal short chain fatty acids profile is changed in Polish depressive women
Skonieczna-Żydecka, K., Grochans, E., Maciejewska, D., Szkup, M., Schneider-Matyka, D., Jurczak, A., Łoniewski, I., Kaczmarczyk, M., Marlicz, W., Czerwińska-Rogowska, M., et al. (2018) · Nutrients · doi:10.3390/nu10121939 · Cited by 284
Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice
Iñiguez, S. D., Riggs, L. M., Nieto, S. J., Dayrit, G., Zamora, N. N., Shawhan, K. L., Cruz, B., & Warren, B. L. (2014) · Stress · doi:10.3109/10253890.2014.910650 · Cited by 269
Rodent models of post-traumatic stress disorder: behavioral assessment
Verbitsky, A., Dopfel, D., & Zhang, N. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0806-x · Cited by 260
Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders
Fakhoury, M. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9152-z · Cited by 258
The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?
Petrik, D., Lagace, D. C., & Eisch, A. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.003 · Cited by 241
Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
Douma, E. H., & de Kloet, E. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.015 · Cited by 232
Epigenetics and the regulation of stress vulnerability and resilience
Zannas, A. S., & West, A. E. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.003 · Cited by 211
Sexual Deprivation Increases Ethanol Intake in Drosophila
Shohat-Ophir, G., Kaun, K. R., Azanchi, R., Mohammed, H., & Heberlein, U. (2012) · Science · doi:10.1126/science.1215932 · Cited by 211
Vicarious Social Defeat Stress Induces Depression-Related Outcomes in Female Mice
Iñiguez, S. D., Flores‐Ramirez, F. J., Riggs, L. M., Alipio, J. B., Garcia-Carachure, I., Hernandez, M. A., Sánchez, D. O. M., Lobo, M. K., Serrano, P. A., Braren, S. H., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.07.014 · Cited by 214
Making Sense of Rodent Models of Anhedonia
Scheggi, S., Montis, M. G. D., & Gambarana, C. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy083 · Cited by 220
Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2
Birey, F., Kloc, M. L., Chavali, M., Hussein, I., Wilson, M., Christoffel, D. J., Chen, T., Frohman, M. A., Robinson, J. K., Russo, S. J., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.046 · Cited by 214
Zebrafish models in neuropsychopharmacology and CNS drug discovery
Khan, K. M., Collier, A. D., Мешалкина, Д. А., Kysil, E. V., Khatsko, S. L., Kolesnikova, T. O., Morzherin, Y. Y., Warnick, J. E., Kalueff, A. V., & Echevarria, D. J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13754 · Cited by 217
Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice
Yang, C., Fujita, Y., Ren, Q., Ma, M., Dong, C., & Hashimoto, K. (2017) · Scientific Reports · doi:10.1038/srep45942 · Cited by 211
Chronic Unpredictable Stress (CUS)-Induced Anxiety and Related Mood Disorders in a Zebrafish Model: Altered Brain Proteome Profile Implicates Mitochondrial Dysfunction
Chakravarty, S., Reddy, B. R., Sudhakar, S. R., Saxena, S., Das, T., Vuppalapaty, M., Swamy, C. V. B., Kumar, A., & Idris, M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063302 · Cited by 187
Peripheral and central mechanisms of stress resilience
Pfau, M. L., & Russo, S. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.004 · Cited by 170
Pain and depression comorbidity: A preclinical perspective
Li, J. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.042 · Cited by 175
Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers
Stepanichev, M. Y., Дыгало, Н. Н., Grigoryan, G. A., Shishkina, G. T., & Gulyaeva, N. V. (2014) · BioMed Research International · doi:10.1155/2014/932757 · Cited by 180
Circuit dynamics of adaptive and maladaptive behaviour
Deisseroth, K. A. (2014) · Nature · doi:10.1038/nature12982 · Cited by 176
A Brief Introduction to the Transduction of Neural Activity into Fos Signal
Chung, L. (2015) · Development & Reproduction · doi:10.12717/dr.2015.19.2.061 · Cited by 164
“Multiple social defeat (e.g. 10 episodes) can lead to depression-like behavior in defeated animals (Krishnan & Nestler, 2011).”
Background
Resveratrol: Twenty Years of Growth, Development and Controversy
Pezzuto, J. M. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.176 · Cited by 173
Update in the methodology of the chronic stress paradigm: internal control matters
Strekalova, T., Couch, Y., Kholod, N., Boyks, M., Malin, D., Leprince, P., & Steinbusch, H. M. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-9 · Cited by 163
Translational approaches to treatment-induced symptoms in cancer patients
Dantzer, R., Meagher, M. W., & Cleeland, C. S. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.88 · Cited by 167
SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
Kim, H.-D., Hesterman, J., Call, T., Magazu, S., Keeley, E., Armenta, K., Kronman, H., Neve, R. L., Nestler, E. J., & Ferguson, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0212-16.2016 · Cited by 158
Self-citation
A mitochondrial bioenergetic basis of depression
Klinedinst, N. J., & Regenold, W. T. (2014) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-014-9584-6 · Cited by 160
Depression as a risk factor for Alzheimer’s disease: Genes, steroids, cytokines and neurogenesis – What do we need to know?
Herbert, J., & Lucassen, P. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.12.001 · Cited by 150
Chronic and acute effects of stress on energy balance: are there appropriate animal models?
Harris, R. B. S. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00361.2014 · Cited by 145
Microglial Over-Activation by Social Defeat Stress Contributes to Anxiety- and Depressive-Like Behaviors
Stein, D. J., Vasconcelos, M., Albrechet‐Souza, L., Ceresér, K. M., & de Almeida, R. M. M. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00207 · Cited by 137
Diet-Derived Fatty Acids, Brain Inflammation, and Mental Health
Melo, H. M., Santos, L. E., & Ferreira, S. T. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00265 · Cited by 136
Animal models of bipolar mania: The past, present and future
Logan, R. W., & McClung, C. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.041 · Cited by 136
Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress
Li, J., Xueyang, J., Cui, W., Wu, C., & Xue-mei, Q. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0391-z · Cited by 135
Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels
Novakovic, M. M., Korshunov, K. S., Grant, R. A., Martin, M. E., Abdala‐Valencia, H., Budinger, G. R. S., Radulović, J., & Prakriya, M. (2023) · Nature Communications · doi:10.1038/s41467-023-40968-6 · Cited by 133
VGF function in depression and antidepressant efficacy
Jiang, C. S., Lin, W.-J., Sadahiro, M., Labonté, B., Ménard, C., Pfau, M. L., Tamminga, C. A., Turecki, G., Nestler, E. J., Russo, S. J., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.233 · Cited by 124
Self-citation
Sucrose Preference Test as a Measure of Anhedonic Behavior in a Chronic Unpredictable Mild Stress Model of Depression: Outstanding Issues
Markov, D. D. (2022) · Brain Sciences · doi:10.3390/brainsci12101287 · Cited by 133
The neuroscience of sadness: A multidisciplinary synthesis and collaborative review
Arias-López, J. A., Williams, C., Raghvani, R., Aghajani, M., Báez, S., Belzung, C., Booij, L., Busatto, G. F., Chiarella, J., Fu, C. H. Y., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.006 · Cited by 138
Deep Brain Stimulation for Intractable Psychiatric Disorders
Goodman, W. K., & Alterman, R. L. (2010) · Annual Review of Medicine · doi:10.1146/annurev-med-052209-100401 · Cited by 116
Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice
Kim, J., Suh, Y.-H., & Chang, K.-A. (2021) · Molecular Brain · doi:10.1186/s13041-020-00726-x · Cited by 116
Evaluation of the Wistar-Kyoto rat model of depression and the role of synaptic plasticity in depression and antidepressant response
Aleksandrova, L. R., Wang, Y. T., & Phillips, A. G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.07.007 · Cited by 114
Neuroactive Steroids and GABAergic Involvement in the Neuroendocrine Dysfunction Associated With Major Depressive Disorder and Postpartum Depression
Maguire, J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00083 · Cited by 113
Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression
Koo, J. W., Chaudhury, D., Han, M.-H., & Nestler, E. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.020 · Cited by 112
Self-citation
Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus
Zheng, Y., Fan, W., Zhang, X., & Dong, E. (2016) · Epigenetics · doi:10.1080/15592294.2016.1146850 · Cited by 111
Animal models of post-traumatic stress disorder and recent neurobiological insights
Whitaker, A. M., Gilpin, N. W., & Edwards, S. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000069 · Cited by 110
Animal Models of PTSD: A Critical Review
Flandreau, E. I., & Tóth, M. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_65 · Cited by 118
Monoamine oxidases in age-associated diseases: New perspectives for old enzymes
Santin, Y., Resta, J., Parini, A., & Mialet‐Perez, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101256 · Cited by 110
Evidence for Inflammation-Associated Depression
Liu, C. S., Adibfar, A., Herrmann, N., Gallagher, D., & Lanctôt, K. L. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_2 · Cited by 113
Depression in Sub-Saharan Africa
Gbadamosi, I., Henneh, I. T., Aluko, O. M., Yawson, E. O., Fokoua, A. R., Koomson, A. E., Torbi, J., Olorunnado, S. E., Lewu, F. S., Yusha’u, Y., et al. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.03.005 · Cited by 133
Astroglia-Derived ATP Modulates CNS Neuronal Circuits
Illés, P., Burnstock, G., & Tang, Y. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.09.006 · Cited by 107
Epigenetic Mechanisms Underlying the Role of Brain-Derived Neurotrophic Factor in Depression and Response to Antidepressants
Duclot, F., & Kabbaj, M. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.107086 · Cited by 103
HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress
Zhong, P., Vickstrom, C. R., Liu, X., Hu, Y., Yu, L., Yu, H.-G., & Liu, Q.-S. (2018) · eLife · doi:10.7554/elife.32420 · Cited by 99
“DOI: https://doi.org/10.7554/eLife.32420 14 of 27 Both CMS and CSDS are commonly-used rodent models of depression (Golden et al., 2011; Krishnan et al., 2007; Krishnan and Nestler, 2011; Willner, 2005).”
BackgroundMethodInfluential
Chronic stress and endothelial dysfunction: mechanisms, experimental challenges, and the way ahead
Sher, L. D., Geddie, H., Olivier, L., Cairns, M., Truter, N., Beselaar, L., & Essop, M. F. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00244.2020 · Cited by 111
Behavioural phenotypes in the cuprizone model of central nervous system demyelination
Sen, M. K., Mahns, D. A., Coorssen, J. R., & Shortland, P. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.08.008 · Cited by 101
Cytokines and tryptophan metabolites can predict depressive symptoms in pregnancy
Sha, Q., Madaj, Z. B., Keaton, S. A., Galvis, M. L. E., Smart, L., Krzyżanowski, S., Fazleabas, A. T., Leach, R. E., Postolache, T. T., Achtyes, E. D., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01801-8 · Cited by 101
Subchronic and mild social defeat stress accelerates food intake and body weight gain with polydipsia-like features in mice
Goto, T., Kubota, Y., Tanaka, Y., Iio, W., Moriya, N., & Toyoda, A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.040 · Cited by 102
Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity
Fang, X., Jiang, S., Wang, J., Bai, Y., Kim, C. S., Blake, D., Weintraub, N. L., Lei, Y., & Lu, X.-Y. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-01004-x · Cited by 95
Sex differences: Transcriptional signatures of stress exposure in male and female brains
Brivio, E., Lopez, J. P., & Chen, A. (2020) · Genes, Brain and Behavior · doi:10.1111/gbb.12643 · Cited by 95
Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/β-Catenin Pathway
Ge, J., Xu, Y., Qin, G., Cheng, J., & Chen, F. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00044 · Cited by 95
Ketamine Rapidly Enhances Glutamate-Evoked Dendritic Spinogenesis in Medial Prefrontal Cortex Through Dopaminergic Mechanisms
Wu, M., Minkowicz, S., Dumrongprechachan, V., Hamilton, P., & Kozorovitskiy, Y. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.022 · Cited by 95
Evidence for the role of corticotropin-releasing factor in major depressive disorder
Waters, R. P., Rivalan, M., Bangasser, D. A., Deussing, J. M., Ising, M., Wood, S. K., Holsboer, F., & Summers, C. H. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.011 · Cited by 93
Laboratory models of post-traumatic stress disorder: The elusive bridge to translation
Dunsmoor, J. E., Cisler, J. M., Fonzo, G. A., Creech, S. K., & Nemeroff, C. B. (2022) · Neuron · doi:10.1016/j.neuron.2022.03.001 · Cited by 100
The hypothalamic-pituitary-adrenal axis as a substrate for stress resilience: Interactions with the circadian clock
Kinlein, S. A., & Karatsoreos, I. N. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100819 · Cited by 101
The role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in depression: Central mediators of pathophysiology and antidepressant activity?
Freudenberg, F., Celikel, T., & Reif, A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.03.005 · Cited by 97
The Stress-Induced Transcription Factor NR4A1 Adjusts Mitochondrial Function and Synapse Number in Prefrontal Cortex
Jeanneteau, F. D., Barr�re, C., Vos, M., de Vries, C. J. M., Rouillard, C., Lévesque, D., Dromard, Y., Moisan, M., Đurić, V., Franklin, T., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2793-17.2017 · Cited by 96
The Interplay of Environmental Exposures and Mental Health: Setting an Agenda
Reuben, A., Manczak, E. M., Cabrera, L. Y., Alegria, M. M., Bucher, M. L., Freeman, E. C., Miller, G. W., Solomon, G. M., & Perry, M. J. (2022) · Environmental Health Perspectives · doi:10.1289/ehp9889 · Cited by 111
Chronic psychosocial stress triggers microglial‐/macrophage‐induced inflammatory responses leading to neuronal dysfunction and depressive‐related behavior
Kokkosis, A. G., Madeira, M. M., Hage, Z., Valais, K., Koliatsis, D., Resutov, E., & Tsirka, S. E. (2023) · Glia · doi:10.1002/glia.24464 · Cited by 89
Modeling treatment-resistant depression
Samuels, B. A., Leonardo, E. D., Gadient, R. A., Williams, A., Zhou, J., David, D. J. P., Gardier, A. M., Wong, E. H. F., & Hen, R. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.017 · Cited by 96
Prenatal chronic mild stress induces depression-like behavior and sex-specific changes in regional glutamate receptor expression patterns in adult rats
Wang, Y., Ma, Y., Hu, J., Cheng, W., Jiang, H., Zhang, X., Li, M., Ren, J., & Li, X.-M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.008 · Cited by 91
Sex differences in stress-induced social withdrawal: Independence from adult gonadal hormones and inhibition of female phenotype by corncob bedding
Trainor, B. C., Takahashi, E. Y., Campi, K. L., Florez, S. A., Greenberg, G. D., Laman-Maharg, A., Laredo, S. A., Orr, V. N., Silva, A. L., & Steinman, M. Q. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.01.011 · Cited by 86
Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation
Jiang, N., Lv, J., Wang, H., Huang, H. M., Wang, Q., Lü, C., Zeng, G., & Liu, X. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117669 · Cited by 86
Circuit-based frameworks of depressive behaviors: The role of reward circuitry and beyond
Knowland, D., & Lim, B. K. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.12.010 · Cited by 88
Sex, stress, and epigenetics: regulation of behavior in animal models of mood disorders
Hodes, G. E. (2013) · Biology of Sex Differences · doi:10.1186/2042-6410-4-1 · Cited by 85
Neuropathic pain, mood, and stress-related disorders: A literature review of comorbidity and co-pathogenesis
Vieira, W. F., Coelho, D. R. A., Litwiler, S. T., McEachern, K. M., Clancy, J. A., Morales-Quezada, L., & Cassano, P. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105673 · Cited by 91
Emerging Role of Flavonoids as the Treatment of Depression
Pannu, A. S., Sharma, P. C., Thakur, V. K., & Goyal, R. K. (2021) · Biomolecules · doi:10.3390/biom11121825 · Cited by 88
Biomarker Approaches in Major Depressive Disorder Evaluated in the Context of Current Hypotheses
Jentsch, M., van Buel, E. M., Bosker, F. J., Gladkevich, A. V., Klein, H. C., Voshaar, R. C. O., Ruhé, H. G., Eisel, U. L., & Schoevers, R. A. (2015) · Biomarkers in Medicine · doi:10.2217/bmm.14.114 · Cited by 84
microRNA-124 targets glucocorticoid receptor and is involved in depression-like behaviors
Wang, S., Mu, R.-H., Li, C., Dong, S., Geng, D., Liu, Q., & Yi, L. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.024 · Cited by 84
Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression
Papp, M., Gruca, P., Łasoń, M., Adham, N., Kiss, B., & Gyertyán, I. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000070 · Cited by 81
Brain serotonergic activation in growth-stunted farmed salmon: adaption versus pathology
Vindas, M. A., Johansen, I. B., Folkedal, O., Höglund, E., Gorissen, M., Flik, G., Kristiansen, T., & Øyvind Øverli, A. (2016) · Royal Society Open Science · doi:10.1098/rsos.160030 · Cited by 77
The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
Burstein, O., & Doron, R. (2018) · Journal of Visualized Experiments · doi:10.3791/58184 · Cited by 82
Aquaporin‐4 Knockout Exacerbates Corticosterone‐Induced Depression by Inhibiting Astrocyte Function and Hippocampal Neurogenesis
Kong, H., Zeng, X., Fan, Y., Yuan, S., Ge, S., Xie, W., Wang, H., & Hu, G. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12222 · Cited by 72
Correction: Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress
Li, J., Xueyang, J., Cui, W., Wu, C., & Xue-mei, Q. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0645-9 · Cited by 72
Melatonin and Depression: A Translational Perspective From Animal Models to Clinical Studies
Tonon, A. C., Pilz, L. K., Markus, R. P., Hidalgo, M. P. L., & Elisabetsky, E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.638981 · Cited by 77
Test, rinse, repeat: A review of carryover effects in rodent behavioral assays
Cnops, V., Iyer, V. R., Parathy, N., Wong, P., & Dawe, G. S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104560 · Cited by 78
Encore: Behavioural animal models of stress, depression and mood disorders
Petković, A., & Chaudhury, D. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.931964 · Cited by 72
Chronic stress disrupts the homeostasis and progeny progression of oligodendroglial lineage cells, associating immune oligodendrocytes with prefrontal cortex hypomyelination
Kokkosis, A. G., Madeira, M. M., Mullahy, M., & Tsirka, S. E. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01512-y · Cited by 73
Loss of phenotype of parvalbumin interneurons in rat prefrontal cortex is involved in antidepressant- and propsychotic-like behaviors following acute and repeated ketamine administration
Zhou, Z., Zhang, G., Li, X., Liu, X., Wang, N., Qiu, L., Liu, W., Zuo, Z., & Yang, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8798-2 · Cited by 64
Chronic Variable Stress Is Responsible for Lipid and DNA Oxidative Disorders and Activation of Oxidative Stress Response Genes in the Brain of Rats
Herbet, M., Korga-Plewko, A., Gawrońska‐Grzywacz, M., Izdebska, M., Piątkowska‐Chmiel, I., Poleszak, E., Wróbel, A., Matysiak, W., Jodłowska‐Jędrych, B., & Dudka, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7313090 · Cited by 67
Therapeutic Potential of Ursolic Acid to Manage Neurodegenerative and Psychiatric Diseases
Ramos-Hryb, A. B., Pazini, F. L., Kaster, M. P., & Rodrigues, A. L. S. (2017) · CNS Drugs · doi:10.1007/s40263-017-0474-4 · Cited by 66
Intranasal Stem Cell Treatment as a Novel Therapy for Subarachnoid Hemorrhage
Nijboer, C. H. A., Kooijman, E., van Velthoven, C. T. J., van Tilborg, E., Tiebosch, I. A., Eijkelkamp, N., Dijkhuizen, R. M., Kesecioğlu, J., & Heijnen, C. J. (2018) · Stem Cells and Development · doi:10.1089/scd.2017.0148 · Cited by 68
Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders
Turek, J., & Gąsior, Ł. (2023) · Pharmacological Reports · doi:10.1007/s43440-022-00444-2 · Cited by 63
Circadian insights into the biology of depression: Symptoms, treatments and animal models
Mendoza, J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112186 · Cited by 67
Behavioral and physiological consequences of enrichment loss in rats
Smith, B. L., Lyons, C. E., Correa, F. G., Benoit, S. C., Myers, B., Solomon, M. B., & Herman, J. P. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.040 · Cited by 66
Drosophila as a Model Organism for the Study of Neuropsychiatric Disorders
O’Kane, C. J. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_110 · Cited by 62
Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice
Yang, L.-P., Jiang, F.-J., Wu, G.-S., Deng, K., Wen, M., Zhou, X., Hong, X., Zhu, M. X., & Luo, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136255 · Cited by 64
Significance of risk polymorphisms for depression depends on stress exposure
Gonda, X., Hullám, G., Antal, P., Eszlári, N., Petschner, P., Hökfelt, T. G. M., Anderson, I. M., Deakin, J. F. W., Juhász, G., & Bagdy, G. (2018) · Scientific Reports · doi:10.1038/s41598-018-22221-z · Cited by 62
Intranasal Delivery of Recombinant AAV Containing BDNF Fused with HA2TAT: a Potential Promising Therapy Strategy for Major Depressive Disorder
Ma, X., Liu, P., Zhang, X., Jiang, W., Jia, M., Wang, C., Dong, Y., Dang, Y., & Gao, C. (2016) · Scientific Reports · doi:10.1038/srep22404 · Cited by 62
Chronic social defeat stress leads to changes of behaviour and memory-associated proteins of young mice
Jianhua, F., Wei, W., Xiaomei, L., & Wang, S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.011 · Cited by 61

Authors: Krishnan, V., & Nestler, E. J.
Affiliations: The University of Texas Southwestern Medical Center (US)
Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Krishnan, Vaishnav
ORCID: Krishnan, Vaishnav
Nestler, Eric J.
Venue: Current Topics in Behavioral Neurosciences
Publisher: Springer Berlin Heidelberg
Published: 2011
Volume: 7
Pages: 121-147
ISSN: 1866-3370 (ISSN-L)
1866-3389
DOI: 10.1007/7854_2010_108
PMC: PMC3270071
OpenAlex: W84932982
Cited by: 528
References: 131
Citations by year: 2026: 13 · 2025: 35 · 2024: 40 · 2023: 38 · 2022: 49 · 2021: 57 · 2020: 42 · 2019: 45 · 2018: 39 · 2017: 42 · 2016: 37 · 2015: 33 · 2014: 27 · 2013: 14 · 2012: 9
FWCI: 71.79
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Current topics in behavioral neurosciences (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH051399, P50MH066172)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: animal models of depression, major depressive disorder, forced swim test, social defeat stress, chronic stress, secondary depression, antidepressant mechanism, behavioral assays, video tracking
MeSH terms: Animals, Antidepressive Agents, Depression, Major Depressive Disorder, Disease Models, Animal, Humans, Stress, Psychological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Animal Models of Depression: Molecular Perspectives

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks