Sex differences: Transcriptional signatures of stress exposure in male and female brains
Open accessAbstract
More than two-thirds of patients suffering from stress-related disorders are women but over two-thirds of suicide completers are men. These are just some examples of the many sex differences in the prevalence and manifestations of stress-related disorders, such as major depressive disorder, post-traumatic stress disorder, and anxiety disorders, which have been extensively documented in clinical research. Nonetheless, the molecular origins of this sex dimorphism are still quite obscure. In response to this lack of knowledge, the NIH recently advocated implementing sex as biological variable in the design of preclinical studies across disciplines. As a result, a newly emerging field within psychiatry is trying to elucidate the molecular causes underlying the clinically described sex dimorphism. Several studies in rodents and humans have already identified many stress-related genes that are regulated by acute and chronic stress in a sex-specific fashion. Furthermore, current transcriptomic studies have shown that pathways and networks in male and female individuals are not equally affected by stress exposure. In this review, we give an overview of transcriptional studies designed to understand how sex influences stress-specific transcriptomic changes in rodent models, as well as human psychiatric patients, highlighting the use of different methodological techniques. Understanding which mechanisms are more affected in males, and which in females, may lead to the identification of sex-specific mechanisms, their selective contribution to stress susceptibility, and their role in the development of stress-related psychiatric disorders.
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Of the 44 documents, 31 were empirical/quantitative studies and 13 were reviews.
“Of the 44 documents, 31 were empirical/quantitative studies30–60 and 13 were reviews.61–73”
From Factors associated with gender and sex differences in anxiety prevalence and comorbidity: A systematic review (2022) · cites this paper as [61]
Sex differences in anxiety disorders may be due to genetic factors.
“(c) genetic factors.30,31,52,61,64,71”
From Factors associated with gender and sex differences in anxiety prevalence and comorbidity: A systematic review (2022) · cites this paper as [61]
Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391 · see citing works
RNA-Seq: a revolutionary tool for transcriptomics
Wang, Z., Gerstein, M., & Snyder, M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2484 · Cited by 13,174 · see citing works
Global quantification of mammalian gene expression control
Schwanhäusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W., & Selbach, M. (2011) · Nature · doi:10.1038/nature10098 · Cited by 6,566 · cited 1× · see citing works
“First, the transcriptome provides a window on a tissue or cell phenotype and its molecular dynamics.(37) Second, the transcriptome is highly dynamic and reflects fast adaptation to the”
BackgroundTHE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION
Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111 · cited 1× · see citing works
“related disorders have in common a strong association to stress exposure as a risk-factor.(12) Since sex has been shown to modulate the stress response and processing at multiple levels, studying how the male and female biological systems process stress might help to under-”
BackgroundStowman, K. (1949) · The Milbank Memorial Fund Quarterly · doi:10.2307/3348165 · Cited by 2,104 · see citing works
The neurobiology of stress and development.
Gunnar, M., & Quevedo, K. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.58.110405.085605 · Cited by 2,011 · cited 1× · see citing works
“(HPA) axis, the cortico-limbic, and the sympathetic adrenomedullary (SAM) systems, which interact with each other to coordinate the stress response.(13,14) Importantly, exposure to stress activates the paraventricular nucleus of the hypothalamus (PVN), which leads to a biological cascade that produces glucocorticoids,…”
BackgroundRNA sequencing: the teenage years
Stark, R., Grzelak, M., & Hadfield, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0150-2 · Cited by 1,906 · see citing works
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832 · see citing works
Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response
Herman, J. P., McKlveen, J. M., Ghosal, S., Kopp, B., Wulsin, A., Makinson, R., Scheimann, J., & Myers, B. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c150015 · Cited by 1,819 · see citing works
Sex bias in neuroscience and biomedical research
Beery, A. K., & Zucker, I. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.002 · Cited by 1,763 · see citing works
Why is depression more common among women than among men?
Kuehner, C. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30263-2 · Cited by 1,752 · see citing works
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Zhang, B., Gaiteri, C., Bodea, L.-G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.030 · Cited by 1,657 · see citing works
Ten years of next-generation sequencing technology
van Dijk, E., Auger, H., Jaszczyszyn, Y., & Thermes, C. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.07.001 · Cited by 1,632 · see citing works
Sex differences in HPA axis responses to stress: a review
Kudielka, B. M., & Kirschbaum, C. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2004.11.009 · Cited by 1,624 · see citing works
Why sex matters for neuroscience
Cahill, L. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1909 · Cited by 1,540 · see citing works
Sex differences in anxiety and depression clinical perspectives
Altemus, M., Sarvaiya, N., & Neill Epperson, C. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.004 · Cited by 1,413 · see citing works
Neurobiology of suicidal behaviour
Mann, J. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1220 · Cited by 1,260 · see citing works
Sex differences in the structural connectome of the human brain
Ingalhalikar, M., Smith, A., Parker, D., Satterthwaite, T. D., Elliott, M. A., Ruparel, K., Hakonarson, H., Gur, R. E., Gur, R. C., & Verma, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316909110 · Cited by 1,223 · see citing works
Normal Sexual Dimorphism of the Adult Human Brain Assessed by In Vivo Magnetic Resonance Imaging
Goldstein, J. M. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.6.490 · Cited by 1,021 · see citing works
The chronic mild stress (CMS) model of depression: History, evaluation and usage
Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.002 · Cited by 959 · see citing works
Gur, R. C., Turetsky, B. I., Matsui, M., Yan, M., Bilker, W., Hughett, P., & Gur, R. E. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04065.1999 · Cited by 909 · see citing works
Female mice liberated for inclusion in neuroscience and biomedical research
Prendergast, B. J., Onishi, K. G., & Zucker, I. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.001 · Cited by 788 · see citing works
Sex differences and stress across the lifespan
Bale, T. L., & Epperson, C. N. (2015) · Nature Neuroscience · doi:10.1038/nn.4112 · Cited by 751 · see citing works
Sex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748 · see citing works
Sex differences in stress-related psychiatric disorders: neurobiological perspectives
Bangasser, D. A., & Valentino, R. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.008 · Cited by 737 · see citing works
Gender Differences in Treatment Response to Sertraline Versus Imipramine in Chronic Depression
Kornstein, S. G., Schatzberg, A. F., Thase, M. E., Yonkers, K. A., McCullough, J. P., Keitner, G. I., Gelenberg, A. J., Thomas, S., Harrison, W. M., & Keller, M. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.9.1445 · Cited by 712 · see citing works
Sex beyond the genitalia: the human brain mosaic
Joel, D., Berman, Z., Tavor, I., Wexler, N., Gaber, O., Stein, Y., Shefi, N., Pool, J., Urchs, S., Margulies, D. S., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509654112 · Cited by 684 · see citing works
(2004) · PubMed · Cited by 681 · see citing works
Martin, L. A., Neighbors, H. W., & Griffith, D. M. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1985 · Cited by 674 · see citing works
Library construction for next-generation sequencing: Overviews and challenges
Head, S. R., Komori, H. K., LaMere, S. A., Whisenant, T. C., Nieuwerburgh, F. V., Salomon, D. R., & Ordoukhanian, P. T. (2014) · BioTechniques · doi:10.2144/000114133 · Cited by 673 · see citing works
Sex differences in brain activation to emotional stimuli: A meta-analysis of neuroimaging studies
Stevens, J. S., & Hamann, S. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.03.011 · Cited by 588 · see citing works
Preclinical models: status of basic research in depression
Nestler, E. J., Gould, E., & Manji, H. K. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01405-1 · Cited by 559 · see citing works
Habituation to repeated stress: Get used to it
Grissom, N., & Bhatnagar, S. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.07.001 · Cited by 552 · see citing works
Animal models of anxiety and depression: how are females different?
Palanza, P. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00010-0 · Cited by 545 · see citing works
Animal Models of Depression: Molecular Perspectives
Krishnan, V., & Nestler, E. J. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2010_108 · Cited by 528 · see citing works
Gender differences in depression: Findings from the STAR*D study
Marcus, S. M., Young, E. A., Kerber, K. B., Kornstein, S., Farabaugh, A. H., Mitchell, J., Wisniewski, S. R., Balasubramani, G. K., Trivedi, M. H., & Rush, A. J. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.09.008 · Cited by 456 · see citing works
Sex differences in neural mechanisms mediating reward and addiction
Becker, J. B., & Chartoff, E. H. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0125-6 · Cited by 455 · see citing works
Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression
Barden, N. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0421 · Cited by 416 · see citing works
Hodes, G. E., Pfau, M. L., Purushothaman, I., Ahn, H. F., Golden, S. A., Christoffel, D. J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M. E., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1392-15.2015 · Cited by 395 · see citing works
Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2
Peña, C. J., Kronman, H. G., Walker, D. M., Cates, H. M., Bagot, R. C., Purushothaman, I., Issler, O., Loh, Y.-H. E., Leong, T., Kiraly, D. D., et al. (2017) · Science · doi:10.1126/science.aan4491 · Cited by 394 · see citing works
Different Neuronal Activity Patterns Induce Different Gene Expression Programs
Tyssowski, K. M., DeStefino, N. R., Cho, J.-H., Dunn, C. J., Poston, R. G., Carty, C. E., Jones, R. D., Chang, S. M., Romeo, P., Wurzelmann, M. K., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.04.001 · Cited by 390 · see citing works
Kim, Y., Yang, G. R., Pradhan, K., Venkataraju, K. U., Bota, M., García del Molino, L. C., Fitzgerald, G., Ram, K., He, M., Levine, J. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.020 · Cited by 389 · see citing works
The recent progress in animal models of depression
Wang, Q., Timberlake, M. A., Prall, K., & Dwivedi, Y. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.008 · Cited by 370 · see citing works
Sex Differences in Stress Response Circuitry Activation Dependent on Female Hormonal Cycle
Goldstein, J. M., Jerram, M. W., Abbs, B., Whitfield, S., & Makris, N. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3021-09.2010 · Cited by 362 · see citing works
Are hormones a “female problem” for animal research?
Shansky, R. M. (2019) · Science · doi:10.1126/science.aaw7570 · Cited by 344 · see citing works
Radley, J., Morilak, D., Viau, V., & Campeau, S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.018 · Cited by 339 · see citing works
Sex differences in the psychopharmacological treatment of depression
Sramek, J. J., Murphy, M. F., & Cutler, N. R. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.4/ncutler · Cited by 334 · see citing works
Bagot, R. C., Cates, H. M., Purushothaman, I., Lorsch, Z. S., Walker, D. M., Wang, J., Huang, X., Schlüter, O. M., Maze, I., Peña, C. J., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.015 · Cited by 333 · see citing works
Iwamoto, K., Kakiuchi, C., Bundo, M., Ikeda, K., & Kato, T. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001437 · Cited by 331 · see citing works
Inclusion of females does not increase variability in rodent research studies
Beery, A. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.06.016 · Cited by 316 · see citing works
Widespread sex differences in gene expression and splicing in the adult human brain
Trabzuni, D., Ramasamy, A., Imran, S., WALKER, R. E., Smith, C., Weale, M. E., Hardy, J., & Ryten, M. (2013) · Nature Communications · doi:10.1038/ncomms3771 · Cited by 296 · see citing works
Eileen Luders, A., Christian Gaser, B., Narr, K. L., & Toga, A. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2261-09.2009 · Cited by 281 · see citing works
The molecular bases of the suicidal brain
Turecki, G. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3839 · Cited by 281 · see citing works
Sex differences and the neurobiology of affective disorders
Rubinow, D. R., & Schmidt, P. J. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0148-z · Cited by 274 · see citing works
Opposite Molecular Signatures of Depression in Men and Women
Seney, M. L., Huo, Z., Cahill, K., French, L., Puralewski, R., Zhang, J., Logan, R. W., Tseng, G., Lewis, D. A., & Sibille, E. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.017 · Cited by 272 · see citing works
The landscape of sex-differential transcriptome and its consequent selection in human adults
Gershoni, M., & Pietrokovski, S. (2017) · BMC Biology · doi:10.1186/s12915-017-0352-z · Cited by 267 · see citing works
Viau, V., Bingham, B., Davis, J., Lee, P., & Wong, M. (2005) · Endocrinology · doi:10.1210/en.2004-0846 · Cited by 266 · see citing works
Conservation, acquisition, and functional impact of sex-biased gene expression in mammals
Naqvi, S., Godfrey, A. K., Hughes, J. F., Goodheart, M. L., Mitchell, R. N., & Page, D. C. (2019) · Science · doi:10.1126/science.aaw7317 · Cited by 258 · see citing works
Sex Differences in Antidepressant Response in Recent Antidepressant Clinical Trials
Khan, A., Brodhead, A. E., Schwartz, K. A., Kolts, R. L., & Brown, W. A. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000168879.03169.ce · Cited by 255 · see citing works
Elevated Cytokine Expression in the Orbitofrontal Cortex of Victims of Suicide
Tonelli, L. H., Stiller, J., Rujescu, D., Giegling, I., Schneider, B., Maurer, K., Schnabel, A., Möller, H. ‐., Chen, H. H., & Postolache, T. T. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01128.x · Cited by 252 · see citing works
Sex differences in glutamate receptor gene expression in major depression and suicide
Gray, A. L., Hyde, T. M., Deep-Soboslay, A., Kleinman, J. E., & Sodhi, M. S. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.91 · Cited by 250 · see citing works
Stress Activation of Cortex and Hippocampus Is Modulated by Sex and Stage of Estrus
Figueiredo, H. F., Dolgas, C. M., & Herman, J. P. (2002) · Endocrinology · doi:10.1210/endo.143.7.8888 · Cited by 237 · see citing works
Iwasaki-Sekino, A., Mano‐Otagiri, A., Ohata, H., Yamauchi, N., & Shibasaki, T. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.09.003 · Cited by 222 · see citing works
Early life stress alters transcriptomic patterning across reward circuitry in male and female mice
Peña, C. J., Smith, M., Ramakrishnan, A., Cates, H. M., Bagot, R. C., Kronman, H. G., Patel, B., Chang, A. B., Purushothaman, I., Dudley, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13085-6 · Cited by 219 · see citing works
Vicarious Social Defeat Stress Induces Depression-Related Outcomes in Female Mice
Iñiguez, S. D., Flores‐Ramirez, F. J., Riggs, L. M., Alipio, J. B., Garcia-Carachure, I., Hernandez, M. A., Sánchez, D. O. M., Lobo, M. K., Serrano, P. A., Braren, S. H., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.07.014 · Cited by 206 · see citing works
Davatzikos, C. A. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.7.635 · Cited by 203 · see citing works
Lutz, P.-E., Tanti, A., Gasecka, A., Barnett-Burns, S., Kim, J. J., Zhou, Y., Chen, G. G., Wakid, M., Shaw, M., Almeida, D., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.16111286 · Cited by 203 · see citing works
Reduced somatostatin in subgenual anterior cingulate cortex in major depression
Tripp, A., Kota, R. S., Lewis, D. A., & Sibille, E. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.014 · Cited by 190 · see citing works
Examining the Intersection of Sex and Stress in Modelling Neuropsychiatric Disorders
Goel, N., & Bale, T. L. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01843.x · Cited by 182 · see citing works
Dunčko, R., Kiss, A., Škultétyová, I., Rusnák, M., & Ježová, D. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(00)00040-8 · Cited by 182 · see citing works
Fighting Females: Neural and Behavioral Consequences of Social Defeat Stress in Female Mice
Newman, E. L., Covington, H. E., Suh, J., Bicakci, M. B., Ressler, K. J., DeBold, J. F., & Miczek, K. A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.005 · Cited by 167 · see citing works
Joel, D., & McCarthy, M. M. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.79 · Cited by 158 · see citing works
Barley, K. M., Dracheva, S. M., & Byne, W. M. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.04.019 · Cited by 155 · see citing works
Sex-biased methylome and transcriptome in human prefrontal cortex
Xu, H., Wang, F., Liu, Y., Yu, Y., Gelernter, J., & Zhang, H. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt516 · Cited by 151 · see citing works
Sterrenburg, L., Gaszner, B., Boerrigter, J., Santbergen, L., Bramini, M., Elliott, E., Chen, A., Peeters, B. W. M. M., Roubos, E. W., & Kozicz, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028128 · Cited by 149 · see citing works
Self-citationKonradi, C. L., Daws, S. E., & Clay, H. B. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.025 · Cited by 148 · see citing works
Patterns in the human brain mosaic discriminate males from females
Chekroud, A. M., Ward, E. J., Rosenberg, M. D., & Holmes, A. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1523888113 · Cited by 148 · see citing works
Vicarious social defeat stress: Bridging the gap between physical and emotional stress
Sial, O. K., Warren, B. L., Parise, L. F., Parise, E. M., & Bolaños‐Guzmán, C. A. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.10.012 · Cited by 134 · see citing works
Babb, J. A., Masini, C. V., Day, H. E. W., & Campeau, S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.051 · Cited by 134 · see citing works
Neuropathological and transcriptomic characteristics of the aged brain
Miller, J. A., Guillozet-Bongaarts, A., Gibbons, L. E., Postupna, N., Renz, A., Beller, A. E., Sunkin, S. M., Ng, L., Rose, S. E., Smith, K. A., et al. (2017) · eLife · doi:10.7554/elife.31126 · Cited by 134 · see citing works
Sex-specific effects of stress on oxytocin neurons correspond with responses to intranasal oxytocin
Steinman, M. Q., Duque-Wilckens, N., Greenberg, G. D., Hao, R., Campi, K. L., Laredo, S. A., Laman-Maharg, A., Manning, C. E., Doig, I. E., Lopez, E. M., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.007 · Cited by 131 · see citing works
Molecular aspects of depression: A review from neurobiology to treatment
Boas, G. R. V., de Lacerda, R. B., Paes, M. M., Gubert, P., Almeida, W. L. D. C., Rescia, V. C., Galdino, P. M., de Carvalho, A. A. V., & Oesterreich, S. A. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.02.024 · Cited by 128 · see citing works
Daskalakis, N. P., Cohen, H., Cai, G., Buxbaum, J. D., & Yehuda, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401660111 · Cited by 124 · see citing works
Shepard, R., Page, C. E., & Coutellier, L. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.038 · Cited by 118 · see citing works
Gass, P., Reichardt, H. M., Strekalova, T. V., Henn, F. A., & Tronche, F. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00518-2 · Cited by 117 · see citing works
Breen, M. S., Tylee, D. S., Maihofer, A. X., Neylan, T. C., Mehta, D., Binder, E. B., Chandler, S. D., Hess, J., Kremen, W. S., Risbrough, V. B., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.220 · Cited by 117 · see citing works
Bland, S. T., Schmid, M. J., Der-Avakian, A., Watkins, L., Spencer, R. L., & Maier, S. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.065 · Cited by 115 · see citing works
Su, Y. A., Wu, J., Zhang, L., Zhang, Q., Su, D. M., He, P., Wang, B.-D., Li, H., Webster, M. J., Group, T. S. B. S., et al. (2008) · International Journal of Biological Sciences · doi:10.7150/ijbs.4.223 · Cited by 113 · see citing works
Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages
Shi, L., Zhang, Z., & Su, B. (2016) · Scientific Reports · doi:10.1038/srep21181 · Cited by 109 · see citing works
Estrogen receptor α drives pro-resilient transcription in mouse models of depression
Lorsch, Z. S., Loh, Y.-H. E., Purushothaman, I., Walker, D. M., Parise, E. M., Salery, M., Cahill, M. E., Hodes, G. E., Pfau, M. L., Kronman, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03567-4 · Cited by 104 · see citing works
Machine learning of brain gray matter differentiates sex in a large forensic sample
Anderson, N. E., Harenski, K. A., Harenski, C. L., Koenigs, M. R., Jean Decety, A., Calhoun, V. D., & Kiehl, K. A. (2018) · Human Brain Mapping · doi:10.1002/hbm.24462 · Cited by 103 · see citing works
Perlman, W. R., Tomaskovic‐Crook, E., Montague, D. M., Webster, M. J., Rubinow, D. R., Kleinman, J. E., & Weickert, C. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.047 · Cited by 102 · see citing works
Shepard, R., & Coutellier, L. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0528-0 · Cited by 97 · see citing works
Marina Barysheva, A., Jahanshad, N., Foland‐Ross, L. C., Altshuler, L. L., & Thompson, P. M. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.03.016 · Cited by 97 · see citing works
An Evolutionarily Conserved Sexual Signature in the Primate Brain
Reinius, B., Saetre, P., Leonard, J. A., Blekhman, R., Merino-Martinez, R., Gilad, Y., & JAZIN, E. E. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000100 · Cited by 95 · see citing works
Sex differences in the stress response in SD rats
Lü, J., Wu, X., Zhu, Q., Li, J., Shi, L., Wu, J., Zhang, Q., Huang, M., & Bao, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.009 · Cited by 95 · see citing works
Seney, M. L., Tripp, A. C., McCune, S., Lewis, D. A., & Sibille, E. L. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.10.005 · Cited by 95 · see citing works
Sterrenburg, L., Gaszner, B., Boerrigter, J. G. J., Santbergen, L., Bramini, M., Roubos, E. W., Peeters, B. W. M. M., & Kozicz, T. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22737 · Cited by 94 · see citing works
Kokras, N., & Dalla, C. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23861 · Cited by 94 · see citing works
Psychiatric Brain Banking: Three Perspectives on Current Trends and Future Directions
Deep‐Soboslay, A., Benes, F. M., Haroutunian, V. H., Ellis, J. K., Kleinman, J. E., & Hyde, T. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.025 · Cited by 93 · see citing works
Lunga, P., & Herbert, J. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01234.x · Cited by 92 · see citing works
Are females more variable than males in gene expression? Meta-analysis of microarray datasets
Itoh, Y., & Arnold, A. P. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0036-8 · Cited by 92 · see citing works
Sex differences in the chronic mild stress model of depression
Franceschelli, A., Herchick, S., Thelen, C., Papadopoulou‐Daifoti, Z., & Pitychoutis, P. M. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000062 · Cited by 89 · see citing works
Greenberg, G. D., Laman-Maharg, A., Campi, K. L., Voigt, H., Orr, V. N., Schaal, L., & Trainor, B. C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00223 · Cited by 89 · see citing works
White matter abnormalities in depression: A categorical and phenotypic diffusion MRI study
Coloigner, J., Batail, J.-M. V., Commowick, O., Corouge, I., Robert, G., Barillot, C., & Drapier, D. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101710 · Cited by 88 · see citing works
Suppressed monocyte gene expression profile in men versus women with PTSD
Neylan, T. C., Sun, B., Rempel, H., Ross, J., Lenoci, M., O’Donovan, A., & Pulliam, L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.12.001 · Cited by 86 · see citing works
Solomon, M. B., Loftspring, M., de Kloet, A. D., Ghosal, S., Jankord, R., Flak, J. N., Wulsin, A. C., Krause, E. G., Zhang, R., Rice, T., et al. (2015) · Endocrinology · doi:10.1210/en.2015-1276 · Cited by 85 · see citing works
Signatures of sex: Sex differences in gene expression in the vertebrate brain
Gegenhuber, B., & Tollkühn, J. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.348 · Cited by 85 · see citing works
Systematic review of genome-wide gene expression studies of bipolar disorder
Seifuddin, F., Pirooznia, M., Judy, J., Goes, F. S., Potash, J. B., & Zandi, P. P. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-213 · Cited by 84 · see citing works
The Role of Genetic Sex in Affect Regulation and Expression of GABA-Related Genes Across Species
Seney, M. L., Chang, L.-C., Oh, H., Wang, X., Tseng, G. C., Lewis, D. A., & Sibille, E. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00104 · Cited by 78 · see citing works
Forced Swimming Differentially Affects Male and Female Brain Corticosteroid Receptors
Karandrea, D., Kittas, C. N., & Kitraki, E. (2002) · Neuroendocrinology · doi:10.1159/000054713 · Cited by 77 · see citing works
Steinman, M. Q., Laredo, S. A., Lopez, E. M., Manning, C. E., Hao, R. C., Doig, I. E., Campi, K. L., Flowers, A. E., Knight, J. K., & Trainor, B. C. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.009 · Cited by 73 · see citing works
Zhang, S., Zhang, H., Ku, S. M., Juarez, B., Morel, C., Tzavaras, N., Montgomery, S. E., Hodes, G. E., Brancato, A., Russo, S. J., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.021 · Cited by 71 · see citing works
Marrocco, J., Petty, G. H., Ríos, M. B., Gray, J. D., Kogan, J. F., Waters, E. M., Schmidt, E. F., Lee, F. S., & McEwen, B. S. (2017) · Nature Communications · doi:10.1038/s41467-017-01014-4 · Cited by 69 · see citing works
Karandrea, D., Kittas, C. N., & Kitraki, E. (2000) · Neuroendocrinology · doi:10.1159/000054555 · Cited by 67 · see citing works
Sex chromosome complement regulates expression of mood-related genes
Seney, M. L., Ekong, K. I., Ding, Y., Tseng, G. C., & Sibille, E. L. (2013) · Biology of Sex Differences · doi:10.1186/2042-6410-4-20 · Cited by 61 · see citing works
Goswami, D. B., May, W. L., Stockmeier, C. A., & Austin, M. C. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06462.x · Cited by 61 · see citing works
Sex differences in neurological and psychiatric disorders
Young, L. J., & Pfaff, D. W. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.005 · Cited by 59 · see citing works
Barde, S. S., Rüegg, J., Prud’homme, J., Ekström, T. J., Palkovits, M., Turecki, G., Bagdy, G., Ihnatko, R., Theodorsson, E., Juhász, G., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617824113 · Cited by 58 · see citing works
Female responses to acute and repeated restraint stress differ from those in males
Zavala, J., Fernandez, A. A., & Gosselink, K. L. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.022 · Cited by 55 · see citing works
Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes
Girgenti, M. J., Wohleb, E. S., Mehta, S. S., Ghosal, S., Fogaça, M. V., & Duman, R. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0642-z · Cited by 54 · see citing works
Zhang, L., Li, H., Hu, X., Benedek, D. M., Fullerton, C. S., Forsten, R. D., Naifeh, J. A., Li, X., Wu, H., Benevides, K. N., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.65 · Cited by 53 · see citing works
Babb, J. A., Masini, C. V., Day, H. E. W., & Campeau, S. (2013) · Stress · doi:10.3109/10253890.2013.840282 · Cited by 51 · see citing works
Hippocampal gene expression induced by cold swim stress depends on sex and handling
Bohacek, J., Manuella, F., Roszkowski, M., & Mansuy, I. M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.026 · Cited by 51 · see citing works
Mychasiuk, R., Muhammad, A., & Kolb, B. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.053 · Cited by 50 · see citing works
Lobentanzer, S., Hanin, G., Klein, J., & Soreq, H. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.017 · Cited by 50 · see citing works
RNA-Seq Reveals Novel Transcriptional Reorganization in Human Alcoholic Brain
Farris, S. P., & Dayne Mayfield, R. (2014) · International Review of Neurobiology · doi:10.1016/b978-0-12-801105-8.00011-4 · Cited by 49 · see citing works
Musazzi, L., Tornese, P., Sala, N., & Popoli, M. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.175 · Cited by 48 · see citing works
Experience and the ever‐changing brain: What the transcriptome can reveal
Rubin, T. G., Gray, J. D., & McEwen, B. S. (2014) · BioEssays · doi:10.1002/bies.201400095 · Cited by 47 · see citing works
Li, S., Papale, L. A., Zhang, Q., Madrid, A., Chen, L., Chopra, P., Keleş, S., Jin, P., & Alisch, R. S. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.11.010 · Cited by 47 · see citing works
Herringa, R. J., Roseboom, P. H., & Kalin, N. H. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301038 · Cited by 44 · see citing works
Sexual dimorphism of Broca's region: More gray matter in female brains in Brodmann areas 44 and 45
Kurth, F., Jäncke, L., & Eileen Luders, A. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23898 · Cited by 43 · see citing works
Cruceanu, C., Tan, P. P. C., Rogić, S., López, J. P., Torres-Platas, S. G., Gigek, C. O., Alda, M., Rouleau, G. A., Pavlidis, P., & Turecki, G. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14101279 · Cited by 41 · see citing works
Guo, L., Chen, Y.-X., Hu, Y., Wu, X., He, Y., Wu, J., Huang, M., Mason, M. R. J., & Bao, A. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.016 · Cited by 39 · see citing works
Integrative Analysis of Sex-Specific microRNA Networks Following Stress in Mouse Nucleus Accumbens
Pfau, M. L., Purushothaman, I., Feng, J., Golden, S. A., Aleyasin, H., Lorsch, Z. S., Cates, H. M., Flanigan, M. E., Ménard, C., Heshmati, M., et al. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00144 · Cited by 35 · see citing works
Morrison, F. G., Miller, M. W., Wolf, E. J., Logue, M. W., Maniates, H., Kwasnik, D., Cherry, J. D., Svirsky, S. E., Restaino, A. C., Hildebrandt, A. M., et al. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.10.027 · Cited by 35 · see citing works
Rosinger, Z. J., Jacobskind, J. S., Guzman, R. M. D., Justice, N. J., & Zuloaga, D. G. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.04.045 · Cited by 34 · see citing works
Sex-Specific Effects of Stress on Mood-Related Gene Expression
Barko, K., Paden, W., Cahill, K. M., Seney, M. L., & Logan, R. W. (2019) · Complex Psychiatry · doi:10.1159/000499105 · Cited by 34 · see citing works
Xing, G., Carlton, J. R., Zhang, L., Jiang, X., Fullerton, C. S., Li, H., & Ursano, R. J. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.013 · Cited by 33 · see citing works
A Slice of the Suicidal Brain: What Have Postmortem Molecular Studies Taught Us?
Almeida, D. M., & Turecki, G. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-016-0736-8 · Cited by 33 · see citing works
Transcriptomic Approaches to Neural Repair
Dulin, J. N., Antunes‐Martins, A., Chandran, V., Costigan, M., Lerch, J. K., Willis, D. E., & Tuszynski, M. H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2599-15.2015 · Cited by 30 · see citing works
Sex difference in mouse hypothalamic transcriptome profile in stress-induced depression model
Karisetty, B. C., Khandelwal, N., Kumar, A., & Chakravarty, S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.04.005 · Cited by 29 · see citing works
Kelly, S. D., Harrell, C. S., & Neigh, G. N. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.12.002 · Cited by 28 · see citing works
Do cortical plasticity mechanisms differ between males and females?
Dachtler, J., & Fox, K. D. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23850 · Cited by 27 · see citing works
Sex-specific hippocampal 5-hydroxymethylcytosine is disrupted in response to acute stress
Papale, L. A., Li, S., Madrid, A., Zhang, Q., Chen, L., Chopra, P., Jin, P., Keleş, S., & Alisch, R. S. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.08.014 · Cited by 26 · see citing works
Puralewski, R., Vasilakis, G. M., & Seney, M. L. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0106-6 · Cited by 25 · see citing works
Lan, N., Hellemans, K. G. C., Ellis, L. A., & Weinberg, J. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12916 · Cited by 24 · see citing works
Chun, L. E., Christensen, J., Woodruff, E. R., Morton, S. J., Hinds, L. R., & Spencer, R. L. (2017) · Stress · doi:10.1080/10253890.2017.1404571 · Cited by 24 · see citing works
Evaluation of tissue collection for postmortem studies of bipolar disorder
Deep‐Soboslay, A., Iglesias, B., Hyde, T. M., Bigelow, L. B., Imamovic, V., Herman, M. M., & Kleinman, J. E. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00607.x · Cited by 22 · see citing works
Wright, E. C., Johnson, S., Hao, R., Kowalczyk, A. S., Greenberg, G. D., Sanchez, E. O., Laman-Maharg, A., Trainor, B. C., & Rosenfeld, C. S. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12475 · Cited by 22 · see citing works
Zhou, Y., Lutz, P., Ibrahim, E., Courtet, P., Tzavara, E., Turecki, G., & Belzeaux, R. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24367 · Cited by 21 · see citing works
Towers, A. E., Oelschlager, M. L., Lorenz, M. R., Gainey, S. J., McCusker, R. H., Krauklis, S. A., & Freund, G. G. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.025 · Cited by 13 · see citing works
Preclinical stress research: where are we headed? An early career investigator’s perspective
Gururajan, A., Kos, A., & López, J. P. (2018) · Stress · doi:10.1080/10253890.2018.1446519 · Cited by 12 · see citing works
Candemir, E., Post, A. M., Dischinger, U., Palme, R., Slattery, D. A., O’Leary, A., & Reif, A. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111927 · Cited by 12 · see citing works
Bassi, S., Seney, M. L., Argibay, P. F., & Sibille, E. L. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.02.006 · Cited by 11 · see citing works
de Lange, G. M. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1341824 · Cited by 10 · see citing works
Gender-Related Characteristics of Responding to Prolonged Psychoemotional Stress in Mice
Avgustinovich, D. F., & Kovalenko, I. L. (2010) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-010-9252-1 · Cited by 6 · see citing works
The Molecular Landscape of the Developing Human Central Nervous System
Zhu, Y., Silbereis, J. C., Pochareddy, S., Li, M., & Šestan, N. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800105-9.00013-5 · Cited by 1 · see citing works
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Farhane-Medina, N. Z., Luque, B., Tabernero, C., & Castillo-Mayén, R. (2022) · Science Progress · doi:10.1177/00368504221135469 · Cited by 409 · see citing works
“Biological factors Conversely, other studies show that differences in anxiety disorders between sexes may be due to (a) differences in the brain structures involved in emotional regulation, which explain the difference in the processing of negative information,(32,39,68) (b) the fluctuations of sexual hormones that af…”
BackgroundResultMaitra, M., Mitsuhashi, H., Rahimian, R., Chawla, A., Yang, J., Fiori, L. M., Davoli, M. A., Perlman, K., Aouabed, Z., Mash, D. C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38530-5 · Cited by 164 · see citing works
Social dominance mediates behavioral adaptation to chronic stress in a sex-specific manner
Karamihalev, S., Brivio, E., Flachskamm, C., Stoffel, R., Schmidt, M. V., & Chen, A. (2020) · eLife · doi:10.7554/elife.58723 · Cited by 98 · see citing works
Self-citationLópez, J. P., Brivio, E., Santambrogio, A., Donno, C. D., Kos, A., Peters, M., Rost, N., Czamara, D., Brückl, T. M., Roeh, S., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe4497 · Cited by 80 · see citing works
Self-citationA review of sex differences in the mechanisms and drivers of overeating
Anversa, R. G., Muthmainah, M., Sketriené, D., Gogos, A., Sumithran, P., & Brown, R. M. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100941 · Cited by 74 · see citing works
Resilience: Safety in the Aftermath of Traumatic Stressor Experiences
Matheson, K., Asokumar, A., & Anisman, H. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.596919 · Cited by 63 · see citing works
Genome-wide Signatures of Early-Life Stress: Influence of Sex
Parel, S. T., & Peña, C. J. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.010 · Cited by 56 · see citing works
Vegetarian diet and depression scores: A meta-analysis
Ocklenburg, S., & Borawski, J. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.07.098 · Cited by 49 · see citing works
Dramatic outcomes in epilepsy: depression, suicide, injuries, and mortality
Mesraoua, B., Deleu, D., Hassan, A. H., Melikyan, G., Lubna, A., Ali, M. A., Tomson, T., Khalil, B. A., Cross, J. H., & Asadi‐Pooya, A. A. (2020) · Current Medical Research and Opinion · doi:10.1080/03007995.2020.1776234 · Cited by 45 · see citing works
Olave, F. A., Aguayo, F. I., Román-Albasini, L., Corrales, W. A., Silva, J. P., González, P. I., Lagos, S., García-Pérez, M. A., Alarcón-Mardones, M., Rojas, P. S., et al. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100440 · Cited by 41 · see citing works
Kwon, D. Y., Xu, B., Zhao, Y.-T., Beagan, J. A., Beagan, J. A., Cui, Y., Xu, B., Zaitseva, D., Phillips‐Cremins, J. E., Blendy, J. A., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27571-3 · Cited by 38 · see citing works
Nordman, J. C., Ma, X., & Li, Z. (2020) · eNeuro · doi:10.1523/eneuro.0147-20.2020 · Cited by 36 · see citing works
The penalty of stress ‐ Epichaperomes negatively reshaping the brain in neurodegenerative disorders
Ginsberg, S. D., Joshi, S., Sharma, S., Guzman, G., Wang, T., Arancio, O., & Chiosis, G. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15525 · Cited by 36 · see citing works
Brain activation elicited by acute stress: An ALE meta-analysis
Qiu, Y., Fan, Z., Zhong, M., Yang, J., Wu, K., Hu, H., Zhang, R., Guo, Y. Q., Lee, T. M. C., & Huang, R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.020 · Cited by 35 · see citing works
Translational models of stress and resilience: An applied neuroscience methodology review
Albayrak, Z. S., Vaz, A., Bordes, J., Ünlü, S., Sep, M. S. C., Vinkers, C. H., Pinto, L., & Eser, H. Y. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104064 · Cited by 39 · see citing works
van Doeselaar, L., Stark, T., Mitra, S., Yang, H., Bordes, J., Stolwijk, L., Engelhardt, C., Kovarova, V., Narayan, S., Brix, L. M., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300722120 · Cited by 30 · see citing works
Landscape transcriptomics as a tool for addressing global change effects across diverse species
Keagy, J. C., Drummond, C. P., Gilbert, K. J., Grozinger, C. M., Hamilton, J. A., Hines, H. M., Lasky, J. R., Logan, C. A., Sawers, R. J. H., & Wagner, T. (2023) · Molecular Ecology Resources · doi:10.1111/1755-0998.13796 · Cited by 31 · see citing works
Brivio, E., Kos, A., Ulivi, A. F., Karamihalev, S., Ressle, A., Stoffel, R., Hirsch, D., Stelzer, G., Schmidt, M. V., López, J. P., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112874 · Cited by 33 · see citing works
Self-citationZoicas, I., Mühle, C., Schmidtner, A. K., Gulbins, E., Neumann, I. D., & Kornhuber, J. (2020) · Cells · doi:10.3390/cells9051239 · Cited by 29 · see citing works
Moore, S. R., Halldorsdottir, T., Martins, J., Lucae, S., Müller‐Myhsok, B., Müller, N. S., Piechaczek, C., Feldmann, L., Freisleder, F. J., Greimel, E., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01756-2 · Cited by 25 · see citing works
Roy, B., & Dwivedi, Y. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105040 · Cited by 25 · see citing works
Huzard, D., Rappeneau, V., Meijer, O. C., Touma, C., Arango-Lievano, M., Garabedian, M. J., & Jeanneteau, F. D. (2020) · Stress · doi:10.1080/10253890.2020.1806226 · Cited by 23 · see citing works
Sex effects in the interaction of acute stress and pain perception
Geva, N., Golan, S., Pinchas, L., & Defrin, R. (2022) · Pain · doi:10.1097/j.pain.0000000000002743 · Cited by 22 · see citing works
Lorello, G., Gautam, M., Barned, C., & Peer, M. (2021) · Anaesthesia · doi:10.1111/anae.15360 · Cited by 18 · see citing works
Counterbalanced microcircuits for Orx1 and Orx2 regulation of stress reactivity
Yaeger, J. D. W., Krupp, K. T., Gale, J., & Summers, C. H. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100059 · Cited by 20 · see citing works
Zhang, X., Eladawi, M. A., Ryan, W. G., Fan, X., Prevoznik, S., Devale, T., Ramnani, B., Malathi, K., Sibille, E. L., McCullumsmith, R. E., et al. (2023) · PNAS Nexus · doi:10.1093/pnasnexus/pgad299 · Cited by 18 · see citing works
Addressing the gender paradox: Effective suicide prevention strategies for women
Qu, D., Zhu, A., & Chen, R. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101613 · Cited by 22 · see citing works
Gender differences in anxiety response to high intensity white noise in rats
Gogokhia, N., Japaridze, N. J., Tizabi, Y., Pataraya, L., & Zhvania, M. G. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135543 · Cited by 18 · see citing works
Gender Differences in Perceived Stress and Its Relationship to Telomere Length in Costa Rican Adults
Méndez-Chacón, E. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.712660 · Cited by 19 · see citing works
Increasing resolution in stress neurobiology: from single cells to complex group behaviors
Miranda, L., Bordes, J., Gasperoni, S., & López, J. P. (2023) · Stress · doi:10.1080/10253890.2023.2186141 · Cited by 15 · see citing works
Wang, J., Zhao, H., & Girgenti, M. J. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.02.012 · Cited by 15 · see citing works
Helman, T., Headrick, J., Vider, J., Peart, J. N., & Stapelberg, N. J. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25115 · Cited by 13 · see citing works
Dinçkol, Ö., Wenger, N. H., Zachry, J. E., & Kutlu, M. G. (2023) · Scientific Reports · doi:10.1038/s41598-023-49686-x · Cited by 12 · see citing works
Genomic factors underlying sex differences in trauma-related disorders
Ponomareva, O. Y., & Ressler, K. J. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100330 · Cited by 14 · see citing works
Swanberg, K. M., Campos, L., Abdallah, C. G., & Juchem, C. (2022) · Chronic Stress · doi:10.1177/24705470221128004 · Cited by 14 · see citing works
Iacono, L. L., Mancini, C., Babicola, L., Pietrosanto, M., Segni, M. D., D’Addario, S. L., Municchi, D., Ielpo, D., Pascucci, T., Cabib, S., et al. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100406 · Cited by 12 · see citing works
Sex differences in mechanisms of disease
Shansky, R. M. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12646 · Cited by 13 · see citing works
Degroat, T. J., Wiersielis, K. R., Denney, K. A., Kodali, S., Daisey, S., Tollkuhn, J., Samuels, B., & Roepke, T. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106920 · Cited by 11 · see citing works
Zhou, Z., Jiang, P., Zhang, P., Lin, X., Zhao, Q., Wen, X., Lin, X., Wang, Y., Yang, Y. F., Jiang, X., et al. (2022) · International Journal of Clinical Oncology · doi:10.1007/s10147-022-02206-9 · Cited by 11 · see citing works
Mancha-Gutiérrez, H. M., Estrada-Camarena, E. M., Mayagoitia-Novales, L., López-Pacheco, E., & López‐Rubalcava, C. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.734054 · Cited by 12 · see citing works
Interactions Between Experience, Genotype and Sex in the Development of Individual Coping Strategies
Ventura, R., Cabib, S., Babicola, L., Andolina, D., Segni, M. D., & Orsini, C. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.785739 · Cited by 11 · see citing works
Rodriguez‐Zas, S. L., Southey, B. R., Rymut, H. E., Rund, L. A., & Johnson, R. W. (2022) · Genes · doi:10.3390/genes14010077 · Cited by 11 · see citing works
Muráni, E., Trakooljul, N., Hadlich, F., Ponsuksili, S., & Wimmers, K. (2021) · Neuroendocrinology · doi:10.1159/000516500 · Cited by 10 · see citing works
Machado, A. G., Silveira, A. C. S., Peres, A. M., Pereira, N. D. S. C., Trindade, A. A., Lúcio, J. A., Lampert, C., August, P. M., Lobo, P. M. S., Jorge, R. O., et al. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2021.1929766 · Cited by 9 · see citing works
Tejos‐Bravo, M., Oakley, R. H., Whirledge, S., Corrales, W. A., Silva, J. P., García‐Rojo, G., Toledo, J. A., Sánchez, W. N., Román-Albasini, L., Aliaga, E., et al. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100306 · Cited by 9 · see citing works
Iqbal, J., Huang, G.-D., Shen, D., Xue, Y.-X., Yang, M., & Jia, X. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1472194 · Cited by 8 · see citing works
Higher Plasma Fibrinogen Level at Admission Is Associated with Post-Stroke Depression at Discharge
Zhu, J., Wang, L., Shao, H., Tang, X., Zhang, L., Zhou, Y., Jiang, Y., Fang, Q., & Cai, X. (2022) · Brain Sciences · doi:10.3390/brainsci12081032 · Cited by 8 · see citing works
Davidson, T., Palarino, J. V., Goode, J. A., & Boardman, J. D. (2021) · Social Science & Medicine · doi:10.1016/j.socscimed.2021.113766 · Cited by 8 · see citing works
Lim, A., Pasini, M., Yun, S., Gill, J., & Koirala, B. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.08.027 · Cited by 8 · see citing works
Accounting Faculty mental health: coping strategies against stress,
Nascimento, E. M., Garcia, M. C., & Cornacchione, E. B. (2021) · Revista Contabilidade & Finanças · doi:10.1590/1808-057x202113960 · Cited by 6 · see citing works
Kim, Y., & Lee, W. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.03.015 · Cited by 6 · see citing works
Vargas, Y., de Oca, M. P.-M., Sánchez‐Jaramillo, E., Jaimes-Hoy, L., Sánchez-Islas, E., Uribe, R. M., Joseph‐Bravo, P., & Charli, J. (2022) · Brain Research · doi:10.1016/j.brainres.2022.148083 · Cited by 5 · see citing works
The long-lasting effects of early life adversities are sex dependent: The signature of miR-34a
D’Addario, S. L., Municchi, D., Mancini, C., Ielpo, D., Babicola, L., Segni, M. D., Iacono, L. L., Ferlazzo, F., Cifani, C., Andolina, D., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.11.035 · Cited by 5 · see citing works
Zhu, W., Li, Y., Ma, X., Yang, H., Wang, Z., Shi, R., Shi, W., & Cong, B. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.1074999 · Cited by 7 · see citing works
Ruat, J., dos Santos, A. H., Heinz, D. E., Nemcova, P., Stoffel, R., Deussing, J. M., Chen, A., & Wotjak, C. T. (2021) · Genes Brain & Behavior · doi:10.1111/gbb.12775 · Cited by 8 · see citing works
Self-citationDonno, C. D., López, J. P., Luecken, M. D., Kos, A., Brivio, E., Bordes, J., Yang, H., Deussing, J. M., Schmidt, M. V., Theis, F. J., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-025-03417-y · Cited by 4 · see citing works
Self-citationA terrified-sound stress causes cognitive impairment in female mice by impairing neuronal plasticity
Gao, S., Zhang, L., Wang, X., Li, R., Han, L., Xiong, X., Jiang, Q., Cheng, D., Xiao, X., Li, H., et al. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148419 · Cited by 4 · see citing works
Yang, M., Tian, S., Han, X., Xu, L., You, J., Wu, M., Cao, Y., Jiang, Y., Zheng, Z., Liu, J., et al. (2024) · Gene · doi:10.1016/j.gene.2024.148966 · Cited by 4 · see citing works
Yamauchi, T., Takahashi, K., Yoshioka, T., Yamada, D., Nakano, Y., Kasai, S., Iriyama, S., Yoshizawa, K., Nishino, S., Miyazaki, S., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-87036-1 · Cited by 4 · see citing works
Distinct behavioural and neurovascular signatures induced by acute and chronic stress in rats
Simões, D. M., Carreira, J., Henriques, A., Gaspar, R., Sanches, E. S., Baptista, F. I., & Silva, A. P. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115706 · Cited by 3 · see citing works
Towards a biochemical approach to occupational stress management
Shackleton, G. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07175 · Cited by 4 · see citing works
Anxiety disorders in the Middle East and North Africa region; 1990 to 2021
Aletaha, R., Kolahi, A., Mousavi, Z. A., Sullman, M. J. M., & Safiri, S. (2025) · Acta Neuropsychiatrica · doi:10.1017/neu.2025.10023 · Cited by 2 · see citing works
Echoes of stress: From molecular whispers to social thunderstorms
López, J. P. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100766 · Cited by 2 · see citing works
Faraji, J., Schatz, N. A., King, S. E., Soltanpour, N., & Metz, G. A. S. (2025) · Current Zoology · doi:10.1093/eep/dvaf031 · Cited by 2 · see citing works
Zinkina, J. V., Butovskaya, M., Shulgin, S. G., & Korotayev, A. (2024) · Social Evolution & History · doi:10.30884/seh/2024.01.04 · Cited by 2 · see citing works
Harro, J. (2022) · Neuromethods · doi:10.1007/978-1-0716-2748-8_1 · Cited by 2 · see citing works
A posterior hypothalamic to midbrain circuit orchestrating nociceptive behaviours in male mice
Ma, Y., Liu, H., Zhao, W.-N., Li, Q., Gao, P., Han, X., Chaudhury, D., Wang, F., Liu, H., Yu, W., et al. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70227 · Cited by 1 · see citing works
Timusheva, N. S., Shaposhnikov, M. V., Николаевна, П. Е., & Moskalev, A. (2025) · Molecular Biology · doi:10.1134/s0026893325700414 · Cited by 1 · see citing works
Lipshutz, S. E., Bentz, A. B., Cochran, E. B., Krajcir, K. J., Kimball, M. G., & Lattin, C. R. (2025) · Molecular Ecology · doi:10.1111/mec.70221 · Cited by 1 · see citing works
Yaeger, J. D. W., John, M. M., Ledesma, L. J., Greschke, T. L., Gale, J. J., Meyer, L. S., Brummels, R. A., Korzan, W. J., Waters, R. P., & Summers, C. H. (2026) · Biology of Sex Differences · doi:10.1186/s13293-026-00858-0 · Cited by 1 · see citing works
Sex-specific neural activation in response to acute and chronic restraint stress in mice
Li, A.-J., McGraw, M., Landsparger, H., Benjamin, L., & Qualls‐Creekmore, E. (2026) · Physiology & Behavior · doi:10.1016/j.physbeh.2026.115334 · Cited by 1 · see citing works
Wajda, N., & Tkaczewska, J. (2026) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2026.105748 · Cited by 1 · see citing works
Epigenetic Adaptation to Local Ecologies as a First Step toward Gene: Culture Co-evolution
Ragsdale, G., & Foley, R. (2022) · Springer eBooks · doi:10.1007/978-3-031-13771-6_8 · Cited by 1 · see citing works
Zavgorodnii, I., Thielmann, B., Літовченко, О. Л., Zabashta, V., Kapustnyk, V. A., Schwarze, R., & Böckelmann, I. (2024) · Healthcare · doi:10.3390/healthcare12232356 · Cited by 1 · see citing works
Alabdulkarem, K. B., Alshammari, G. M., Alyousef, A. A., MOHAMMED, M. A., Fattiny, S. Z. A., Alqahtani, I. Z., & Yahya, M. A. (2024) · Healthcare · doi:10.3390/healthcare12232419 · Cited by 2 · see citing works
A Terrified Sound Stress Impairs Learning And Memory Ability of Adult FemalePreprint
Gao, S., Zhang, L., Wang, X., Han, L., Xiao, X., Xiong, X., Li, R., Ni, L., & Yang, J. (2021) · Research Square · doi:10.21203/rs.3.rs-1081663/v1
Stressors: Psychological and neurobiological processes
Anisman, H., & Kusnecov, A. W. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91904-3.00005-7
Neuroendocrine Mechanisms of Depression
Binder, E. B., & Deussing, J. M. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197640654.003.0033
Opsasnick, L. A., Zhao, W., Schmitz, L., Ratliff, S. M., Faul, J. D., Zhou, X., Needham, B. L., & Smith, J. A. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.100994
Muyeed, A., Bhuiyan, M. L., Rumi, M. H., Talukder, A., & Rahman, R. (2025) · Research Square · doi:10.21203/rs.3.rs-5699580/v1
Sex-Specific Neural Adaptations to Acute and Chronic Restraint Stress in MicePreprint
Li, A., McGraw, M., Landsparger, H., Benjamin, L., & Qualls‐Creekmore, E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.20.655203
Bridging the gap: Ghrelin and the female stress response to acute non-discriminatory social defeat
MacAulay, B., Smith, A., & Abizaid, A. B. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.07.018
Bhamidi, S., Sunderland, G. R., Southey, B. R., Villamil, M. B., Johnson, R. W., & Rodriguez‐Zas, S. L. (2025) · Genes Brain & Behavior · doi:10.1111/gbb.70036
Asch, R., Martin, N. H., García-Milian, R., Fowles, K., Dileone, R., Cai, Z., Liston, C. M., & Esterlis, I. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.09.021 · Cited by 1 · see citing works
In-hospital psychological stress and post-hospital outcomes
Ford, D. M., Lawton, R., Teale, E. A., & O'Connor, D. B. (2026) · Journal of Health Psychology · doi:10.1177/13591053251398884
Muyeed, A., Bhuiyan, M. L., Rumi, M. H., Talukder, A., & Rahman, R. (2026) · Discover Psychology · doi:10.1007/s44202-026-00677-9
Milewski, T. M., Mahach, K. M., Miller-Crews, I., Hofmann, H. A., & Curley, J. P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.30.721920
A female-specific role for Slit1 in prenatal stress-induced depression vulnerability
Xu, K., Chen, T., Yang, Y., Liu, W., Guo, H., Gong, Z., Ma, X., Liu, J., Lu, Y., Zhang, H., et al. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e00916
Doostparast, A., Kermani, B., Semnani, F., Ghandhari, M., Zarei‐Ghanavati, S., & Eslampoor, A. (2026) · Clinical ophthalmology · doi:10.2147/opth.s552382
Prefrontal-medullary circuitry is necessary for sex-specific responses to metabolic stress in rats
Dearing, C. G., Lukinic, E., McCartney, C., Pace, S. A., & Myers, B. (2026) · Endocrinology · doi:10.1210/endocr/bqag071
Neurotrophic Glucocorticoid Signalling
Jeanneteau, F. D. (2026) · Receptors · doi:10.3390/receptors5030024
Hisey, E. E., Beatty, Z. G., Otten, J., Klengel, C., Dillmann, L. J., Mayeaux, M. R., Kearney, M. G., Hartmann, J., Carlezon, W. A., Klengel, T., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03829-4
Kirazoğlu, M. İ., Bıçkıcı, M. M., Koç, A. E., Özmen, E. S., & Sarı, Y. (2026) · Akdeniz Medical Journal · doi:10.53394/akd.1760526
Refosco, A., Geelhaar, L., Daniel, D. B., Solhaug, A., Eriksen, G. S., Smeland, H. Y., Lied, G. A., Goksøyr, A., Kögel, T., & Dierkes, J. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.129255
- Authors
- Brivio, E., Lopez, J. P., & Chen, A.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Department of Stress Neurobiology and Neurogenetics Max Planck Institute of Psychiatry Munich Germany
- Corresponding author
- Chen, Alon
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2020-02-06
- Volume
- 19
- Issue
- 3
- Pages
- e12643-e12643
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W3003701482
- Cited by
- 95
- References
- 159
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 8 · 2023: 11 · 2022: 15 · 2021: 20 · 2020: 11
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Genes Brain & Behavior (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- H2020 European Research Council (260463)
- Alexander von Humboldt-Stiftung
- European Molecular Biology Organization (EMBO‐ALTF 650‐2016)
- Pratt Foundation
- Nella and Leon Benoziyo Center for Neurological Diseases, Weizmann Institute of Science
- Bundesministerium für Bildung und Forschung (01KU1501A)
- Israel Science Foundation (1565/15, 1916/12)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- sex differences, sexual dimorphism, stress-related disorders, gene expression signatures, stress response, brain transcriptomics, sex as a biological variable, rodent models, major depressive disorder, post-traumatic stress disorder, anxiety disorders, stress vulnerability, sex-specific gene regulation
- MeSH terms
- Animals, Brain, Female, Humans, Male, Sex Characteristics, Stress, Psychological, Transcriptome
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