Boosting Slow Oscillations during Sleep to Improve Memory Function in Elderly People: A Review of the Literature
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Sleep represents a crucial time window for the consolidation of memory traces. In this view, some brain rhythms play a pivotal role, first of all the sleep slow waves. In particular, the neocortical slow oscillations (SOs), in coordination with the hippocampal ripples and the thalamocortical spindles, support the long-term storage of the declarative memories. The aging brain is characterized by a disruption of this complex system with outcomes on the related cognitive functions. In recent years, the advancement of the comprehension of the sleep-dependent memory consolidation mechanisms has encouraged the development of techniques of SO enhancement during sleep to induce cognitive benefits. In this review, we focused on the studies reporting on the application of acoustic or electric stimulation procedures in order to improve sleep-dependent memory consolidation in older subjects. Although the current literature is limited and presents inconsistencies, there is promising evidence supporting the perspective to non-invasively manipulate the sleeping brain electrophysiology to improve cognition in the elderly, also shedding light on the mechanisms underlying the sleep-memory relations during healthy and pathological aging.
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Closed-loop auditory stimulation has shown promise with clinical populations including people with schizophrenia, older adults, and children with ADHD.
“For example, closed-loop auditory stimulation has shown promise with clinical populations including people with schizophrenia [32] older adults [33], and children with ADHD [34].”
From Sleep and memory consolidation in healthy, neurotypical children, and adults: a summary of systematic reviews and meta-analyses. (2023) · cites this paper as [33]
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- Authors
- Salfi, F., D’Atri, A., Tempesta, D., De Gennaro, L., & Ferrara, M.
- Affiliations
- University of L'Aquila (IT)
- Sapienza University of Rome (IT)
- Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy
- Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
- Venue
- Brain Sciences
- Publisher
- MDPI AG
- Published
- 2020-05-15
- Volume
- 10
- Issue
- 5
- Pages
- 300
- ISSN
- 2076-3425 (ISSN-L)
- PMC
- PMC7287854
- OpenAlex
- W3024065707
- Cited by
- 36
- References
- 87
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Brain Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sleep slow oscillations, sleep-dependent memory consolidation, brain aging, hippocampal ripples, non-invasive brain stimulation
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