Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732

Ferroptosis as a p53-mediated activity during tumour suppression

Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2238 · Cited by 3,029

Autophagy promotes ferroptosis by degradation of ferritin

Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2016) · Autophagy · doi:10.1080/15548627.2016.1187366 · Cited by 2,332

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Yang, W. S., Kim, K. J., Gaschler, M. M., Patel, M., Shchepinov, M. S., & Stockwell, B. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603244113 · Cited by 2,329

Two to tango: Regulation of Mammalian iron metabolism

Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W., & Kimmelman, A. C. (2014) · Nature · doi:10.1038/nature13148 · Cited by 2,084

Glutaminolysis and transferrin regulate ferroptosis

Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069

Ferroptosis is an autophagic cell death process

Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., & Jiang, X. (2016) · Cell Research · doi:10.1038/cr.2016.95 · Cited by 1,899

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876

RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A. J., Yang, W. S., Fridman, D. J., Wolpaw, A. J., Smukste, I., Peltier, J. M., Boniface, J. J., et al. (2007) · Nature · doi:10.1038/nature05859 · Cited by 1,631

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Seiler, A., Schneider, M., Förster, H., Roth, S., Wirth, E. K., Culmsee, C., Plesnila, N., Kremmer, E., Rådmark, O., Wurst, W., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.005 · Cited by 1,470

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

Kagan, V. E., Tyurin, V. A., Jiang, J., Tyurina, Y. Y., Ritov, V. B., Amoscato, A. A., Osipov, A. N., Belikova, N. A., Kapralov, A. A., Kini, V., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio727 · Cited by 1,256

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Skouta, R., Dixon, S. J., Wang, J., Dunn, D. E., Orman, M., Shimada, K., Rosenberg, P. A., Lo, D. C., Weinberg, J. M., Linkermann, A., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411006a · Cited by 1,146

Synchronized renal tubular cell death involves ferroptosis

Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.-S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415518111 · Cited by 1,126

Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins

Sato, H., Tamba, M., Ishii, T., & Bannai, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11455 · Cited by 1,109

Identification of ACSL4 as a biomarker and contributor of ferroptosis

Yuan, H., Li, X., Zhang, X., Kang, R., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.124 · Cited by 1,071

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Dixon, S. J., Winter, G. E., Musavi, L. S., Lee, E. D., Snijder, B., Rebsamen, M., Superti-Furga, G., & Stockwell, B. R. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00245 · Cited by 1,043

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Shimada, K., Skouta, R., Kaplan, A., Yang, W. S., Hayano, M., Dixon, S. J., Brown, L. M., Valenzuela, C. A., Wolpaw, A. J., & Stockwell, B. R. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2079 · Cited by 1,017

Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells

Imai, H., & Nakagawa, Y. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01197-8 · Cited by 767

Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

Ou, Y., Wang, S.-J., Li, D., Chu, B., & Gu, W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607152113 · Cited by 765

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Dowdle, W. E., Nyfeler, B., Nagel, J., Elling, R. A., Liu, S., Triantafellow, E., Menon, S., Wang, Z., Honda, A., Pardee, G., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3053 · Cited by 759

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G. W., & Kopf, M. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20140857 · Cited by 672

HSPB1 as a novel regulator of ferroptotic cancer cell death

Sun, X., Ou, Z., Xie, M., Kang, R., Fan, Y., Niu, X., Wang, H., Cao, L., & Tang, D. (2015) · Oncogene · doi:10.1038/onc.2015.32 · Cited by 666

Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc− cystine transporter: a new action for an old drug

Gout, P., Buckley, A., Simms, C., & Bruchovsky, N. (2001) · Leukemia · doi:10.1038/sj.leu.2402238 · Cited by 640

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

Kwon, M.-Y., Park, E., Lee, S.-J., & Chung, S. W. (2015) · Oncotarget · doi:10.18632/oncotarget.5162 · Cited by 612

Iron‐dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

Louandre, C., Ezzoukhry, Z., Godin, C., Barbare, J., Mazière, J., Chauffert, B., & Galmiche, A. (2013) · International Journal of Cancer · doi:10.1002/ijc.28159 · Cited by 602

Oxytosis: a novel form of programmed cell death

Shirlee Tan, B. S. P., David Schubert, B. S. P., & Pamela Maher, B. S. P. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013394741 · Cited by 522

Acyl-CoA:Lysophospholipid Acyltransferases

Shindou, H., & Shimizu, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r800046200 · Cited by 478

The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents

Yu, Y., Xie, Y., Cao, L., Yang, L., Yang, M., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1054549 · Cited by 468

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

Wang, S.-J., Li, D., Ou, Y., Jiang, L., Chen, Y., Zhao, Y., & Gu, W. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.022 · Cited by 462

Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors.

Lachaier, E., Louandre, C., Godin, C., Saidak, Z., Baert, M., Diouf, M., Chauffert, B., & Galmiche, A. (2014) · PubMed · Cited by 420

Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis

Nomura, K., Imai, H., Koumura, T., Kobayashi, T., & Nakagawa, Y. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510183 · Cited by 373

Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene

Imai, H., Hirao, F., Sakamoto, T., Sekine, K., Mizukura, Y., Saito, M., Kitamoto, T., Hayasaka, M., Hanaoka, K., & Nakagawa, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00734-4 · Cited by 357

An essential role for functional lysosomes in ferroptosis of cancer cells

Torii, S., Shintoku, R., Kubota, C., Yaegashi, M., Torii, R., Sasaki, M., Suzuki, T., Mori, M., Yoshimoto, Y., Takeuchi, T., et al. (2016) · Biochemical Journal · doi:10.1042/bj20150658 · Cited by 349

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

Schneider, M., Forster, H., Boersma, A., Seiler, A., Wehnes, H., Sinowatz, F., Neumüller, C., Deutsch, M. J., Walch, A., de Angelis, M. H., et al. (2009) · The FASEB Journal · doi:10.1096/fj.09-132795 · Cited by 332

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

Carlson, B. A., Tobe, R., Yefremova, E., Tsuji, P. A., Hoffmann, V. J., Schweizer, U., Gladyshev, V. N., Hatfield, D. L., & Conrad, M. (2016) · Redox Biology · doi:10.1016/j.redox.2016.05.003 · Cited by 316

Oxidative stress and lipotoxicity

Hauck, A. K., & Bernlohr, D. A. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066597 · Cited by 298

Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Plays a Major Role in Preventing Oxidative Injury to Cells

Arai, M., Imai, H., Koumura, T., Yoshida, M., Emoto, K., Umeda, M., Chiba, N., & Nakagawa, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.4924 · Cited by 297

Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Suppresses Apoptosis Mediated by a Mitochondrial Death Pathway

Nomura, K., Imai, H., Koumura, T., Arai, M., & Nakagawa, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29294 · Cited by 285

Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

Hashidate-Yoshida, T., Harayama, T., Hishikawa, D., Morimoto, R., Hamano, F., Tokuoka, S. M., Eto, M., Tamura-Nakano, M., Yanobu-Takanashi, R., Mukumoto, Y., et al. (2015) · eLife · doi:10.7554/elife.06328 · Cited by 270

The Nuclear Form of Phospholipid Hydroperoxide Glutathione Peroxidase Is a Protein Thiol Peroxidase Contributing to Sperm Chromatin Stability

Conrad, M., Moreno, S. G., Sinowatz, F., Ursini, F., Kölle, S., Roveri, A., Brielmeier, M., Wurst, W., Maiorino, M., & Bornkamm, G. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7637-7644.2005 · Cited by 270

NCOA4 deficiency impairs systemic iron homeostasis

Bellelli, R., Federico, G., Matte’, A., Colecchia, D., Iolascon, A., Chiariello, M., Santoro, M., De Franceschi, L., & Carlomagno, F. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.065 · Cited by 248

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

Canli, Ö., Alankuş, Y. B., Grootjans, S., Vegi, N., Hültner, L., Hoppe, P. S., Schroeder, T., Vandenabeele, P., Bornkamm, G. W., & Greten, F. R. (2016) · Blood · doi:10.1182/blood-2015-06-654194 · Cited by 247

Depletion of Selenoprotein GPx4 in Spermatocytes Causes Male Infertility in Mice

Imai, H., Hakkaku, N., Iwamoto, R., Suzuki, J., Suzuki, T., Tajima, Y., Konishi, K., Minami, S., Ichinose, S., Ishizaka, K., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016139 · Cited by 233

Ferroptosis is involved in acetaminophen induced cell death

Lőrincz, T., Jemnitz, K., Kardon, T., Mandl, J., & Szarka, A. (2015) · Pathology & Oncology Research · doi:10.1007/s12253-015-9946-3 · Cited by 219

Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: An update

Yan, S. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i12.3492 · Cited by 219

Failure of the Expression of Phospholipid Hydroperoxide Glutathione Peroxidase in the Spermatozoa of Human Infertile Males1

Imai, H., Suzuki, K., Ishizaka, K., Ichinose, S., Oshima, H., Okayasu, I., Emoto, K., Umeda, M., & Nakagawa, Y. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.2.674 · Cited by 212

The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

Liu, Y., Wang, W., Li, Y., Xiao, Y., Cheng, J., & Jia, J. (2015) · Biological & Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00048 · Cited by 189

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

Tobaben, S., Grohm, J., Seiler, A., Conrad, M., Plesnila, N., & Culmsee, C. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.92 · Cited by 186

Suppression of Leukotriene Formation in RBL-2H3 Cells That Overexpressed Phospholipid Hydroperoxide Glutathione Peroxidase

Imai, H., Narashima, K., Arai, M., Sakamoto, H., Chiba, N., & Nakagawa, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.1990 · Cited by 169

Cardiolipin and Its Different Properties in Mitophagy and Apoptosis

Li, X.-X., Tsoi, B., Li, Y.-F., Kurihara, H., & He, R.-R. (2015) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155415574818 · Cited by 167

Combined Deficiency in Glutathione Peroxidase 4 and Vitamin E Causes Multiorgan Thrombus Formation and Early Death in Mice

Wortmann, M., Schneider, M., Pircher, J., Hellfritsch, J., Aichler, M., Vegi, N., Kölle, P., Kuhlencordt, P., Walch, A., Pohl, U., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.279984 · Cited by 158

Caspase-Independent Cell Death Is Involved in the Negative Effect of EGF Receptor Inhibitors on Cisplatin in Non–Small Cell Lung Cancer Cells

Yamaguchi, H., Hsu, J. L., Chen, C., Wang, Y., Hsu, M., Chang, S.-S., Du, Y., Ko, H., Herbst, R. S., & Hung, M. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2621 · Cited by 133

Glutathione Peroxidase 4 Is Required for Maturation of Photoreceptor Cells

Ueta, T., Inoue, T., Furukawa, T., Tamaki, Y., Nakagawa, Y., Imai, H., & Yanagi, Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.335174 · Cited by 129

Import into Mitochondria of Phospholipid Hydroperoxide Glutathione Peroxidase Requires a Leader Sequence

Arai, M., Imai, H., Sumi, D., Imanaka, T., Takano, T., Chiba, N., & Nakagawa, Y. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1525 · Cited by 129

Cellular protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity

Kang, Y., Tiziani, S., Park, G., Kaul, M., & Paternostro, G. (2014) · Nature Communications · doi:10.1038/ncomms4672 · Cited by 129

Known unknowns of cardiolipin signaling: The best is yet to come

Maguire, J. J., Tyurina, Y. Y., Mohammadyani, D., Kapralov, A. A., Anthonymuthu, T. S., Qu, F., Amoscato, A. A., Sparvero, L. J., Tyurin, V. A., Planas-Iglesias, J., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.08.001 · Cited by 121

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress

Henke, N., Albrecht, P., Bouchachia, I., Ryazantseva, M., Knoll, K., Lewerenz, J., Kaznacheyeva, E. V., Maher, P. A., & Methner, A. (2013) · Cell Death and Disease · doi:10.1038/cddis.2012.216 · Cited by 101

Permeabilization of the Mitochondrial Outer Membrane by Bax/Truncated Bid (tBid) Proteins as Sensitized by Cardiolipin Hydroperoxide Translocation

Korytowski, W., Basova, L., Pilat, A. K., Kernstock, R. M., & Girotti, A. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.188516 · Cited by 92

Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia

Smith, A. C., Mears, A. J., Bunker, R., Ahmed, A., MacKenzie, M., Schwartzentruber, J. A., Beaulieu, C. L., Ferretti, E., FORGE Canada Consortium, Majewski, J., et al. (2014) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2013-102218 · Cited by 87

Targeted Disruption of Glutathione Peroxidase 4 in Mouse Skin Epithelial Cells Impairs Postnatal Hair Follicle Morphogenesis that Is Partially Rescued through Inhibition of COX-2

Sengupta, A., Lichti, U. F., Carlson, B. A., Cataisson, C., Ryscavage, A. O., Mikulec, C. D., Conrad, M., Fischer, S. M., Hatfield, D. L., & Yuspa, S. H. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.52 · Cited by 86

RSL3 and Erastin differentially regulate redox signaling to promote Smac mimetic-induced cell death

Dächert, J., Schoeneberger, H., Rohde, K., & Fulda, S. (2016) · Oncotarget · doi:10.18632/oncotarget.11687 · Cited by 76

Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase Suppressed Cell Death Due to Oxidative Damage in Rat Basophile Leukemia Cells (RBL-2H3)

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Protection from inactivation of the adenine nucleotide translocator during hypoglycaemia-induced apoptosis by mitochondrial phospholipid hydroperoxide glutathione peroxidase

IMAI, H., KOUMURA, T., NAKAJIMA, R., NOMURA, K., & NAKAGAWA, Y. (2003) · Biochemical Journal · doi:10.1042/bj20021342 · Cited by 67

Involvement of Phospholipid Hydroperoxide Glutathione Peroxidase in the Modulation of Prostaglandin D2 Synthesis

Sakamoto, H., Imai, H., & Nakagawa, Y. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003191200 · Cited by 67

Molecular Cloning and Functional Expression of a cDNA for Rat Phospholipid Hydroperoxide Glutathione Peroxidase: 3'-Untranslated Region of the Gene Is Necessary for Functional Expression

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Redox reactions in mammalian spermatogenesis and the potential targets of reactive oxygen species under oxidative stress

Fujii, J., & Imai, H. (2014) · Spermatogenesis · doi:10.4161/21565562.2014.979108 · Cited by 53

Glutathione peroxidase 4 plays an important role in oxidative homeostasis and wound repair in corneal epithelial cells

Sakai, O., Uchida, T., Imai, H., & Ueta, T. (2016) · FEBS Open Bio · doi:10.1002/2211-5463.12141 · Cited by 46

Abnormal Uterus with Polycysts, Accumulation of Uterine Prostaglandins, and Reduced Fertility in Mice Heterozygous for Acyl-CoA Synthetase 4 Deficiency

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Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene

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Role of GPx4 in human vascular endothelial cells, and the compensatory activity of brown rice on GPx4 ablation condition

Sakai, O., Yasuzawa, T., Yoshie, S., Ueta, T., Imai, H., Sawabe, A., & Ueshima, S. (2016) · Pathophysiology · doi:10.1016/j.pathophys.2016.11.002 · Cited by 35

New Strategy of Functional Analysis of PHGPx Knockout Mice Model Using Transgenic Rescue Method and Cre-LoxP System

Imai, H. (2009) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.09-94r · Cited by 32

Identification of the Positive Regulatory and Distinct Core Regions of Promoters, and Transcriptional Regulation in Three Types of Mouse Phospholipid Hydroperoxide Glutathione Peroxidase

Imai, H., Saito, M., Kirai, N., Hasegawa, J., Konishi, K., Hattori, H., Nishimura, M., Naito, S., & Nakagawa, Y. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj186 · Cited by 30

Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase Modulates Acetyl-CoA, 1-O-Alkyl-2-lyso-sn-glycero-3-phosphocholine Acetyltransferase Activity

Sakamoto, H., Tosaki, T., & Nakagawa, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204190200 · Cited by 27

Role of Glutathione Peroxidase 4 in Glutamate-Induced Oxytosis in the Retina

Sakai, O., Uchida, T., Roggia, M. F., Imai, H., Ueta, T., & Amano, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130467 · Cited by 26

Molecular cloning and functional expression of nucleolar phospholipid hydroperoxide glutathione peroxidase in mammalian cells

Nakamura, T., Imai, H., Tsunashima, N., & Nakagawa, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.183 · Cited by 25

Protective Role of Glutathione Peroxidase 4 in Laser-Induced Choroidal Neovascularization in Mice

Roggia, M. F., Imai, H., Shiraya, T., Noda, Y., & Ueta, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098864 · Cited by 23

Role of Glutathione Peroxidase 4 in Conjunctival Epithelial Cells

Sakai, O., Uchida, T., Imai, H., Ueta, T., & Amano, S. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15463 · Cited by 21

Role of Glutathione Peroxidase 4 in Corneal Endothelial Cells

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Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

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GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment

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Current understanding of osteoarthritis pathogenesis and relevant new approaches

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The application of Ferroptosis in diseases

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Inhibition of ferroptosis attenuates tissue damage and improves long‐term outcomes after traumatic brain injury in mice

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