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Cited by 30T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

Longevity of T-Cell Memory following Acute Viral Infection

Walker, Joshua M., Slifka, Mark K.·2010·Advances in Experimental Medicine and Biology
DOI 10.1007/978-1-4419-6451-9_8
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Abstract

Investigation of T-cell-mediated immunity following acute viral infection represents an area of research with broad implications for both fundamental immunology research as well as vaccine development. Here, we review techniques that are used to assess T-cell memory including limiting dilution analysis, enzyme-linked immunospot (ELISPOT) assays, intracellular cytokine staining (ICCS) and peptide-MHC Class I tetramer staining. The durability of T-cell memory is explored in the context of several acute viral infections including vaccinia virus (VV), measles virus (MV) and yellow fever virus (YFV). Following acute infection, different virus-specific T-cell subpopulations exhibit distinct cytokine profiles and these profiles change over the course of infection. Differential regulation of the cytotoxic proteins, granzyme A, granzyme B and perforin are also observed in virus-specific T cells following infection. As a result of this work, we have gained a broader understanding of the kinetics and magnitude of antiviral T-cell immunity as well as new insight into the patterns of immunodominance and differential regulation of cytokines and cytotoxicity-associated molecules. This information may eventually lead to the generation of more effective vaccines that elicit T-cell memory with the optimal combination of functional characteristics required for providing protective immunity against infectious disease.

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Crossref · 10.1007/978-1-4419-6451-9_8

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  • Antigen stimulation from infections results in immunological memory.

    “Besides promoting recovery, such antigen stimulation results in immunological memory [41,42].”

    From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [41]

  • The low number of naive T cells versus T cells is a consequence of reduced thymic output from the involuted thymus.

    “The low number of naive T cells versus T cells [41,42] is a consequence of the reduced thymic output from the involuted thymus.”

    From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [41]

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Authors
Walker, J. M., & Slifka, M. K.
Affiliations
Vaccine and Gene Therapy Institute (US)
Corresponding author
Slifka, Mark K.
ORCID
Venue
Advances in Experimental Medicine and Biology
Publisher
Springer New York
Published
2010
Volume
684
Pages
96-107
ISSN
0065-2598 (ISSN-L)
DOI
10.1007/978-1-4419-6451-9_8
OpenAlex
W2230586685
Cited by
30
References
82
Citations by year
2025: 1 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2012: 2
FWCI
1.84
Type
book chapter
Language
en
Open access
closed
Locations
  • Advances in experimental medicine and biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (AI064843, AI063675, R41AI063675, R21AI064843)
  • National Center for Research Resources (P51RR000163, RR-00163.)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
T cell memory, acute viral infection, T cell immunity, vaccinia virus, measles virus, yellow fever virus, immunodominance, cytokine profile, cytotoxicity, granzyme A, granzyme B, perforin, tetramer staining, ELISPOT, limiting dilution analysis, intracellular cytokine staining
MeSH terms
Animals, Humans, Immunologic Memory, Lymphocyte Activation, Virus Diseases, T-Lymphocyte Subsets

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