General aspects of neurodegeneration

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227 · see citing works

Mechanisms Underlying Ubiquitination

Pickart, C. M. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.503 · Cited by 3,731 · see citing works

Phases of Aβ-deposition in the human brain and its relevance for the development of AD

Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490 · see citing works

Neurodegenerative Tauopathies

Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480 · see citing works

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurdo, J., Taddei, N., Ramponi, G., Dobson, C. M., & Stefani, M. (2002) · Nature · doi:10.1038/416507a · Cited by 2,434 · see citing works

Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

Bence, N., Sampat, R. M., & Kopito, R. R. (2001) · Science · doi:10.1126/science.292.5521.1552 · Cited by 2,192 · see citing works

A Drosophila model of Parkinson's disease

Feany, M., & Bender, W. (2000) · Nature · doi:10.1038/35006074 · Cited by 2,145 · see citing works

α-Synuclein is phosphorylated in synucleinopathy lesions

Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M., Shen, J., Takio, K., & Iwatsubo, T. (2002) · Nature Cell Biology · doi:10.1038/ncb748 · Cited by 1,906 · see citing works

Aggresomes, inclusion bodies and protein aggregation

Kopito, R. R. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01852-3 · Cited by 1,906 · see citing works

Oxidative Damage Is the Earliest Event in Alzheimer Disease

Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885 · see citing works

Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions

Saudou, F., Finkbeiner, S. M., Devys, D., & Greenberg, M. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81782-1 · Cited by 1,598 · see citing works

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., & Lee, V. M. ‐. (2000) · Science · doi:10.1126/science.290.5493.985 · Cited by 1,551 · see citing works

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Götz, J., Chen, F., van Dorpe, J., & Nitsch, R. M. (2001) · Science · doi:10.1126/science.1062097 · Cited by 1,526 · see citing works

Unfolding the role of protein misfolding in neurodegenerative diseases

Soto, C. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1007 · Cited by 1,506 · see citing works

Role of Free Radicals in the Neurodegenerative Diseases: Therapeutic Implications for Antioxidant Treatment

Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502 · see citing works

Mechanisms of Apoptosis

Reed, J. C. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64779-7 · Cited by 1,286 · see citing works

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

Blum, D. L., Torch, S., Lambeng, N., Nissou, M.-F., Benabid, A., Sadoul, R., & Verna, J. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00003-x · Cited by 1,246 · see citing works

Chaperone Suppression of α-Synuclein Toxicity in a <i>Drosophila</i> Model for Parkinson's Disease

Auluck, P. K., Chan, H. Y. E., Trojanowski, J. Q., Lee, V. M.-Y., & Bonini, N. M. (2002) · Science · doi:10.1126/science.1067389 · Cited by 1,227 · see citing works

Metal-triggered Structural Transformations, Aggregation, and Fibrillation of Human α-Synuclein

Uversky, V. N., Li, J., & Fink, A. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105343200 · Cited by 1,103 · see citing works

Neurotoxicity induces cleavage of p35 to p25 by calpain

Lee, M.-S., Kwon, Y. T., Li, M., Peng, J., Friedlander, R. M., & Tsai, L. (2000) · Nature · doi:10.1038/35012636 · Cited by 1,057 · see citing works

Ubiquitination of a new form of α-synuclein by parkin from human brain: implications for Parkinson's disease

Shimura, H., Schlossmacher, M. G., Hattori, N., Frosch, M. P., Trockenbacher, A., Schneider, R., Mizuno, Y., Kosik, K. S., & Selkoe, D. J. (2001) · Science · doi:10.1126/science.1060627 · Cited by 1,053 · see citing works

What does it mean to be natively unfolded?

Uversky, V. N. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02649.x · Cited by 985 · see citing works

Cellular Defenses against Unfolded Proteins

Sherman, M. Y., & Goldberg, A. L. (2001) · Neuron · doi:10.1016/s0896-6273(01)00177-5 · Cited by 984 · see citing works

Ataxin-1 Nuclear Localization and Aggregation

Klement, I. A., Skinner, P. J., Kaytor, M. D., Yi, H. L., Hersch, S. M., Clark, H. B., Zoghbi, H. Y., & Orr, H. T. (1998) · Cell · doi:10.1016/s0092-8674(00)81781-x · Cited by 956 · see citing works

Calpain and caspase: can you tell the difference?

Wang, K. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01479-4 · Cited by 912 · see citing works

Amyloid β-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A Review

Allan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786 · see citing works

A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome

Zhou, B., Westaway, S. K., Levinson, B., Johnson, M., Gitschier, J. M., & Hayflick, S. J. (2001) · Nature Genetics · doi:10.1038/ng572 · Cited by 756 · see citing works

Dementia with Lewy bodies.

McKeith, I. G. (2004) · Europe PMC (PubMed Central) · Cited by 756 · see citing works

Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression

Griffin, W., Sheng, J. G., Royston, M., Gentleman, S., McKenzie, J., Graham, D. I., Roberts, G., & Mrak, R. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00136.x · Cited by 751 · see citing works

α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress

Hsu, L. J., Sagara, Y., Arroyo, A., Rockenstein, E. M., Sisk, A., Mallory, M. E., Wong, J., Takenouchi, T., Hashimoto, M., & Masliah, E. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64553-1 · Cited by 716 · see citing works

Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

Takahashi, R. H., Milner, T. A., Li, F., Nam, E. E., Edgar, M. A., Yamaguchi, H., Beal, M. F., Xu, H., Greengard, P., & Gouras, G. K. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64463-x · Cited by 706 · see citing works

Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease

Gao, H., Jiang, J., Wilson, B. C., Zhang, W., Hong, J., & Liu, B. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00928.x · Cited by 690 · see citing works

The Herbicide Paraquat Causes Up-regulation and Aggregation of α-Synuclein in Mice

Manning-Bog, A., McCormack, A. L., Li, J., Uversky, V. N., Fink, A. L., & Monte, D. A. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100560200 · Cited by 684 · see citing works

Parkinson's Disease Is Associated with Oxidative Damage to Cytoplasmic DNA and RNA in Substantia Nigra Neurons

Zhang, J., Perry, G. L., Smith, M. A., Robertson, D., Olson, S. J., Graham, D. G., & Montine, T. J. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65396-5 · Cited by 636 · see citing works

Chemistry and Biochemistry of Oxidative Stress in Neurodegenerative Disease

Sayre, L. M., Smith, M. A., & Perry, G. L. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013372922 · Cited by 614 · see citing works

β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

Masliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., & Mucke, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211412398 · Cited by 607 · see citing works

A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis

Perez, R. G., Waymire, J. C., Lin, E., Liu, J. J., Guo, F., & Zigmond, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03090.2002 · Cited by 598 · see citing works

Altered proteasomal function in sporadic Parkinson’s disease

St. P. McNaught, K., Belizaire, R., Isacson, O., Jenner, P., & Olanow, C. W. (2003) · Experimental Neurology · doi:10.1006/exnr.2002.8050 · Cited by 573 · see citing works

Failure of the ubiquitin-proteasome system in Parkinson’s disease

McNaught, K. S. P., Olanow, C. W., Halliwell, B., Isacson, O., & Jenner, P. (2001) · Nature Reviews Neuroscience · doi:10.1038/35086067 · Cited by 519 · see citing works

Alzheimer's disease – do tauists and baptists finally shake hands?

Mudher, A. K., & Lovestone, S. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02031-2 · Cited by 512 · see citing works

Energetics in the pathogenesis of neurodegenerative diseases

Beal, M. F. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01584-8 · Cited by 472 · see citing works

Synucleinopathies

Galvin, J. E., Lee, V. M. ‐., & Trojanowski, J. Q. (2001) · Archives of Neurology · doi:10.1001/archneur.58.2.186 · Cited by 466 · see citing works

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

Lassmann, H., Bancher, C., Breitschopf, H., Węgiel, J., Bobinski, M., Jellinger, K. A., & Wı́sniewski, H. M. (1995) · Acta Neuropathologica · doi:10.1007/bf00294257 · Cited by 458 · see citing works

Is there a cause-and-effect relationship between α-synuclein fibrillization and Parkinson’s disease?

Goldberg, M. S., & Lansbury, P. T. (2000) · Nature Cell Biology · doi:10.1038/35017124 · Cited by 456 · see citing works

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

Stadelmann, C., Deckwerth, T., Srinivasan, A., Bancher, C., Brück, W., Jellinger, K. A., & Lassmann, H. (1999) · American Journal of Pathology · doi:10.1016/s0002-9440(10)65460-0 · Cited by 449 · see citing works

The ubiquitin‐proteasome pathway and proteasome inhibitors

Myung, J., Kim, K. B., & Crews, C. M. (2001) · Medicinal Research Reviews · doi:10.1002/med.1009 · Cited by 447 · see citing works

Ubiquitin Conjugation Is Not Required for the Degradation of Oxidized Proteins by Proteasome

Shringarpure, R., Grune, T., Mehlhase, J., & Davies, K. J. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206279200 · Cited by 438 · see citing works

Histological Evidence of Protein Aggregation in Mutant SOD1 Transgenic Mice and in Amyotrophic Lateral Sclerosis Neural Tissues

Watanabe, M., Dykes‐Hoberg, M., Culotta, V., Price, D. L., Wong, P. C., & Rothstein, J. D. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0443 · Cited by 432 · see citing works

Phosphorylated α-Synuclein Is Ubiquitinated in α-Synucleinopathy Lesions

Hasegawa, M., Fujiwara, H., Nonaka, T., Wakabayashi, K., Takahashi, H., Lee, V. M.-Y., Trojanowski, J. Q., Mann, D., & Iwatsubo, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208046200 · Cited by 428 · see citing works

The impact of systemic infection on the progression of neurodegenerative disease

Perry, V. H., Newman, T. A., & Cunningham, C. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1032 · Cited by 428 · see citing works

Increased Caspase 3 and Bax Immunoreactivity Accompany Nuclear GAPDH Translocation and Neuronal Apoptosis in Parkinson's Disease

Tatton, N. A. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7489 · Cited by 411 · see citing works

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA

Reddy, P. H., Williams, M., Charles, V., Garrett, L. J., Pike-Buchanan, L., Whetsell, W. O., Miller, G., & Tagle, D. A. (1998) · Nature Genetics · doi:10.1038/2510 · Cited by 399 · see citing works

Glutathione, iron and Parkinson’s disease

Bharath, S., Hsu, M., Kaur, D., Rajagopalan, S., & Andersen, J. K. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01174-7 · Cited by 394 · see citing works

Loss of normal huntingtin function: new developments in Huntington's disease research

Cattaneo, E. F. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01721-5 · Cited by 383 · see citing works

Redox-active iron mediates amyloid-β toxicity

Rottkamp, C. A., Raina, A. K., Zhu, X., Gaier, E., Bush, A. I., Atwood, C., Chevion, M., Perry, G. L., & Smith, M. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00494-9 · Cited by 376 · see citing works

Sequence of Aβ-protein deposition in the human medial temporal lobe

Thal, D. R., Rüb, U., Schultz, C., Sassin, I., Ghebremedhin, E., Del Tredici, K., Braak, E., & Braak, H. (2000) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1093/jnen/59.8.733 · Cited by 370 · see citing works

Neurons May Live for Decades with Neurofibrillary Tangles

Morsch, R., Simon, W., & Coleman, P. D. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199902000-00008 · Cited by 370 · see citing works

Iron misregulation in the brain: a primary cause of neurodegenerative disorders

Ke, Y., & Qian, Z. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00353-3 · Cited by 339 · see citing works

Protein misfolding and disease; protein refolding and therapy

Soto, C. A. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02486-3 · Cited by 339 · see citing works

Parkin Localizes to the Lewy Bodies of Parkinson Disease and Dementia with Lewy Bodies

Schlossmacher, M. G., Frosch, M. P., Gai, W., Medina, M., Sharma, N., Forno, L. S., Ochiishi, T., Shimura, H., Sharon, R., Hattori, N., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61113-3 · Cited by 324 · see citing works

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila

Chan, H. Y. E. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.19.2811 · Cited by 322 · see citing works

Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease

Yamamoto, A., Shin, R., Hasegawa, K., Naiki, H., Sato, H., Yoshimasu, F., & Kitamoto, T. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.t01-1-01061.x · Cited by 313 · see citing works

A one-hit model of cell death in inherited neuronal degenerations

Clarke, G. D., Collins, R. A., Leavitt, B. R., Andrews, D. F., Hayden, M. R., Lumsden, C. J., & McInnes, R. R. (2000) · Nature · doi:10.1038/35018098 · Cited by 303 · see citing works

Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease

Albers, D. S., & Beal, M. F. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6781-6_16 · Cited by 297 · see citing works

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

Trojanowski, J. Q., Goedert, M., Iwatsubo, T., & Lee, V. M. ‐. (1998) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400432 · Cited by 297 · see citing works

Regulation of Transcription by Ubiquitination without Proteolysis

Kaiser, P., Flick, K. M., Wittenberg, C., & Reed, S. I. (2000) · Cell · doi:10.1016/s0092-8674(00)00036-2 · Cited by 292 · see citing works

Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy

Kikuchi, A., Takeda, A., Onodera, H., Kimpara, T., Hisanaga, K., Sato, N., Nunomura, A., Castellani, R. J., Perry, G. L., Smith, M. A., et al. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0466 · Cited by 289 · see citing works

The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer’s and Parkinson’s diseases1,2 11Guest Editors: Mark A. Smith and George Perry 22This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

Giasson, B. I., Ischiropoulos, H., Lee, V. M. ‐., & Trojanowski, J. Q. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00804-3 · Cited by 281 · see citing works

Mitochondria and degenerative disorders

Orth, M., & Schapira, A. H. V. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1425 · Cited by 278 · see citing works

Discussion

Lovestone, S., & Reynolds, C. H. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00577-5 · Cited by 278 · see citing works

Aggresome‐related biogenesis of Lewy bodies

McNaught, K. S. P., Shashidharan, P., Perl, D. P., Jenner, P. G., & Olanow, C. W. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02301.x · Cited by 277 · see citing works

The Yeast Frataxin Homologue Mediates Mitochondrial Iron Efflux

Radisky, D. C., Babcock, M. C., & Kaplan, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.4497 · Cited by 277 · see citing works

In Situ and in Vitro Study of Colocalization and Segregation of α-Synuclein, Ubiquitin, and Lipids in Lewy Bodies

Gai, W. P., Yuan, H. X., Li, X. Q., Power, J. T. H., Blumbergs, P. C., & Jensen, P. H. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7527 · Cited by 272 · see citing works

Pathogenic role of glial cells in Parkinson's disease

Teismann, P., Tieu, K., Cohen, O. S., Choi, D., Wu, D. C., Marks, D., Vila, M., Jackson-Lewis, V. R., & Przedborski, S. (2002) · Movement Disorders · doi:10.1002/mds.10332 · Cited by 272 · see citing works

Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases

Chiti, F., Calamai, M., Taddei, N., Stefani, M., Ramponi, G., & Dobson, C. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212527999 · Cited by 272 · see citing works

Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease

Lotharius, J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.20.2395 · Cited by 267 · see citing works

Sequestration of iron by Lewy bodies in Parkinson's disease

Castellani, R. J., Siedlak, S. L., Perry, G., & Smith, M. A. (2000) · Acta Neuropathologica · doi:10.1007/s004010050001 · Cited by 265 · see citing works

Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer’s disease and Parkinson’s disease

Tabner, B. J., Turnbull, S., El‐Agnaf, O. M. A., & Allsop, D. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00801-8 · Cited by 261 · see citing works

Biochemical Characterization of the Core Structure of α-Synuclein Filaments

Miake, H., Mizusawa, H., Iwatsubo, T., & Hasegawa, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110551200 · Cited by 255 · see citing works

Glutathione Depletion in PC12 Results in Selective Inhibition of Mitochondrial Complex I Activity

Jha, N., Jurma, O. P., Lalli, G., Liu, Y., Pettus, E. H., Greenamyre, J. T., Liu, R.-M., Forman, H. J., & Andersen, J. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000120200 · Cited by 252 · see citing works

Alpha‐synuclein in Lewy Body Disease and Alzheimer's Disease

Hashimoto, M., & Masliah, E. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00552.x · Cited by 251 · see citing works

Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

Bogdanov, M., Andreassen, O. A., Dedeoglu, A., Ferrante, R. J., & Beal, M. F. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00689.x · Cited by 248 · see citing works

Mitochondrial dysfunction in Parkinson's disease

Greenamyre, J. T., MacKenzie, G. M., Peng, T., & Stephans, S. E. (1999) · Biochemical Society Symposia · doi:10.1042/bss0660085 · Cited by 248 · see citing works

Functional Neurobiology of Aging

(2001) · Elsevier eBooks · doi:10.1016/b978-0-12-351830-9.x5000-8 · Cited by 246 · see citing works

Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease

Yamamoto, A., Shin, R., Hasegawa, K., Naiki, H., Sato, H., YOSHIMASU, F., & Kitamoto, T. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01061.x · Cited by 246 · see citing works

Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development

Floyd, R. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00293-7 · Cited by 240 · see citing works

Iron and neurodegenerative disorders

Thompson, K. J., Shoham, S., & Connor, J. R. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00510-x · Cited by 235 · see citing works

Crosslinking of α-synuclein by advanced glycation endproducts — an early pathophysiological step in Lewy body formation?

Münch, G., Lüth, H. J., Wong, A., Arendt, T., Hirsch, E., Ravid, R., & Riederer, P. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00096-x · Cited by 231 · see citing works

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

Chung, K. K. K., Dawson, V. L., & Dawson, T. M. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01998-6 · Cited by 223 · see citing works

Huntington's Disease Intranuclear Inclusions Contain Truncated, Ubiquitinated Huntingtin Protein

Sieradzan, K. A., Mechan, A. O., Jones, L. A., Wanker, E. E., Nukina, N., & Mann, D. M. A. (1999) · Experimental Neurology · doi:10.1006/exnr.1998.7005 · Cited by 207 · see citing works

Tubulin Seeds α-Synuclein Fibril Formation

Alim, M., Hossain, M. S., Arima, K., Takeda, K., Izumiyama, Y., Nakamura, M., Kaji, H., Shinoda, T., Hisanaga, S., & Uéda, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m102981200 · Cited by 198 · see citing works

Superoxide dismutase and the death of motoneurons in ALS

Beckman, J. S., Estévez, Á. G., Crow, J. P., & Barbeito, L. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01981-0 · Cited by 196 · see citing works

Inflammation in Parkinson's disease.

McGeer, P. L., Yasojima, K., & McGeer, E. G. (2001) · PubMed · Cited by 196 · see citing works

Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration

Stewart, V. C., & Heales, S. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01327-8 · Cited by 191 · see citing works

Intracellular APP Processing and Aβ Production in Alzheimer Disease

Wilson, C., Doms, R. W., & Lee, V. M. ‐. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199908000-00001 · Cited by 187 · see citing works

“Fatal Attractions” of Proteins: A Comprehensive Hypothetical Mechanism Underlying Alzheimer's Disease and Other Neurodegenerative Disorders

Trojanowski, J. Q., & LEE, V. M. ‐. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05561.x · Cited by 184 · see citing works

Mechanisms of neurodegeneration in amyotrophic lateral sclerosis: Figure 1

Cluskey, S., & Ramsden, D. B. (2001) · Molecular Pathology · doi:10.1136/mp.54.6.386 · Cited by 183 · see citing works

Contribution of somal Lewy bodies to neuronal death

Tompkins, M. M., & Hill, W. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00874-3 · Cited by 182 · see citing works

Apoptotic death sensor: an organelle's alter ego?

Bratton, S. B., & Cohen, G. M. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01718-1 · Cited by 181 · see citing works

Caspases, Apoptosis, and Alzheimer Disease: Causation, Correlation, and Confusion

Roth, K. A. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.9.829 · Cited by 175 · see citing works

Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer’s disease

Sly, L. M., KRZESICKI, R. F., Brashler, J. R., Buhl, A.-L., McKinley, D. D., Carter, D. B., & Chin, J. E. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00730-4 · Cited by 174 · see citing works

α-Synuclein-positive structures in cases with sporadic Alzheimer’s disease: morphology and its relationship to tau aggregation

Arai, Y., Yamazaki, M., Mori, O., Muramatsu, H., Asano, G., & Katayama, Y. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03082-1 · Cited by 173 · see citing works

Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies

Ferrer, I., Blanco, R. E., Carmona, M., Puig, B., Barrachina, M., Gómez, C., & Ambrosio, S. (2001) · Journal of Neural Transmission · doi:10.1007/s007020100015 · Cited by 172 · see citing works

Activation of Caspase-8 in the Alzheimer's Disease Brain

Rohn, T. T., Head, E., Nesse, W. H., Cotman, C. W., & Cribbs, D. H. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0449 · Cited by 171 · see citing works

Induction of neuronal death by α‐synuclein

Saha, R. A., Ninkina, N. N., Hanger, D. P., Anderton, B. H., Davies, A. M., & Buchman, V. L. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00210.x · Cited by 169 · see citing works

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

Castellani, R. J., Perry, G. L., Siedlak, S. L., Nunomura, A., Shimohama, S., Zhang, J., Montine, T. J., Sayre, L. M., & Smith, M. A. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02514-9 · Cited by 169 · see citing works

Cell death mechanisms in neurodegeneration

Jellinger, K. A. (2001) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2001.tb00134.x · Cited by 166 · see citing works

Apoptosis in the in Vivo Mammalian Forebrain

Dikranian, K. T., Ishimaru, M. J., Tenkova, T. I., Labruyere, J., Qin, Y., Ikonomidou, C., & Olney, J. W. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0411 · Cited by 163 · see citing works

Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer’s disease

Wong, A. O., Lüth, H., Deuther‐Conrad, W., Dukić-Stefanović, S., Gasic‐Milenkovic, J., Arendt, T., & Münch, G. W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02872-4 · Cited by 159 · see citing works

THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS

YASE, Y. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92903-0 · Cited by 155 · see citing works

Abortive apoptosis in Alzheimer's disease

Raina, A. K., Hochman, A., Zhu, X., Rottkamp, C. A., Nunomura, A., Siedlak, S. L., Boux, H. A., Castellani, R. J., Perry, G. L., & Smith, M. A. (2001) · Acta Neuropathologica · doi:10.1007/s004010100378 · Cited by 153 · see citing works

Mitochondria, Ca2+ and neurodegenerative disease

Krieger, C., & Duchen, M. R. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01842-3 · Cited by 147 · see citing works

Protein surveillance machinery in brains with spinocerebellar ataxia type 3: Redistribution and differential recruitment of 26S proteasome subunits and chaperones to neuronal intranuclear inclusions

Schmidt, T., Lindenberg, K. S., Krebs, A., Schöls, L. J., Laccone, F. A., Herms, J. W., Rechsteiner, M., Rieß, O., & Landwehrmeyer, G. B. (2002) · Annals of Neurology · doi:10.1002/ana.10101 · Cited by 146 · see citing works

α-Synuclein Affects the MAPK Pathway and Accelerates Cell Death

Iwata, A., Maruyama, M., Kanazawa, I., & Nukina, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103736200 · Cited by 139 · see citing works

Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegeneration

Citron, B. A., Suo, Z., SantaCruz, K. S., Davies, P. J., Qin, F., & Festoff, B. W. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00062-6 · Cited by 138 · see citing works

Evidence for caspase‐mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease

Chan, S. L., Griffin, W. S. T., & Mattson, M. P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990801)57:3 · Cited by 137 · see citing works

Protein misfolding in Alzheimer’s and Parkinson’s disease: genetics and molecular mechanisms

Forloni, G., Terreni, L., Bertani, I., Fogliarino, S., Invernizzi, R. W., Assini, A., Ribizzi, G., Negro, A., Calabrese, E., & Volonté, M. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00076-3 · Cited by 132 · see citing works

Energy Requirement for Caspase Activation and Neuronal Cell Death

Nicotera, P., Leist, M., Fava, E., Berliocchi, L., & Volbracht, C. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00261.x · Cited by 132 · see citing works

Overexpression of human α-synuclein causes dopamine neuron death in primary human mesencephalic culture

Zhou, W., Schaack, J. B., Zawada, W. M., & Freed, C. R. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03292-9 · Cited by 129 · see citing works

Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

Guo, Q., Sebastian, L., Sopher, B. L., Miller, M. W., Glazner, G. W., Ware, C. B., Martin, G. M., & Mattson, M. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4125 · Cited by 124 · see citing works

Mitochondrial DNA Deletions/Rearrangements in Parkinson Disease and Related Neurodegenerative Disorders

Gu, G., Reyes, P. F., Golden, G. T., Woltjer, R. L., Hulette, C., Montine, T. J., & Zhang, J. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.7.634 · Cited by 122 · see citing works

Visualization of defective mitochondrial function in skeletal muscle fibers of patients with sporadic amyotrophic lateral sclerosis

Vielhaber, S., Winkler, K., Kirches, E., Kunz, D., Büchner, M., Feistner, H., Elger, C. E., Ludolph, A. C., Riepe, M. W., & Kunz, W. S. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00236-1 · Cited by 121 · see citing works

Interleukin-1 and the Immunogenetics of Alzheimer Disease

Mrak, R. E., & Griffin, W. S. T. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.6.471 · Cited by 119 · see citing works

Overexpression of Neutrophil Neuronal Nitric Oxide Synthase in Parkinson's Disease

Gatto, E. M., Galdo, N. A. R., Carreras, M. C., Cherñavsky, A. C., Rubio, A., Satz, M. L., & Poderoso, J. J. (2000) · Nitric Oxide · doi:10.1006/niox.2000.0288 · Cited by 117 · see citing works

Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures

Egaña, J. T., Zambrano, C. A., Núñez, M. T., González-Billault, C. E., & Maccioni, R. B. (2003) · BioMetals · doi:10.1023/a:1020727218493 · Cited by 114 · see citing works

A Close Association of TorsinA and α-Synuclein in Lewy Bodies

Sharma, N., Hewett, J. W., Ozelius, L. J., Ramesh, V., McLean, P. J., Breakefield, X. O., & Hyman, B. T. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61700-2 · Cited by 112 · see citing works

Mutant and Wild-Type α-Synuclein Interact with Mitochondrial Cytochrome C Oxidase

Elkon, H., Don, J., Melamed, E., Ziv, I., Shirvan, A., & Offen, D. (2002) · Journal of Molecular Neuroscience · doi:10.1385/jmn:18:3:229 · Cited by 103 · see citing works

Influence of neuromelanin on oxidative pathways within the human substantia nigra

Double, K. L., Ben-Shachar, D., Youdim, M. B. H., Zecca, L., Riederer, P., & Gerlach, M. (2002) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(02)00218-0 · Cited by 102 · see citing works

Lipoperoxidation Is Selectively Involved in Progressive Supranuclear Palsy

Odetti, P. R., Garibaldi, S., Norese, R., Angelini, G., Marinelli, L., Valentini, S., Menini, S., Traverso, N., Zaccheo, D., Siedlak, S. L., et al. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.5.393 · Cited by 93 · see citing works

Brain proteasomal function in sporadic Parkinson's disease and related disorders

Furukawa, Y., Vigouroux, S., Wong, H., Guttman, M., Rajput, A. H., Ang, L. C., Briand, M., Kish, S. J., & Briand, Y. (2002) · Annals of Neurology · doi:10.1002/ana.10207 · Cited by 91 · see citing works

Induction of Nitric Oxide Synthase and Microglial Responses Precede Selective Cell Death Induced by Chronic Impairment of Oxidative Metabolism

Calingasan, N. Y., Park, L. C. H., Calo, L. L., Trifiletti, R. R., Gandy, S., & Gibson, G. E. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65602-7 · Cited by 85 · see citing works

Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders

Kovács, G. G., Klöppel, S., Fischer, I., Dorner, S., Lindeck‐Pozza, E., Birner, P., Bötefür, I. C., Pilz, P. K. D., Volk, B., & Budka, H. (2003) · Neuroreport · doi:10.1097/00001756-200301200-00014 · Cited by 81 · see citing works

Mitochondria and the pathogenesis of ALS

Beal, M. F. (2000) · Brain · doi:10.1093/brain/123.7.1291 · Cited by 80 · see citing works

Further Evidence for Mitochondrial Dysfunction in Progressive Supranuclear Palsy

Albers, D. S., Swerdlow, R. H., Manfredi, G., Gajewski, C. D., Yang, L., Parker, W. D., & Beal, M. F. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7607 · Cited by 72 · see citing works

Mechanisms of Neurodegenerative Disorders

Wolozin, B. L., & Behl, C. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.793 · Cited by 70 · see citing works

Protein aggregates and dementia: is there a common toxicity?

Lovestone, S. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.2.152 · Cited by 69 · see citing works

New Leads on the 'How' of Alzheimer's

Marx, J. L. (2001) · Science · doi:10.1126/science.293.5538.2192 · Cited by 65 · see citing works

Protein dynamics, folding and misfolding: from basic physical chemistry to human conformational diseases

Ferreira, S. T., & Felice, F. G. D. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02491-7 · Cited by 62 · see citing works

Late‐onset neurodegenerative diseases—the role of protein insolubility

Johnson, W. G. (2000) · Journal of Anatomy · doi:10.1046/j.1469-7580.2000.19640609.x · Cited by 61 · see citing works

Proteolytic Processing of Familial British Dementia-associated BRI Variants

Kim, S., Creemers, J. W. M., Chu, S., Thinakaran, G., & Sisodia, S. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108739200 · Cited by 58 · see citing works

Protein aggregation in Huntington’s disease

Hoffner, G., & Djian, P. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01398-6 · Cited by 57 · see citing works

Transglutaminase Activity, Protein, and mRNA Expression Are Increased in Progressive Supranuclear Palsy

Zemaitaitis, M. O., Kim, S.-Y., Halverson, R. A., Troncoso, J. C., Lee, J. M., & Muma, N. A. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.2.173 · Cited by 57 · see citing works

Morphological and Biochemical Correlations of Abnormal Tau Filaments in Progressive Supranuclear Palsy

Takahashi, M., Weidenheim, K. M., Dickson, D. W., & Ksiezak-Reding, H. (2002) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1093/jnen/61.1.33 · Cited by 56 · see citing works

Ubiquitin binding proteins protect ubiquitin conjugates from disassembly

Hartmann‐Petersen, R., Hendil, K. B., & Gordon, C. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03874-7 · Cited by 56 · see citing works

The cerebral proteopathies

Walker, L. C., & LeVine, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00160-3 · Cited by 51 · see citing works

Huntington's disease: new hope for therapeutics

McMurray, C. T. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01997-4 · Cited by 51 · see citing works

Protein Disulfide Isomerase in Alzheimer Disease

Kim, H. T., Russell, R. L., Raina, A. K., Harris, P. L. R., Siedlak, S. L., Zhu, X., Petersen, R. B., Shimohama, S., Smith, M. A., & Perry, G. L. (2000) · Antioxidants and Redox Signaling · doi:10.1089/15230860050192260 · Cited by 48 · see citing works

Detection of DNA base-excision repair activity for oxidative lesions in adult rat brain mitochondria

Chen, D., Lan, J. Q., Pei, W., & Chen, J. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000715)61:2 · Cited by 47 · see citing works

Heterogeneity of Nigral and Cortical Lewy Bodies Differentiated by Amplified Triple-Labeling for Alpha-Synuclein, Ubiquitin, and Thiazin Red

Sakamoto, M., Uchihara, T., Hayashi, M., Nakamura, A., Kikuchi, E., Mizutani, T., Mizusawa, H., & Hirai, S. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7961 · Cited by 47 · see citing works

Increased Expression and Redistribution of the Antiapoptotic Molecule Bcl-xL in Parkinson's Disease

Hartmann, A., Prigent, A., Vila, M., Abbas, N., Perier, C., Faucheux, B. A., Vyas, S., & Hirsch, É. C. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0494 · Cited by 46 · see citing works

Apoptosis and age-related disorders: role of caspase-dependent and caspase-independent pathways

Nicotera, P. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(01)00500-8 · Cited by 45 · see citing works

Autotoxicity and Alzheimer Disease

McGeer, P. L., & McGeer, E. G. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.789 · Cited by 44 · see citing works

Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1

Boutajangout, A., Leroy, K., Touchet, N., Authelet, M., Blanchard, V., Tremp, G. L., Pradier, L., & Brion, J. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02461-2 · Cited by 40 · see citing works

Defining neurodegenerative diseases

Williams, A. C. (2002) · BMJ · doi:10.1136/bmj.324.7352.1465 · Cited by 37 · see citing works

Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy

Borghi, R., Giliberto, L., Assini, A., Delacourte, A., Perry, G. L., Smith, M. A., Strocchi, P. M., Zaccheo, D., & Tabaton, M. (2002) · Neurology · doi:10.1212/wnl.58.4.589 · Cited by 37 · see citing works

Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration

Gómez‐Tortosa, E., Gonzalo, I., Newell, K. L., de Yébenes, J. G., Vonsattel, J. P., & Hyman, B. T. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0495-3 · Cited by 36 · see citing works

The ceruloplasmin and hydrogen peroxide system induces α-synuclein aggregation in vitro

Kim, K. S., Choi, S. Y., Kwon, H. Y., Won, M. H., Kang, T., & Kang, J. H. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01435-9 · Cited by 36 · see citing works

Progressive Supranuclear Palsy and Corticobasal Degeneration

Lessig, S., & Litvan, I. (2014) · Oxford University Press eBooks · doi:10.1093/med/9780199928453.003.0011 · Cited by 36 · see citing works

Parkinson's disease and related neurodegenerative synucleinopathies linked to progressive accumulations of synuclein aggregates in brain

Trojanowski, J. Q., & Lee, V. M.-Y. (2001) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(00)00065-1 · Cited by 32 · see citing works

Neurological disease: UPS stops delivering!

Miller, R. J., & Wilson, S. M. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)00011-1 · Cited by 32 · see citing works

Pathogenesis of Neurodegenerative Disorders

Mattson, M. P. (2001) · Humana Press eBooks · doi:10.1385/159259106x · Cited by 31 · see citing works

Neuronal and glial DNA fragmentation in Pick's disease

Gleckman, A. M., Jiang, Z., Liu, Y., & Smith, T. W. (1999) · Acta Neuropathologica · doi:10.1007/s004010051051 · Cited by 28 · see citing works

Pathological Peptide Folding in Alzheimers Disease and Other Conformational Disorders

Mager, P. P., Penke, B., Walter, R., Harkany, T., & Härtig, W. (2002) · Current Medicinal Chemistry · doi:10.2174/0929867023369169 · Cited by 26 · see citing works

The Proteasome: Destroy to Live

Abramova, E. B., Sharova, N. P., & Карпов, В. Л. (2002) · Molecular Biology · doi:10.1023/a:1020654926226 · Cited by 24 · see citing works

On the survival time of a tangled neuron in the hippocampal CA4 region in parkinsonism dementia complex of Guam

Schwab, C., Schulzer, M., Steele, J. C., & McGeer, P. L. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00005-6 · Cited by 24 · see citing works

Apoptosis Techniques and Protocols

LeBlanc, A. C. (2002) · Humana Press eBooks · doi:10.1385/1592591884 · Cited by 23 · see citing works

Alzheimer's disease: Its diagnosis and pathogenesis

Kril, J. J., & Halliday, G. M. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)48016-0 · Cited by 22 · see citing works

Sequence analysis of tau in familial and sporadic progressive supranuclear palsy

Morris, H. R. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.3.388 · Cited by 21 · see citing works

Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as α-Synucleinopathies

Goedert, M., Jakes, R., Crowther, R. A., & Spillantini, M. G. (2003) · Humana Press eBooks · doi:10.1385/1-59259-142-6:33 · Cited by 21 · see citing works

Engineered modeling and the secrets of Parkinson's disease

Vila, M., Wu, D. C., & Przedborski, S. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01984-6 · Cited by 18 · see citing works

Mechanisms of Neuronal Apoptosis and Excitotoxicity

Mattson, M. P. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-106-0_1 · Cited by 17 · see citing works

Neurodegeneration in the age of molecular biology

Golbe, L. I. (2002) · BMJ · doi:10.1136/bmj.324.7352.1467 · Cited by 15 · see citing works

Neural degeneration in Parkinson's disease.

Riederer, P. F., Reichmann, H., Janetzky, B., Sian, J., Lesch, K., Lange, K. W., Double, K. L., Nagatsu, T., & Gerlach, M. (2001) · PubMed · Cited by 14 · see citing works

Parkinson’s Disease. Methods and Protocols

Jellinger, K. A. (2001) · European Journal of Neurology · doi:10.1046/j.1468-1331.2001.0257h.x · Cited by 13 · see citing works

Oxidative Alterations in Neurodegenerative Diseases

Markesbery, W. R., Montine, T. J., & Lovell, M. A. (2003) · Humana Press eBooks · doi:10.1385/1-59259-106-x:21 · Cited by 13 · see citing works

Oxidative Stress Indices in Parkinson's Disease: Biochemical Determination

Youdim, M. B. H., Driguès, N., & Mandel, S. A. (2003) · Humana Press eBooks · doi:10.1385/1-59259-142-6:137 · Cited by 11 · see citing works

Progressive Supranuclear Palsy and Corticobasal Degeneration

Dickson, D. W. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50015-9 · Cited by 10 · see citing works

A one-hit model of cell death in inherited neuronal degenerations

Bortolotto, Z. A., Clarke, V. R. J., Delany, C. M., Parry, M., Smolders, I. J., Vignes, M., Ho, K. H., Miu, P., Brinton, B. T., Fantaske, R. P., et al. (2001) · Cited by 9 · see citing works

Apoptosis vs Nonapoptotic Mechanisms in Neurodegeneration

Jellinger, K. A. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-297-5_2 · Cited by 6 · see citing works

Apoptotic and Oxidative Indicators in Alzheimer's Disease

Raina, A. K., Sayre, L. M., Atwood, C., Rottkamp, C. A., Hochman, A., Zhu, X., Obrenovich, M. E., Shimohama, S., Nunomura, A., Takeda, A., et al. (2003) · Humana Press eBooks · doi:10.1385/1-59259-188-4:225 · Cited by 6 · see citing works

Inflammation, Free Radicals, Glycation, Metabolism and Apoptosis, and Heavy Metals

Mattson, M. P. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50025-1 · Cited by 5 · see citing works

Neurobiology of Disorders with Lewy Bodies

Hansen, L. A., & Masliah, E. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50016-0 · Cited by 4 · see citing works

Parkinson's Disease. Diagnosis and Management

Jellinger, K. A. (2002) · European Journal of Neurology · doi:10.1046/j.1468-1331.2002.04131.x · Cited by 4 · see citing works

Gallyas-positive argyrophilic and ubiquitinated filamentous inclusions in rapidly progressive motor neuron disease: immunohistochemical and electron microscopic studies

Katayama, S., Watanabe, C., Kohriyama, T., Yamamura, Y., Mao, J., Ohishi, H., Nishisaka, T., Inai, K., Tanaka, E., & Nakamura, S. (2000) · Acta Neuropathologica · doi:10.1007/s004019900156 · Cited by 3 · see citing works

Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights substrates of disability

Sperfeld (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199911)46:5 · Cited by 2 · see citing works

Parkinson's Disease

Silva, M. T., & Schapira, A. H. V. (2003) · Humana Press eBooks · doi:10.1385/1-59259-106-x:53 · Cited by 2 · see citing works

The Pathogenesis of Amyotrophic Lateral Sclerosis

Appel, S. H., & Smith, R. G. (2003) · Humana Press eBooks · doi:10.1385/1-59259-106-x:149 · Cited by 2 · see citing works

Untitled work

Cann, S. A. H., Netten, J. P. V., & Netten, C. V. (2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200003)47:3

Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects

Parchi, P., Giese, A., Capellari, S., Brown, P., Schulz-Schaeffer, W., Windl, O., Zerr, I., Budka, H., Kopp, N., Piccardo, P., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199908)46:2

Untitled work

Mattson, M. (1999) · doi:10.1002/(sici)1097-4547(19991001)58:1

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

Cavalli, A., Bolognesi, M. L., Minarini, A., Rosini, M., Tumiatti, V., Recanatini, M., & Melchiorre, C. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm7009364 · Cited by 1,152 · see citing works

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

Shimura, H., Schwartz, D., Gygi, S. P., & Kosik, K. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m305838200 · Cited by 469 · see citing works

Role of oxidative stress in epileptic seizures

Shin, E., Jeong, J. H., Chung, Y. H., Kim, W.-K., Ko, K.-H., Bach, J., Hong, J., Yoneda, Y., & Kim, H. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.03.025 · Cited by 424 · see citing works

Direct Stimulation of Adult Neural Stem Cells In Vitro and Neurogenesis In Vivo by Vascular Endothelial Growth Factor

Schänzer, A., Wachs, F., Wilhelm, D., Acker, T., Cooper‐Kuhn, C. M., Beck, H., Winkler, J., Aigner, L., Plate, K. H., & Kuhn, H. G. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00060.x · Cited by 366 · see citing works

The Relevance of Iron in the Pathogenesis of Parkinson's Disease

Götz, M. E., Double, K. L., Gerlach, M., Youdim, M. B. H., & RIEDERERE, P. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.017 · Cited by 342 · see citing works

Role of oxidative stress in neurodegeneration: recent developments in assay methods for oxidative stress and nutraceutical antioxidants

Cui, K., Luo, X., Xu, K., & Murthy, M. R. V. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.05.023 · Cited by 334 · see citing works

Mercury Toxicity and Neurodegenerative Effects

Carocci, A., Rovito, N., Sinicropi, M. S., & Genchi, G. (2013) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-3-319-03777-6_1 · Cited by 322 · see citing works

Multidrug Resistance-Associated Proteins: Expression and Function in the Central Nervous System

Dallas, S., Miller, D. S., & Bendayan, R. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.2.3 · Cited by 295 · see citing works

Brain, aging and neurodegeneration: Role of zinc ion availability

Mocchegiani, E., Bertoni–Freddari, C., Marcellini, F., & Malavolta, M. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.04.005 · Cited by 280 · see citing works

Recent advances in our understanding of neurodegeneration

Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274 · see citing works

Effects of natural antioxidants in neurodegenerative disease

Albarracín, S. L., Stab, B., Casas, Z., Sutachan, J. J., Samudio, I. J., González, J., Gonzalo, L., Capani, F., Morales, L., & Barreto, G. E. (2012) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000028 · Cited by 273 · see citing works

Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy

Puttachary, S., Sharma, S., Stark, S., & Thippeswamy, T. (2015) · BioMed Research International · doi:10.1155/2015/745613 · Cited by 262 · see citing works

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Sairazi, N. S. M., & Sirajudeen, K. N. S. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/6565396 · Cited by 250 · see citing works

JNK Signalling: A Possible Target to Prevent Neurodegeneration

Borsello, T., & Forloni, G. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207780858384 · Cited by 224 · see citing works

Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia

Martins‐de‐Souza, D., Gattaz, W. F., Schmitt, A., Rewerts, C., Maccarrone, G., Dias‐Neto, E., & Turck, C. W. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0847-2 · Cited by 203 · see citing works

Oxidative stress in epilepsy

Geronzi, U., Lotti, F., & Grosso, S. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1465410 · Cited by 197 · see citing works

Deleterious Effects of Minocycline in Animal Models of Parkinson’s Disease and Huntington’s Disease

Diguet, E., Fernagut, P., Wei, X., Du, Y., Rouland, R., Gross, C., Bezard, E., & Tison, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03372.x · Cited by 189 · see citing works

From combinations to multitarget-directed ligands: A continuum in Alzheimer’s disease polypharmacology

Albertini, C., Salerno, A., de Sena Murteira Pinheiro, P., & Bolognesi, M. L. (2021) · Medicinal Research Reviews · doi:10.1002/med.21699 · Cited by 179 · see citing works

Metal Ion Physiopathology in Neurodegenerative Disorders

Bolognin, S., Luigi Messori, A., & Zatta, P. F. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8102-1 · Cited by 157 · see citing works

Alzheimer disease: mercury as pathogenetic factor and apolipoprotein E as a moderator.

Mutter, J., Naumann, J., Sadaghiani, C., Schneider, R., & Walach, H. (2004) · PubMed · Cited by 143 · see citing works

Proteomic mapping provides powerful insights into functional myelin biology

Taylor, C. M., Marta, C. B., Claycomb, R. J., Han, D. K., Rasband, M. N., Coetzee, T., & Pfeiffer, S. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400922101 · Cited by 102 · see citing works

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Martinelli, C., Pucci, C., Battaglini, M., Marino, A., & Ciofani, G. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201901589 · Cited by 111 · see citing works

Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems

Cacciatore, I., Baldassarre, L., Fornasari, E., Mollica, A., & Pinnen, F. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/240146 · Cited by 106 · see citing works

The N-methyl-D-aspartate antagonist memantine retards progression of Huntington’s disease

Beister, A., Kraus, P., Kuhn, W., Dose, M., Weindl, A., & Gerlach, M. (2004) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-0579-5_14 · Cited by 98 · see citing works

Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review

Khanam, H., Ali, A., Asif, M., & Shamsuzzaman (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.08.006 · Cited by 100 · see citing works

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer’s disease

Rosini, M., Simoni, E., Bartolini, M., Tarozzi, A., Matera, R., Milelli, A., Hrelia, P., Andrisano, V., Bolognesi, M. L., & Melchiorre, C. (2011) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2011.09.001 · Cited by 90 · see citing works

Overstimulation of PrPC Signaling Pathways by Prion Peptide 106-126 Causes Oxidative Injury of Bioaminergic Neuronal Cells

Pietri, M., Caprini, A., Mouillet‐Richard, S., Pradines, E., Ermonval, M., Grassi, J. J., Kellermann, O., & Schneider, B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602774200 · Cited by 88 · see citing works

The Helix-Loop-Helix Inhibitor of Differentiation (ID) Proteins Induce Post-Mitotic Terminally Differentiated Sertoli Cells to Re-Enter the Cell Cycle and Proliferate

Chaudhary, J., Sadler‐Riggleman, I., Ague, J. M., & Skinner, M. K. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.104.035717 · Cited by 87 · see citing works

Exosomes and the Prion Protein: More than One Truth

Hartmann, A., Muth, C., Dabrowski, O., Krasemann, S., & Glatzel, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00194 · Cited by 87 · see citing works

Selectivity of the ubiquitin pathway for oxidatively modified proteins: relevance to protein precipitation diseases

Dudek, E. J., Shang, F., Liu, Q. L., Valverde, P., Hobbs, M., & Taylor, A. (2005) · The FASEB Journal · doi:10.1096/fj.05-4049fje · Cited by 86 · see citing works

Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds

Rojas-García, A., Fernández‐Ochoa, Á., Cádiz‐Gurrea, M. D. L. L., Arraéz-Román, D., & Segura‐Carretero, A. (2023) · Nutrients · doi:10.3390/nu15020449 · Cited by 87 · see citing works

Activation of Transcription Factor Nrf-2 and Its Downstream Targets in Response to Moloney Murine Leukemia Virusts1-Induced Thiol Depletion and Oxidative Stress in Astrocytes

Qiang, W., Cahill, J. M., Liu, J., Kuang, X., Liu, N., Scofield, V. L., Voorhees, J. R., Reid, A. J., Yan, M., Lynn, W. S., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.21.11926-11938.2004 · Cited by 78 · see citing works

Nanoneurotherapeutics approach intended for direct nose to brain delivery

Md, S., Mustafa, G., Baboota, S., & Ali, J. (2015) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2015.1052081 · Cited by 77 · see citing works

Loss of Hsp110 Leads to Age-Dependent Tau Hyperphosphorylation and Early Accumulation of Insoluble Amyloid β

Eroglu, B., Moskophidis, D., & Mivechi, N. F. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01493-09 · Cited by 78 · see citing works

Neuro-protective Mechanisms of Lycium barbarum

Xing, X., Liu, F., Xiao, J., & So, K. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8393-y · Cited by 75 · see citing works

Alpha-terpinyl acetate: A natural monoterpenoid from Elettaria cardamomum as multi-target directed ligand in Alzheimer’s disease

Chowdhury, S., & Kumar, S. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103892 · Cited by 69 · see citing works

Rotenone induces aggregation of γ-tubulin protein and subsequent disorganization of the centrosome: Relevance to formation of inclusion bodies and neurodegeneration

Diaz-Corrales, F. J. J., Asanuma, M., Miyazaki, I., Miyoshi, K., & Ogawa, N. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.044 · Cited by 67 · see citing works

Is there a relation between extremely low frequency magnetic field exposure, inflammation and neurodegenerative diseases? A review of in vivo and in vitro experimental evidence

Mattsson, M., & Simkó, M. (2012) · Toxicology · doi:10.1016/j.tox.2012.06.011 · Cited by 65 · see citing works

Proteinopathies, neurodegenerative disorders with protein aggregation-based pathology

Shelkovnikova, T. A., Kulikova, A. A., Tsvetkov, P. O., Peters, O. M., Бачурин, С. О., Buchman, V. L., & Ninkina, N. N. (2012) · Molecular Biology · doi:10.1134/s0026893312020161 · Cited by 62 · see citing works

Impact of selenium, iron, copper and zinc in on/off Parkinson’s patients on L-dopa therapy

Qureshi, G. A., Qureshi, A. A., Memon, S. A., & Parvez, S. H. (2006) · Springer eBooks · doi:10.1007/978-3-211-33328-0_24 · Cited by 63 · see citing works

Parkinson’s disease as a multisystem disorder

Klingelhoefer, L., & Reichmann, H. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1692-0 · Cited by 58 · see citing works

Changing Paradigm from one Target one Ligand Towards Multi-target Directed Ligand Design for Key Drug Targets of Alzheimer Disease: An Important Role of In Silico Methods in Multi-target Directed Ligands Design

Kumar, A., Tiwari, A. K., & Sharma, A. K. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180315141643 · Cited by 59 · see citing works

Coordination abilities of N-terminal fragments of α-synuclein towards copper(II) ions: A combined potentiometric and spectroscopic study

Kowalik‐Jankowska, T., Rajewska, A., Wiśniewska, K., Grzonka, Z., & Jezierska, J. (2005) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2005.08.008 · Cited by 59 · see citing works

The influence of cerebrovascular risk factors on incident dementia in patients with Parkinson's disease

Haugarvoll, K., Aarsland, D., Wentzel‐Larsen, T., & Larsen, J. O. (2005) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2005.00389.x · Cited by 57 · see citing works

Molecules of Natural Origin, Semi-synthesis and Synthesis with Anti-Inflammatory and Anticancer Utilities

Lourenço, A. M., Ferreira, L. M., & Branco, P. S. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802083644 · Cited by 54 · see citing works

Exploring the Contribution of Estrogen to Amyloid-Beta Regulation: A Novel Multifactorial Computational Modeling Approach

Anastasio, T. J. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00016 · Cited by 49 · see citing works

New 5-Unsubstituted Dihydropyridines with Improved CaV1.3 Selectivity as Potential Neuroprotective Agents against Ischemic Injury

Tenti, G., Parada, E., Leon, R. M., Egea, J., Martínez‐Revelles, S., Briones, A. M., Sridharan, V., López, M. G., Ramos, M. T., & Menéndez, J. C. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm500263v · Cited by 48 · see citing works

Recent advances in enzymeless-based electrochemical sensors to diagnose neurodegenerative diseases

Song, Z., Zhou, Y., Han, X., Qin, J., & Tang, X. (2021) · Journal of Materials Chemistry B · doi:10.1039/d0tb02745f · Cited by 47 · see citing works

Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting

Su, Y., Chiu, H. W., Hung, J.-C., & Hong, J. (2014) · APOPTOSIS · doi:10.1007/s10495-014-1016-x · Cited by 46 · see citing works

The role of α-synuclein and tau in neurodegenerative movement disorders

Wenning, G. K., & Jellinger, K. A. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000168241.53853.32 · Cited by 42 · see citing works

Betanodavirus Induces Oxidative Stress-Mediated Cell Death That Prevented by Anti-Oxidants and Zfcatalase in Fish Cells

Chang, C., Su, Y.-C., Her, G.-M., Ken, C., & Hong, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025853 · Cited by 41 · see citing works

CHIP-mediated hyperubiquitylation of tau promotes its self-assembly into the insoluble tau filaments

Kim, J. H., Lee, J., Choi, W. H., Park, S., Park, S. H., Lee, J. H., Lim, S. M., Mun, J. Y., Cho, H., Han, D., et al. (2021) · Chemical Science · doi:10.1039/d1sc00586c · Cited by 39 · see citing works

Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy

Fantacuzzi, M., Amoroso, R., Carradori, S., & Filippis, B. D. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114242 · Cited by 36 · see citing works

A common vaccine for fighting neurodegenerative disorders: recharging immunity for homeostasis

Schwartz, M., & Kipnis, J. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.06.010 · Cited by 34 · see citing works

Design, synthesis, biological evaluation and docking studies of sulfonyl isatin derivatives as monoamine oxidase and caspase-3 inhibitors

Tavari, M., Malan, S. F., & Joubert, J. (2016) · MedChemComm · doi:10.1039/c6md00228e · Cited by 33 · see citing works

Analysis of the mitochondrial genome of cheetahs (Acinonyx jubatus) with neurodegenerative disease

Burger, P. A., Steinborn, R., Walzer, C., Petit, T., Mueller, M., & Schwarzenberger, F. (2004) · Gene · doi:10.1016/j.gene.2004.05.020 · Cited by 33 · see citing works

The potential neuroprotective effects of stingless bee honey

Zulkifli, N. A., Hassan, Z., Mustafa, M. Z., Azman, W. N. W., Hadie, S. N. H., Ghani, N., & Zin, A. A. M. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1048028 · Cited by 33 · see citing works

Higher Aluminum Concentration in Alzheimer’s Disease After Box–Cox Data Transformation

Rusina, R., Matěj, R., Kašparová, L., Kukal, J., & Urban, P. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9246-y · Cited by 32 · see citing works

The NCAM‐derived P2 peptide facilitates recovery of cognitive and motor function and ameliorates neuropathology following traumatic brain injury

Klementiev, B., Novikova, T., Korshunova, I., Berezin, V., & Bock, E. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06245.x · Cited by 31 · see citing works

Identification of 4,6-diaryl-1,4-dihydropyridines as a new class of neuroprotective agents

Tenti, G., Egea, J., Villarroya, M., Leon, R. M., Fernández, J. C., Padín, J. F., Sridharan, V., Ramos, M. T., & Menéndez, J. C. (2013) · MedChemComm · doi:10.1039/c3md20345j · Cited by 30 · see citing works

Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6‐aminonicotinamide

Penkowa, M., Quintana, A., Carrasco, J., Giralt, M., Molinero, A., & Hidalgo, J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20154 · Cited by 29 · see citing works

3‐Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases

Matos, M. J., Rodríguez‐Enríquez, F., Borges, F., Santana, L., Uriarte, E., Estrada, M., Rodrı́guez-Franco, M. I., Laguna, R., & Viña, D. (2015) · ChemMedChem · doi:10.1002/cmdc.201500408 · Cited by 29 · see citing works

Advances in Research on Neurodegeneration

(2003) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-0643-3 · Cited by 28 · see citing works

JUICES OF PRICKLY PEAR FRUITS (OPUNTIA SPP.) AS FUNCTIONAL FOODS

Zenteno-Ramírez, G., Juárez-Flores, B. I., Aguirre‐Rivera, J. R., Monreal-Montes, M., García, J. M., Serratosa, M. P., Santos, M. A., Pérez, M. D. O., & Rendón-Huerta, J. A. (2018) · Italian Journal of Food Science · doi:10.14674/ijfs-921 · Cited by 27 · see citing works

A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells

Cacciatore, I., Fornasari, E., Baldassarre, L., Cornacchia, C., Fulle, S., Filippo, E. S. D., Pietrangelo, T., & Pinnen, F. (2013) · Pharmaceuticals · doi:10.3390/ph6010054 · Cited by 25 · see citing works

Design and synthesis of novel senkyunolide analogues as neuroprotective agents

Fang, Y., Wang, R., Wang, Q., Sun, Y., Xie, S., Yang, Z., Li, M., Jin, Y., & Yang, S. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.01.018 · Cited by 24 · see citing works

Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases?

Carradori, S., Fantacuzzi, M., Ammazzalorso, A., Angeli, A., Filippis, B. D., Galati, S., Petzer, A., Petzer, J. P., Poli, G., Tuccinardi, T., et al. (2022) · Molecules · doi:10.3390/molecules27227816 · Cited by 23 · see citing works

Inhibition of BACE1, MAO‐B, cholinesterase enzymes, and anti‐amyloidogenic potential of selected natural phytoconstituents: Multi‐target‐directed ligand approach

Chowdhury, S., & Kumar, S. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13571 · Cited by 22 · see citing works

Role of natural bioactive compounds in the management of neurodegenerative disorders

Mursal, M., Kumar, A. B., Hasan, S. M., Hussain, S., Singh, K., Kushwaha, S. P., Arif, M., Singh, R., Singh, D., Mohammad, A., et al. (2023) · Intelligent Pharmacy · doi:10.1016/j.ipha.2023.09.006 · Cited by 22 · see citing works

Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer’s disease

Frey, C., Bonert, A., Kratzsch, T., Rexroth, G., Rösch, W. H., Müller-Spahn, F., Maurer, K., Müller, W. E. G., & Eckert, A. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0481-y · Cited by 22 · see citing works

Redox Sensitivity of Tyrosine Hydroxylase Activity and Expression in Dopaminergic Dysfunction

Giovanni, G. D., Pessia, M., & Maio, R. D. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712800792938 · Cited by 21 · see citing works

Lewy Body Disorders

Jellinger, K. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-30377-2_15 · Cited by 21 · see citing works

Determination of levels of oxidative stress and nitrosative stress in patients with epilepsy

Erşan, S., Çiğdem, B., Bakır, D., & Doğan, H. O. (2020) · Epilepsy Research · doi:10.1016/j.eplepsyres.2020.106352 · Cited by 19 · see citing works

Synthesis and in vitro evaluation of pteridine analogues as monoamine oxidase B and nitric oxide synthase inhibitors

Prins, L. H. A., Petzer, J. P., & Malan, S. F. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.09.019 · Cited by 19 · see citing works

Effects of L-NAME, a non-specific nitric oxide synthase inhibitor, on AlCl3-induced toxicity in the rat forebrain cortex

Stevanović, I. D., Jovanović, M., Jelenković, A., Čolić, M. J., Stojanović, I. R., & Ninković, M. (2009) · Journal of Veterinary Science · doi:10.4142/jvs.2009.10.1.15 · Cited by 19 · see citing works

PrPC interacts with potassium channel tetramerization domain containing 1 (KCTD1) protein through the PrP51-136 region containing octapeptide repeats

Huang, T., Xu, J., Xiang, J., Lu, Y., Chen, R., Huang, L., Xiao, G., & Sun, G. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.081 · Cited by 18 · see citing works

Mildronate and its Neuroregulatory Mechanisms: Targeting the Mitochondria, Neuroinflammation, and Protein Expression

Klusa, V. Z., Beitnere, U., Pupure, J., Isajevs, S., Rumaks, J., Svirskis, Š., Dzirkale, Z., & Kalvinsh, I. (2013) · Medicina · doi:10.3390/medicina49070047 · Cited by 18 · see citing works

β-Synuclein-Derived Peptides With Neuroprotective Activity: An Alternative Treatment of Neurodegenerative Disorders?

Windisch, M., Hutter‐Paier, B., Schreiner, E., & Wronski, R. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:24:1:155 · Cited by 18 · see citing works

Bilirubin encephalopathy: A study of neuronal subpopulations and neurodegenerative mechanisms in 12 autopsy cases

Hachiya, Y., & Hayashi, M. (2007) · Brain and Development · doi:10.1016/j.braindev.2007.08.013 · Cited by 18 · see citing works

Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders

Galano, A., Guzmán‐López, E. G., & Reiter, R. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111584 · Cited by 16 · see citing works

Identifying Alzheimer’s disease-related proteins by LRRGD

Zhao, T., Hu, Y., Zang, T., & Cheng, L. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-3124-7 · Cited by 16 · see citing works

Stilbenes from Vine Extracts: Therapeutic Potential and Mechanisms

Brás, L. P., Luís, Â., Chatel, G., Socorro, S., & Duarte, A. P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178269 · Cited by 14 · see citing works

Activity-dependent survival of neurons in culture: a model of slow neurodegeneration

Schoenfeld, E., & Segal, M. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0256-3 · Cited by 13 · see citing works

Computational Modeling of Multi-target-Directed Inhibitors Against Alzheimer’s Disease

Kumar, A., & Sharma, A. K. (2017) · Neuromethods · doi:10.1007/978-1-4939-7404-7_19 · Cited by 10 · see citing works

Effects of antiepileptic drugs on dynamic thiol/disulphide homeostasis in children with idiopathic epilepsy

Arhan, E., Kurt, A. N. Ç., Neşeli̇oğlu, S., Yerel, O., Uçar, H. K., Aydın, K., & Serdaroğlu, A. (2018) · Seizure · doi:10.1016/j.seizure.2018.12.019 · Cited by 10 · see citing works

Oxidative stress and Na,K-ATPase activity differential regulation in brainstem and forebrain of Wistar Audiogenic rats may lead to increased seizure susceptibility

Parreira, G. M., Resende, M. D. A., Garcia, I. J. P., Sartori, D. B., Umeoka, E. H. D. L., Godoy, L. D., Garcia‐Cairasco, N., Barbosa, L. A., Santos, H. D. L., & Tilelli, C. Q. (2017) · Brain Research · doi:10.1016/j.brainres.2017.12.001 · Cited by 9 · see citing works

Advances in our Understanding of Neurodegeneration

Jellinger, K. A. (2007) · Elsevier eBooks · doi:10.1016/b978-044452809-4/50142-3 · Cited by 9 · see citing works

Molecular Neurobiology of Retinal Degeneration

Sharma, R. (2007) · Springer eBooks · doi:10.1007/978-0-387-30374-1_3 · Cited by 9 · see citing works

Interactions Between the Ubiquitin–Proteasome System, Nrf2, and the Cannabinoidome as Protective Strategies to Combat Neurodegeneration: Review on Experimental Evidence

Monsalvo-Maraver, L. Á., Ovalle-Noguez, E. A., Nava-Osorio, J., Maya-López, M., Rangel‐López, E., Túnez, I., Tinkov, A. A., Tizabi, Y., Aschner, M., Santamarı́a, A., et al. (2024) · Neurotoxicity Research · doi:10.1007/s12640-024-00694-3 · Cited by 8 · see citing works

Role of Selenium, Iron, Copper, and Zinc in Parkinsonism

Qureshi, G. A., Syed, S. A., & Parvez, S. H. (2007) · Elsevier eBooks · doi:10.1016/b978-044452809-4/50171-x · Cited by 8 · see citing works

ISKNV Triggers AMPK/mTOR-Mediated Autophagy Signaling through Oxidative Stress, Inducing Antioxidant Enzyme Expression and Enhancing Viral Replication in GF-1 Cells

Hsueh, T.-C., Chen, P.-H., & Hong, J.-R. (2024) · Viruses · doi:10.3390/v16060914 · Cited by 7 · see citing works

Infectious spleen and kidney necrosis virus induces the reactive oxidative species/Nrf2-mediated oxidative stress response for the regulation of mitochondrion-mediated Bax/Bak cell death signals in GF-1 cells

Chen, P.-H., Hsueh, T.-C., & Hong, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.958476 · Cited by 7 · see citing works

Dopamine induces supernumerary centrosomes and subsequent cell death through Cdk2 up-regulation in dopaminergic neuronal cells

Díaz-Corrales, F., Asanuma, M., Miyazaki, I., Miyoshi, K., Hattori, N., & Ogawa, N. (2008) · Neurotoxicity research · doi:10.1007/bf03033854 · Cited by 6 · see citing works

Molecular Hybridization

Zhang, S., Saathoff, J. M., & Liu, H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-101011-2.00008-8 · Cited by 8 · see citing works

The multitarget approach as a green tool in medicinal chemistry

Vlocskó, R. B., Apaydın, S., Török, B., & Török, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822248-5.00016-4 · Cited by 6 · see citing works

Engineering piperlongumine-inspired analogs as Nrf2-dependent neuroprotectors against oxidative damage by an electrophilicity-based strategy

Wang, Q., Dong, L., Liu, X., Dai, F., Jin, X., & Zhou, B. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.12.011 · Cited by 5 · see citing works

Multifunctional Enzyme Inhibition for Neuroprotection - A Focus on MAO, NOS, and AChE Inhibitors

Joubert, J., Petzer, J. P., Prins, L. H. A., Repsold, B. P., & Malan, S. F. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-803959-5.50005-2 · Cited by 5 · see citing works

Potent, selective and reversible hMAO-B inhibition by benzalphthalides: Synthesis, enzymatic and cellular evaluations and virtual docking and predictive studies

del Olmo, E., Barboza, B., Delgado‐Esteban, M., Escala, N., Jiménez-Blasco, D., López‐Pérez, J. L., de la Fuente, L. C., Quezada, E., Munín, J., Viña, D., et al. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107255 · Cited by 4 · see citing works

Neurodegenerative Erkrankungen (ZNS) - Eine aktuelle Übersicht

Ka, J. (2014) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 4 · see citing works

Iron Deficiency and Excess in the Brain: Implications for Cognitive Impairment and Neurodegeneration

Youdim, M. B. H., Gerlach, M., & Riederer, P. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-462-9_6 · Cited by 3 · see citing works

Recent advances in our understanding of neurodegeneration

Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274 · see citing works

Basic mechanisms of neurodegeneration: a critical update

Jellinger, K. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01010.x · Cited by 608 · see citing works

Advances in our Understanding of Neurodegeneration

Jellinger, K. A. (2007) · Elsevier eBooks · doi:10.1016/b978-044452809-4/50142-3 · Cited by 9 · see citing works

Protein aggregation and degradation mechanisms in neurodegenerative diseases.

Takalo, M., Salminen, A., Soininen, H. S., Hiltunen, M. O., & Haapasalo, A. (2013) · Europe PMC (PubMed Central) · Cited by 219 · see citing works

The Mechanistic Approach Involved in the Progression of Neurodegenerative Disorders

Rather, M. A., Khan, A., Alsharani, S., Jahan, S., Siddiqui, A. J., Mehan, S., & Alexiou, A. T. (2023) · Springer eBooks · doi:10.1007/978-981-99-3848-3_2