Sequence of Aβ-protein deposition in the human medial temporal lobe
Abstract
The deposition of Abeta protein (Abeta) and the development of neurofibrillary changes are important histopathological hallmarks of Alzheimer disease (AD). In this study, the medial temporal lobe serves as a model for the changes in the anatomical distribution pattern of different types of Abeta-deposits occurring in the course of AD, as well as for the relationship between the development of Abeta-deposition and that of neurofibrillary pathology. In the first of 4 phases of beta-amyloidosis, diffuse non-neuritic plaques are deposited in the basal temporal neocortex. The same plaque type appears in the second phase within the external entorhinal layers pre-beta and pre-gamma, and fleecy amyloid deposits occur in the internal entorhinal layers pri-alpha, pri-beta, pri-gamma, and in CA1. In the third phase, Abeta-deposits emerge in the molecular layer of the fascia dentata, and band-like Abeta-deposits occur in the subpial portion of the molecular layer of both the entorhinal region and the temporal neocortex. In addition, confluent lake-like Abeta-deposits appear in the parvopyramidal layer of the presubicular region. The fourth phase is characterized by diffuse and core-only plaques in CA4. Diffuse plaques evolve sporadically in the external entorhinal layer pre-alpha. Parallel to the evolution of beta-amyloidosis as represented by the 4 phases, neuritic plaques gradually make their appearance in the temporal neocortex, entorhinal region, CA1, the molecular layer of the fascia dentata, and CA4. A prerequisite for their development is the presence of Abeta and the presence of neurofibrillary tangles in neurons targeting the regions where neuritic plaques evolve. Each of the different types of Abeta-deposits, including neuritic plaques, plays a specific role in the distinct developmental sequence as represented by the 4 phases so that the medial temporal lobe inexorably becomes involved to an ever greater extent. The step-for-step involvement of connected anatomical subfields highlights the importance of the entorhino-hippocampal pathways for the expansion of beta-amyloidosis. The 4 phases in the evolution of beta-amyloidosis correlate significantly with the stages of the neurofibrillary pathology proposed by Braak and Braak.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some of the variability in neuritic plaque detection may be due to the evolution of the NP as part of the disease process.
“Some of the variability may be due to the evolution of the NP as part of the disease process (52-54).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [52]
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Self-citationHsu, S. M., Raine, L., & Fanger, H. (1981) · Journal of Histochemistry & Cytochemistry · doi:10.1177/29.4.6166661 · Cited by 14,248 · see citing works
Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works
Some Methods for Strengthening the Common χ 2 Tests
Cochran, W. G. (1954) · Biometrics · doi:10.2307/3001616 · Cited by 3,718 · see citing works
Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories
Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656 · see citing works
Self-citationHYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542 · see citing works
Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525 · see citing works
Uber eine eigenartige Erkrankung der Hirnrinde
Alzheimer, A. (1907) · Medical Entomology and Zoology · Cited by 1,503 · see citing works
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380 · see citing works
Amyloid, the presenilins and Alzheimer’s disease
Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370 · see citing works
Masters, C. L., Multhaup, G., Simms, G., Pottgiesser, J., Martins, R. N., & Beyreuther, K. T. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04000.x · Cited by 1,043 · see citing works
Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease
(1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00057-2 · Cited by 981 · see citing works
Price, J. L., Davis, P. B., Morris, J. C., & White, D. L. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90006-6 · Cited by 818 · see citing works
Braak, F., Braak, H., & Mandelkow, E. (1994) · Acta Neuropathologica · doi:10.1007/bf00293315 · Cited by 773 · see citing works
Self-citationThe Pathogenesis of Senile Plaques
DICKSON, D. W. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199704000-00001 · Cited by 753 · see citing works
Arriagada, P. V., Marzloff, K., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.9.1681 · Cited by 638 · see citing works
Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections
Braak, H., & Braak, E. (1991) · Brain Pathology · doi:10.1111/j.1750-3639.1991.tb00661.x · Cited by 598 · see citing works
Self-citationLemere, C. A., Blusztajn, J. K., Yamaguchi, H., Wisniewski, T., Saido, T. C., & Selkoe, D. J. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0003 · Cited by 584 · see citing works
Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease
Griffin, W. S. T., Sheng, J. G., Roberts, G. W., & Mrak, R. E. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199503000-00014 · Cited by 546 · see citing works
Organization of the entorhinal—hippocampal system: A review of current anatomical data
Witter, M. P. (1993) · Hippocampus · doi:10.1002/hipo.1993.4500030707 · Cited by 534 · see citing works
Irizarry, M. C., Soriano, F., McNamara, M., Page, K. J., Schenk, D., Games, D., & Hyman, B. T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-18-07053.1997 · Cited by 497 · see citing works
Memory‐related neural systems in Alzheimer's disease: An anatomic study
Hyman, B. T., Hoesen, G. W. V., & Damasio, A. R. (1990) · Neurology · doi:10.1212/wnl.40.11.1721 · Cited by 449 · see citing works
Braak, H., Braak, E., Grundke-Iqbal, I., & Iqbal, K. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90288-0 · Cited by 432 · see citing works
Self-citationThe presenilins and Alzheimer's disease
Hutton, M. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.10.1639 · Cited by 368 · see citing works
The human entorhinal cortex: normal morphology and lamina-specific pathology in various diseases
Braak, H., & Braak, E. (1992) · Neuroscience Research · doi:10.1016/0168-0102(92)90014-4 · Cited by 340 · see citing works
Self-citationHyman, B., Marzloff, K., & Arriagada, P. (1993) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199311000-00006 · Cited by 294 · see citing works
Bouras, C., Hof, P. R., Giannakopoulos, P., Michel, J.-P., & Morrison, J. H. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.2.138 · Cited by 280 · see citing works
Entorhinal-hippocampal connections: a speculative view of their function
Jones, R. S. G. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90018-h · Cited by 259 · see citing works
Nishimura, M., Yu, G., Lévesque, G., Zhang, D. M., Ruel, L., Chen, F., Milman, P., Holmes, E., Liang, Y., Kawarai, T., et al. (1999) · Nature Medicine · doi:10.1038/5526 · Cited by 218 · see citing works
Leverenz, J. B., & Raskind, M. A. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6777 · Cited by 214 · see citing works
Phinney, A. L., Deller, T., Stalder, M., Calhoun, M. E., Frotscher, M., Sommer, B., Staufenbiel, M., & Jucker, M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08552.1999 · Cited by 187 · see citing works
McGowan, E. M., Sanders, S., Iwatsubo, T., Takeuchi, A., Saido, T. C., Zehr, C., Yu, X., Uljon, S., Wang, R., Mann, D. M. A., et al. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0243 · Cited by 180 · see citing works
Chapter 20 Neuropathological hallmarks of Alzheimer's and Parkinson's diseases
Braak, H., de Vos, R. A. I., Jansen, E. N. H., Bratzke, H., & Braak, E. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)64021-2 · Cited by 150 · see citing works
Self-citationMorphological characteristics of layer II projection neurons in the rat medial entorhinal cortex
Klink, R., & Alonso, Á. (1997) · Hippocampus · doi:10.1002/(sici)1098-1063(1997)7:5 · Cited by 137 · see citing works
Rudelli, R. D., Ambler, M. W., & Wı́sniewski, H. M. (1984) · Acta Neuropathologica · doi:10.1007/bf00690393 · Cited by 129 · see citing works
Yamaguchi, H., Sugihara, S., Ogawa, A., Saido, T. C., & Ihara, Y. (1998) · Acta Neuropathologica · doi:10.1007/s004010050790 · Cited by 110 · see citing works
van de Nes, J. A. P., Kamphorst, W., Ravid, R., & Swaab, D. F. (1998) · Acta Neuropathologica · doi:10.1007/s004010050872 · Cited by 106 · see citing works
An ‘anatomical cascade hypothesis’ for Alzheimer's disease
Hardy, J. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90033-5 · Cited by 79 · see citing works
Thal, D. R., Sassin, I., Schultz, C., Haass, C., Braak, E., & Braak, H. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199902000-00010 · Cited by 77 · see citing works
Self-citationWisniewski, H. M., Sadowski, M., Jakubowska-Sadowswka, K., Tarnawski, M., & Wegiel, J. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199807000-00004 · Cited by 71 · see citing works
Berr, C., Hauw, J., Delaère, P., Duyckaerts, C. J., & Amouyel, P. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90763-3 · Cited by 69 · see citing works
Kalus, P., Braak, H., Braak, E., & Böhl, J. (1989) · Brain Research · doi:10.1016/0006-8993(89)90164-9 · Cited by 57 · see citing works
Self-citationRegional Variation in the Distribution of Apolipoprotein E and Aβ in Alzheimerʼs Disease
Gearing, M., Schneider, J. A., Robbins, R. S., Hollister, R. D., Mori, H., Games, D., Hyman, B. T., & Mirra, S. S. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199511000-00010 · Cited by 57 · see citing works
Thal, D. R., Arendt, T., Waldmann, G., Holzer, M., Zedlick, D., Rüb, U., & Schober, R. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00090-6 · Cited by 53 · see citing works
Self-citationSilver Labeling of Alzheimer Neurofibrillary Changes and Brain β-Amyloid
Iqbal, K., Braak, H., Braak, E., & Grundke, I. (1993) · Journal of Histotechnology · doi:10.1179/his.1993.16.4.335 · Cited by 52 · see citing works
Self-citationHyman, B. T., Damasio, H., Damasio, A. R., & Hoesen, G. W. V. (1989) · Annual Review of Public Health · doi:10.1146/annurev.pu.10.050189.000555 · Cited by 46 · see citing works
Kida, E., Wisniewski, K. E., & Wı́sniewski, H. M. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11678-p · Cited by 35 · see citing works
Akiyama, H., Tago, H., Itagaki, S., & McGeer, P. L. (1990) · Acta Neuropathologica · doi:10.1007/bf00296114 · Cited by 31 · see citing works
Ghebremedhin, E., Braak, H., Braak, E., & Sahm, J. (1998) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(97)00197-0 · Cited by 23 · see citing works
Self-citationSubpial β/A4 amyloid deposition occurs between astroglial processes in Alzheimer-type dementia
Yamaguchi, H., Nakazato, Y., Yamazaki, T., Shoji, M., Kawarabayashi, T., & Hirai, S. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90934-l · Cited by 20 · see citing works
Alzheimer’s Disease and Neuroanatomy: Hypotheses and Proposals
Duyckaerts, C. J., Delaère, P., & Hauw, J. (1992) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-46776-9_15 · Cited by 16 · see citing works
Thal, D. R., Glas, A., Schneider, W., & Schober, R. (1997) · Acta Neuropathologica · doi:10.1007/s004010050701 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490 · see citing works
Self-citationHyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works
Self-citationNelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works
“Some of the variability may be due to the evolution of the NP as part of the disease process (52 Y 54).”
BackgroundSelf-citationLimbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., Rademakers, R., Alafuzoff, I., Attems, J., Brayne, C., et al. (2019) · Brain · doi:10.1093/brain/awz099 · Cited by 1,547 · see citing works
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease
Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968 · see citing works
The pathological process underlying Alzheimer’s disease in individuals under thirty
Braak, H., & Del Tredici, K. (2011) · Acta Neuropathologica · doi:10.1007/s00401-010-0789-4 · Cited by 812 · see citing works
Self-citationSpreading of pathology in neurodegenerative diseases: a focus on human studies
Brettschneider, J., Tredici, K. D., Lee, V. M.-Y., & Trojanowski, J. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3887 · Cited by 790 · see citing works
Self-citationNeuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship
Nelson, P. T., Braak, H., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181919a48 · Cited by 643 · see citing works
Self-citationProtein transmission in neurodegenerative disease
Peng, C., Trojanowski, J. Q., & Lee, V. M.-Y. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0333-7 · Cited by 625 · see citing works
Alzheimer's Disease: From Pathology to Therapeutic Approaches
Jakob‐Roetne, R., & Jacobsen, H. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802808 · Cited by 626 · see citing works
Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
Sardar Sinha, M., Ansell-Schultz, A., Civitelli, L., Hildesjö, C., Larsson, M., Lannfelt, L., Ingelsson, M., & Hallbeck, M. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1868-1 · Cited by 527 · see citing works
Isolation of glia from Alzheimer’s mice reveals inflammation and dysfunction
Orre, M., Kamphuis, W., Osborn, L. M., Jansen, A. H. P., Kooijman, L., Bossers, K., & Hol, E. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.06.004 · Cited by 394 · see citing works
Thal, D. R., Ghebremedhin, E., Orantes, M., & Wiestler, O. D. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.12.1287 · Cited by 384 · see citing works
Self-citationThe Development of Amyloid β Protein Deposits in the Aged Brain
Thal, D. R., Capetillo-Zarate, E., Del Tredici, K., & Braak, H. (2006) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2006.6.re1 · Cited by 234 · see citing works
Self-citationCortical Microinfarcts and Demyelination Significantly Affect Cognition in Brain Aging
Kövari, E., Gold, G., Herrmann, F. R., Canuto, A., Hof, P. R., Michel, J.-P., Bouras, C., & Giannakopoulos, P. (2004) · Stroke · doi:10.1161/01.str.0000110791.51378.4e · Cited by 202 · see citing works
Kril, J., Patel, S., Harding, A., & Halliday, G. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0477-5 · Cited by 190 · see citing works
Reactive glia show increased immunoproteasome activity in Alzheimer’s disease
Orre, M., Kamphuis, W., Dooves, S., Kooijman, L., Chan, E. T., Kirk, C. J., Dimayuga Smith, V., Koot, S., Mamber, C., Jansen, A. H., et al. (2013) · Brain · doi:10.1093/brain/awt083 · Cited by 180 · see citing works
. Identification of Alzheimer and vascular lesion thresholds for mixed dementia.
Gold, G., Giannakopoulos, P., Herrmann, F. R., Bouras, C., & Kovari, E. (2007) · Brain · doi:10.1093/brain/awm228 · Cited by 163 · see citing works
Zeineh, M. M., Chen, Y., Kitzler, H. H., Hammond, R., Vogel, H., & Rutt, B. K. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.05.022 · Cited by 151 · see citing works
Alzheimer’s disease, cerebrovascular disease, and the β-amyloid cascade
Honjo, K., Black, S. E., & Verhoeff, N. P. L. G. (2012) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100015547 · Cited by 152 · see citing works
Thal, D. R., Griffin, W. S. T., & Braak, H. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00411.x · Cited by 134 · see citing works
Self-citationHypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
March-Diaz, R., Lara-Ureña, N., Romero-Molina, C., Heras-Garvin, A., Ortega-de San Luis, C., Alvarez-Vergara, M. I., Sanchez-Garcia, M. A., Sanchez-Mejias, E., Davila, J. C., Rosales-Nieves, A. E., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00054-2 · Cited by 125 · see citing works
Cortical microinfarcts and demyelination affect cognition in cases at high risk for dementia
Kövari, E., Gold, G., Herrmann, F. R., Canuto, A., Hof, P. R., Bouras, C., & Giannakopoulos, P. (2007) · Neurology · doi:10.1212/01.wnl.0000257094.10655.9a · Cited by 128 · see citing works
General aspects of neurodegeneration
Jellinger, K. A. (2003) · Journal of Neural Transmission. Supplementa · doi:10.1007/978-3-7091-0643-3_7 · Cited by 126 · see citing works
Tau Oligomer–Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease
Taddei, R. N., Perbet, R., Mate de Gerando, A., Wiedmer, A. E., Sanchez-Mico, M., Connors Stewart, T., Gaona, A., Melloni, A., Amaral, A. C., Duff, K., et al. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2023.3530 · Cited by 110 · see citing works
Thal, D. R., Papassotiropoulos, A., Saido, T. C., Griffin, W. S. T., Mrak, R. E., Kölsch, H., Tredici, K. D., Attems, J., & Ghebremedhin, E. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0707-9 · Cited by 103 · see citing works
Self-citationPathological Substrates of Cognitive Decline in Alzheimer’s Disease
Giannakopoulos, P., Kövari, E., Gold, G., von Gunten, A., Hof, P. R., & Bouras, C. (2009) · Frontiers of Neurology and Neuroscience · doi:10.1159/000197881 · Cited by 101 · see citing works
Thal, D. R., Attems, J., & Ewers, M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141461 · Cited by 100 · see citing works
Frank, S., Copanaki, E., Burbach, G. J., Müller, U. C., & Deller, T. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.075 · Cited by 86 · see citing works
In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease
Tournier, B. B., Tsartsalis, S., Ceyzériat, K., Garibotto, V., & Millet, P. (2020) · Cells · doi:10.3390/cells9091941 · Cited by 79 · see citing works
Knopman, D. S., Jack, C. R., Wiste, H. J., Weigand, S. D., Vemuri, P., Lowe, V. J., Kantarci, K., Gunter, J. L., Senjem, M. L., Mielke, M. M., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.182 · Cited by 68 · see citing works
Kobayashi, K., Hayashi, M., Nakano, H., Shimazaki, M., Sugimori, K., & Koshino, Y. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6606 · Cited by 58 · see citing works
Hascup, K. N., & Hascup, E. R. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160041 · Cited by 57 · see citing works
Mathur, R., Ince, P. G., Minett, T., Garwood, C. J., Shaw, P. J., Matthews, F. E., Brayne, C., Simpson, J. E., Wharton, S. B., & on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · PLOS ONE · doi:10.1371/journal.pone.0118463 · Cited by 52 · see citing works
Nyakas, C., Felszeghy, K., Szabó, R., Keijser, J. N., Luiten, P. G. M., Szombathelyi, Z., & Tihanyi, K. (2009) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00078.x · Cited by 46 · see citing works
Capetillo-Zarate, E., Staufenbiel, M., Abramowski, D., Haass, C., Escher, A., Stadelmann, C., Yamaguchi, H., Wiestler, O. D., & Thal, D. R. (2006) · Brain · doi:10.1093/brain/awl176 · Cited by 45 · see citing works
Self-citationSuelves, N., Saleki, S., Ibrahim, T., Palomares, D., Moonen, S., Koper, M. J., Vrancx, C., Vadukul, D. M., Papadopoulos, N., Viceconte, N., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01578-x · Cited by 43 · see citing works
Self-citationSantos, M., Gold, G., Kövari, E., Herrmann, F. R., Hof, P. R., Bouras, C., & Giannakopoulos, P. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01101.x · Cited by 32 · see citing works
In vivo [ <sup>18</sup> F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease
Day, G. S., Gordon, B. A., Perrin, R. J., Cairns, N. J., Beaumont, H., Schwetye, K., Ferguson, C., Sinha, N., Bucelli, R., Musiek, E. S., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000005064 · Cited by 26 · see citing works
- Authors
- Thal, D. R., Rüb, U., Schultz, C., Sassin, I., Ghebremedhin, E., Del Tredici, K., Braak, E., & Braak, H.
- Affiliations
- Goethe University Frankfurt (DE)
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-08
- Volume
- 59
- Issue
- 8
- Pages
- 733-748
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- OpenAlex
- W10604852
- Cited by
- 370
- References
- 52
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 16 · 2023: 15 · 2022: 29 · 2021: 21 · 2020: 26 · 2019: 7 · 2018: 20 · 2017: 8 · 2016: 20 · 2015: 12 · 2014: 8 · 2013: 17 · 2012: 14
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid-beta deposition, Alzheimer's disease, medial temporal lobe, neurofibrillary tangles, neuritic plaques, entorhinal cortex, hippocampus, Braak stages, CA1, CA4, dentate gyrus, temporal neocortex
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neural Pathways, Temporal Lobe, Amyloid beta-Peptides, Cerebral Amyloid Angiopathy, Neurofibrillary Tangles, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review