Tumor hypoxia: its impact on cancer therapy

Statistical Method in Biological Assay.

Healy, M. J. R., & Finney, D. J. (1979) · Journal of the Royal Statistical Society. Series A (General) · doi:10.2307/2982559 · Cited by 3,586

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

Thomlinson, R. H., & Gray, L. H. (1955) · British Journal of Cancer · doi:10.1038/bjc.1955.55 · Cited by 2,219

The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy

Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., & Scott, O. C. A. (1953) · The British Journal of Radiology · doi:10.1259/0007-1285-26-312-638 · Cited by 2,158

Technical Report Series 935

(2006) · Technical Report Series 936 · doi:10.2471/trs.02.935 · Cited by 1,096

Statistical Method in Biological Assay.

Barton, D. E., & Finney, D. J. (1966) · Biometrika · doi:10.2307/2334099 · Cited by 813

Radiation Biology in Cancer Research

Nias, A. H. W. (1980) · British Journal of Cancer · doi:10.1038/bjc.1980.293 · Cited by 778

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

Tannock, I. F. (1968) · British Journal of Cancer · doi:10.1038/bjc.1968.34 · Cited by 763

The radiobiology of cultured mammalian cells

Elkind, M. M., & Whitmore, G. F. (1967) · Gordon and Breach eBooks · Cited by 684

Growth Kinetics of Tumours

Lord, B. I. (1978) · British Journal of Cancer · doi:10.1038/bjc.1978.97 · Cited by 669

II. Clinical Application

Churchill-Davidson, I., Sanger, C., & Thomlinson, R. H. (1957) · The British Journal of Radiology · doi:10.1259/0007-1285-30-356-406 · Cited by 609

Hypoxic fractions of solid tumors: Experimental techniques, methods of analysis, and a survey of existing data

Moulder, J. E., & Rockwell, S. (1984) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(84)90301-8 · Cited by 606

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells.

Teicher, B. A., Lazo, J. S., & Sartorelli, A. C. (1981) · PubMed · Cited by 555

Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation

Brown, J. M. (1979) · The British Journal of Radiology · doi:10.1259/0007-1285-52-620-650 · Cited by 526

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin

Hewitt, H. B., Blake, E. R., & Walder, A. S. (1976) · British Journal of Cancer · doi:10.1038/bjc.1976.37 · Cited by 474

Definitive evidence for hypoxic cells influencing cure in cancer therapy.

Bush, R. S., Jenkin, R. D. T., Allt, W. E. C., Beale, F. A., Bean, H. A., Dembo, A. J., & Pringle, J. F. (1978) · PubMed Central · Cited by 416

Characteristics of a Serially Transplanted Mouse Mammary Tumor and Its Tissue-Culture-Adapted Derivative

(1972) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/49.3.735 · Cited by 397

A marker for hypoxic cells in tumours with potential clinical applicability

Chapman, J. D., Franko, A. J., & Sharplin, J. (1981) · British Journal of Cancer · doi:10.1038/bjc.1981.79 · Cited by 306

Radiation and High-Dose Metronidazole in Supratentorial Glioblastomas

Urtasun, R., Band, P., Chapman, J. D., Feldstein, M. L., Mielke, B., & Fryer, C. (1976) · New England Journal of Medicine · doi:10.1056/nejm197606172942503 · Cited by 306

The Phenomenon of Reoxygenation and Its Implications for Fractionated Radiotherapy

Kallman, R. F. (1972) · Radiology · doi:10.1148/105.1.135 · Cited by 294

The hypoxic tumor cell: A target for selective cancer chemotherapy

Kennedy, K. A., Teicher, B. A., Rockwell, S., & Sartorelli, A. C. (1980) · Biochemical Pharmacology · doi:10.1016/0006-2952(80)90235-x · Cited by 287

Changes of cell proliferation characteristics in a rat rhabdomyosarcoma before and after X-irradiation

Hermens, A. F., & Barendsen, G. W. (1969) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(69)90065-6 · Cited by 269

Oxygen diffusion and the distribution of cellular radiosensitivity in tumours

Tannock, I. F. (1972) · The British Journal of Radiology · doi:10.1259/0007-1285-45-535-515 · Cited by 264

Experimental radiotherapy of a rat rhabdomyosarcoma with 15 MeV neutrons and 300 kV X-rays

Barendsen, G. W., & Broerse, J. J. (1970) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(70)90006-x · Cited by 255

Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor.

Tannock, I. F. (1970) · PubMed · Cited by 242

Primary radiotherapy of larynx and pharynx carcinoma—An analysis of some factors influencing local control and survival

Overgaard, J., Sand Hansen, H., Jøsrgensen, K., & Hjelm Hansen, M. (1986) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(86)90058-1 · Cited by 239

A Multicomponent X-ray Survival Curve for Mouse Lymphosarcoma Cells irradiated in vivo

POWERS, W. E., & TOLMACH, L. J. (1963) · Nature · doi:10.1038/197710b0 · Cited by 225

Quantitative measurements of oxygen tension in normal tissues and in the tumours of patients before and after radiotherapy

Cater, D. B., & Silver, I. A. (1960) · Acta Radiologica · doi:10.3109/00016926009171671 · Cited by 223

A Survival Curve for Mammalian Leukaemia Cells Irradiated 'in vivo (Implications for the Treatment of Mouse Leukaemia by Whole-Body Irradiation)

Hewitt, H. B., & Wilson, C. W. (1959) · British Journal of Cancer · doi:10.1038/bjc.1959.9 · Cited by 216

Proliferation-dependent cytotoxicity of anticancer agents: a review.

Valeriote, F. A., & van Putten, L. (1975) · PubMed · Cited by 214

Oxygenation status of a transplantable tumor during fractionated radiation therapy.

Putten, L. M. V., & Kallman, R. F. (1968) · PubMed · Cited by 208

Perfluorochemical Emulsions Can Increase Tumor Radiosensitivity

Teicher, B. A., & Rose, C. M. (1984) · Science · doi:10.1126/science.6695191 · Cited by 204

Tumor Blood Circulation: Angiogenesis, Vascular Morphology and Blood Flow of Experimental and Human Tumors

(2020) · CRC Press eBooks · doi:10.1201/9780429283024 · Cited by 202

Repair of Potentially Lethal Radiation Damage In Vitro and In Vivo

Little, J. B., Hahn, G. M., Frindel, E., & Tubiana, M. (1973) · Radiology · doi:10.1148/106.3.689 · Cited by 194

31P NMR spectroscopy of in vivo tumors

Ng, T. C., Evanochko, W. T., Hiramoto, R. N., Ghanta, V. K., Lilly, M. B., Lawson, A. J., Corbett, T. H., Durant, J. R., & Glickson, J. D. (1982) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(82)90190-1 · Cited by 191

On the Access of Blood-Borne Dyes to Various Tumour Regions

Goldacre, R. J., & Sylvén, B. (1962) · British Journal of Cancer · doi:10.1038/bjc.1962.36 · Cited by 183

Experimental radiotherapy of a rat rhabdomyosarcoma with 15 MeV neutrons and 300 kV X-rays

Barendsen, G. W., & Broerse, J. J. (1969) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(69)90051-6 · Cited by 183

An estimation of changes in the proportions and absolute numbers of hypoxic cells after irradiation of transplanted C3H mouse mammary tumours

Howes, A. E. (1969) · The British Journal of Radiology · doi:10.1259/0007-1285-42-498-441 · Cited by 181

Chemical sensitizers for hypoxic cells: A decade of experience in clinical radiotherapy

Dische, S. (1985) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(85)80015-3 · Cited by 179

Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

Keyes, S. R., Fracasso, P. M., Heimbrook, D. C., Rockwell, S., Sligar, S. G., & Sartorelli, A. C. (1984) · PubMed · Cited by 176

Hypoxia in neoplastic tissue

Vaupel, P. (1977) · Microvascular Research · doi:10.1016/0026-2862(77)90106-6 · Cited by 174

The gross response of an experimental tumour to single doses of x-rays.

Thomlinson, R. H., & Craddock, E. A. (1967) · British Journal of Cancer · doi:10.1038/bjc.1967.10 · Cited by 170

Rodent tumor models in experimental cancer therapy

van der Kogel, A. J. (1988) · Radiotherapy and Oncology · doi:10.1016/0167-8140(88)90271-x · Cited by 167

Hyperbaric oxygen: the Medical Research Council trials and their clinical significance

Dische, S. (1978) · The British Journal of Radiology · doi:10.1259/0007-1285-51-611-888 · Cited by 154

A Factor of Importance in the Radio Sensitivity of Tumours

Mottram, J. C. (1936) · British Journal of Radiology · doi:10.1259/0007-1285-9-105-606 · Cited by 152

Binding of 3H-misonidazole to solid human tumors as a measure of tumor hypoxia

Urtasun, R. C., Chapman, J. D., Raleigh, J. A., Franko, A. J., & Koch, C. J. (1986) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(86)90273-7 · Cited by 148

Cellular Radiosensitivity and Tumor Radiation Response in the EMT6 Tumor Cell System

Rockwell, S., & Kallman, R. F. (1973) · Radiation Research · doi:10.2307/3573534 · Cited by 144

Vascular occlusion and tumour cell death

Denekamp, J., Hill, S. A., & Hobson, B. (1983) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(83)90426-1 · Cited by 140

Radiobiologic basis of oxygen as a modifying factor in radiation therapy.

Gray, L. H. (1961) · PubMed · Cited by 140

Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors.

Rotin, D., Robinson, B., & Tannock, I. F. (1986) · PubMed · Cited by 134

Intracapillary oxyhemoglobin saturation of malignant tumors in humans

Mueller‐Klieser, W., Vaupel, P. W., Manz, R., & Schmidseder, R. (1981) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(81)90036-5 · Cited by 130

The effect of oxygen on cellular survival and recovery after radiation

Littbrand, B., & Révész, L. (1969) · British Journal of Radiology · doi:10.1259/0007-1285-42-504-914 · Cited by 123

The detection and measurement of hypoxic cells in solid tumors

Chapman, J. D. (1984) · Cancer · doi:10.1002/1097-0142(19841201)54:11<2441::aid-cncr2820541122>3.0.co;2-s · Cited by 117

ESR studies of O2 uptake by Chinese hamster ovary cells during the cell cycle.

Lai, C., Hopwood, L. E., Hyde, J. S., & Łukiewicz, S. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.4.1166 · Cited by 116

The Effect of Tissue Oxygen Tension on the Radiosensitivity of Leukaemia Cells Irradiated In Situ in the Livers of Leukaemic Mice

Hewitt, H. B., & Wilson, C. W. (1959) · British Journal of Cancer · doi:10.1038/bjc.1959.75 · Cited by 113

Use of a perfluorochemical emulsion to improve oxygenation in a solid tumor

Rockwell, S. (1985) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(85)90367-0 · Cited by 110

Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions

Tannock, I. F., & Guttman, P. (1981) · British Journal of Cancer · doi:10.1038/bjc.1981.37 · Cited by 109

Oxygen tension in human tumors: in vivo mapping using CT-guided probes.

Gatenby, R. A., Coia, L. R., Richter, M. P., Katz, H. R., Moldofsky, P. J., Engstrom, P., Brown, D. Q., Brookland, R. K., & Broder, G. (1985) · Radiology · doi:10.1148/radiology.156.1.4001408 · Cited by 102

The effect of hypoxia on the growth and radiation response of mammalian cells in culture

Bedford, J. S., & Mitchell, J. B. (1974) · British Journal of Radiology · doi:10.1259/0007-1285-47-562-687 · Cited by 101

Quantitative evaluation of the radiosensitivity of cells of a transplantable rhabdomyosarcoma in the rat

Reinhold, H. S. (1966) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(66)90087-9 · Cited by 100

The Effect of Oxygen Breathing and Radiotherapy upon the Tissue Oxygen Tension of some Human Tumours

Evans, N. T. S., & Naylor, P. F. D. (1963) · British Journal of Radiology · doi:10.1259/0007-1285-36-426-418 · Cited by 100

Influence of tumour size on hypoxic fraction and therapeutic sensitivity of Lewis lung tumour

Stanley, J. A., Shipley, W. U., & Steel, G. G. (1977) · British Journal of Cancer · doi:10.1038/bjc.1977.160 · Cited by 96

Biological Bases and Clinical Implications of Tumor Radioresistance

(1980) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/64.4.991-a · Cited by 93

Carbogen breathing during radiation therapy The radiation therapy oncology group study

Rubin, P., Hanley, J. A., Keys, H. M., Marcial, V. A., & Brady, L. W. (1979) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(79)90946-5 · Cited by 90

Demonstration of radiosensitization of hypoxic cells in solid tumours by metronidazole

Begg, A. C., SHELDON, P. W., & Foster, J. L. (1974) · British Journal of Radiology · doi:10.1259/0007-1285-47-559-399 · Cited by 89

Effect of Heat and Ionizing Radiation on Normal and Neoplastic Tissue of the C3H Mouse

Thrall, D. Ε., Gillette, E. L., & Dewey, W. C. (1975) · Radiation Research · doi:10.2307/3574160 · Cited by 84

Cell cycle distribution of chronically hypoxic cells and determination of the clonogenic potential of cells accumulated in G2 + M phases after irradiation of a solid tumor in vivo.

Pallavicini, M. G., Lalande, M., Miller, R. G., & Hill, R. P. (1979) · PubMed · Cited by 80

The labelling of EMT-6 tumours in BALB/C mice with14C-misonidazole

Garrecht, B. M., & Chapman, J. D. (1983) · British Journal of Radiology · doi:10.1259/0007-1285-56-670-745 · Cited by 79

A clinical trial of Fluosol DA 20% in advanced squamous cell carcinoma of the head and neck

Rose, C., Lustig, R. A., Mcintosh, N. L., & Teicher, B. A. (1986) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(86)90164-1 · Cited by 77

Misonidazole and other hypoxia markers: Metabolism and applications

Franko, A. J. (1986) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(86)90257-9 · Cited by 77

In vivotesting of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique

Rauth, A. M., & Kaufman, K. (1975) · British Journal of Radiology · doi:10.1259/0007-1285-48-567-209 · Cited by 73

On the nature of the radiobiologically hypoxic fraction in tumors

Sutherland, R. M., & Franko, A. J. (1980) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(80)90215-1 · Cited by 72

A Rapid Method for studying Tumour Blood Supply using Systemic Dyes

Goldacre, R. J., & Sylvén, B. (1959) · Nature · doi:10.1038/184063a0 · Cited by 70

The Effect of Oxygen on the Response of Spontaneous Tumours in Mice to Radiotherapy

Du Sault, L. A. (1963) · The British Journal of Radiology · doi:10.1259/0007-1285-36-430-749 · Cited by 64

Demonstration of an Anoxic Component in a Mouse Tumor-Cell Population by in Vivo Assay of Survival Following Irradiation

Powers, W. E., & Tolmach, L. J. (1964) · Radiology · doi:10.1148/83.2.328 · Cited by 64

The effect of prolonged hypoxia on growth and viability of Chinese hamster cells

Born, R., Hug, O., & Trott, K.-R. (1976) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(76)90151-6 · Cited by 62

Dose-response curve and split-dose recovery in human skin cancer

Trott, K.-R., Maciejewski, B., Preuss-Bayer, G., & Skołyszewski, J. (1984) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(84)80048-1 · Cited by 61

Cell killing, radiosensitization and cell cycle redistribution induced by chronic hypoxia

Spiro, I. J., Rice, G. C., Durand, R. E., Stickler, R., & Ling, C. (1984) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(84)90332-8 · Cited by 54

Oxygenation of malignant tumors after localized microwave hyperthermia

Vaupel, P. W., Otte, J., & Manz, R. (1982) · Radiation and Environmental Biophysics · doi:10.1007/bf01323754 · Cited by 50

The Effect of Hypoxia on the Generation Time of Mammalian Cells

Koch, C. J., Kruuv, J., & Frey, H. E. (1973) · Radiation Research · doi:10.2307/3573446 · Cited by 49

Oxygenation in radiotherapy.

Churchill‐Davidson, I. (1959) · PubMed · Cited by 49

In vivo-in vitro tumour cell lines: characteristics and limitations as models for human cancer.

Rockwell, S. (1980) · PubMed · Cited by 48

Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia

Vaupel, P. W., Manz, R., Müller-Klieser, W., & Grunewald, W. A. (1979) · Microvascular Research · doi:10.1016/0026-2862(79)90405-9 · Cited by 48

Changes in misonidazole binding with hypoxic fraction in mouse tumors

Hirst, D. G., Hazlehurst, J. L., & Brown, J. (1985) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(85)90251-2 · Cited by 48

Tumour oxygenation under normobaric and hyperbaric conditions

Mueller‐Klieser, W., Vaupel, P. W., & Manz, R. (1983) · British Journal of Radiology · doi:10.1259/0007-1285-56-668-559 · Cited by 47

Oxygenation and reoxygenation in 'sandwich' tumours.

Hs, R., Blachiwiecz, B., & Blok, A. P. R. (1977) · PubMed · Cited by 46

Effects of extreme hypoxia on the growth and viability of EMT6/SF mouse tumor cells in vitro.

Shrieve, D. C., Deen, D. F., & Harris, J. (1983) · PubMed · Cited by 43

Quantitative Radiosensitivity Studies of Solid Carcinomas In Vivo: Methodology and Effect of Anoxia 2

Clifton, K. H., Briggs, R. C., & Stone, H. B. (1966) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/36.5.965 · Cited by 42

Binding of misonidazole to V79 spheroids and fragments of dunning rat prostatic and human colon carcinomas in vitro: Diffusion of oxygen and reactive metabolites

Franko, A. J., & Koch, C. J. (1984) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(84)90343-2 · Cited by 42

Cell Cycle Kinetics of Aerated, Hypoxic and Re‐Aerated Cells In Vitro Using Flow Cytometric Determination of Cellular Dna and Incorporated Bromodeoxyuridine

Shrieve, D. C., & Begg, A. C. (1985) · Cell Proliferation · doi:10.1111/j.1365-2184.1985.tb00707.x · Cited by 41

EXPLOITATION OF THE OXYGEN ENHANCEMENT RATIO IN CLINICAL PRACTICE

Duncan, W. R. (1973) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a070953 · Cited by 41

Thein VitroSensitivity of Chronically Hypoxic EMT6/SF Cells to X-radiation and Hypoxic Cell Radiosensitizers

Shrieve, D. C., & Harris, J. (1985) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008514551131 · Cited by 39

Inhibition of cell-cycle progression by acute treatment with various degrees of hypoxia: Modifications induced by low concentrations of misonidazole present during hypoxia

Pettersen, E. O., & Lindmo, T. (1983) · British Journal of Cancer · doi:10.1038/bjc.1983.271 · Cited by 38

Response of Anoxic C3H Mouse Mammary Carcinoma Isotransplants (1–25 mm3) to X Irradiation 2

Suit, H. D., & Shalek, R. J. (1963) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/31.3.479 · Cited by 36

Cell Proliferation In Emt6 Tumors Treated With Single Doses of X‐Rays Or Hydroxyurea. I. Experimental Results

Rockwell, S., Frindel, E., Valleron, A., et al. (1978) · Cell Proliferation · doi:10.1111/j.1365-2184.1978.tb00895.x · Cited by 35

Kryomicrophotometry as a Method for Analyzing the Intracapillary HbO2 Saturation of Organs Under Different O2 Supply Conditions

Grunewald, W. A., & Lübbers, D. W. (1976) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3273-2_8 · Cited by 33

Modification of radiation response

Suit, H. D. (1984) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(84)90418-8 · Cited by 30

Deoxycytidylate shortage is a cause of G1 arrest of ascites tumor cells under oxygen deficiency

Löffler, M., Schimpff-Weiland, G., & Follmann, H. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80251-8 · Cited by 30

An appraisal of in vivo assays of excised tumours.

Hill, R. P. (1980) · Europe PMC (PubMed Central) · Cited by 28

Cellular and Molecular Repair of X-Ray-Induced Damage: Dependence on Oxygen Tension and Nutritional Status

Spiro, I. J., Kennedy, K. A., Stickler, R., & Ling, C. C. (1985) · Radiation Research · doi:10.2307/3576311 · Cited by 28

Comparative chemosensitivity of exponential- versus plateau-phase cells in both in vitro model systems.

Pr, T. (1976) · PubMed · Cited by 23

In vitro hypoxic cytotoxicity of nitroimidazoles: Uptake and cell cycle phase specificity

Sutherland, R. M., Keng, P., Conroy, P. J., McDermott, D., Bareham, B. J., & Passalacqua, W. (1982) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(82)90726-x · Cited by 22

“Oxygen Effect” and Tumor Size as Related to Response of C3H/Ba Adenocarcinoma to Local X Irradiation

Suit, H. D., Schlachter, L. B., & Andrews, J. R. (1960) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/24.6.1271 · Cited by 20

The in Vitro Sensitivities to Radiation and Misonidazole of Mouse Bone Marrow Cells Derived from Different Microenvironments

Allalunis‐Turner, J., & Chapman, J. D. (1985) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008514552641 · Cited by 11

Hypoxia mediated binding of misonidazole in non-malignant tissue

Asey, J. S., Hoffman, J. M., Spence, A. M., et al. (1986) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(86)90271-3 · Cited by 8

31P NMR spectroscopy of in vivo tumors

Ng, T., Evanochko, W. T., Hiramoto, R. N., et al. (1984) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(84)90147-4 · Cited by 5

Clinical development and potential of photothermal and photodynamic therapies for cancer

Li, X., Lovell, J. F., Yoon, J., & Chen, X. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0410-2 · Cited by 3,456

Drug penetration in solid tumours

Minchinton, A. I., & Tannock, I. F. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1893 · Cited by 2,805

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662

Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response

Vaupel, P., & Harrison, L. (2004) · The Oncologist · doi:10.1634/theoncologist.9-90005-4 · Cited by 761

Untitled work

(2001) · PubMed · Cited by 605