Effects of transderman nicotine on mood and sleep in nonsmoking major depresssed patients
Abstract
The role of nicotine as an indirect cholinergic agent in sleep has been studied in normal subjects. There are no studies of its effects on sleep in depressed patients. Nicotine transdermal patches (17.5 mg), were studied in eight depressed patients (DSM-III-R) and eight normal volunteers. Subjects wore placebo and nicotine patches for 24 h. Depressed patients showed increased REM sleep without changes in other sleep variables. They also showed a short term improvement of mood. Normal volunteers had sleep fragmentation, and reduction of REM sleep time. No major side effects were reported in either group.
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Mecamylamine and the nicotine patch decrease symptoms of depression in depressed non-smoking patients and patients with Tourette's syndrome.
“the non-competitive, non-selective nAChR antagonist mecamylamine as well as the nicotine patch, decrease symptoms of depression in depressed non-smoking patients and patients with Tourette's syndrome (Dursun and Kutcher, 1999; Mihailescu and Drucker-Colin, 2000; Salin-Pascual et al., 1995; Salin-Pascual et al., 1996).”
From It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood (2008) · cites this paper as Salin-Pascual et al., 1995
Nicotine patch can alleviate symptoms of depression in non-smokers.
“nicotine patch can alleviate symptoms of depression in non-smokers (Salin-Pascual et al., 1995)”
From It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood (2008) · cites this paper as Salin-Pascual et al., 1995
Blockade rather than activation of nAChRs results in antidepressant-like effects in human subjects.
“Data in human subjects support the idea that blockade rather than activation of nAChRs results in antidepressant-like effects.”
From It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood (2008) · cites this paper as Salin-Pascual et al., 1995
Many studies have reported that nicotine can improve symptoms of depression under some conditions.
“many studies have reported that nicotine can improve symptoms of depression under some conditions (Salin-Pascual et al., 1995; Tizabi et al., 1999)”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Salin-Pascual et al., 1995
Nicotine delivered through skin patches can improve mood in non-smokers, potentially through sustained desensitization of nAChRs.
“Nicotine delivered through skin patches can also improve mood in non-smokers (Salin-Pascual et al., 1995; Salin-Pascual et al., 1996), potentially through sustained desensitization of nAChRs (Mineur and Picciotto, 2010; Picciotto et al., 2008).”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Salin-Pascual et al., 1995
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- Authors
- Salín-Pascual, R. J., Galicia-Polo, L., Drucker-Colín, R., de la Fuente, J. R., Drucker-Colín, R., & Salín-Pascual, R. J.
- Affiliations
- Universidad Nacional Autónoma de México (MX)
- Venue
- Psychopharmacology
- Published
- 1995-10
- Volume
- 121
- Issue
- 4
- Pages
- 476-479
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1977034414
- Cited by
- 113
- References
- 17
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 9
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- transdermal nicotine, nicotine patch, major depressive disorder, non-smokers, REM sleep, sleep fragmentation, mood improvement, placebo-controlled
- MeSH terms
- Adult, Affect, Analysis of Variance, Depressive Disorder, Female, Humans, Male, Middle Aged, Nicotine, Sleep
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