Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens

Cador, M.; Taylor, J. R.; Robbins, T. W.

doi:10.1007/bf02246039

Cited by 159Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens

Cador, M., Taylor, J. R., Robbins, T. W.·1991·Psychopharmacology

DOI 10.1007/bf02246039

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Abstract

Three experiments examined the behavioural, pharmacological and neural specificity of the previously reported potentiation of responding with conditioned reinforcement following intra-accumbens d-amphetamine, by studying the effects of intra-accumbens dopamine (DA) and noradrenaline, using an acquisition of a new response procedure. In experiment 1, the effects of intra-cerebral DA infusions (5, 20, 50 micrograms/2 microliters) were compared in four conditions: (i) intra-accumbens DA following positive pairing of the conditioned stimulus (CS) and water during training; (ii) as (i) but also following a systemic dose of the DA receptor antagonist alpha-flupenthixol; (iii) intra-accumbens DA following random pairing of the CS and water during training; and (iv) as (i) but with intra-caudate rather than intra-accumbens DA. The results showed that only with intra-accumbens DA in the positive pairing condition was there a significant dose-dependent increase in responding. In experiment 2, the effects of a higher range of doses (20, 100, 200 micrograms) and smaller infusion volume (5, 25, 50 micrograms/l microliters) of intra-accumbens DA were studied, in comparison with a similar range of doses (5, 25, 50 micrograms/l microliters) of intra-accumbens noradrenaline (NA). Only DA produced a selective, dose-dependent increase in responding with conditioned reinforcement. In experiment 3 neurotoxic lesions of the dorsal noradrenergic bundle (DNAB) using 6-hydroxydopamine producing profound (about 90%) depletion of cortical and nucleus accumbens NA levels had no effect on the increased responding with conditioned reinforcement produced by intra-accumbens d-amphetamine (3, 10, 30 micrograms/l microliters).(ABSTRACT TRUNCATED AT 250 WORDS)

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Conditioned reinforcement as indicated by lever-pressing is amplified by systemic injections or intra-accumbens injections of dopaminergic drugs such as amphetamine and pipradrol, which increase extracellular levels of dopamine in the accumbens.
“Such conditioned reinforcement as indicated by lever-pressing is amplified by systemic injections (Hill, 1970; Robbins, 1975; Robbins, 1976) or intra-accumbens injections of dopaminergic drugs such as amphetamine and pipradrol (Taylor and Robbins, 1984; Cador et al., 1991; Kelley and Delfs, 1991; Wolterink et al., 1993), which increase extracellular levels of dopamine in the accumbens.”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Cador et al., 1991
Injections of dopaminergic drugs into other dopamine terminal regions are not effective for conditioned reinforcement.
“On the other hand, injections of these drugs into other dopamine terminal regions are not effective (Cador et al., 1991; Kelley and Delfs, 1991).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Cador et al., 1991

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Authors: Cador, M., Taylor, J. R., & Robbins, T. W.
Affiliations: University of Cambridge (GB)
ORCID: Cador, M.
Taylor, J. R.
Robbins, T. W.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1991-09
Volume: 104
Issue: 3
Pages: 377-385
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/bf02246039
OpenAlex: W2031739149
Cited by: 158
References: 29
Citations by year: 2025: 3 · 2024: 1 · 2023: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 5
FWCI: 2.61
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nucleus accumbens, conditioned reinforcement, dopamine, norepinephrine, d-amphetamine, alpha-flupenthixol, dorsal noradrenergic bundle, 6-hydroxydopamine lesion, caudate nucleus, random pairing, dose-response relationship
MeSH terms: Animals, Brain Chemistry, Caudate Nucleus, Conditioning, Operant, Corpus Striatum, Dextroamphetamine, Dopamine, Dose-Response Relationship, Drug, Injections, Intraventricular, Male, Norepinephrine, Nucleus Accumbens, Rats, Inbred Strains, Reward, Oxidopamine, Rats

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Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens

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