Bilateral intra-accumbens self-administration ofd-amphetamine: Antagonism with intra-accumbens SCH-23390 and sulpiride

Phillips, Gavin D.; Robbins, Trevor W.; Everitt, Barry J.

doi:10.1007/bf02249339

Cited by 116Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Bilateral intra-accumbens self-administration ofd-amphetamine: Antagonism with intra-accumbens SCH-23390 and sulpiride

Phillips, Gavin D., Robbins, Trevor W., Everitt, Barry J.·1994·Psychopharmacology

DOI 10.1007/bf02249339

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Abstract

The efficacy of d-amphetamine to support a selective bilateral intra-accumbens self-administration response was examined. Bilateral intra-accumbens infusions of d-amphetamine were made contingent upon the acquisition of a lever-pressing response. Two identical levers were available within the operant chamber. Depression of the drug lever resulted in the intra-accumbens delivery of 1 microgram d-amphetamine; responses upon the second, control lever were recorded but had no programmed consequences. Animals were not 'primed' with non-contingent infusions of d-amphetamine at any time during these experiments. Nonetheless, animals readily acquired a selective response upon the drug lever. Removal of the d-amphetamine moiety from the infusate resulted in a large decline in responding, and the abolition of the selectivity of the response for the drug lever. Adulteration of the infusate with either the D1 dopamine receptor antagonist SCH-23390 or the D2 dopamine receptor antagonist sulpiride enhanced the rate of response selectively upon the drug lever. Reductions in the dose of d-amphetamine also increased the rate of response. The effect of co-adulteration of the infusate with both SCH-23390 and sulpiride together was purely additive. The implications of these data for the methodology of intracranial drug self-administration, and the relationship between D1 and D2 dopamine receptors within the nucleus accumbens are discussed.

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Drugs that enhance operant responding for food rewards, such as amphetamine, are most effective when administered into the NAc, whereas DA receptor antagonists administered into the NAc block the stimulant effects.
“Moreover, drugs that enhance operant responding for such food rewards, such as amphetamine, are most effective when administered into the NAc, whereas DA receptor antagonists administered into the NAc block the stimulant effects [57,311].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [311]

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Authors: Phillips, G. D., Robbins, T. W., & Everitt, B. J.
Affiliations: University of York (GB)
University of Cambridge (GB)
ORCID: Robbins, Trevor W.
Everitt, Barry J.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1994-04
Volume: 114
Issue: 3
Pages: 477-485
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/bf02249339
OpenAlex: W1977404224
Cited by: 116
References: 71
Citations by year: 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 2 · 2017: 1 · 2016: 9 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 1
FWCI: 2.72
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: d-amphetamine, nucleus accumbens, self-administration, dopamine D1 receptor, dopamine D2 receptor, SCH 23390, sulpiride, dopamine receptor antagonism, drug selectivity
MeSH terms: Animals, Benzazepines, Conditioning, Operant, Dextroamphetamine, Dose-Response Relationship, Drug, Injections, Male, Nucleus Accumbens, Self Administration, Sulpiride, Rats

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Bilateral intra-accumbens self-administration ofd-amphetamine: Antagonism with intra-accumbens SCH-23390 and sulpiride

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