Fatigue in older adults: an early indicator of the aging process?
Abstract
The aim of this paper is to give an overview of research on fatigue in older adults, with a focus on fatigue as an early indicator of the aging process. Fatigue is a strong predictor of functional limitations, disability, mortality, and other adverse outcomes in young-old and old-old populations, between men and women, and in different geographic localities. Several biological, physiological and social explanations are proposed: fatigue may be seen not only as a self-reported indicator of frailty, defined as a physiologic state of increased vulnerability to stressors, which results from decreased physiologic reserves and even dysregulation of multiple physiologic systems, but also this state may be accelerated because of the cumulative impact of social, mental and biological factors throughout life.
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Weight reduction can reduce fatigue.
“and fatigue.(Avlund 2010)”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Avlund 2010
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Self-citationAre Self-ratings of Functional Ability Reliable?
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Self-citationA WAIS longitudinal study of cognitive development during the life span from ages 50 to 70
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Self-citationAge-related complaints in women and their determinants based on a representative community study
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Tiredness and Onset of Walking Limitations in Older Adults
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Self-citationChanges in social relations in old age. Are they influenced by functional ability?
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Self-citationGenetic priming of a proinflammatory profile predicts low IQ in octogenarians
Krabbe, K. S., Mortensen, E. L., Avlund, K., Pilegaard, H., Christiansen, L., Pedersen, B. K., Schroll, M., Jørgensen, T., Pedersen, B. K., & Brüünsgaard, H. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.013 · Cited by 31 · see citing works
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Self-citationWHY DO IMMINENT VICTIMS OF A CARDIAC EVENT FEEL SO TIRED?
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The cumulative effect of smoking at age 50, 60, and 70 on functional ability at age 75
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Self-citationInvestigating tiredness in Australian general practice. Do pathology tests help in diagnosis?
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Self-citationAbdominal syndromes and functional ability in the elderly
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Self-citationThe Lived Experience of Feeling Very Tired: A Study Using the Parse Research Method
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Cognitive function and functional ability in daily life
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Stability and change in physical activity in old age: the role of changes in disability
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Self-citationRelationship as an Inherent Component in Healthy Women’s Fatigue
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Flagged first, then by citations
Research works printed but not linked: 1
- [8]8. National Institute of Aging. Workshop on Unexplained Fatigue in the Elderly. Workshop Summary. National Institute of Aging, 2007.
Cited by
Sorted by citations
Cox, K. H., Pipingas, A., & Scholey, A. B. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114552744 · Cited by 368 · see citing works
Successful aging: Advancing the science of physical independence in older adults
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“(Avlund 2010) In addition, DR can promote proper redox status (Hofer, Fontana, Anton, Weiss, Villareal, Malayappan, and Leeuwenburgh 2008;Ivanova and Yankova 2013), anti-inflammatory action(Chung, Cesari, Anton, Marzetti, Giovannini, Seo, Carter, Yu, and Leeuwenburgh 2009), and cellular quality…”
BackgroundHealth Inequality - determinants and policies
Diderichsen, F., Andersen, I., Manuel, C., The Working Group of the Danish Review on Social Determinants of Health, Andersen, A.-M. N., Bach, E., Baadsgaard, M., Brønnum-Hansen, H., Hansen, F. K., Jeune, B., et al. (2012) · Scandinavian Journal of Public Health · doi:10.1177/1403494812457734 · Cited by 247 · see citing works
Hortobágyi, T., Lesinski, M., Gäbler, M., VanSwearingen, J. M., Malatesta, D., & Granacher, U. (2015) · Sports Medicine · doi:10.1007/s40279-015-0371-2 · Cited by 204 · see citing works
- Authors
- Avlund, K.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Avlund, Kirsten
- Venue
- Aging Clinical and Experimental Research
- Published
- 2010-04
- Volume
- 22
- Issue
- 2
- Pages
- 100-115
- ISSN
- 1594-0667 (ISSN-L)
- 1720-8319
- OpenAlex
- W2045905210
- Cited by
- 226
- References
- 158
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 14 · 2023: 16 · 2022: 13 · 2021: 24 · 2020: 20 · 2019: 22 · 2018: 17 · 2017: 9 · 2016: 13 · 2015: 12 · 2014: 20 · 2013: 10 · 2012: 10
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Aging Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Velux Stiftung
- Nordea-fonden
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- fatigue, older adults, aging, frailty, functional limitations, disability, mortality, sex differences, biological stressors, cumulative risk factors
- MeSH terms
- Aged, Aging, Austria, Depression, Europe, Fatigue, Female, Germany, Humans, Male, Middle Aged, Sex Characteristics, Spain, Prevalence
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