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Impact of cereal fibre on glucose-regulating factors
Open accessAbstract
Aims/hypothesis Insoluble dietary fibre intake is associated, by unknown mechanisms, with a reduced risk of type 2 diabetes. We investigated whether a short-term dietary intervention with purified insoluble fibres influences acute and delayed responses of glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1.Methods Fourteen healthy women with NGT were studied for 300 min on six to eight occasions. Subjects consumed three matched portions of control (C) or fibre-enriched bread (10.4-10.6 g/portion; wheat fibre [WF], oat fibre [OF], and, in a substudy [n=9], resistant starch [RS]) followed by control (C-C, C-WF, C-OF, C-RS) on subsequent days.Results Fibre enrichment accelerated the early insulin response (fibrextime interaction p=0.026 for WF, p<0.001 for OF, p=0.126 for RS; time of maximal concentration [T(max)], C 57.9+/-5.9, WF 49.3+/-2.5 [p=0.086], OF 46.1+/-2.9 [p=0.026], RS 46.7+/-5.8 min [p=0.029]). It was also associated with an earlier postprandial GIP response after OF (T(max), C 83.6+/-7.2, WF 70.7+/-6.0 [p=0.054], OF 64.3+/-6.9 [p=0.022], RS 60.0+/-5.0 [p>0.15]). Increased fibre intake for 24 h was further associated with a reduced postprandial glucose response on the following day subsequent to ingestion of a control meal (AUC(C-C) 4,140+/-401, AUC(C-WF) 2,850+/-331 [p=0.007], AUC(C-OF) 2,830+/-277 [p=0.011]), with no difference in maximal concentration and T(max) of glucose responses. No differences in insulin responses were observed 24 h after the fibre-enriched diets compared with control (p>0.15). Colonic fermentation was increased only on study days C-OF (p=0.017) and C-RS (p=0.016).Conclusions/interpretation The consumption of highly purified insoluble dietary fibres accelerated the acute GIP and insulin response and was further associated with enhanced postprandial carbohydrate handling the following day upon ingestion of a control meal.
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“There is much evidence in the literature to support an association between dietary fibre intake and insulin sensitivity [30,31,32,33,34,35].”
From The Health Benefits of Dietary Fibre (2020) · cites this paper as [30]
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Cites
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Self-citationWhole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study
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Sorted by citations
Effects of Dietary Fiber and Its Components on Metabolic Health
Lattimer, J. M., & Haub, M. D. (2010) · Nutrients · doi:10.3390/nu2121266 · Cited by 1,333
The Health Benefits of Dietary Fibre
Barber, T. M., Kabisch, S., Pfeiffer, A. F. H., & Weickert, M. O. (2020) · Nutrients · doi:10.3390/nu12103209 · Cited by 892
Self-citationde Munter, J. S. L., Hu, F. B., Spiegelman, D., Franz, M., & van Dam, R. M. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040261 · Cited by 734
Metabolic effects of dietary fiber consumption and prevention of diabetes
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Self-citationKaczmarczyk, M. M., Miller, M. J., & Freund, G. G. (2012) · Metabolism · doi:10.1016/j.metabol.2012.01.017 · Cited by 554
Metadata
- Authors
- Weickert, M. O., Mohlig, M., Koebnick, C., Holst, J. J., Namsolleck, P., Ristow, M., Osterhoff, M., Rochlitz, H., Rudovich, N., Spranger, J., & Pfeiffer, A. F. H.
- Affiliations
- German Institute of Human Nutrition (DE)
- University of Copenhagen (DK)
- Corresponding author
- Weickert, M. O.
- ORCID
- Venue
- Diabetologia
- Published
- 2005-09-20
- Volume
- 48
- Issue
- 11
- Pages
- 2343-2353
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2072769007
- Semantic Scholar
- b10feda04b4d8ed4862c51ab6b94b48bd97681f1
- Cited by
- 194
- References
- 54
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 10 · 2020: 9 · 2019: 11 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 19
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- insoluble dietary fiber, cereal fiber, type 2 diabetes prevention, glycemic response, insulin response, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, wheat fiber, oat fiber, resistant starch, colonic fermentation, postprandial blood glucose, healthy women, gastrointestinal hormones, dietary intervention
- MeSH terms
- Adult, Blood Glucose, Bread, Edible Grain, Colon, Dietary Fiber, Gastric Inhibitory Polypeptide, Glucose, Humans, Hydrogen, Insulin, Random Allocation, Starch, Cross-Over Studies, Area Under Curve, Glucagon-Like Peptide 1
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