Cited by 133Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

Circadian disruption and SCN control of energy metabolism

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Kalsbeek, Andries, Scheer, Frank A., Perreau-Lenz, Stephanie, La Fleur, Susanne E., Yi, Chun-Xia, Fliers, Eric, Buijs, Ruud M.·2011·FEBS Letters

Abstract

In this review we first present the anatomical pathways used by the suprachiasmatic nuclei to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high‐energy food, also a well‐lighted and fully resonating biological clock may help to withstand the increasing “diabetogenic” pressure of today's 24/7 society.

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Crossref · 10.1016/j.febslet.2011.03.021

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  • The master clock regulates the body's metabolism through controlling body functions and synchronizing peripheral clocks in almost all cells, including heart, liver, muscle and adipose tissue.

    “This master clock regulates the body's metabolism through controlling body functions, and synchronizing peripheral clocks in almost all cells in the body, including the body's key tissues such as the heart, liver, muscle and adipose tissue 3, 4, 5, 6.”
  • Circadian rhythm disturbances may be a major contributor to the contemporary global epidemics of T2DM, CVD and obesity.

    “In the light of this, it has been suggested that the resulting circadian rhythm disturbances may be a major contributor to the contemporary global epidemics of T2DM, CVD and obesity 3, 5, 6, 7, 11, 15, 16, 17, 18, 19.”

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  1. [71]Perreau-Lenz S Feeding conditions affect vasopressin and Per2, but not Per1, gene expression in the rat suprachiasmatic nucleus Control of the daily melatonin rhythm. A model of time distribution by the biological clock mediated through the autonomic nervous system, Chapter 5, Dissertation 2004 University of Amsterdam

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Authors
Kalsbeek, A., Scheer, F. A., Perreau-Lenz, S., La Fleur, S. E., Yi, C.-X., Fliers, E., & Buijs, R. M.
Affiliations
  • Netherlands Institute for Neuroscience (NL)
  • Brigham and Women's Hospital (US)
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (MX)
Corresponding author
Kalsbeek, Andries
Venue
FEBS Letters
Publisher
Wiley
Published
2011-03-15
Volume
585
Issue
10
Pages
1412-1426
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2065239869
Cited by
133
References
191
Citations by year
2026: 8 · 2025: 11 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 9 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 15 · 2012: 13
FWCI
1.40
Type
journal article
Language
en
Open access
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Site cant be reached (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion)
Funders
NIH (P30HL101299, R01HL094806)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
circadian rhythm, suprachiasmatic nucleus, energy metabolism, energy homeostasis, orexin system, glucose metabolism, cardiovascular system, circadian misalignment, diabetes mellitus, light exposure, biological clock
MeSH terms
Adipose Tissue, Animals, Autonomic Nervous System, Circadian Rhythm, Energy Metabolism, Hormones, Humans, Suprachiasmatic Nucleus

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