Metformin Alleviates Hepatosteatosis by Restoring SIRT1-Mediated Autophagy Induction via an AMP-Activated Protein Kinase-Independent Pathway

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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Metformin Inhibits Hepatic Gluconeogenesis in Mice Independently of the LKB1/AMPK Pathway via a Decrease in Hepatic Energy State

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Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

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Sirt1 protects against high-fat diet-induced metabolic damage

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AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network

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Autophagy in the Cellular Energetic Balance

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Caloric restriction

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

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A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

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Molecular mechanism of action of metformin: old or new insights?

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The Hypoxia-Inducible MicroRNA Cluster miR-199a∼214 Targets Myocardial PPARδ and Impairs Mitochondrial Fatty Acid Oxidation

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Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5

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Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis

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Autophagy, polyphenols and healthy ageing

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Characterization of macroautophagic flux in vivo using a leupeptin-based assay

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Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: pathophysiological implications

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Hepatocyte suspensions and cultures as tools in experimental carcinogenesis

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ΔNp63&alpha Overexpression Induces Downregulation of Sirt1 and an Accelerated Aging Phenotype in the Mouse

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Autophagy and Regulation of Lipid Metabolism

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Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction

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Evidence for Selective Mitochondrial Autophagy and Failure in Aging

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Transcription factor Snail is a novel regulator of adipocyte differentiation via inhibiting the expression of peroxisome proliferator-activated receptor γ

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Intracerebroventricular Injection of Metformin Induces Anorexia in Rats

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Thiazolidinediones improve hepatic fibrosis in rats with non‐alcoholic steatohepatitis by activating the adenosine monophosphate‐activated protein kinase signalling pathway

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Dietary Oleate Has Beneficial Effects on Every Step of Non-Alcoholic Fatty Liver Disease Progression in a Methionine- and Choline-Deficient Diet-Fed Animal Model

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Metformin and Cancer in Type 2 Diabetes

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Metformin, metabolic stress, and mitochondria. Focus on “A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells”

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Metformin as a tool to target aging

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Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

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Metabolic Control of Longevity

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Mitophagy in neurodegeneration and aging

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Targeting autophagy in obesity: from pathophysiology to management

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A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

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Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age

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New mechanisms of metformin action: Focusing on mitochondria and the gut

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Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation

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Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway

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Metformin restores parkin-mediated mitophagy, suppressed by cytosolic p53

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Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases

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Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy

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The interplay between nonalcoholic fatty liver disease and atherosclerotic cardiovascular disease

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Could sirtuin activities modify ALS onset and progression?

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The pivotal role of dysregulated autophagy in the progression of non-alcoholic fatty liver disease

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Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection

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New findings in AMP-activated protein kinase

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Coptidis Rhizoma Water Extract Stimulates 5＇-AMP-Activated Protein Kinase in Rat Skeletal Muscle

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Homogenous Fluorescent Assays for Characterizing Small-Molecule Activators of AMP-Activated Protein Kinase (AMPK)

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