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Cited by 81Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudyNeurotransmitter Receptor Influence on Behavior

Reduced nicotine reward in obesity: cross-comparison in human and mouse

Blendy, Julie A., Strasser, Andrew, Walters, Carrie L., Perkins, Kenneth A., Patterson, Freda, Berkowitz, Robert, Lerman, Caryn·2005·Psychopharmacology
DOI 10.1007/s00213-005-2167-9
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Abstract

Rationale Tobacco use and obesity lead to significant morbidity and mortality.Objective This study was conducted to investigate the factors maintaining smoking behavior in lean and obese individuals by utilizing a mouse/human cross-validation model of nicotine reward.Methods In humans, a cigarette choice paradigm was used to examine the relative reinforcing value of nicotine in obese and non-obese smokers. Conditioned place preference (CPP) for nicotine was assessed in mice fed standard low fat rodent chow and mice rendered obese by a high fat diet.Results In humans, obese smokers self-administered nicotine via cigarettes significantly less often than non-obese smokers and showed attenuated hedonic effects of nicotine-containing cigarettes compared to denicotinized cigarettes. Similarly, mice exposed to a high fat diet did not exhibit nicotine CPP, relative to control mice. mRNA levels for mu-opiate and leptin receptors were also downregulated in the ventral tegmental area of these mice.Conclusions Together, these studies provide the first evidence for reduced nicotine reward in obese subjects and suggest that this may be mediated by dietary influences on the endogenous opioid system.

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  • Obese individuals show lower rates of nicotine and marijuana abuse than non-obese individuals.

    “obese individuals show lower rates of nicotine (37) and marijuana abuse (38) than non-obese individuals.”

    From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [37]

  • Human studies found an inverse relationship between BMI and illicit drug use and lower risk for substance use disorders in obese individuals, including lower rates of nicotine and marijuana abuse.

    “Similarly, human studies found an inverse relationship between BMI and illicit drug use (21) and a lower risk for substance use disorders in obese individuals (22), including lower rates of nicotine (23) and marijuana (24) abuse.”

    From The Addictive Dimensionality of Obesity (2013) · cites this paper as [23]

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Authors
Blendy, J. A., Strasser, A., Walters, C. L., Perkins, K. A., Patterson, F., Berkowitz, R., & Lerman, C.
Affiliations
  • University of Pennsylvania (US)
  • University of Pittsburgh (US)
  • Children's Hospital of Philadelphia (US)
Corresponding author
  • Blendy, Julie A.
  • Lerman, Caryn
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2005-02-18
Volume
180
Issue
2
Pages
306-315
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s00213-005-2167-9
OpenAlex
W2048511472
Cited by
81
References
76
Citations by year
2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 9 · 2013: 5 · 2012: 3
FWCI
3.20
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1f31da015949-01)
  • U.S. Public Health Service (P5084718)
  • National Institute on Drug Abuse (1F31 DA 015949, R01DA011649, DA116-49-01A2)
  • National Cancer Institute
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
nicotine reward, obesity, smoking behavior, conditioned place preference, nicotine self-administration, high-fat diet, mu-opioid receptor, leptin receptor, ventral tegmental area, endogenous opioid system
MeSH terms
Cyclic AMP, Animals, Female, Humans, Male, Nicotine, Obesity, Receptors, Cell Surface, Reward, RNA, Messenger, Smoking, Receptors, Opioid, mu, Ventral Tegmental Area, Mice, Receptors, Leptin

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