Cited by 170Substance Abuse Treatment and OutcomesHeart Rate Variability and Autonomic ControlNeurotransmitter Receptor Influence on Behavior

Cue-elicited heart rate variability and attentional bias predict alcohol relapse following treatment

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Garland, Eric L., Franken, Ingmar H. A., Howard, Matthew O.·2012·Psychopharmacology

Abstract

Rationale Identification of malleable neurocognitive predictors of relapse among alcohol-dependent individuals is important for the optimization of health care delivery and clinical services. Objectives Given that alcohol cue-reactivity can predict relapse, we evaluated cue-elicited high-frequency heart rate variability (HFHRV) and alcohol attentional bias (AB) as potential relapse risk indices. Method Alcohol-dependent patients in long-term residential treatment who had participated in mindfulness-oriented therapy or an addiction support group completed a spatial cueing task as a measure of alcohol AB and an affect-modulated alcohol cue-reactivity protocol while HFHRV was assessed. Results Post-treatment HFHRV cue-reactivity and alcohol AB significantly predicted the occurrence and timing of relapse by 6-month follow-up, independent of treatment condition and after controlling for alcohol dependence severity. Alcohol-dependent patients who relapsed exhibited a significantly greater HFHRV reactivity to stress-primed alcohol cues than patients who did not relapse. Conclusions Cue-elicited HFHRV and alcohol AB can presage relapse and may therefore hold promise as prognostic indicators in clinical settings.

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  • MORE did not significantly increase self-reported mindfulness, nor did it result in significant decrements in craving, but it significantly reduced symptoms associated with chronic pain and prescription opioid misuse.

    “Contrary to their hypotheses, MORE did not significantly increase self-reported mindfulness, nor did it result in significant decrements in craving, but significantly reduced symptoms associated with chronic pain and prescription opioid misuse.”

    From Mindfulness-Based Interventions for the Treatment of Substance and Behavioral Addictions: A Systematic Review (2018) · cites this paper as [30]

    The Introduction and Methods describe MORE in a trial involving alcohol-dependent patients, but do not report the claimed results for self-reported mindfulness, craving, chronic pain, or prescription opioid misuse. Searches for those outcomes found no passage in our copy that evaluates the claim. (LLM, conf=0.76)

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Authors
Garland, E. L., Franken, I. H. A., & Howard, M. O.
Affiliations
  • Florida State University (US)
  • Erasmus University Rotterdam (NL)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Garland, Eric L.
Venue
Psychopharmacology
Published
2011-12-28
Volume
222
Issue
1
Pages
17-26
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W2107603646
Cited by
170
References
70
Citations by year
2026: 7 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 9 · 2020: 18 · 2019: 20 · 2018: 19 · 2017: 10 · 2016: 12 · 2015: 16 · 2014: 9 · 2013: 13 · 2012: 6
FWCI
6.75
Type
journal article
Language
en
Open access
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders
  • National Institute on Drug Abuse (R03DA032517)
  • National Center for Complementary and Integrative Health (T32AT003378)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
alcohol relapse, alcoholism, heart rate variability, attentional bias, alcohol cue reactivity, relapse risk prediction, addiction support groups, residential treatment, prognostic factors
MeSH terms
Adult, Alcoholism, Attention, Cues, Female, Follow-Up Studies, Heart Rate, Humans, Male, Recurrence, Self-Help Groups, Severity of Illness Index, Cognitive Behavioral Therapy, Treatment Outcome

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