Nicotine enhances trace cued fear conditioning but not delay cued fear conditioning in C57BL/6 mice
Abstract
Nicotine facilitates hippocampus-dependent contextual but not hippocampus-independent cued delay fear conditioning. To test if the effects of nicotine are specific to contextual fear conditioning or would extend to another hippocampus-dependent version of fear conditioning, we compared the effects of nicotine on cued delay and cued trace fear conditioning in male and female C57BL/6 mice. Unlike cued delay fear conditioning, cued trace fear conditioning is hippocampus dependent. Thus, if nicotine enhances hippocampus-dependent fear conditioning, nicotine should enhance trace fear conditioning. For both trace and delay conditioning, five 30 s, 85 dB white noise conditioned stimuli (CS) were paired with five 2 s, 0.5 mA footshock unconditioned stimuli (US). In the trace paradigm, a 30-s period was inserted between CS offset and US onset. The CS and US co-terminated in the delay paradigm. Testing occurred 24 h later. The data indicate that nicotine (given on training and testing day) enhances trace but not delay cued fear conditioning. No sex differences were found. For delay cued fear conditioning a high level of freezing to the CS was found. Thus, a second experiment examined if the lack of enhancement of delay cued fear conditioning by nicotine was due to a ceiling effect. The CS duration was decreased to 15 s and only one CS-US pairing was used for delay and trace cued fear conditioning. Although overall levels of freezing to the cue were lower in the second experiment, nicotine still enhanced trace fear conditioning but did not enhance delay fear conditioning. Taken together, the results of the present experiments suggest that nicotine enhances hippocampus-dependent versions of fear conditioning.
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Nicotine enhances hippocampus-dependent contextual and cued trace fear conditioning, but not cued delay fear conditioning.
“Nicotine is known to enhance hippocampus-dependent contextual and cued trace fear conditioning, but not cued delay fear conditioning [198].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [198]
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Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
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Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training
Gould, T. J., & Stephen Higgins, J. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00057-1 · Cited by 123 · see citing works
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Modulation of Hippocampus-Dependent Learning and Synaptic Plasticity by Nicotine
Kenney, J. W., & Gould, T. J. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8037-9 · Cited by 242 · see citing works
Self-citationWithdrawal from Chronic Nicotine Administration Impairs Contextual Fear Conditioning in C57BL/6 Mice
Davis, J. A., James, J. R., Siegel, S. J., & Gould, T. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2853-05.2005 · Cited by 146 · see citing works
Self-citationBridging the interval: Theory and neurobiology of trace conditioning
Raybuck, J. D., & Lattal, K. M. (2014) · Behavioural Processes · doi:10.1016/j.beproc.2013.08.016 · Cited by 114 · see citing works
Davis, J. A., Kenney, J. W., & Gould, T. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3242-07.2007 · Cited by 107 · see citing works
Self-citationNicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders
Kutlu, M. G., & Gould, T. J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.029 · Cited by 97 · see citing works
Self-citationDavis, J. A., & Gould, T. J. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0624-8 · Cited by 72 · see citing works
Self-citationKenney, J. W., Adoff, M. D., Wilkinson, D. S., & Gould, T. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2283-7 · Cited by 67 · see citing works
Self-citationMechanistic insights into nicotine withdrawal
Paolini, M., & De Biasi, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.075 · Cited by 66 · see citing works
Nicotine enhances both foreground and background contextual fear conditioning
Davis, J. A., Porter, J., & Gould, T. J. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.026 · Cited by 65 · see citing works
Self-citationNicotine addiction and psychiatric disorders
Kutlu, M. G., Parikh, V., & Gould, T. J. (2015) · International Review of Neurobiology · doi:10.1016/bs.irn.2015.08.004 · Cited by 65 · see citing works
Self-citationPortugal, G. S., Wilkinson, D. S., Kenney, J. W., Sullivan, C., & Gould, T. J. (2012) · Behavior Genetics · doi:10.1007/s10519-011-9489-7 · Cited by 58 · see citing works
Self-citationNicotine and Hippocampus-Dependent Learning: Implications for Addiction
Gould, T. J. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:2:93 · Cited by 61 · see citing works
Hippocampal nAChRs mediate nicotine withdrawal-related learning deficits
Davis, J. A., & Gould, T. J. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.02.003 · Cited by 60 · see citing works
Self-citationRaybuck, J. D., & Gould, T. J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06580.x · Cited by 53 · see citing works
Self-citationGenetic background differences and nonassociative effects in mouse trace fear conditioning.
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Wilkinson, D. S., Turner, J. R., Blendy, J. A., & Gould, T. J. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2808-8 · Cited by 32 · see citing works
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- Authors
- Gould, T. J., Feiro, O., & Moore, D.
- Affiliations
- Temple University (US)
- Corresponding author
- Gould, Thomas J.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 155
- Issue
- 1
- Pages
- 167-173
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2010171011
- Cited by
- 78
- References
- 4
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2019: 1 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine, trace fear conditioning, delay fear conditioning, cued fear conditioning, hippocampal-dependent memory, contextual fear, freezing behavior, sex differences, C57BL/6 mice
- MeSH terms
- Analysis of Variance, Animals, Behavior, Animal, Conditioning, Classical, Cues, Fear, Female, Male, Mice, Inbred C57BL, Nicotine, Time Factors, Nicotinic Agonists, Mice
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