Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats

Resstel, Leonardo B.M.; Joca, Sâmia R.L.; Moreira, Fabrício A.; Corrêa, Fernando M.A.; Guimarães, Francisco S.

doi:10.1016/j.bbr.2006.05.016

Cited by 182Cannabis and Cannabinoid ResearchMedicinal Plant Extracts EffectsMemory and Neural Mechanisms

Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats

Resstel, Leonardo B.M., Joca, Sâmia R.L., Moreira, Fabrício A., Corrêa, Fernando M.A., Guimarães, Francisco S.·2006·Behavioural Brain Research

DOI 10.1016/j.bbr.2006.05.016

Open this paper in CoChat — free account

Abstract

Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that induces anxiolytic-like effects similar to diazepam in animal models of innate aversive behavior. However, the effects of CBD contextual conditioned fear have not been studied. Therefore, the aim of this work was to compare the behavioral and cardiovascular effects of CBD and diazepam, a prototype anxiolytic, in animals submitted to a contextual conditioned fear paradigm. Male Wistar rats were submitted to a 10min conditioning session (six footshocks, 2.5 mA, 3s, delivered at pseudo-random intervals). The behavioral and cardiovascular responses to the context were measured 24h later in a 10 min test session. Diazepam (2.5 mg/kg), FG-7142 (8 mg/kg), a benzodiazepine inverse agonist, or CBD (10 mg/kg) were administered i.p. before the test session. Conditioned rats submitted to the aversive context exhibited more freezing behavior and a larger increase in blood pressure and heart rate as compared to non-conditioned animals. These effects were attenuated by CBD and diazepam in the conditioned animals. These drugs did not have any effect in non-conditioned rats. FG-7142 treatment failed to change the behavioral and cardiovascular responses to the aversive context. In conclusion, the results suggest that CBD has anxiolytic-like properties similar to those of diazepam in a rat model of conditioned fear to context.

Integrity signals

Registry

Crossref · 10.1016/j.bbr.2006.05.016

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Systemic administration of CBD reduces conditioned contextual fear.
“reduces conditioned contextual fear (Resstel et al., 2006).”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Resstel et al., 2006

Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483 · see citing works
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957 · see citing works
Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580 · see citing works
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
Bisogno, T., Hanuš, L., PETROCELLIS, L. D., Tchilibon, S., Ponde, D. E., Brandi, I., Moriello, A. S., Davis, J. B., Mechoulam, R., & Marzo, V. D. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704327 · Cited by 1,315 · see citing works
Conditional and unconditional components of post-shock freezing
Fanselow, M. S. (1980) · Pavlovian Journal of Biological Science · doi:10.1007/bf03001163 · Cited by 1,153 · see citing works
The neuroanatomical and neurochemical basis of conditioned fear
Fendt, M., & Fanselow, M. S. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00016-0 · Cited by 1,092 · see citing works
Agonistic properties of cannabidiol at 5-HT1a receptors
Russo, E. B., Burnett, A., Hall, B., & Parker, K. K. (2005) · Neurochemical Research · doi:10.1007/s11064-005-6978-1 · Cited by 878 · see citing works
New Vistas on Amygdala Networks in Conditioned Fear
Paré, D., Quirk, G. J., & Ledoux, J. E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00153.2004 · Cited by 841 · see citing works
Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats
Maren, S., Aharonov, G., & Fanselow, M. S. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00088-0 · Cited by 765 · see citing works
Temporally Graded Retrograde Amnesia of Contextual Fear after Hippocampal Damage in Rats: Within-Subjects Examination
Anagnostaras, S., Maren, S., & Fanselow, M. S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-01106.1999 · Cited by 656 · see citing works
Anxiogenic stimuli in the elevated plus-maze
Treit, D., Menard, J., & Royan, C. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90492-c · Cited by 628 · see citing works
Action of cannabidiol on the anxiety and other effects produced by ?9-THC in normal subjects
Zuardi, A. W., Shirakawa, I., Finkelfarb, E., & Karniol, I. G. (1982) · Psychopharmacology · doi:10.1007/bf00432554 · Cited by 608 · see citing works
Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: with and without diazepam pretreatment
Beck, C., & Fibiger, H. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00709.1995 · Cited by 547 · see citing works
Cannabidiol: An Overview of Some Pharmacological Aspects
Mechoulam, R., Parker, L. A., & Gallily, R. (2002) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.2002.tb05998.x · Cited by 511 · see citing works
Marihuana Chemistry
Mechoulam, R. (1970) · Science · doi:10.1126/science.168.3936.1159 · Cited by 494 · see citing works
Endocannabinoid system and stress and anxiety responses
VIVEROS, M., MARCO, E., & FILE, S. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.029 · Cited by 485 · see citing works
Passive and active reactions to fear-eliciting stimuli.
Blanchard, R. J., & Blanchard, D. C. (1969) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0027676 · Cited by 415 · see citing works
Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs
Martin, B. R., Compton, D. M., Thomas, B. F., Prescott, W. R., Little, P., Razdan, R. K., Johnson, M. R., Melvin, L. S., Mechoulam, R., & Ward Susan, J. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90349-7 · Cited by 410 · see citing works
Antianxiety effect of cannabidiol in the elevated plus-maze
Guimarães, F. S., Chiaretti, T. M., Graeff, F. G., & Zuardi, A. W. (1990) · Psychopharmacology · doi:10.1007/bf02244012 · Cited by 379 · see citing works
Chemical Basis of Hashish Activity
Mechoulam, R., Shani, A., Edery, H., & Grunfeld, Y. (1970) · Science · doi:10.1126/science.169.3945.611 · Cited by 331 · see citing works
Electrolytic Lesions of the Fimbria/Fornix, Dorsal Hippocampus, or Entorhinal Cortex Produce Anterograde Deficits in Contextual Fear Conditioning in Rats
Maren, S., & Fanselow, M. S. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.3752 · Cited by 324 · see citing works
Pharmacological characterization of cannabinoids in the elevated plus maze.
Onaivi, E. S., Green, M. R., & Martin, B. R. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13195-9 · Cited by 312 · see citing works
Effects of cannabidiol (CBD) on regional cerebral blood flow
Crippa, J. A. D. S., Zuardi, A. W., Garrido, G. E. J., Wichert-Ana, L., Guarnieri, R., Ferrari, L., Azevedo-Marques, P. M., Hallak, J. E. C., McGuire, P. K., & Busatto, G. F. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300340 · Cited by 307 · see citing works
Cannabidiol interferes with the effects of Δ9-tetrahydrocannabinol in man
Karniol, I. G., Shirakawa, I., Kasinski, N., Pfeferman, A., & Carlini, E. A. (1974) · European Journal of Pharmacology · doi:10.1016/0014-2999(74)90129-0 · Cited by 303 · see citing works
Antipsychotic effect of cannabidiol.
Zuardi, A. W., Morais, S. L., Guimarães, F. S., & Mechoulam, R. (1995) · PubMed · Cited by 264 · see citing works
Self-citation
Comparative Receptor Binding Analyses of Cannabinoid Agonists and Antagonists
Thomas, B. F., Gilliam, A. F., Burch, D. F., Roche, M. J., & Seltzman, H. H. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37365-3 · Cited by 242 · see citing works
Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents.
Compton, D. M., Johnson, M. R., Melvin, L. S., & Martin, B. R. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11216-0 · Cited by 216 · see citing works
Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in mice
Moreira, F. A., & Guimarães, F. S. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.02.040 · Cited by 206 · see citing works
Self-citation
Conditional analgesia, defensive freezing, and benzodiazepines.
Fanselow, M. S., & Helmstetter, F. J. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.2.233 · Cited by 199 · see citing works
Effects of cannabidiol in animal models predictive of antipsychotic activity
Zuardi, A. W., Antunes Rodrigues, J., & Cunha, J. M. (1991) · Psychopharmacology · doi:10.1007/bf02244189 · Cited by 191 · see citing works
Complex pharmacology of natural cannabivoids: Evidence for partial agonist activity of Δ9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors
Petitet, F., Jeantaud, B., Reibaud, M., Impérato, A., & Dubroeucq, M. C. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00238-0 · Cited by 180 · see citing works
Conditional analgesia, defensive freezing, and benzodiazepines.
Fanselow, M. S., & Helmstetter, F. J. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.2.233 · Cited by 159 · see citing works
A role for cannabinoid CB1 receptors in mood and anxiety disorders
Witkin, J. M., Tzavara, E. T., & Nomikos, G. G. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00005 · Cited by 156 · see citing works
The role of amygdaloid central nucleus in the retention of differential pavlovian conditioning of bradycardia in rabbits
Gentile, C. G., Jarrell, T. W., Teich, A. H., McCabe, P. M., & Schneiderman, N. (1986) · Behavioural Brain Research · doi:10.1016/0166-4328(86)90226-3 · Cited by 153 · see citing works
Discriminative fear conditioning to context expressed by multiple measures of fear in the rat
Antoniadis, E. A., & McDonald, R. J. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00056-4 · Cited by 151 · see citing works
Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats.
Fadda, P., Robinson, L., Fratta, W., Pertwee, R., & Riedel, G. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.08.009 · Cited by 122 · see citing works
Conditioned fear to environmental context: cardiovascular and behavioral components in the rat
Carrive, P. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02029-1 · Cited by 119 · see citing works
Central amygdaloid nucleus lesion attenuates exaggerated hemodynamic responses to noise stress in the spontaneously hypertensive rat
Galeno, T. M., Hoesen, G. W. V., & Brody, M. J. (1984) · Brain Research · doi:10.1016/0006-8993(84)91257-5 · Cited by 112 · see citing works
Destruction of intrinsic neurons in the lateral hypothalamus disrupts the classical conditioning of autonomic but not behavioral emotional responses in the rat
Iwata, J., LeDoux, J. E., & Reis, D. J. (1986) · Brain Research · doi:10.1016/0006-8993(86)91055-3 · Cited by 108 · see citing works
Stimulation in prefrontal cortex area inhibits cardiovascular and motor components of the defence reaction in rats
Al-Maskati, H. A., & Zbrożyna, A. W. (1989) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(89)90084-2 · Cited by 76 · see citing works
Effect of citalopram, a selective serotonin reuptake inhibitor, on the acquisition of conditioned freezing
Inoue, T., Hashimoto, S., Tsuchiya, K., Izumi, T., Ohmori, T., & Koyama, T. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00391-3 · Cited by 66 · see citing works
Induction of NGFI-B mRNA following contextual fear conditioning and its blockade by diazepam
Malkani, S., & Rosen, J. B. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00130-3 · Cited by 44 · see citing works
Participation of the Cannabinoid System in the Regulation of Emotional- Like Behaviour
Valverde, O. (2005) · Current Pharmaceutical Design · doi:10.2174/138161205774370780 · Cited by 40 · see citing works
Behavioural and cardiovascular responses during latent inhibition of conditioned fear: measurement by telemetry and conditioned freezing
Zhang, W., Murphy, C. A., & Feldon, J. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.02.016 · Cited by 38 · see citing works
Cardiovascular and behavioural components of conditioned fear to context after ganglionic and α-adrenergic blockade
Carrive, P. (2002) · Autonomic Neuroscience · doi:10.1016/s1566-0702(02)00039-5 · Cited by 34 · see citing works
Mechanisms of action of midazolam on expression of contextual fear in rats
Pain, L., Launoy, G. D., Fouquet, N., et al. (2002) · British Journal of Anaesthesia · doi:10.1093/bja/aef228 · Cited by 30 · see citing works
A central cholinergic link in the cardiovascular effects of the benzodiazepine receptor partial inverse agonist FG 7142
Berntson, G. G., Hart, S., Ruland, S. F., & Sarter, M. F. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00166-2 · Cited by 26 · see citing works
Cardiovascular effects of the benzodiazepine receptor partial inverse agonist FG 7142 in rats
Quigley, K. S., Sarter, M. F., Hart, S., & Berntson, G. G. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90033-7 · Cited by 25 · see citing works
Cholinergic inputs to the rat medial prefrontal cortex mediate potentiation of the cardiovascular defensive response by the anxiogenic benzodiazepine receptor partial inverse agonist FG 7142
Hart, S., Sarter, M. F., & Berntson, G. G. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00269-9 · Cited by 24 · see citing works
Inhibition of the cataleptic effect of tetrahydrocannabinol by other constituents of Cannabis sativa L.
Formukong, E. A., EVANS, A. T., & Evans, F. J. (1988) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1988.tb05198.x · Cited by 21 · see citing works
Effect of repeated methamphetamine pretreatment on freezing behavior induced by conditioned fear stress
Tsuchiya, K., Inoue, T., & Koyama, T. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(96)00017-2 · Cited by 20 · see citing works
Anxiolytic properties of cannabidiol
da Fonseca, G. E. M., & Vieira‐Coelho, M. A. (2018) · Drugs of the Future · doi:10.1358/dof.2018.043.08.2847832 · Cited by 5 · see citing works

Flagged first, then by citations

Sorted by citations

Safety and side effects of cannabidiol, a Cannabis sativa constituent
Machado Bergamaschi, M., Helena Costa Queiroz, R., Waldo Zuardi, A., & Alexandre S. Crippa, J. (2011) · Current Drug Safety · doi:10.2174/157488611798280924 · Cited by 558 · see citing works
Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
Campos, A. C., Moreira, F. A., Gomes, F. V., Del Bel, E. A., & Guimarães, F. S. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2011.0389 · Cited by 475 · see citing works
Self-citation
Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing
Fusar-Poli, P., Crippa, J. A., Bhattacharyya, S., Borgwardt, S. J., Allen, P., Martin-Santos, R., Seal, M., Surguladze, S. A., O’Carrol, C., Atakan, Z., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.519 · Cited by 465 · see citing works
Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats
Campos, A. C., & Guimarães, F. S. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1168-x · Cited by 364 · see citing works
Self-citation
Antidepressant‐like effects of cannabidiol in mice: possible involvement of 5‐HT1Areceptors
Zanelati, T., Biojone, C., Moreira, F., Guimarães, F., & Joca, S. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00521.x · Cited by 366 · see citing works
Self-citation
Phytocannabinoids as novel therapeutic agents in {CNS} disorders.
Hill, A. J., Williams, C. M., Whalley, B. J., & Stephens, G. J. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.09.002 · Cited by 312 · see citing works
Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age
Crippa, J. A., Guimarães, F. S., Campos, A. C., & Zuardi, A. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02009 · Cited by 308 · see citing works
Self-citation
Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders
García-Gutiérrez, M. S., Navarrete, F., Gasparyan, A., Austrich-Olivares, A., Sala, F., & Manzanares, J. (2020) · Biomolecules · doi:10.3390/biom10111575 · Cited by 306 · see citing works
5‐HT1Areceptors are involved in the cannabidiol‐induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats
Resstel, L. B. M., Tavares, R. F., Lisboa, S. F. S., Joca, S. R. L., Corrêa, F. M. A., & Guimarães, F. S. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00046.x · Cited by 283 · see citing works
Self-citation
The endocannabinoid system as a target for novel anxiolytic drugs
Patel, S., Hill, M. N., Cheer, J. F., Wotjak, C. T., & Holmes, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.033 · Cited by 233 · see citing works
Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: involvement of 5HT1A receptors and previous stressful experience
Fogaça, M. V., Reis, F. M. C. V., Campos, A. C., & Guimarães, F. S. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.10.012 · Cited by 153 · see citing works
Self-citation
Involvement of the prelimbic prefrontal cortex on cannabidiol-induced attenuation of contextual conditioned fear in rats
Lemos, J. I., Resstel, L. B., & Guimarães, F. S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.09.045 · Cited by 146 · see citing works
Self-citation
Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors
Campos, A. C., Ferreira, F. R., & Guimarães, F. S. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.08.012 · Cited by 139 · see citing works
Self-citation
Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice
Schiavon, A. P., Bonato, J. M., Milani, H., Guimarães, F. S., & Weffort de Oliveira, R. M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.017 · Cited by 135 · see citing works
Self-citation
Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors
Soares, V. D. P., Campos, A. C., Bortoli, V. C. D., Zangrossi, H., Guimarães, F. S., & Zuardi, A. W. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.05.004 · Cited by 112 · see citing works
Self-citation
Prohedonic effect of cannabidiol in a rat model of depression
Shoval, G., Shbiro, L., Hershkovitz, L., Hazut, N., Zalsman, G., Mechoulam, R., & Weller, A. (2016) · Neuropsychobiology · doi:10.1159/000443890 · Cited by 110 · see citing works
Anxiolytic-like effects induced by acute reversible inactivation of the bed nucleus of stria terminalis
Resstel, L. B. M., Alves, F. H. F., Reis, D. G., Crestani, C. C., Corrêa, F. M. A., & Guimarães, F. S. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.007 · Cited by 107 · see citing works
Self-citation
Cannabidiol injected into the bed nucleus of the stria terminalis reduces the expression of contextual fear conditioning via 5-HT 1A receptors
Gomes, F. V., Reis, D. G., Alves, F. H., Corrêa, F. M., Guimarães, F. S., & Resstel, L. B. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881110389095 · Cited by 97 · see citing works
Self-citation
A Systematic Review and Meta-Analysis of the Haemodynamic Effects of Cannabidiol
Sultan, S. R., Millar, S. A., England, T. J., & O'Sullivan, S. E. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00081 · Cited by 95 · see citing works
“…al., 2005 Mice MCAO 3 mg/kg i.p. Pre and 3 h post-occlusion MBP and HR: 2 h post-occlusion No changes on MBP or HR CBF: during 4 h post-occlusion ↑CBF Resstel et al., 2006 Rats Stress (fear) 10 mg/kg i.p. Pre-test Pre-stress and during 10 min post-stress ↓MBP and HR post-stress Hayakawa et al.,…”
BackgroundInfluential
Effects of intra-infralimbic prefrontal cortex injections of cannabidiol in the modulation of emotional behaviors in rats: Contribution of 5HT1A receptors and stressful experiences
Marinho, A. L. Z., Vila-Verde, C., Fogaça, M. V., & Guimarães, F. S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.023 · Cited by 68 · see citing works
Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats
Campos, A. C., de Paula Soares, V., Carvalho, M. C., Ferreira, F. R., Vicente, M. A., Brandão, M. L., Zuardi, A. W., Zangrossi, H., & Guimarães, F. S. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2878-7 · Cited by 65 · see citing works
Cannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT1A receptor
Gomes, F. V., Alves, F. H. F., Guimarães, F. S., Correa, F. M. A., Resstel, L. B. M., & Crestani, C. C. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.09.007 · Cited by 27 · see citing works

Susquehanna Chorale Spring Concert "Roots and Wings"
Hawkins, D. (2017)
An overview on synthetic and biological activities of cannabidiol (CBD) and its derivatives
Wang, X., Zhang, H., Liu, Y., Yang, X., Yang, B., Li, H., & Chen, L. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106810 · Cited by 57 · see citing works
Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol
Crippa, J. A., Crippa, A. C. S., Hallak, J. E. C., Martín‐Santos, R., & Zuardi, A. W. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00359 · Cited by 71 · see citing works
Constituents of Cannabis Sativa L. II: Absence of Cannabidiol in an African Variant
Turner, C. E., & Hadley, K. W. (1973) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600620214 · Cited by 59 · see citing works
A role for cannabidiol in psychiatry? Keep calm and follow the drug development rules
Gobbi, G. (2019) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2019.1584680 · Cited by 3 · see citing works

Authors: Resstel, L. B. M., Joca, S. R. L., Moreira, F. A., Corrêa, F. M. A., & Guimarães, F. S.
Affiliations: Universidade de São Paulo (BR)
Corresponding author: Guimarães, Francisco S.
ORCID: Resstel, Leonardo B.M.
Joca, Sâmia R.L.
Moreira, Fabrício A.
Guimarães, Francisco S.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2006-09
Volume: 172
Issue: 2
Pages: 294-298
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2006.05.016
OpenAlex: W2068728468
Cited by: 182
References: 53
Citations by year: 2026: 4 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 13 · 2021: 16 · 2020: 12 · 2019: 7 · 2018: 12 · 2017: 9 · 2016: 5 · 2015: 8 · 2014: 4 · 2013: 4 · 2012: 15
FWCI: 5.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: cannabidiol, diazepam, anxiolytic effects, cardiovascular response, blood pressure, heart rate, freezing behavior, benzodiazepine inverse agonist, FG 7142, cannabis
MeSH terms: Analysis of Variance, Animals, Association Learning, Blood Pressure, Cannabidiol, Carbolines, Conditioning, Classical, Diazepam, Environment, Fear, Heart Rate, Male, Anti-Anxiety Agents, Rats, Wistar, Freezing Reaction, Cataleptic, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks