The incentive amplifying effects of nicotine are reduced by selective and non-selective dopamine antagonists in rats
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Nicotine is a psychomotor stimulant with 'reinforcement enhancing' effects--the actions of nicotine in the brain increase responding for non-nicotine rewards. We hypothesized that this latter effect of nicotine depends on increased incentive properties of anticipatory cues; consistent with this hypothesis, multiple laboratories have reported that nicotine increases sign tracking, i.e. approach to a conditioned stimulus (CS), in Pavlovian conditioned-approach tasks. Incentive motivation and sign tracking are mediated by mesolimbic dopamine (DA) transmission and nicotine facilitates mesolimbic DA release. Therefore, we hypothesized that the incentive-promoting effects of nicotine would be impaired by DA antagonists. To test this hypothesis, separate groups of rats were injected with nicotine (0.4mg/kg base) or saline prior to Pavlovian conditioning sessions in which a CS (30s illumination of a light or presentation of a lever) was immediately followed by a sweet reward delivered in an adjacent location. Both saline and nicotine pretreated rats exhibited similar levels of conditioned approach to the reward location (goal tracking), but nicotine pretreatment significantly increased approach to the CS (sign tracking), regardless of type (lever or light). The DAD1 antagonist SCH-23390 and the DAD2/3 antagonist eticlopride reduced conditioned approach in all rats, but specifically reduced goal tracking in the saline pretreated rats and sign tracking in the nicotine pretreated rats. The non-selective DA antagonist flupenthixol reduced sign-tracking in nicotine rats at all doses tested; however, only the highest dose of flupenthixol reduced goal tracking in both nicotine and saline groups. The reductions in conditioned approach behavior, especially those by SCH-23390, were dissociated from simple motor suppressant effects of the antagonists. These experiments are the first to investigate the effects of dopaminergic drugs on the facilitation of sign-tracking engendered by nicotine and they implicate dopaminergic systems both in conditioned approach as well as the incentive-promoting effects of nicotine.
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In animals, cue attraction predicts cue-induced reinstatement of nicotine self-administration, while nicotine administration enhances cue-induced approach behavior, an effect disrupted by dopamine antagonists.
“Similarly in animals, cue attraction predicts cue-induced reinstatement of nicotine self-administration, while in converse, nicotine administration enhances cue-induced approach behavior (Palmatier, Kellicut, Brianna Sheppard, Brown, & Robinson, 2014; Versaggi, King, & Meyer, 2016), an effect which is disrupted by dopamine antagonists (Palmatier et al., 2014).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Palmatier, Kellicut, Brianna Sheppard, Brown, & Robinson, 2014
In animals, cue attraction predicts cue-induced reinstatement of nicotine self-administration, while nicotine administration enhances cue-induced approach behavior, an effect disrupted by dopamine antagonists.
“Similarly in animals, cue attraction predicts cue-induced reinstatement of nicotine self-administration, while in converse, nicotine administration enhances cue-induced approach behavior (Palmatier, Kellicut, Brianna Sheppard, Brown, & Robinson, 2014; Versaggi, King, & Meyer, 2016), an effect which is disrupted by dopamine antagonists (Palmatier et al., 2014).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Palmatier et al., 2014
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Cites
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564 · see citing works
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127 · see citing works
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
Nicotine replacement therapy for smoking cessation
Stead, L. F., Perera, R., Bullen, C., Mant, D., Hartmann‐Boyce, J., Cahill, K., & Lancaster, T. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000146.pub4 · Cited by 2,514 · see citing works
Dissecting components of reward: ‘liking’, ‘wanting’, and learning
Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.014 · Cited by 1,942 · see citing works
Subsecond dopamine release promotes cocaine seeking
Phillips, P. E. M., Stuber, G. D., Heien, M. L. A. V., Wightman, R. M., & Carelli, R. M. (2003) · Nature · doi:10.1038/nature01476 · Cited by 1,113 · see citing works
A selective role for dopamine in stimulus-reward learning
Flagel, S. B., Clark, J. J., Robinson, T. E., Mayo, L., Czuj, A., Willuhn, I., Akers, C. A., Clinton, S. M., Phillips, P. E. M., & Akil, H. (2011) · Nature · doi:10.1038/nature09588 · Cited by 1,026 · see citing works
Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli
Mirenowicz, J., & Schultz, W. (1996) · Nature · doi:10.1038/379449a0 · Cited by 829 · see citing works
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
Corrigall, W. A., Franklin, K. B. J., Coen, K. M., & Clarke, P. B. S. (1992) · Psychopharmacology · doi:10.1007/bf02245149 · Cited by 829 · see citing works
Corrigall, W. A., Coen, K. M., & Adamson, K. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)90401-4 · Cited by 740 · see citing works
Dopamine operates as a subsecond modulator of food seeking
Roitman, M. F., Stuber, G. D., Phillips, P. E. M., Wightman, R. M., & Carelli, R. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3823-03.2004 · Cited by 718 · see citing works
Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens
Day, J. J., Roitman, M. F., Wightman, R. M., & Carelli, R. M. (2007) · Nature Neuroscience · doi:10.1038/nn1923 · Cited by 710 · see citing works
Parkinson, J. A., Olmstead, M. C., Burns, L. H., Robbins, T. W., & Everitt, B. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02401.1999 · Cited by 555 · see citing works
Floresco, S. B., Block, A. E., & Tse, M. T. L. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.008 · Cited by 405 · see citing works
Di Ciano, P., Cardinal, R. N., Cowell, R. A., Little, S. J., & Everitt, B. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09471.2001 · Cited by 354 · see citing works
Nicotine and nonnicotine factors in cigarette addiction
Rose, J. E. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0250-x · Cited by 348 · see citing works
Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat.
Pfaus, J. G., & Phillips, A. G. (1991) · Behavioral Neuroscience · doi:10.1037//0735-7044.105.5.727 · Cited by 320 · see citing works
Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat
Pfaus, J. G., & Phillips, A. G. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.5.727 · Cited by 320 · see citing works
Donny, E. C., Chaudhri, N., Caggiula, A. R., Evans-Martin, F. F., Booth, S., Gharib, M. A., Clements, L. A., & Sved, A. F. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1473-3 · Cited by 304 · see citing works
The role of dopamine in the accumbens core in the expression of Pavlovian‐conditioned responses
Saunders, B. T., & Robinson, T. E. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08217.x · Cited by 293 · see citing works
Robinson, D. L., Heien, M. L. A. V., & Wightman, R. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10477.2002 · Cited by 290 · see citing works
Self-citationParkinson, J. A., Dalley, J. W., Cardinal, R. N., Bamford, A., Fehnert, B., Lachenal, G., Rudarakanchana, N., Halkerston, K. M., Robbins, T. W., & Everitt, B. J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00291-7 · Cited by 288 · see citing works
Transient changes in mesolimbic dopamine and their association with ‘reward’
Wightman, R. M., & Robinson, D. L. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01005.x · Cited by 280 · see citing works
Self-citationChaudhri, N., Caggiula, A. R., Donny, E. C., Palmatier, M. I., Liu, X., & Sved, A. F. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0178-1 · Cited by 271 · see citing works
Self-citationThe Role of Nicotine in Smoking: A Dual-Reinforcement Model
Caggiula, A. R., Donny, E. C., Palmatier, M. I., Liu, X., Chaudhri, N., & Sved, A. F. (2008) · Nebraska Symposium on Motivation · doi:10.1007/978-0-387-78748-0_6 · Cited by 226 · see citing works
Self-citationNicotine as a reinforcer in human subjects and laboratory animals
Henningfield, J. E., & Goldberg, S. R. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(83)90405-7 · Cited by 214 · see citing works
Dalley, J. W., Lääne, K., Theobald, D. E. H., Armstrong, H. C., Corlett, P. R., Chudasama, Y., & Robbins, T. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502080102 · Cited by 214 · see citing works
Acquas, E., Carboni, E., Leone, P., & Di Chiara, G. (1989) · Psychopharmacology · doi:10.1007/bf00442800 · Cited by 207 · see citing works
Effects of Nicotine in Experimental Animals and Humans: An Update on Addictive Properties
Foll, B. L., & Goldberg, S. R. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-69248-5_12 · Cited by 194 · see citing works
Tomie, A., Grimes, K. L., & Pohorecky, L. A. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.12.003 · Cited by 176 · see citing works
Brown, H. D., McCutcheon, J. E., Cone, J. J., Ragozzino, M. E., & Roitman, M. F. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07914.x · Cited by 171 · see citing works
Reward uncertainty enhances incentive salience attribution as sign-tracking
Anselme, P., Robinson, M. J. F., & Berridge, K. C. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.006 · Cited by 170 · see citing works
The phasic reward signal of primate dopamine neurons
Schultz, W. (1997) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)60841-8 · Cited by 169 · see citing works
Palmatier, M. I., Evans-Martin, F. F., Hoffman, A., Caggiula, A. R., Chaudhri, N., Donny, E. C., Liu, X., Booth, S., Gharib, M. A., Craven, L., et al. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0183-4 · Cited by 169 · see citing works
Self-citationPhillips, A. G., & Fibiger, H. C. (1979) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(79)90328-9 · Cited by 166 · see citing works
Individual variation in resisting temptation: Implications for addiction
Saunders, B. T., & Robinson, T. E. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.008 · Cited by 165 · see citing works
Nicotine enhances responding with conditioned reinforcement
Olausson, P., Jentsch, J. D., & Taylor, J. R. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1575-y · Cited by 141 · see citing works
Chaudhri, N., Caggiula, A. R., Donny, E. C., Booth, S., Gharib, M., Craven, L., Palmatier, M. I., Liu, X., & Sved, A. F. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0522-0 · Cited by 123 · see citing works
Self-citationHolland, P. C. (1979) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037//0097-7403.5.2.178 · Cited by 109 · see citing works
Repeated nicotine exposure enhances responding with conditioned reinforcement
Olausson, P., Jentsch, J. D., & Taylor, J. R. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1702-9 · Cited by 101 · see citing works
Chaudhri, N., Caggiula, A. R., Donny, E. C., Booth, S., Gharib, M. A., Craven, L., Palmatier, M. I., Liu, X., & Sved, A. F. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0454-8 · Cited by 96 · see citing works
Self-citationThe D1 dopamine receptor antagonist, SCH 23390 reduces locomotor activity and rearing in rats
Hoffman, D. C., & Beninger, R. J. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90401-0 · Cited by 93 · see citing works
Peartree, N. A., Hood, L. E., Thiel, K. J., Sanabria, F., Pentkowski, N. S., Chandler, K. N., & Neisewander, J. L. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.10.001 · Cited by 90 · see citing works
Besheer, J., Palmatier, M. I., Metschke, D. M., & Bevins, R. A. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1621-9 · Cited by 85 · see citing works
Self-citationHolland, P. C. (1979) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.5.2.178 · Cited by 84 · see citing works
Meck, W. H., Cheng, R., MacDonald, C. J., Gainetdinov, R. R., Caron, M. G., & Çevik, M. Ö. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.042 · Cited by 76 · see citing works
Reinforcement enhancing effects of nicotine via smoking
Perkins, K. A., & Karelitz, J. L. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3054-4 · Cited by 74 · see citing works
Reinforcement enhancing effect of nicotine and its attenuation by nicotinic antagonists in rats
Liu, X., Palmatier, M. I., Caggiula, A. R., Donny, E. C., & Sved, A. F. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0863-3 · Cited by 72 · see citing works
Self-citationOdum, L. E., O’Dell, K. A., & Schepers, J. S. (2012) · Journal of Pharmacy Practice · doi:10.1177/0897190012451909 · Cited by 68 · see citing works
Rats prefer cocaine over nicotine in a two-lever self-administration choice test
Manzardo, A. M., Stein, L., & Belluzzi, J. D. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03215-2 · Cited by 67 · see citing works
Nomifensine amplifies subsecond dopamine signals in the ventral striatum of freely‐moving rats
Robinson, D. L., & Wightman, R. M. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02559.x · Cited by 67 · see citing works
Self-citationRecent and Remote Extinction Cues Reduce Spontaneous Recovery
Brooks, D. C. (2000) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/027249900392986 · Cited by 67 · see citing works
Cue-Reactors: Individual Differences in Cue-Induced Craving after Food or Smoking Abstinence
Mahler, S. V., & de Wit, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015475 · Cited by 66 · see citing works
Uslaner, J. M., Dell’Orco, J., Pevzner, A., & Robinson, T. E. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301653 · Cited by 61 · see citing works
Ivanova, S. А., & Greenshaw, A. J. (1997) · Psychopharmacology · doi:10.1007/s002130050441 · Cited by 60 · see citing works
Reinforcing effects of nicotine as a function of smoking status.
Perkins, K. A., Gerlach, D., Broge, M., Fonte, C. A., & Wilson, A. S. (2001) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.9.3.243 · Cited by 60 · see citing works
Palmatier, M. I., Liu, X., Donny, E. C., Caggiula, A. R., & Sved, A. F. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301623 · Cited by 57 · see citing works
Self-citationPalmatier, M. I., Marks, K. R., Jones, S. A., Freeman, K. S., Wissman, K. M., & Sheppard, A. B. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2892-9 · Cited by 50 · see citing works
Self-citationGore, B. B., & Zweifel, L. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5532-12.2013 · Cited by 50 · see citing works
Nicotine serves as a feature-positive modulator of Pavlovian appetitive conditioning in rats
Palmatier, M. I., Peterson, J., Wilkinson, J. L., & Bevins, R. A. (2004) · Behavioural Pharmacology · doi:10.1097/01.fbp.0000132915.11693.8e · Cited by 48 · see citing works
Self-citationChen, H., Sharp, B. M., Matta, S. G., & Wu, Q. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.149 · Cited by 47 · see citing works
Palmatier, M. I., O’Brien, L. C., & Hall, M. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2439-5 · Cited by 38 · see citing works
Self-citationSharf, R., Lee, D. Y., & Ranaldi, R. (2005) · Brain Research · doi:10.1016/j.brainres.2004.11.041 · Cited by 32 · see citing works
Krause, M. A., Cusato, B., & Domjan, M. P. (2003) · Journal of comparative psychology · doi:10.1037/0735-7036.117.1.76 · Cited by 31 · see citing works
Reinforcing Effects of Smoking: More Than a Feeling
Lerman, C. E., & Audrain-McGovern, J. E. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.02.014 · Cited by 29 · see citing works
Perkins, K. A., & Karelitz, J. L. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.05.016 · Cited by 27 · see citing works
Reinforcing effects of nicotine as a function of smoking status.
Perkins, K. A., Gerlach, D., Broge, M., et al. (2001) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.9.3.243 · Cited by 27 · see citing works
Palmatier, M. I., & Bevins, R. A. (2002) · Neuropsychobiology · doi:10.1159/000048682 · Cited by 24 · see citing works
Self-citationEuphoriant effects of nicotine in smokers: fact or artifact?
Dar, R., Kaplan, R., Shaham, L., & Frenk, H. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0662-2 · Cited by 22 · see citing works
Sheppard, A. B., Lehmann, J., Cope, Z. A., & Brown, R. W. (2009) · Behavioral Neuroscience · doi:10.1037/a0017536 · Cited by 16 · see citing works
Self-citationConditional discrimination: the role of CS-alone trials
Bueno, J. L. O., & Moreira, R. D. C. M. (1998) · Behavioural Processes · doi:10.1016/s0376-6357(97)00060-0 · Cited by 11 · see citing works
Agu�, C. (1972) · Psychopharmacology · doi:10.1007/bf00403651 · Cited by 10 · see citing works
Timing Information Provided by Trial-Stimulus Onset and Offset in a Sign-Tracking Procedure
Christian, B. J., Hurst, P. W., Allred, T., & Palya, W. L. (1983) · Perceptual and Motor Skills · doi:10.2466/pms.1983.57.3f.1119 · Cited by 1 · see citing works
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“…of nicotine self-administration, while conversely, nicotine administration enhances cue-induced approach behavior (Palmatier, Kellicut, Brianna Sheppard, Brown, & Robinson, 2014; Versaggi, King, & Meyer, 2016), an effect that is disrupted by dopamine antagonists (Palmatier et al., 2014).”
Versaggi, C. L., King, C. P., & Meyer, P. J. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4341-7 · Cited by 60 · see citing works
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Madayag, A. C., Stringfield, S. J., Reissner, K. J., Boettiger, C. A., & Robinson, D. L. (2017) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.13354 · Cited by 50 · see citing works
Self-citationYager, L. M., & Robinson, T. E. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3962-6 · Cited by 34 · see citing works
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Palmatier, M. I., Smith, A. L., Odineal, E. M., Williams, E. A., Sheppard, A. B., & Bradley, C. A. (2019) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntz053 · Cited by 28 · see citing works
Self-citationEffects of nicotine self-administration on incentive salience in male Sprague Dawley rats
Overby, P. F., Daniels, C. W., Franco, A. P. D., Goenaga, J. G., Powell, G. L., Gipson, C. D., & Sanabria, F. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4829-4 · Cited by 24 · see citing works
Loney, G. C., King, C. P., & Meyer, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-81955-5 · Cited by 24 · see citing works
Fiorenza, A. M., Shnitko, T. A., Sullivan, K. M., Vemuru, S. R., Gómez‐A, A., Esaki, J. Y., Boettiger, C. A., Cunha, C. D., & Robinson, D. L. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13636 · Cited by 20 · see citing works
Self-citationOrbitofrontal participation in sign- and goal-tracking conditioned responses: Effects of nicotine
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Self-citationRussell, T. I., & Robinson, M. J. F. (2019) · Behavioral Neuroscience · doi:10.1037/bne0000311 · Cited by 17 · see citing works
Lynch, W. J., Bakhti‐Suroosh, A., Abel, J. M., & Davis, C. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05732-4 · Cited by 13 · see citing works
Garcia‐Rivas, V., Fiancette, J.-F., Cannella, N., Carbo‐Gas, M., Renault, P., Tostain, J., & Deroche‐Gamonet, V. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00159 · Cited by 12 · see citing works
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The incentive amplifying effects of nicotine: Roles in alcohol seeking and consumption
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Khoo, S. Y., Uhrig, A., Samaha, A., & Chaudhri, N. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113238 · Cited by 5 · see citing works
Maddux, J.-M. N., Gonzales, L., & Kregar, N. P. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1004368 · Cited by 2 · see citing works
Pochapski, J. A., Gómez‐A, A., Stringfield, S. J., Jaggers, H., Boettiger, C. A., Cunha, C. D., & Robinson, D. L. (2024) · Scientific Reports · doi:10.1038/s41598-024-64036-1 · Cited by 1 · see citing works
Self-citationLópez, S., & Luís, J. (2019) · Cited by 1 · see citing works
- Authors
- Palmatier, M. I., Kellicut, M. R., Brianna Sheppard, A., Brown, R. W., & Robinson, D. L.
- Affiliations
- East Tennessee State University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Palmatier, Matthew I.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 126
- Pages
- 50-62
- ISSN
- 0091-3057 (ISSN-L)
- PMC
- PMC4440414
- OpenAlex
- W2045356156
- Cited by
- 21
- References
- 71
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- Digital Commons - East Tennessee State University (East Tennessee State University) (submittedVersion)
- UNC Libraries
- Funders
- East Tennessee State University — Office of Research and Sponsored Programs
- NIAAA (P60 AA011605)
- UNC Bowles Center for Alcohol Studies
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotine, incentive motivation, sign-tracking, goal tracking, Pavlovian conditioned approach, dopamine antagonists, mesolimbic dopamine system, dopamine D1 receptor, D2/D3 dopamine receptors, SCH 23390, eticlopride, flupenthixol, psychostimulants
- MeSH terms
- Central Nervous System Stimulants, Animals, Benzazepines, Conditioning, Classical, Cues, Dose-Response Relationship, Drug, Drug Interactions, Flupenthixol, Male, Nicotine, Reinforcement, Psychology, Salicylamides, Dopamine Antagonists, Rats
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