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Risk factor SORL1: from genetic association to functional validation in Alzheimer’s disease

Andersen, Olav M., Rudolph, Ina-Maria, Willnow, Thomas E.·2016·Acta Neuropathologica
DOI 10.1007/s00401-016-1615-4PMC PMC5073117
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  • SorLA is involved in the trafficking and recycling of APP; by binding to the retromer complex, SorLA redirects APP from early endosomes back to the Golgi apparatus, reducing amyloidogenic processing of APP.

    “First, SorLA is involved in the trafficking and recycling of APP. By binding to the retromer complex, SorLA redirects APP from the early endosomes back to the Golgi apparatus through the recycling pathway. This in turn results to reduced amyloidogenic processing of APP, by preventing it from being targeted to the late endosome compartments, where APP is cleaved into Aβ by the β- and γ-secretases.”

    From Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease (2021) · cites this paper as [20]

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Metadata

Authors
Andersen, O. M., Rudolph, I.-M., & Willnow, T. E.
Venue
Acta Neuropathologica
Publisher
Springer Science and Business Media LLC
Published
2016-09-16
Volume
132
Issue
5
Pages
653-665
ISSN
  • 0001-6322
  • 1432-0533
DOI
10.1007/s00401-016-1615-4
PMC
PMC5073117
Cited by
83
References
12
Language
en
Licence
creativecommons.org/licenses/by/4.0 (unspecified)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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