Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis
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There is growing evidence of activated microglia and inflammatory processes in the cerebral cortex in amyotrophic lateral sclerosis (ALS). Activated microglia is characterized by increased expression of the 18 kDa translocator protein (TSPO) in the brain and may be a useful biomarker of inflammation. In this study, we evaluated neuroinflammation in ALS patients using a radioligand of TSPO, (18)F-DPA-714. Ten patients with probable or definite ALS (all right-handed, without dementia, and untreated by riluzole or other medication that might bias the binding on the TSPO), were enrolled prospectively and eight healthy controls matched for age underwent a PET study. Comparison of the distribution volume ratios between both groups were performed using a Mann-Whitney's test. Significant increase of distribution of volume ratios values corresponding to microglial activation was found in the ALS sample in primary motor, supplementary motor and temporal cortex (p = 0.009, p = 0.001 and p = 0.004, respectively). These results suggested that the cortical uptake of (18)F-DPA-714 was increased in ALS patients during the "time of diagnosis" phase of the disease. This finding might improve our understanding of the pathophysiology of ALS and might be a surrogate marker of efficacy of treatment on microglial activation.
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Elevated macrophage markers in ALS CSF are presumably due to increased CNS microglia or their activation.
“presumably due to increased CNS microglia or their activation, as suggested by positron emission tomography (PET) imaging using radiotracers specific for activated microglia [423,424].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [423]
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- Authors
- Corcia, P., Tauber, C., Vercoullie, J., Arlicot, N., Prunier, C., Praline, J., Nicolas, G., Venel, Y., Hommet, C., Baulieu, J.-L., Cottier, J.-P., Roussel, C., Kassiou, M., Guilloteau, D., & Ribeiro, M.-J.
- Affiliations
- Université de Tours (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- Corresponding author
- Corcia, Philippe
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-12-31
- Volume
- 7
- Issue
- 12
- Pages
- e52941
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3534121
- OpenAlex
- W2051387942
- Cited by
- 249
- References
- 42
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 8 · 2023: 13 · 2022: 19 · 2021: 28 · 2020: 28 · 2019: 20 · 2018: 13 · 2017: 21 · 2016: 23 · 2015: 23 · 2014: 25 · 2013: 6
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
- Funders
- FP7 Health (FP7/2007-2013)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- amyotrophic lateral sclerosis, microglial activation, neuroinflammation, translocator protein (TSPO), [18F]DPA-714, positron emission tomography, distribution volume ratio, cerebral cortex, primary motor cortex, supplementary motor area, temporal cortex, biomarkers
- MeSH terms
- Aged, Amyotrophic Lateral Sclerosis, Brain, Female, Humans, Inflammation, Male, Middle Aged, Radionuclide Imaging, Microglia, Receptors, GABA, Molecular Imaging, Neuroimaging
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